UI Index

Salvage-Radiation Therapy and Regional Hyperthermia for Biochemically Recurrent Prostate Cancer after Radical Prostatectomy (Results of the Planned Interim Analysis).

Cancers

Beck M, Ghadjar P, Mehrhof F, Zips D, Paulsen F, Wegener D, Burock S, Kaul D, Stromberger C, Nadobny J, Ott OJ, Fietkau R, Budach V, Wust P, Müller AC, Zschaeck S.
PMID: 33800872
Cancers (Basel). 2021 Mar 06;13(5). doi: 10.3390/cancers13051133.

Efforts to improve the outcome of prostate cancer (PC) patients after radical prostatectomy (RP) include adjuvant or salvage radiation therapy (SRT), but still up to 50% of patients develop a disease progression after radiotherapy (RT). Regional hyperthermia (HT) is...

Moderately hypofractionated radiotherapy as definitive treatment for localized prostate cancer: Pattern of practice in German-speaking countries : A survey of the Prostate Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO) and the Working Party on Radiation Oncology of the German Cancer Society (DKG-ARO).

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Shelan M, Aebersold DM, Albrecht C, Böhmer D, Flentje M, Ganswindt U, Höcht S, Hölscher T, Müller AC, Niehoff P, Pinkawa M, Schmidt-Hegemann NS, Sedlmayer F, Wolf F, Zamboglou C, Zips D, Wiegel T, Ghadjar P.
PMID: 34463814
Strahlenther Onkol. 2021 Nov;197(11):993-1000. doi: 10.1007/s00066-021-01820-2. Epub 2021 Aug 31.

PURPOSE: Various randomized phase III clinical trials have compared moderately hypofractionated to normofractionated radiotherapy (RT). These modalities showed similar effectiveness without major differences in toxicity. This project was conducted by the Prostate Cancer Expert Panel of the German Society...

Next-Generation Sequencing of Advanced GI Tumors Reveals Individual Treatment Options.

JCO precision oncology

Bitzer M, Ostermann L, Horger M, Biskup S, Schulze M, Ruhm K, Hilke F, Öner Ö, Nikolaou K, Schroeder C, Riess O, Fend F, Zips D, Hinterleitner M, Zender L, Tabatabai G, Beha J, Malek NP.
PMID: 32923905
JCO Precis Oncol. 2020 Mar 30;4. doi: 10.1200/PO.19.00359. eCollection 2020.

PURPOSE: Precision oncology connects highly complex diagnostic procedures with patient histories to identify individualized treatment options in interdisciplinary molecular tumor boards (MTBs). Detailed data on MTB-guided treatments and outcome with a focus on advanced GI cancers have not been...

Differential transcription profiling of the phage LUZ19 infection process in different growth media.

RNA biology

Brandão A, Pires DP, Coppens L, Voet M, Lavigne R, Azeredo J.
PMID: 33448239
RNA Biol. 2021 Nov;18(11):1778-1790. doi: 10.1080/15476286.2020.1870844. Epub 2021 Jan 15.

RNA sequencing of phage-infected bacterial cultures offers a snapshot of transcriptional events occurring during the infection process, providing insights into the phage transcriptional organization as well as the bacterial response. To better mimic real environmental contexts, we performed RNA-seq...

Correction to: Value of PET imaging for radiation therapy.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Lapa C, Nestle U, Albert NL, Baues C, Beer A, Buck A, Budach V, Bütof R, Combs SE, Derlin T, Eiber M, Fendler WP, Furth C, Gani C, Gkika E, Grosu AL, Henkenberens C, Ilhan H, Löck S, Marnitz-Schulze S, Miederer M, Mix M, Nicolay NH, Niyazi M, Pöttgen C, Rödel CM, Schatka I, Schwarzenboeck SM, Todica AS, Weber W, Wegen S, Wiegel T, Zamboglou C, Zips D, Zöphel K, Zschaeck S, Thorwarth D, Troost EGC.
PMID: 34617130
Strahlenther Onkol. 2022 Jan;198(1):80-82. doi: 10.1007/s00066-021-01851-9.

