Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 25 to 36 of 77 entries
Sorted by: Best Match Show Resources per page
Mitotic recombination between homologous chromosomes drives genomic diversity in diatoms.

Current biology : CB

Bulankova P, Sekulić M, Jallet D, Nef C, van Oosterhout C, Delmont TO, Vercauteren I, Osuna-Cruz CM, Vancaester E, Mock T, Sabbe K, Daboussi F, Bowler C, Vyverman W, Vandepoele K, De Veylder L.
PMID: 34102110
Curr Biol. 2021 Aug 09;31(15):3221-3232.e9. doi: 10.1016/j.cub.2021.05.013. Epub 2021 Jun 07.

Diatoms, an evolutionarily successful group of microalgae, display high levels of intraspecific genetic variability in natural populations. However, the contribution of various mechanisms generating such diversity is unknown. Here we estimated the genetic micro-diversity within a natural diatom population...

Diversity, prevalence, and expression of cyanase genes (cynS) in planktonic marine microorganisms.

The ISME journal

Mao X, Chen J, van Oosterhout C, Zhang H, Liu G, Zhuang Y, Mock T.
PMID: 34408267
ISME J. 2021 Aug 18; doi: 10.1038/s41396-021-01081-y. Epub 2021 Aug 18.

Cyanate is utilized by many microbes as an organic nitrogen source. The key enzyme for cyanate metabolism is cyanase, converting cyanate to ammonium and carbon dioxide. Although the cyanase gene cynS has been identified in many species, the diversity,...

Correction to 'Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer'.

NAR cancer

Wiegmans AP, Ward A, Ivanova E, Duijf PHG, Adams MN, Najib IM, Van Oosterhout R, Sadowski MC, Kelly G, Morrical SW, O'Byrne K, Lee JS, Richard DJ.
PMID: 34570837
NAR Cancer. 2021 Sep 22;3(3):zcab041. doi: 10.1093/narcan/zcab041. eCollection 2021 Sep.

[This corrects the article DOI: 10.1093/nar/zcab022.].

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium.

Frontiers in genetics

McErlean P, Kelly A, Dhariwal J, Kirtland M, Watson J, Ranz I, Smith J, Saxena A, Cousins DJ, Van Oosterhout A, Solari R, Edwards MR, Johnston SL, Lavender P.
PMID: 33362848
Front Genet. 2020 Dec 10;11:585746. doi: 10.3389/fgene.2020.585746. eCollection 2020.

BACKGROUND: Asthma is a chronic airway disease driven by complex genetic-environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.METHODS: We piloted genome-wide profiling of the enhancer-associated histone modification H3K27ac in BECs...

Mitotic recombination between homologous chromosomes drives genomic diversity in diatoms.

Current biology : CB

Bulankova P, Sekulić M, Jallet D, Nef C, van Oosterhout C, Delmont TO, Vercauteren I, Osuna-Cruz CM, Vancaester E, Mock T, Sabbe K, Daboussi F, Bowler C, Vyverman W, Vandepoele K, De Veylder L.
PMID: 34102110
Curr Biol. 2021 Aug 09;31(15):3221-3232.e9. doi: 10.1016/j.cub.2021.05.013. Epub 2021 Jun 07.

Diatoms, an evolutionarily successful group of microalgae, display high levels of intraspecific genetic variability in natural populations. However, the contribution of various mechanisms generating such diversity is unknown. Here we estimated the genetic micro-diversity within a natural diatom population...

Identification of asthma associated microRNAs in bronchial biopsies.

The European respiratory journal

Roffel MP, Boudewijn IM, van Nijnatten JLL, Faiz A, Vermeulen CJ, van Oosterhout AJ, Affleck K, Timens W, Bracke KR, Maes T, Heijink IH, Brandsma CA, van den Berge M.
PMID: 34446467
Eur Respir J. 2021 Aug 26; doi: 10.1183/13993003.01294-2021. Epub 2021 Aug 26.

Changes in microRNA (miRNA) expression can contribute to the pathogenesis of many diseases, including asthma. We aimed to identify miRNAs that are differentially expressed between asthma patients and healthy controls and explored their association with clinical and inflammatory parameters...

Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer.

