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In-situ surface-enhanced Raman scattering based on MTi.

Journal of hazardous materials

Quan Y, Su R, Yang S, Chen L, Wei M, Liu H, Yang J, Gao M, Li B.
PMID: 33517057
J Hazard Mater. 2021 Jun 15;412:125209. doi: 10.1016/j.jhazmat.2021.125209. Epub 2021 Jan 22.

Real-time and in-situ monitoring of chemical reactions has attracted great attention in many fields. In this work, we in-situ monitored the photodegradation reaction process of methylene blue (MB) by Surface enhanced Raman scattering (SERS) technique. An effective and versatile...

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Quan Y, Su R, Yang S, et al. In-situ surface-enhanced Raman scattering based on MTi. J Hazard Mater. 2021;412:125209doi: 10.1016/j.jhazmat.2021.125209.
Quan, Y., Su, R., Yang, S., Chen, L., Wei, M., Liu, H., Yang, J., Gao, M., & Li, B. (2021). In-situ surface-enhanced Raman scattering based on MTi. Journal of hazardous materials, 412125209. https://doi.org/10.1016/j.jhazmat.2021.125209
Quan, Yingnan, et al. "In-situ surface-enhanced Raman scattering based on MTi." Journal of hazardous materials vol. 412 (2021): 125209. doi: https://doi.org/10.1016/j.jhazmat.2021.125209
Quan Y, Su R, Yang S, Chen L, Wei M, Liu H, Yang J, Gao M, Li B. In-situ surface-enhanced Raman scattering based on MTi. J Hazard Mater. 2021 Jun 15;412:125209. doi: 10.1016/j.jhazmat.2021.125209. Epub 2021 Jan 22. PMID: 33517057.
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Distance Between the Tumour and Nipple as a Predictor of Axillary Lymph Node Involvement in Breast Cancer.

Cancer management and research

Yang J, Yang Q, Mukherjee A, Lv Q.
PMID: 33469363
Cancer Manag Res. 2021 Jan 11;13:193-199. doi: 10.2147/CMAR.S262413. eCollection 2021.

PURPOSE: The possibility of axillary node metastasis via the lymphatics might be related to a cancer's location within the breast. Previous studies of this topic had small sample sizes, inaccuracies because of subjective differences, and the inability to depict...

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Yang J, Yang Q, Mukherjee A, et al. Distance Between the Tumour and Nipple as a Predictor of Axillary Lymph Node Involvement in Breast Cancer. Cancer Manag Res. 2021;13:193-199doi: 10.2147/CMAR.S262413.
Yang, J., Yang, Q., Mukherjee, A., & Lv, Q. (2021). Distance Between the Tumour and Nipple as a Predictor of Axillary Lymph Node Involvement in Breast Cancer. Cancer management and research, 13193-199. https://doi.org/10.2147/CMAR.S262413
Yang, Jiqiao, et al. "Distance Between the Tumour and Nipple as a Predictor of Axillary Lymph Node Involvement in Breast Cancer." Cancer management and research vol. 13 (2021): 193-199. doi: https://doi.org/10.2147/CMAR.S262413
Yang J, Yang Q, Mukherjee A, Lv Q. Distance Between the Tumour and Nipple as a Predictor of Axillary Lymph Node Involvement in Breast Cancer. Cancer Manag Res. 2021 Jan 11;13:193-199. doi: 10.2147/CMAR.S262413. eCollection 2021. PMID: 33469363; PMCID: PMC7810584.
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Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics.

mAbs

Wei B, Woon N, Dai L, Fish R, Tai M, Handagama W, Yin A, Sun J, Maier A, McDaniel D, Kadaub E, Yang J, Saggu M, Woys A, Pester O, Lambert D, Pell A, Hao Z, Magill G, Yim J, Chan J, Yang L, Macchi F, Bell C, Deperalta G, Chen Y.
PMID: 34965193
MAbs. 2022 Jan-Dec;14(1):2007564. doi: 10.1080/19420862.2021.2007564.

Rapid release of biopharmaceutical products enables a more efficient drug manufacturing process. Multi-attribute methods that target several product quality attributes (PQAs) at one time are an essential pillar of the rapid-release strategy. The novel, high-throughput, and nondestructive multi-attribute Raman...

