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Showing 4465 to 4471 of 4471 entries
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Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.

Cancer discovery

Wu HC, Rérolle D, Berthier C, Hleihel R, Sakamoto T, Quentin S, Benhenda S, Morganti C, Wu C, Conte L, Rimsky S, Sebert M, Clappier E, Souquere S, Gachet S, Soulier J, Durand S, Trowbridge JJ, Bénit P, Rustin P, Hajj HE, Raffoux E, Ades L, Itzykson R, Dombret H, Fenaux P, Espeli O, Kroemer G, Brunetti L, Mak TW, Lallemand-Breitenbach V, Bazarbachi A, Falini B, Ito K, Martelli MP, de Thé H.
PMID: 34301789
Cancer Discov. 2021 Jul 23; doi: 10.1158/2159-8290.CD-21-0177. Epub 2021 Jul 23.

Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and overall association with favorable therapeutic responses remain incompletely understood. Here we demonstrate that an oncogenic mutant form...

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Wu HC, Rérolle D, Berthier C, et al. Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy. Cancer Discov. 2021;doi: 10.1158/2159-8290.CD-21-0177.
Wu, H. C., Rérolle, D., Berthier, C., Hleihel, R., Sakamoto, T., Quentin, S., Benhenda, S., Morganti, C., Wu, C., Conte, L., Rimsky, S., Sebert, M., Clappier, E., Souquere, S., Gachet, S., Soulier, J., Durand, S., Trowbridge, J. J., Bénit, P., Rustin, P., Hajj, H. E., Raffoux, E., Ades, L., Itzykson, R., Dombret, H., Fenaux, P., Espeli, O., Kroemer, G., Brunetti, L., Mak, T. W., Lallemand-Breitenbach, V., Bazarbachi, A., Falini, B., Ito, K., Martelli, M. P., & de Thé, H. (2021). Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy. Cancer discovery, . https://doi.org/10.1158/2159-8290.CD-21-0177
Wu, Hsin-Chieh, et al. "Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy." Cancer discovery vol. (2021). doi: https://doi.org/10.1158/2159-8290.CD-21-0177
Wu HC, Rérolle D, Berthier C, Hleihel R, Sakamoto T, Quentin S, Benhenda S, Morganti C, Wu C, Conte L, Rimsky S, Sebert M, Clappier E, Souquere S, Gachet S, Soulier J, Durand S, Trowbridge JJ, Bénit P, Rustin P, Hajj HE, Raffoux E, Ades L, Itzykson R, Dombret H, Fenaux P, Espeli O, Kroemer G, Brunetti L, Mak TW, Lallemand-Breitenbach V, Bazarbachi A, Falini B, Ito K, Martelli MP, de Thé H. Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy. Cancer Discov. 2021 Jul 23; doi: 10.1158/2159-8290.CD-21-0177. Epub 2021 Jul 23. PMID: 34301789.
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GADD45α alleviates the CDDP resistance of SK-OV3/cddp cells via redox-mediated DNA damage.

Oncology letters

Zhang QZ, Wen F, Yang HL, Cao YY, Peng RG, Wang YM, Nie L, Qin YK, Wu JJ, Zhao X, Zi D.
PMID: 34429760
Oncol Lett. 2021 Oct;22(4):720. doi: 10.3892/ol.2021.12981. Epub 2021 Aug 10.

Epithelial ovarian cancer has the highest mortality rate of all malignant ovarian cancer types. Great progress has been made in the treatment of ovarian cancer in recent years. However, drug resistance has led to a low level of 5-year...

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Zhang QZ, Wen F, Yang HL, et al. GADD45α alleviates the CDDP resistance of SK-OV3/cddp cells via redox-mediated DNA damage. Oncol Lett. 2021;22(4):720doi: 10.3892/ol.2021.12981.
Zhang, Q. Z., Wen, F., Yang, H. L., Cao, Y. Y., Peng, R. G., Wang, Y. M., Nie, L., Qin, Y. K., Wu, J. J., Zhao, X., & Zi, D. (2021). GADD45α alleviates the CDDP resistance of SK-OV3/cddp cells via redox-mediated DNA damage. Oncology letters, 22(4), 720. https://doi.org/10.3892/ol.2021.12981
Zhang, Qi-Zhu, et al. "GADD45α alleviates the CDDP resistance of SK-OV3/cddp cells via redox-mediated DNA damage." Oncology letters vol. 22,4 (2021): 720. doi: https://doi.org/10.3892/ol.2021.12981
Zhang QZ, Wen F, Yang HL, Cao YY, Peng RG, Wang YM, Nie L, Qin YK, Wu JJ, Zhao X, Zi D. GADD45α alleviates the CDDP resistance of SK-OV3/cddp cells via redox-mediated DNA damage. Oncol Lett. 2021 Oct;22(4):720. doi: 10.3892/ol.2021.12981. Epub 2021 Aug 10. PMID: 34429760; PMCID: PMC8371983.
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Comparison of Interferon-α-based therapy and nucleos(t)ide analogs in preventing adverse outcomes in patients with chronic hepatitis B.

