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Showing 253 to 264 of 276 entries
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Integrating Somatic and Germline Next-Generation Sequencing Into Routine Clinical Oncology Practice.

JCO precision oncology

Hicks JK, Howard R, Reisman P, Adashek JJ, Fields KK, Gray JE, McIver B, McKee K, O'Leary MF, Perkins RM, Robinson E, Tandon A, Teer JK, Markowitz J, Rollison DE.
PMID: 34095711
JCO Precis Oncol. 2021 May 20;5. doi: 10.1200/PO.20.00513. eCollection 2021.

Next-generation sequencing (NGS) is rapidly expanding into routine oncology practice. Genetic variations in both the cancer and inherited genomes are informative for hereditary cancer risk, prognosis, and treatment strategies. Herein, we focus on the clinical perspective of integrating NGS...

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8.

Nature immunology

Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP.
PMID: 34937933
Nat Immunol. 2022 Jan;23(1):23-32. doi: 10.1038/s41590-021-01095-w. Epub 2021 Dec 22.

Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates

Pteropods make thinner shells in the upwelling region of the California Current Ecosystem.

Scientific reports

Mekkes L, Renema W, Bednaršek N, Alin SR, Feely RA, Huisman J, Roessingh P, Peijnenburg KTCA.
PMID: 33462349
Sci Rep. 2021 Jan 18;11(1):1731. doi: 10.1038/s41598-021-81131-9.

Shelled pteropods are widely regarded as bioindicators for ocean acidification, because their fragile aragonite shells are susceptible to increasing ocean acidity. While short-term incubations have demonstrated that pteropod calcification is negatively impacted by ocean acidification, we know little about...

Evaluation of Collagen Alterations in Early Precursor Lesions of High Grade Serous Ovarian Cancer by Second Harmonic Generation Microscopy and Mass Spectrometry.

Cancers

Gant KL, Jambor AN, Li Z, Rentchler EC, Weisman P, Li L, Patankar MS, Campagnola PJ.
PMID: 34199725
Cancers (Basel). 2021 Jun 04;13(11). doi: 10.3390/cancers13112794.

No abstract available.

Risso's dolphins perform spin dives to target deep-dwelling prey.

Royal Society open science

Visser F, Keller OA, Oudejans MG, Nowacek DP, Kok ACM, Huisman J, Sterck EHM.
PMID: 34966548
R Soc Open Sci. 2021 Dec 01;8(12):202320. doi: 10.1098/rsos.202320. eCollection 2021 Dec.

Foraging decisions of deep-diving cetaceans can provide fundamental insight into food web dynamics of the deep pelagic ocean. Cetacean optimal foraging entails a tight balance between oxygen-conserving dive strategies and access to deep-dwelling prey of sufficient energetic reward. Risso's...

Antigen-presenting innate lymphoid cells orchestrate neuroinflammation.

Nature

Grigg JB, Shanmugavadivu A, Regen T, Parkhurst CN, Ahmed A, Joseph AM, Mazzucco M, Gronke K, Diefenbach A, Eberl G, Vartanian T, Waisman A, Sonnenberg GF.
PMID: 34853467
Nature. 2021 Dec;600(7890):707-712. doi: 10.1038/s41586-021-04136-4. Epub 2021 Dec 01.

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with multiple demyelinating and neurodegenerative diseases

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8.

Nature immunology

Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP.
PMID: 34937933
Nat Immunol. 2021 Dec 22; doi: 10.1038/s41590-021-01095-w. Epub 2021 Dec 22.

Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates

Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity.

The Journal of investigative dermatology

Maifeld A, Wild J, Karlsen TV, Rakova N, Wistorf E, Linz P, Jung R, Birukov A, Gimenez-Rivera VA, Wilck N, Bartolomaeus T, Dechend R, Kleinewietfeld M, Forslund SK, Krause A, Kokolakis G, Philipp S, Clausen BE, Brand A, Waisman A, Kurschus FC, Wegner J, Schultheis M, Luft FC, Boschmann M, Kelm M, Wiig H, Kuehne T, Müller DN, Karbach S, Markó L.
PMID: 34237339
J Invest Dermatol. 2022 Jan;142(1):166-178.e8. doi: 10.1016/j.jid.2021.06.013. Epub 2021 Jul 06.

Sodium can accumulate in the skin at concentrations exceeding serum levels. A high sodium environment can lead to pathogenic T helper 17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which IL-17‒producing T helper 17 cells play...

Changes in the role of explanatory factors for socioeconomic inequalities in physical performance: a comparative study of three birth cohorts.

International journal for equity in health

Klokgieters SS, Kok AAL, Visser M, van Groenou MIB, Huisman M.
PMID: 34895239
Int J Equity Health. 2021 Dec 11;20(1):252. doi: 10.1186/s12939-021-01592-2.

BACKGROUND: Due to societal changes and changes in the availability of health promoting factors, explanatory factors of socioeconomic inequalities in health (SIH) may change with time. We investigate differences in the relative importance of behavioural, social and psychological factors...

General practitioners' role in shared decision-making about palliative cancer treatment: qualitative study.

The British journal of general practice : the journal of the Royal College of General Practitioners

Bos-van den Hoek D, Velden NV, Huisman R, Laarhoven HV, Tange D, Wind J, Smets E, Henselmans I.
PMID: 34990389
Br J Gen Pract. 2021 Oct 26; doi: 10.3399/BJGP.2021.0446. Epub 2021 Oct 26.

BACKGROUND: General practitioners (GPs) are well-positioned to enhance shared decision-making (SDM) about treatment for patients with advanced cancer. However, to date, little is known about GPs' views on their contribution to SDM.AIM: To explore GPs' perspectives on their role...

Cornelia de Lange syndrome and the Cohesin complex: Abstracts from the 9th Biennial Scientific and Educational Virtual Symposium 2020.

American journal of medical genetics. Part A

Oliver C, Groves L, Hansen BD, Salehi M, Kheradmand S, Carrico CS, Caudill P, Mattingly M, Dorsett D, Chea S, Singh VP, Krantz ID, Huisman S, Deardorff MA, Kline AD.
PMID: 34877788
Am J Med Genet A. 2021 Dec 07; doi: 10.1002/ajmg.a.62591. Epub 2021 Dec 07.

Cornelia de Lange syndrome (CdLS) is a spectrum disorder due to variants in genes of the cohesin protein complex. The following abstracts are from the Cornelia de Lange Syndrome Scientific and Educational Symposium held virtually in October 2020. Aspects...

Iron depletion: an ameliorating factor for sickle cell disease?.

ISRN hematology

Giordano PC, Huisman W, Harteveld CL.
PMID: 22084698
ISRN Hematol. 2011;2011:473152. doi: 10.5402/2011/473152. Epub 2011 Jul 05.

We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of...

Showing 253 to 264 of 276 entries