NAR cancer

Wiegmans AP, Ward A, Ivanova E, Duijf PHG, Adams MN, Najib IM, Van Oosterhout R, Sadowski MC, Kelly G, Morrical SW, O'Byrne K, Lee JS, Richard DJ.
PMID: 34316709
NAR Cancer. 2021 Jun 15;3(2):zcab022. doi: 10.1093/narcan/zcab022. eCollection 2021 Jun.

Chemotherapy is used as a standard-of-care against cancers that display high levels of inherent genome instability. Chemotherapy induces DNA damage and intensifies pressure on the DNA repair pathways that can lead to deregulation. There is an urgent clinical need...

The National Evaluation of Malawi's PMTCT Program (NEMAPP) study: 24-month HIV-exposed infant outcomes from a prospective cohort study.

HIV medicine

van Lettow M, Tippett Barr BA, van Oosterhout JJ, Schouten E, Jahn A, Kalua T, Auld A, Nyirenda R, Wadonda N, Kim E, Landes M.
PMID: 34970836
HIV Med. 2021 Dec 30; doi: 10.1111/hiv.13209. Epub 2021 Dec 30.

OBJECTIVES: Data on long-term HIV-free survival in breastfeeding, HIV-exposed infants (HEIs) are limited. The National Evaluation of Malawi's Prevention of Mother-to-Child Transmission (PMTCT) Program (NEMAPP), conducted between 2014 and 2018, evaluated mother-to-child transmission (MTCT) and infant outcomes up to...

Regression discontinuity analysis demonstrated varied effect of Treat-All on CD4 testing among Southern African countries.

Journal of clinical epidemiology

Zaniewski E, Brazier E, Ostinelli CHD, Wood R, Osler M, Technau KG, van Oosterhout JJ, Maxwell N, van Dijk J, Prozesky H, Fox MP, Bor J, Nash D, Egger M.
PMID: 34487837
J Clin Epidemiol. 2021 Dec;140:101-110. doi: 10.1016/j.jclinepi.2021.09.001. Epub 2021 Sep 03.

OBJECTIVE: To determine whether Treat-All policy impacted laboratory testing practices of antiretroviral therapy (ART) programs in Southern Africa.STUDY DESIGN AND SETTING: We used HIV cohort data from Lesotho, Malawi, Mozambique, South Africa, Zambia and Zimbabwe in a regression discontinuity...

Drug-Drug Interaction Potential with Once-Weekly Isoniazid/Rifapentine (3HP) for the Treatment of Latent Tuberculosis Infection.

Clinical pharmacokinetics

Marzolini C, Gibbons S, van Oosterhout JJ, Khoo S.
PMID: 34905153
Clin Pharmacokinet. 2021 Dec 14; doi: 10.1007/s40262-021-01098-8. Epub 2021 Dec 14.

No abstract available.

Sex-specific differences and how to handle them in early psoriatic arthritis.

Arthritis research & therapy

Passia E, Vis M, Coates LC, Soni A, Tchetverikov I, Gerards AH, Kok MR, Vos PAJM, Korswagen L, Fodili F, Goekoop-Ruiterman YPM, van der Kaap J, van Oosterhout M, Luime JJ.
PMID: 35016726
Arthritis Res Ther. 2022 Jan 11;24(1):22. doi: 10.1186/s13075-021-02680-y.

OBJECTIVES: The prevalence of psoriatic arthritis (PsA) is the same in men and women; however, the latter experience a higher burden of disease and are affected more frequently by polyarthritis. Here, we performed an early PsA cohort analysis to...

Remote robotic endovascular thrombectomy for acute ischaemic stroke.

BMJ neurology open

Singer J, VanOosterhout S, Madder R.
PMID: 34263168
BMJ Neurol Open. 2021 Jun 30;3(1):e000141. doi: 10.1136/bmjno-2021-000141. eCollection 2021.

BACKGROUND: In acute ischaemic stroke, endovascular thrombectomy (ET) significantly reduces disability compared with thrombolytic therapy, but access to ET is currently limited. Leveraging telerobotic technology to disseminate neurosurgical expertise could increase access to ET. This proof-of-concept evaluation was performed...

Showing 25 to 36 of 77 entries