No abstract available.

Retrospective analysis of recurrence patterns and clinical outcome of grade II meningiomas following postoperative radiotherapy.

Radiation oncology (London, England)

Hoffmann E, Clasen K, Frey B, Ehlers J, Behling F, Skardelly M, Bender B, Schittenhelm J, Reimold M, Tabatabai G, Zips D, Eckert F, Paulsen F.
PMID: 34172069
Radiat Oncol. 2021 Jun 25;16(1):116. doi: 10.1186/s13014-021-01825-2.

BACKGROUND: Atypical meningiomas exhibit a high tendency for tumor recurrence even after multimodal therapy. Information regarding recurrence patterns after additive radiotherapy is scarce but could improve radiotherapy planning and therapy decision. We conducted an analysis of recurrence patterns with...

TRPM8 is required for survival and radioresistance of glioblastoma cells.

Oncotarget

Klumpp D, Frank SC, Klumpp L, Sezgin EC, Eckert M, Edalat L, Bastmeyer M, Zips D, Ruth P, Huber SM.
PMID: 29221175
Oncotarget. 2017 Sep 30;8(56):95896-95913. doi: 10.18632/oncotarget.21436. eCollection 2017 Nov 10.

TRPM8 is a Ca

MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients.

Cancers

Unsoeld M, Lamprecht U, Traub F, Hermes B, Scharpf M, Potkrajcic V, Zips D, Paulsen F, Eckert F.
PMID: 32295076
Cancers (Basel). 2020 Apr 13;12(4). doi: 10.3390/cancers12040959.

No abstract available.

Quantitative, Multi-institutional Evaluation of MR Thermometry Accuracy for Deep-Pelvic MR-Hyperthermia Systems Operating in Multi-vendor MR-systems Using a New Anthropomorphic Phantom.

Cancers

Curto S, Aklan B, Mulder T, Mils O, Schmidt M, Lamprecht U, Peller M, Wessalowski R, Lindner LH, Fietkau R, Zips D, Bellizzi GG, van Holthe N, Franckena M, Paulides MM, van Rhoon GC.
PMID: 31684057
Cancers (Basel). 2019 Nov 02;11(11). doi: 10.3390/cancers11111709.

Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance...

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects .

Oncoimmunology

Eckert F, Jelas I, Oehme M, Huber SM, Sonntag K, Welker C, Gillies SD, Strittmatter W, Zips D, Handgretinger R, Schilbach K.
PMID: 28680762
Oncoimmunology. 2017 Apr 28;6(6):e1323161. doi: 10.1080/2162402X.2017.1323161. eCollection 2017.

NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and differentiation of the tumor cells....

SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy.

Clinical and translational radiation oncology

De-Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Jawad JA, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Bayer C, Belka C, Pigorsch S, Combs SE, Lohaus F, Linge A, Krause M, Baumann M, Zips D, Menegakis A.
PMID: 29594214
Clin Transl Radiat Oncol. 2017 Jul 14;5:28-36. doi: 10.1016/j.ctro.2017.06.004. eCollection 2017 Aug.

INTRODUCTION: Outcome after postoperative radiochemotherapy (RT-CT) for patients with advanced head and neck squamous cell carcinomas (HNSCC) remains unsatisfactory, especially among those with HPV negative tumours. Therefore, new biomarkers are needed to further define subgroups for individualised therapeutic approaches....

Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy.

Clinical and translational radiation oncology

Leibfarth S, Winter RM, Lyng H, Zips D, Thorwarth D.
PMID: 30294681
Clin Transl Radiat Oncol. 2018 Sep 20;13:29-37. doi: 10.1016/j.ctro.2018.09.002. eCollection 2018 Nov.

PURPOSE: To review the potential and challenges of integrating diffusion weighted magnetic resonance imaging (DWI) into radiotherapy (RT).CONTENT: Details related to image acquisition of DWI for RT purposes are discussed, along with the challenges with respect to geometric accuracy...