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Wei B, Woon N, Dai L, et al. Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics. MAbs. 2022;14(1):2007564doi: 10.1080/19420862.2021.2007564.
Wei, B., Woon, N., Dai, L., Fish, R., Tai, M., Handagama, W., Yin, A., Sun, J., Maier, A., McDaniel, D., Kadaub, E., Yang, J., Saggu, M., Woys, A., Pester, O., Lambert, D., Pell, A., Hao, Z., Magill, G., Yim, J., Chan, J., Yang, L., Macchi, F., Bell, C., Deperalta, G., & Chen, Y. (2022). Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics. mAbs, 14(1), 2007564. https://doi.org/10.1080/19420862.2021.2007564
Wei, Bingchuan, et al. "Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics." mAbs vol. 14,1 (2022): 2007564. doi: https://doi.org/10.1080/19420862.2021.2007564
Wei B, Woon N, Dai L, Fish R, Tai M, Handagama W, Yin A, Sun J, Maier A, McDaniel D, Kadaub E, Yang J, Saggu M, Woys A, Pester O, Lambert D, Pell A, Hao Z, Magill G, Yim J, Chan J, Yang L, Macchi F, Bell C, Deperalta G, Chen Y. Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics. MAbs. 2022 Jan-Dec;14(1):2007564. doi: 10.1080/19420862.2021.2007564. PMID: 34965193.
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Identification of differentially expressed long non-coding RNAs in mice intestines after severe burns and a preliminary study into the key gene H19.

Journal of burn care & research : official publication of the American Burn Association

Qiu W, Deng Y, Zhuang M, Wang P, Li C, Li Y, Zhu B, Zhang P, Li D, Sun Y, Yang J, Cao S, Sun Y.
PMID: 33512532
J Burn Care Res. 2021 Jan 29; doi: 10.1093/jbcr/irab017. Epub 2021 Jan 29.

BACKGROUND: The intestine is considered the key organ in stress response to severe burns and injury to intestine after severe burns can be fatal. However, the injury and subsequent repair of intestinal tissues after severe burns at the genetic...

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Qiu W, Deng Y, Zhuang M, et al. Identification of differentially expressed long non-coding RNAs in mice intestines after severe burns and a preliminary study into the key gene H19. J Burn Care Res. 2021;doi: 10.1093/jbcr/irab017.
Qiu, W., Deng, Y., Zhuang, M., Wang, P., Li, C., Li, Y., Zhu, B., Zhang, P., Li, D., Sun, Y., Yang, J., Cao, S., & Sun, Y. (2021). Identification of differentially expressed long non-coding RNAs in mice intestines after severe burns and a preliminary study into the key gene H19. Journal of burn care & research : official publication of the American Burn Association, . https://doi.org/10.1093/jbcr/irab017
Qiu, Wei, et al. "Identification of differentially expressed long non-coding RNAs in mice intestines after severe burns and a preliminary study into the key gene H19." Journal of burn care & research : official publication of the American Burn Association vol. (2021). doi: https://doi.org/10.1093/jbcr/irab017
Qiu W, Deng Y, Zhuang M, Wang P, Li C, Li Y, Zhu B, Zhang P, Li D, Sun Y, Yang J, Cao S, Sun Y. Identification of differentially expressed long non-coding RNAs in mice intestines after severe burns and a preliminary study into the key gene H19. J Burn Care Res. 2021 Jan 29; doi: 10.1093/jbcr/irab017. Epub 2021 Jan 29. PMID: 33512532.
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Profiling T cell receptor β-chain in responders after immunization with recombinant hepatitis B vaccine.

The journal of gene medicine

Yan D, Yang J, Ji Z, Wang J, Lu X, Huang Y, Zhong C, Li L.
PMID: 34048625
J Gene Med. 2021 Sep;23(9):e3367. doi: 10.1002/jgm.3367. Epub 2021 Jun 17.

BACKGROUND: T cells with edited T cell receptor β-chain variable (TRBV) are involved in the immune response to recombinant hepatitis B surface antigen (rHBsAg) vaccine and the production of hepatitis B surface antibody (HBsAb). The immune repertoire (IR) profile...

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Yan D, Yang J, Ji Z, et al. Profiling T cell receptor β-chain in responders after immunization with recombinant hepatitis B vaccine. J Gene Med. 2021;23(9):e3367doi: 10.1002/jgm.3367.
Yan, D., Yang, J., Ji, Z., Wang, J., Lu, X., Huang, Y., Zhong, C., & Li, L. (2021). Profiling T cell receptor β-chain in responders after immunization with recombinant hepatitis B vaccine. The journal of gene medicine, 23(9), e3367. https://doi.org/10.1002/jgm.3367
Yan, Dong, et al. "Profiling T cell receptor β-chain in responders after immunization with recombinant hepatitis B vaccine." The journal of gene medicine vol. 23,9 (2021): e3367. doi: https://doi.org/10.1002/jgm.3367
Yan D, Yang J, Ji Z, Wang J, Lu X, Huang Y, Zhong C, Li L. Profiling T cell receptor β-chain in responders after immunization with recombinant hepatitis B vaccine. J Gene Med. 2021 Sep;23(9):e3367. doi: 10.1002/jgm.3367. Epub 2021 Jun 17. PMID: 34048625.
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Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP).

