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Showing 73 to 84 of 98 entries
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Targeting the Y-box Binding Protein-1 Axis to Overcome Radiochemotherapy Resistance in Solid Tumors.

International journal of radiation oncology, biology, physics

Lettau K, Khozooei S, Kosnopfel C, Zips D, Schittek B, Toulany M.
PMID: 34166770
Int J Radiat Oncol Biol Phys. 2021 Nov 15;111(4):1072-1087. doi: 10.1016/j.ijrobp.2021.06.021. Epub 2021 Jun 21.

Multifunctional Y-box binding protein-1 (YB-1) is highly expressed in different human solid tumors and is involved in various cellular processes. DNA damage is the major mechanism by which radiochemotherapy (RCT) induces cell death. On induction of DNA damage, a...

Hypofractionated preoperative radiotherapy for high risk soft tissue sarcomas in a geriatric patient population.

Radiology and oncology

Potkrajcic V, Traub F, Hermes B, Scharpf M, Kolbenschlag J, Zips D, Paulsen F, Eckert F.
PMID: 34821137
Radiol Oncol. 2021 Nov 19;55(4):459-466. doi: 10.2478/raon-2021-0038.

BACKGROUND: Standard therapy for localised, resectable high risk soft tissue sarcomas consists of wide excision and radiotherapy over several weeks. This treatment schedule is hardly feasible in geriatric and frail patients. In order not to withhold radiotherapy from these...

Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy.

International journal of cancer

Tawk B, Wirkner U, Schwager C, Rein K, Zaoui K, Federspil PA, Adeberg S, Linge A, Ganswindt U, Hess J, Unger K, Tinhofer I, Budach V, Lohaus F, Krause M, Guberina M, Stuschke M, Balermpas P, Rödel C, Grosu AL, Schäfer H, Zips D, Combs SE, Pigorsch S, Zitzelsberger H, Baumeister P, Kirchner T, Bewerunge-Hudler M, Weichert W, Hess J, Herpel E, Belka C, Baumann M, Debus J, Abdollahi A.
PMID: 34648658
Int J Cancer. 2022 Feb 15;150(4):603-616. doi: 10.1002/ijc.33842. Epub 2021 Nov 08.

Biomarkers with relevance for loco-regional therapy are needed in human papillomavirus negative aka HPV(-) head and neck squamous cell carcinoma (HNSCC). Based on the premise that DNA methylation pattern is highly conserved, we sought to develop a reliable and...

Correction: ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy.

The pharmacogenomics journal

Guberina M, Sak A, Pöttgen C, Tinhofer-Keilholz I, Budach V, Balermpas P, Von der Grün J, Rödel CM, Gkika E, Grosu AL, Abdollahi A, Debus J, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, De-Colle C, Welz S, Linge A, Lohaus F, Baretton G, Gauler T, Baumann M, Krause M, Schuler M, Bankfalvi A, Höing B, Lang S, Stuschke M.
PMID: 33009516
Pharmacogenomics J. 2021 Apr;21(2):273. doi: 10.1038/s41397-020-00193-6.

No abstract available.

Differential transcription profiling of the phage LUZ19 infection process in different growth media.

RNA biology

Brandão A, Pires DP, Coppens L, Voet M, Lavigne R, Azeredo J.
PMID: 33448239
RNA Biol. 2021 Nov;18(11):1778-1790. doi: 10.1080/15476286.2020.1870844. Epub 2021 Jan 15.

RNA sequencing of phage-infected bacterial cultures offers a snapshot of transcriptional events occurring during the infection process, providing insights into the phage transcriptional organization as well as the bacterial response. To better mimic real environmental contexts, we performed RNA-seq...

Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator.

Clinical and translational radiation oncology

De-Colle C, Nachbar M, Mӧnnich D, Boeke S, Gani C, Weidner N, Heinrich V, Winter J, Tsitsekidis S, Dohm O, Zips D, Thorwarth D.
PMID: 33553697
Clin Transl Radiat Oncol. 2021 Jan 22;27:103-108. doi: 10.1016/j.ctro.2020.12.005. eCollection 2021 Mar.

INTRODUCTION: The hybrid magnetic resonance linear accelerator (MRL) has the potential to test novel concepts in breast cancer patients such as daily MR-guided real-time plan adaptation. Before starting clinical trials, preparatory studies for example of the MR-dependent electron stream...

[(CF3)4Au2(C5H5N)2]--a new alkyl gold(II) derivative with a very short Au-Au bond.

