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Showing 193 to 198 of 198 entries
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Sense and Immunity: Context-Dependent Neuro-Immune Interplay.

Frontiers in immunology

Foster SL, Seehus CR, Woolf CJ, Talbot S.
PMID: 29163530
Front Immunol. 2017 Nov 03;8:1463. doi: 10.3389/fimmu.2017.01463. eCollection 2017.

The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine...

Human cells and networks of pain: Transforming pain target identification and therapeutic development.

Neuron

Renthal W, Chamessian A, Curatolo M, Davidson S, Burton M, Dib-Hajj S, Dougherty PM, Ebert AD, Gereau RW, Ghetti A, Gold MS, Hoben G, Menichella DM, Mercier P, Ray WZ, Salvemini D, Seal RP, Waxman S, Woolf CJ, Stucky CL, Price TJ.
PMID: 33957072
Neuron. 2021 May 05;109(9):1426-1429. doi: 10.1016/j.neuron.2021.04.005.

Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose...

A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening.

Molecular biology of the cell

Boivin B, Roet KCD, Huang X, Karhohs KW, Rohban MH, Sandoe J, Wiskow O, Maeda R, Grantham A, Dornon MK, Shao J, Frost D, Baker D, Eggan K, Carpenter AE, Woolf CJ.
PMID: 34910584
Mol Biol Cell. 2021 Dec 15;mbcE21100481. doi: 10.1091/mbc.E21-10-0481. Epub 2021 Dec 15.

Patient stem cell-derived models enable imaging of complex disease phenotypes and the development of scalable drug discovery platforms. Current preclinical methods for assessing cellular activity do not, however, capture the full intricacies of disease-induced disturbances, and instead typically focus...

Switchable Induced-Transmission Filters Enabled by Vanadium Dioxide.

Nano letters

Wan C, Woolf D, Hessel CM, Salman J, Xiao Y, Yao C, Wright A, Hensley JM, Kats MA.
PMID: 34958595
Nano Lett. 2021 Dec 27; doi: 10.1021/acs.nanolett.1c02296. Epub 2021 Dec 27.

An induced-transmission filter (ITF) uses an ultrathin metallic layer positioned at an electric-field node within a dielectric thin-film bandpass filter to select one transmission band while suppressing other bands that would have been present without the metal layer. We...

Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor.

Pediatric blood & cancer

Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C.
PMID: 34693628
Pediatr Blood Cancer. 2021 Oct 24;e29401. doi: 10.1002/pbc.29401. Epub 2021 Oct 24.

BACKGROUND: Wilms tumor is the most common childhood kidney cancer. Two distinct histological subtypes of Wilms tumor have been described: tumors lacking anaplasia (the favorable subtype) and tumors displaying anaplastic features (the unfavorable subtype). Children with favorable disease generally...

Towards Modelling Genetic Kidney Diseases with Human Pluripotent Stem Cells.

Nephron

Rooney KM, Woolf AS, Kimber SJ.
PMID: 33774632
Nephron. 2021;145(3):285-296. doi: 10.1159/000514018. Epub 2021 Mar 26.

BACKGROUND: Kidney disease causes major suffering and premature mortality worldwide. With no cure for kidney failure currently available, and with limited options for treatment, there is an urgent need to develop effective pharmaceutical interventions to slow or prevent kidney...

Showing 193 to 198 of 198 entries