Bioorganic chemistry

Wang MR, Huang LF, Guo C, Yang J, Dong S, Tang JJ, Gao JM.
PMID: 34894577
Bioorg Chem. 2021 Dec 05;119:105536. doi: 10.1016/j.bioorg.2021.105536. Epub 2021 Dec 05.

Neuroinflammation plays a key etiological role in the progressive neuronal damage of neurodegenerative diseases. Our phenotypic-based screening discovered 1,6-O,O-diacetylbritannilactone (OABL, 1) from Inula britannica exhibited the potential anti-neuroinflammatory activity as well as a favorable blood-brain barrier penetration. 1 and...

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Wang MR, Huang LF, Guo C, et al. Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP). Bioorg Chem. 2021;119:105536doi: 10.1016/j.bioorg.2021.105536.
Wang, M. R., Huang, L. F., Guo, C., Yang, J., Dong, S., Tang, J. J., & Gao, J. M. (2021). Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP). Bioorganic chemistry, 119105536. https://doi.org/10.1016/j.bioorg.2021.105536
Wang, Min-Ran, et al. "Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP)." Bioorganic chemistry vol. 119 (2021): 105536. doi: https://doi.org/10.1016/j.bioorg.2021.105536
Wang MR, Huang LF, Guo C, Yang J, Dong S, Tang JJ, Gao JM. Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP). Bioorg Chem. 2021 Dec 05;119:105536. doi: 10.1016/j.bioorg.2021.105536. Epub 2021 Dec 05. PMID: 34894577.
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Abuse-Tolerant Electrolytes for Lithium-Ion Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Chen Z, Chao Y, Li W, Wallace GG, Bussell T, Ding J, Wang C.
PMID: 34105300
Adv Sci (Weinh). 2021 Jun;8(11):e2003694. doi: 10.1002/advs.202003694. Epub 2021 Mar 18.

Safety issues currently limit the development of advanced lithium-ion batteries (LIBs) and this is exacerbated when they are misused or abused. The addition of small amounts of fillers or additives into common liquid electrolytes can greatly improve resistance to...

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Chen Z, Chao Y, Li W, et al. Abuse-Tolerant Electrolytes for Lithium-Ion Batteries. Adv Sci (Weinh). 2021;8(11):e2003694doi: 10.1002/advs.202003694.
Chen, Z., Chao, Y., Li, W., Wallace, G. G., Bussell, T., Ding, J., & Wang, C. (2021). Abuse-Tolerant Electrolytes for Lithium-Ion Batteries. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(11), e2003694. https://doi.org/10.1002/advs.202003694
Chen, Zhiqi, et al. "Abuse-Tolerant Electrolytes for Lithium-Ion Batteries." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 8,11 (2021): e2003694. doi: https://doi.org/10.1002/advs.202003694
Chen Z, Chao Y, Li W, Wallace GG, Bussell T, Ding J, Wang C. Abuse-Tolerant Electrolytes for Lithium-Ion Batteries. Adv Sci (Weinh). 2021 Jun;8(11):e2003694. doi: 10.1002/advs.202003694. Epub 2021 Mar 18. PMID: 34105300; PMCID: PMC8188208.
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Evaluation of prognostic value of neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure or severe liver injury from chronic HBV infection.

European journal of gastroenterology & hepatology

Sun J, Guo H, Yu X, Chen J, Zhu H, Qi X, Zhang X, Han J, Liu X, Yang J, Wang J, Qian Z, Huang Y, Mao R, Zhang J.
PMID: 34074984
Eur J Gastroenterol Hepatol. 2021 May 31; doi: 10.1097/MEG.0000000000002207. Epub 2021 May 31.

BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) is associated with bacterial infection and poor outcome. Neutrophil-to-lymphocyte ratio (NLR) is used to assess bacterial infection and immune dysfunction in numerous diseases. We aimed to evaluate NLR as a prognostic biomarker...