Chemical communications (Cambridge, England)

Zopes D, Hegemann C, Tyrra W, Mathur S.
PMID: 22836874
Chem Commun (Camb). 2012 Sep 11;48(70):8805-7. doi: 10.1039/c2cc33735e. Epub 2012 Jul 26.

A new gold(II) species [(CF(3))(4)Au(2)(C(5)H(5)N)(2)] with a very short unsupported Au-Au bond (250.62(9) pm) was generated by photo irradiation of a silver aurate, [Ag(Py)(2)][Au(CF(3))(2)], unambiguously characterized by (19)F and (109)Ag NMR studies.

Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations : An overview and recommendations of the consortium academic radiation oncology of the German Society for Radiation Oncology (DEGRO).

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Dapper H, Belka C, Bock F, Budach V, Budach W, Christiansen H, Debus J, Distel L, Dunst J, Eckert F, Eich H, Eicheler W, Engenhart-Cabillic R, Fietkau R, Fleischmann DF, Frerker B, Giordano FA, Grosu AL, Herfarth K, Hildebrandt G, Kaul D, Kölbl O, Krause M, Krug D, Martin D, Matuschek C, Medenwald D, Nicolay NH, Niewald M, Oertel M, Petersen C, Pohl F, Raabe A, Rödel C, Rübe C, Schmalz C, Schmeel LC, Steinmann D, Stüben G, Thamm R, Vordermark D, Vorwerk H, Wiegel T, Zips D, Combs SE.
PMID: 34786605
Strahlenther Onkol. 2021 Nov 16; doi: 10.1007/s00066-021-01861-7. Epub 2021 Nov 16.

The new Medical Licensing Regulations 2025 (Ärztliche Approbationsordnung, ÄApprO) will soon be passed by the Federal Council (Bundesrat) and will be implemented step by step by the individual faculties in the coming months. The further development of medical studies...

Automatic 3D Monte-Carlo-based secondary dose calculation for online verification of 1.5 T magnetic resonance imaging guided radiotherapy.

Physics and imaging in radiation oncology

Nachbar M, Mönnich D, Dohm O, Friedlein M, Zips D, Thorwarth D.
PMID: 34307914
Phys Imaging Radiat Oncol. 2021 Jun 21;19:6-12. doi: 10.1016/j.phro.2021.05.002. eCollection 2021 Jul.

BACKGROUND AND PURPOSE: Hybrid magnetic resonance linear accelerator (MR-Linac) systems represent a novel technology for online adaptive radiotherapy. 3D secondary dose calculation (SDC) of online adapted plans is required to assure patient safety. Currently, no 3D-SDC solution is available...

Analyses of molecular subtypes and their association to mechanisms ofradioresistance in patients with HPV-negative HNSCC treated bypostoperative radiochemotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Patil S, Tawk B, Grosser M, Lohaus F, Gudziol V, Kemper M, Nowak A, Haim D, Tinhofer I, Budach V, Guberina M, Stuschke M, Balermpas P, Rödel C, Schäfer H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Boeke S, Zips D, Baretton GB, Baumann M, Krause M, Löck S, Linge A.
PMID: 34999136
Radiother Oncol. 2022 Jan 06; doi: 10.1016/j.radonc.2021.12.049. Epub 2022 Jan 06.

PURPOSE: To assess the relation of the previously reported classification of molecular subtypes to the outcome of patients with HNSCC treated with postoperative radio(chemo)therapy (PORT-C), and to assess the association of these subtypes with gene expressions reflecting known mechanisms...

Effect of Severe Water Stress on Aspects of Crassulacean Acid Metabolism in Xerosicyos.

Plant physiology

Bastide B, Sipes D, Hann J, Ting IP.
PMID: 12232003
Plant Physiol. 1993 Dec;103(4):1089-1096. doi: 10.1104/pp.103.4.1089.

Xerosicyos danguyi H.Humb. (Cucurbitaceae) is a Crassulacean acid metabolism (CAM) species native to Madagascar. Previously, it was shown that when grown under good water conditions, it is a typical CAM plant, but when water stressed, it shifts to a...

Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing.

Cell systems

Ando H, Lemire S, Pires DP, Lu TK.
PMID: 26973885
Cell Syst. 2015 Sep 23;1(3):187-196. doi: 10.1016/j.cels.2015.08.013.

Bacteria are central to human health and disease, but existing tools to edit microbial consortia are limited. For example, broad-spectrum antibiotics are unable to accurately manipulate bacterial communities. Bacteriophages can provide highly specific targeting of bacteria, but assembling well-defined...

Showing 73 to 84 of 98 entries