Clinics and research in hepatology and gastroenterology

Mao QG, Liang HQ, Yin YL, Tang JM, Yang JE, Wu CC, Chen Y, Zhang MY, Liu YY, Zheng XT, Zhuang LY, Chen SD.
PMID: 34303003
Clin Res Hepatol Gastroenterol. 2022 Jan;46(1):101758. doi: 10.1016/j.clinre.2021.101758. Epub 2021 Jul 21.

BACKGROUND: Whether interferon (IFN)-α therapy is better than nucleos(t)ide analogs (NAs) in the prevention of adverse outcomes, including hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) is still uncertain or controversial. This study aimed to compare the...

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Mao QG, Liang HQ, Yin YL, et al. Comparison of Interferon-α-based therapy and nucleos(t)ide analogs in preventing adverse outcomes in patients with chronic hepatitis B. Clin Res Hepatol Gastroenterol. 2021;46(1):101758doi: 10.1016/j.clinre.2021.101758.
Mao, Q. G., Liang, H. Q., Yin, Y. L., Tang, J. M., Yang, J. E., Wu, C. C., Chen, Y., Zhang, M. Y., Liu, Y. Y., Zheng, X. T., Zhuang, L. Y., & Chen, S. D. (2022). Comparison of Interferon-α-based therapy and nucleos(t)ide analogs in preventing adverse outcomes in patients with chronic hepatitis B. Clinics and research in hepatology and gastroenterology, 46(1), 101758. https://doi.org/10.1016/j.clinre.2021.101758
Mao, Qian-Guo, et al. "Comparison of Interferon-α-based therapy and nucleos(t)ide analogs in preventing adverse outcomes in patients with chronic hepatitis B." Clinics and research in hepatology and gastroenterology vol. 46,1 (2022): 101758. doi: https://doi.org/10.1016/j.clinre.2021.101758
Mao QG, Liang HQ, Yin YL, Tang JM, Yang JE, Wu CC, Chen Y, Zhang MY, Liu YY, Zheng XT, Zhuang LY, Chen SD. Comparison of Interferon-α-based therapy and nucleos(t)ide analogs in preventing adverse outcomes in patients with chronic hepatitis B. Clin Res Hepatol Gastroenterol. 2022 Jan;46(1):101758. doi: 10.1016/j.clinre.2021.101758. Epub 2021 Jul 21. PMID: 34303003.
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Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction.

Pharmacotherapy

Lin XB, Lui KY, Guo PH, Liu XM, Liang T, Hu XG, Tong L, Wu JJ, Xia YZ, Chen P, Zhong GP, Chen X, Cai CJ.
PMID: 34655497
Pharmacotherapy. 2022 Jan;42(1):23-33. doi: 10.1002/phar.2634. Epub 2021 Oct 25.

STUDY OBJECTIVES: This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and to explore the optimal dosing strategies in specific clinical scenarios for invasive fungal infections (IFIs)...

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Lin XB, Lui KY, Guo PH, et al. Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction. Pharmacotherapy. 2021;42(1):23-33doi: 10.1002/phar.2634.
Lin, X. B., Lui, K. Y., Guo, P. H., Liu, X. M., Liang, T., Hu, X. G., Tong, L., Wu, J. J., Xia, Y. Z., Chen, P., Zhong, G. P., Chen, X., & Cai, C. J. (2022). Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction. Pharmacotherapy, 42(1), 23-33. https://doi.org/10.1002/phar.2634
Lin, Xiao-Bin, et al. "Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction." Pharmacotherapy vol. 42,1 (2022): 23-33. doi: https://doi.org/10.1002/phar.2634
Lin XB, Lui KY, Guo PH, Liu XM, Liang T, Hu XG, Tong L, Wu JJ, Xia YZ, Chen P, Zhong GP, Chen X, Cai CJ. Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction. Pharmacotherapy. 2022 Jan;42(1):23-33. doi: 10.1002/phar.2634. Epub 2021 Oct 25. PMID: 34655497.
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Application of artificial intelligence in gastrointestinal disease: a narrative review.

Annals of translational medicine

Zhou J, Hu N, Huang ZY, Song B, Wu CC, Zeng FX, Wu M.
PMID: 34430629
Ann Transl Med. 2021 Jul;9(14):1188. doi: 10.21037/atm-21-3001.