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Sun J, Guo H, Yu X, et al. Evaluation of prognostic value of neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure or severe liver injury from chronic HBV infection. Eur J Gastroenterol Hepatol. 2021;doi: 10.1097/MEG.0000000000002207.
Sun, J., Guo, H., Yu, X., Chen, J., Zhu, H., Qi, X., Zhang, X., Han, J., Liu, X., Yang, J., Wang, J., Qian, Z., Huang, Y., Mao, R., & Zhang, J. (2021). Evaluation of prognostic value of neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure or severe liver injury from chronic HBV infection. European journal of gastroenterology & hepatology, . https://doi.org/10.1097/MEG.0000000000002207
Sun, Jian, et al. "Evaluation of prognostic value of neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure or severe liver injury from chronic HBV infection." European journal of gastroenterology & hepatology vol. (2021). doi: https://doi.org/10.1097/MEG.0000000000002207
Sun J, Guo H, Yu X, Chen J, Zhu H, Qi X, Zhang X, Han J, Liu X, Yang J, Wang J, Qian Z, Huang Y, Mao R, Zhang J. Evaluation of prognostic value of neutrophil-to-lymphocyte ratio in patients with acute-on-chronic liver failure or severe liver injury from chronic HBV infection. Eur J Gastroenterol Hepatol. 2021 May 31; doi: 10.1097/MEG.0000000000002207. Epub 2021 May 31. PMID: 34074984.
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Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application.

Artificial organs

Yang J, Dang H, Xu Y.
PMID: 34855994
Artif Organs. 2021 Dec 01; doi: 10.1111/aor.14126. Epub 2021 Dec 01.

BACKGROUND: Decellularized extracellular matrixs (dECMs) derived from organs and tissues have emerged as a promising tool, as they encompass the characteristics of an ideal tissue scaffold: complex composition, vascular networks and unique tissue-specific architecture. Consequently, their use has propagated...

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Yang J, Dang H, Xu Y. Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application. Artif Organs. 2021;doi: 10.1111/aor.14126.
Yang, J., Dang, H., & Xu, Y. (2021). Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application. Artificial organs, . https://doi.org/10.1111/aor.14126
Yang, Jiamin, et al. "Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application." Artificial organs vol. (2021). doi: https://doi.org/10.1111/aor.14126
Yang J, Dang H, Xu Y. Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application. Artif Organs. 2021 Dec 01; doi: 10.1111/aor.14126. Epub 2021 Dec 01. PMID: 34855994.
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Tailoring the Electronic Structure of an Atomically Dispersed Zinc Electrocatalyst: Coordination Environment Regulation for High Selectivity Oxygen Reduction.

Angewandte Chemie (International ed. in English)

Jia Y, Xue Z, Yang J, Liu Q, Xian J, Zhong Y, Sun Y, Zhang X, Liu Q, Yao D, Li G.
PMID: 34716639
Angew Chem Int Ed Engl. 2022 Jan 10;61(2):e202110838. doi: 10.1002/anie.202110838. Epub 2021 Nov 25.

Accurately regulating the selectivity of the oxygen reduction reaction (ORR) is crucial to renewable energy storage and utilization, but challenging. A flexible alteration of ORR pathways on atomically dispersed Zn sites towards high selectivity ORR can be achieved by...

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Jia Y, Xue Z, Yang J, et al. Tailoring the Electronic Structure of an Atomically Dispersed Zinc Electrocatalyst: Coordination Environment Regulation for High Selectivity Oxygen Reduction. Angew Chem Int Ed Engl. 2021;61(2):e202110838doi: 10.1002/anie.202110838.
Jia, Y., Xue, Z., Yang, J., Liu, Q., Xian, J., Zhong, Y., Sun, Y., Zhang, X., Liu, Q., Yao, D., & Li, G. (2022). Tailoring the Electronic Structure of an Atomically Dispersed Zinc Electrocatalyst: Coordination Environment Regulation for High Selectivity Oxygen Reduction. Angewandte Chemie (International ed. in English), 61(2), e202110838. https://doi.org/10.1002/anie.202110838
Jia, Yaling, et al. "Tailoring the Electronic Structure of an Atomically Dispersed Zinc Electrocatalyst: Coordination Environment Regulation for High Selectivity Oxygen Reduction." Angewandte Chemie (International ed. in English) vol. 61,2 (2022): e202110838. doi: https://doi.org/10.1002/anie.202110838
Jia Y, Xue Z, Yang J, Liu Q, Xian J, Zhong Y, Sun Y, Zhang X, Liu Q, Yao D, Li G. Tailoring the Electronic Structure of an Atomically Dispersed Zinc Electrocatalyst: Coordination Environment Regulation for High Selectivity Oxygen Reduction. Angew Chem Int Ed Engl. 2022 Jan 10;61(2):e202110838. doi: 10.1002/anie.202110838. Epub 2021 Nov 25. PMID: 34716639.
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Homologous Strategy to Construct High-Performance Coupling Electrodes for Advanced Potassium-Ion Hybrid Capacitors.