OBJECTIVE: We collected evidence on the application of artificial intelligence (AI) in gastroenterology field. The review was carried out from two aspects of endoscopic types and gastrointestinal diseases, and briefly summarized the challenges and future directions in this field.BACKGROUND:...

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Zhou J, Hu N, Huang ZY, et al. Application of artificial intelligence in gastrointestinal disease: a narrative review. Ann Transl Med. 2021;9(14):1188doi: 10.21037/atm-21-3001.
Zhou, J., Hu, N., Huang, Z. Y., Song, B., Wu, C. C., Zeng, F. X., & Wu, M. (2021). Application of artificial intelligence in gastrointestinal disease: a narrative review. Annals of translational medicine, 9(14), 1188. https://doi.org/10.21037/atm-21-3001
Zhou, Jun, et al. "Application of artificial intelligence in gastrointestinal disease: a narrative review." Annals of translational medicine vol. 9,14 (2021): 1188. doi: https://doi.org/10.21037/atm-21-3001
Zhou J, Hu N, Huang ZY, Song B, Wu CC, Zeng FX, Wu M. Application of artificial intelligence in gastrointestinal disease: a narrative review. Ann Transl Med. 2021 Jul;9(14):1188. doi: 10.21037/atm-21-3001. PMID: 34430629; PMCID: PMC8350704.
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Systems of Career Influences: A Conceptual Model for Evaluating the Professional Development of Women in Academic Medicine.

Chang SN, Magrane D, Helitzer D, Morahan P, Cardinali G, Wu CC, Gleason K.
UIID-AD: 545
2012;21:1244-1251. doi: 10.1089/jwh.2012.3638.

Background: Surprisingly little research is available to explain the well-documented organizational and societal influences on persistent inequities in advancement of women faculty. Methods: The Systems of Career Influences Model is a framework for exploring factors influencing women’s progression to...

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Chang SN, Magrane D, Helitzer D, et al. Systems of Career Influences: A Conceptual Model for Evaluating the Professional Development of Women in Academic Medicine. 2012;21:1244-1251doi: 10.1089/jwh.2012.3638.
Chang, S. N., Magrane, D., Helitzer, D., Morahan, P., Cardinali, G., Wu, C. C., & Gleason, K. (2012). Systems of Career Influences: A Conceptual Model for Evaluating the Professional Development of Women in Academic Medicine. 211244-1251. https://doi.org/10.1089/jwh.2012.3638
Chang, S N, et al. "Systems of Career Influences: A Conceptual Model for Evaluating the Professional Development of Women in Academic Medicine." vol. 21 (2012): 1244-1251. doi: https://doi.org/10.1089/jwh.2012.3638
Chang SN, Magrane D, Helitzer D, Morahan P, Cardinali G, Wu CC, Gleason K. Systems of Career Influences: A Conceptual Model for Evaluating the Professional Development of Women in Academic Medicine. 2012;21:1244-1251. doi: 10.1089/jwh.2012.3638. UIID-AD: 545.
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Perceptions of Skill Development of Participants in Three National Career Development Programs for Women Faculty in Academic Medicine.

Chang SN, Magrane D, Helitzer DL, Newbill SL, Morahan PS, Cardinali G, Wu CC.
UIID-AD: 465
2014;89:896-903. doi: 10.1097/acm.0000000000000251.

Purpose: The Association of American Medical Colleges (AAMC) and Drexel University College of Medicine have designed and implemented national career development programs (CDPs) to help women faculty acquire and strengthen skills needed for success in academic medicine. The authors...

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Chang SN, Magrane D, Helitzer DL, et al. Perceptions of Skill Development of Participants in Three National Career Development Programs for Women Faculty in Academic Medicine. 2014;89:896-903doi: 10.1097/acm.0000000000000251.
Chang, S. N., Magrane, D., Helitzer, D. L., Newbill, S. L., Morahan, P. S., Cardinali, G., & Wu, C. C. (2014). Perceptions of Skill Development of Participants in Three National Career Development Programs for Women Faculty in Academic Medicine. 89896-903. https://doi.org/10.1097/acm.0000000000000251
Chang, S N, et al. "Perceptions of Skill Development of Participants in Three National Career Development Programs for Women Faculty in Academic Medicine." vol. 89 (2014): 896-903. doi: https://doi.org/10.1097/acm.0000000000000251
Chang SN, Magrane D, Helitzer DL, Newbill SL, Morahan PS, Cardinali G, Wu CC. Perceptions of Skill Development of Participants in Three National Career Development Programs for Women Faculty in Academic Medicine. 2014;89:896-903. doi: 10.1097/acm.0000000000000251. UIID-AD: 465.
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Showing 4465 to 4471 of 4471 entries