Nano-micro letters

Xu Y, Ruan J, Pang Y, Sun H, Liang C, Li H, Yang J, Zheng S.
PMID: 34138205
Nanomicro Lett. 2020 Oct 30;13(1):14. doi: 10.1007/s40820-020-00524-z.

Potassium-ion hybrid capacitors (PIHCs) have been considered as promising potentials in mid- to large-scale storage system applications owing to their high energy and power density. However, the process involving the intercalation of K

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Xu Y, Ruan J, Pang Y, et al. Homologous Strategy to Construct High-Performance Coupling Electrodes for Advanced Potassium-Ion Hybrid Capacitors. Nanomicro Lett. 2020;13(1):14doi: 10.1007/s40820-020-00524-z.
Xu, Y., Ruan, J., Pang, Y., Sun, H., Liang, C., Li, H., Yang, J., & Zheng, S. (2020). Homologous Strategy to Construct High-Performance Coupling Electrodes for Advanced Potassium-Ion Hybrid Capacitors. Nano-micro letters, 13(1), 14. https://doi.org/10.1007/s40820-020-00524-z
Xu, Ying, et al. "Homologous Strategy to Construct High-Performance Coupling Electrodes for Advanced Potassium-Ion Hybrid Capacitors." Nano-micro letters vol. 13,1 (2020): 14. doi: https://doi.org/10.1007/s40820-020-00524-z
Xu Y, Ruan J, Pang Y, Sun H, Liang C, Li H, Yang J, Zheng S. Homologous Strategy to Construct High-Performance Coupling Electrodes for Advanced Potassium-Ion Hybrid Capacitors. Nanomicro Lett. 2020 Oct 30;13(1):14. doi: 10.1007/s40820-020-00524-z. PMID: 34138205; PMCID: PMC8187694.
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Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study.

Cancer communications (London, England)

Wang Y, Qiao L, Yang J, Li X, Duan Y, Liu J, Chen S, Li H, Liu D, Fang T, Ma J, Li X, Ye F, Wan J, Wei J, Xu Q, Guo E, Jin P, Wu M, Zhang L, Xia Y, Wu Y, Shao J, Feng Y, Zhang Q, Yang Z, Chen G, Zhang Q, Li X, Wang S, Hu J, Wang X, Tan MP, Takabe K, Kong B, Yang Q, Ma D, Gao Q.
PMID: 34738326
Cancer Commun (Lond). 2021 Dec;41(12):1373-1386. doi: 10.1002/cac2.12233. Epub 2021 Nov 05.

BACKGROUND: To date, there is no approved blood-based biomarker for breast cancer detection. Herein, we aimed to assess semaphorin 4C (SEMA4C), a pivotal protein involved in breast cancer progression, as a serum diagnostic biomarker.METHODS: We included 6,213 consecutive inpatients...

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Wang Y, Qiao L, Yang J, et al. Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study. Cancer Commun (Lond). 2021;41(12):1373-1386doi: 10.1002/cac2.12233.
Wang, Y., Qiao, L., Yang, J., Li, X., Duan, Y., Liu, J., Chen, S., Li, H., Liu, D., Fang, T., Ma, J., Li, X., Ye, F., Wan, J., Wei, J., Xu, Q., Guo, E., Jin, P., Wu, M., Zhang, L., Xia, Y., Wu, Y., Shao, J., Feng, Y., Zhang, Q., Yang, Z., Chen, G., Zhang, Q., Li, X., Wang, S., Hu, J., Wang, X., Tan, M. P., Takabe, K., Kong, B., Yang, Q., Ma, D., & Gao, Q. (2021). Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study. Cancer communications (London, England), 41(12), 1373-1386. https://doi.org/10.1002/cac2.12233
Wang, Ya, et al. "Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study." Cancer communications (London, England) vol. 41,12 (2021): 1373-1386. doi: https://doi.org/10.1002/cac2.12233
Wang Y, Qiao L, Yang J, Li X, Duan Y, Liu J, Chen S, Li H, Liu D, Fang T, Ma J, Li X, Ye F, Wan J, Wei J, Xu Q, Guo E, Jin P, Wu M, Zhang L, Xia Y, Wu Y, Shao J, Feng Y, Zhang Q, Yang Z, Chen G, Zhang Q, Li X, Wang S, Hu J, Wang X, Tan MP, Takabe K, Kong B, Yang Q, Ma D, Gao Q. Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study. Cancer Commun (Lond). 2021 Dec;41(12):1373-1386. doi: 10.1002/cac2.12233. Epub 2021 Nov 05. PMID: 34738326; PMCID: PMC8696225.
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