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Showing 25 to 36 of 201 entries
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A novel serum biomarker quintet reveals added prognostic value when combined with standard clinical parameters in prostate cancer patients by predicting biochemical recurrence and adverse pathology.

PloS one

Athanasiou A, Tennstedt P, Wittig A, Huber R, Straub O, Schiess R, Steuber T.
PMID: 34767586
PLoS One. 2021 Nov 12;16(11):e0259093. doi: 10.1371/journal.pone.0259093. eCollection 2021.

The objective was to determine the prognostic utility of a new biomarker combination in prostate cancer (PCa) patients undergoing Radical Prostatectomy (RP). Serum samples and clinical data of 557 men who underwent RP for PCa with pathological stage (pT)

Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses.

Circulation research

Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S.
PMID: 34789007
Circ Res. 2022 Jan 07;130(1):67-79. doi: 10.1161/CIRCRESAHA.121.320029. Epub 2021 Nov 18.

BACKGROUND: Circular RNAs (circRNAs) are generated by back splicing of mostly mRNAs and are gaining increasing attention as a novel class of regulatory RNAs that control various cellular functions. However, their physiological roles and functional conservation in vivo are...

Prediction and analysis of redox-sensitive cysteines using machine learning and statistical methods.

Biological chemistry

Keßler M, Wittig I, Ackermann J, Koch I.
PMID: 34261205
Biol Chem. 2021 Jan 06;402(8):925-935. doi: 10.1515/hsz-2020-0321. Print 2021 Jul 27.

Reactive oxygen species are produced by a number of stimuli and can lead both to irreversible intracellular damage and signaling through reversible post-translational modification. It is unclear which factors contribute to the sensitivity of cysteines to redox modification. Here,...

The "springform" technique in cranioplasty: custom made 3D-printed templates for intraoperative modelling of polymethylmethacrylate cranial implants.

Acta neurochirurgica

Pöppe JP, Spendel M, Schwartz C, Winkler PA, Wittig J.
PMID: 34873659
Acta Neurochir (Wien). 2021 Dec 06; doi: 10.1007/s00701-021-05077-7. Epub 2021 Dec 06.

BACKGROUND: Manual moulding of cranioplasty implants after craniectomy is feasible, but does not always yield satisfying cosmetic results. In contrast, 3D printing can provide precise templates for intraoperative moulding of polymethylmethacrylate (PMMA) implants in cranioplasty. Here, we present a...

Calibration of XPS - energy scale for determination of the oxidation states of doping elements in SnO 2 powders.

Analytical and bioanalytical chemistry

Dobler D, Oswald S, Wetzig K.
PMID: 12397485
Anal Bioanal Chem. 2002 Oct;374(4):646-9. doi: 10.1007/s00216-002-1448-y. Epub 2002 Aug 28.

X-ray photoelectron spectroscopy (XPS) has been used to investigate the oxidation states of doping elements in doped SnO(2) powders. Because of low conductivity, however, charging and resulting peak shift is observed. To obtain the real peak position a suitable...

Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes.

EMBO molecular medicine

Vidali S, Gerlini R, Thompson K, Urquhart JE, Meisterknecht J, Aguilar-Pimentel JA, Amarie OV, Becker L, Breen C, Calzada-Wack J, Chhabra NF, Cho YL, da Silva-Buttkus P, Feichtinger RG, Gampe K, Garrett L, Hoefig KP, Hölter SM, Jameson E, Klein-Rodewald T, Leuchtenberger S, Marschall S, Mayer-Kuckuk P, Miller G, Oestereicher MA, Pfannes K, Rathkolb B, Rozman J, Sanders C, Spielmann N, Stoeger C, Szibor M, Treise I, Walter JH, Wurst W, Mayr JA, Fuchs H, Gärtner U, Wittig I, Taylor RW, Newman WG, Prokisch H, Gailus-Durner V, Hrabě de Angelis M.
PMID: 34750991
EMBO Mol Med. 2021 Dec 07;13(12):e14397. doi: 10.15252/emmm.202114397. Epub 2021 Nov 08.

Mitochondrial disorders are clinically and genetically diverse, with isolated complex III (CIII) deficiency being relatively rare. Here, we describe two affected cousins, presenting with recurrent episodes of severe lactic acidosis, hyperammonaemia, hypoglycaemia and encephalopathy. Genetic investigations in both cases...

Post mortem brain temperature and its influence on quantitative MRI of the brain.

Magma (New York, N.Y.)

Berger C, Bauer M, Wittig H, Scheurer E, Lenz C.
PMID: 34714448
MAGMA. 2021 Oct 29; doi: 10.1007/s10334-021-00971-8. Epub 2021 Oct 29.

OBJECTIVE: MRI temperature sensitivity presents a major issue in in situ post mortem MRI (PMMRI), as the tissue temperatures differ from living persons due to passive cooling of the deceased. This study aims at computing brain temperature effects on...

Stationäre Versorgung von Hautkrankheiten in Deutschland: Multi-Source-Analyse zum aktuellen und zukünftigen Bedarf.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Augustin M, Girbig G, Kis A, Bechara FG, Hertl M, Hischke S, Kaufmann R, Löffler H, Müller CS, Simon JC, Strömer K, Welzel J, Wetzig T, Elsner P, Augustin J, Löser C, Biedermann T.
PMID: 34662492
J Dtsch Dermatol Ges. 2021 Oct;19:25-54. doi: 10.1111/ddg.14620_g.

No abstract available.

Successful Treatment of an Immune-Mediated Colitis Induced by Checkpoint Inhibitor Therapy in a Patient with Advanced Melanoma.

Case reports in gastroenterology

Paparoupa M, Stupperich S, Goerg-Reifenberg L, Wittig A, Schuppert F.
PMID: 33250697
Case Rep Gastroenterol. 2020 Oct 29;14(3):554-560. doi: 10.1159/000511252. eCollection 2020.

Immune checkpoint inhibitors (ICIs) have been used as immunotherapeutic agents in several malignancies because of their ability to modify the T cell-mediated response against tumor cells. Dual checkpoint inhibition improves remission rates in patients with metastatic melanoma compared to...

Tribute to Hanna Reisler.

The journal of physical chemistry. A

Wittig C, Sanov A, Reid S, Krylov A.
PMID: 31366202
J Phys Chem A. 2019 Aug 01;123(30):6381-6383. doi: 10.1021/acs.jpca.9b04339.

No abstract available.

Outcomes of Diabetic Macular Edema Eyes with Limited Early Response in the VISTA and VIVID Studies.

Ophthalmology. Retina

Pieramici D, Singh RP, Gibson A, Saroj N, Vitti R, Berliner AJ, Zeitz O, Metzig C, Soo Y, Zhu X, Boyer DS.
PMID: 31047609
Ophthalmol Retina. 2018 Jun;2(6):558-566. doi: 10.1016/j.oret.2017.10.014. Epub 2017 Dec 19.

PURPOSE: To evaluate benefit of continued treatment in diabetic macular edema (DME) eyes showing a limited early response to treatment.DESIGN: Post hoc analysis of VISTA and VIVID.PARTICIPANTS: 818 patients (eyes) with DME.METHODS: Eyes with baseline central subfield thickness (CST)...

PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy.

Frontiers in physiology

Farini A, Villa C, Di Silvestre D, Bella P, Tripodi L, Rossi R, Sitzia C, Gatti S, Mauri P, Torrente Y.
PMID: 32508664
Front Physiol. 2020 May 19;11:403. doi: 10.3389/fphys.2020.00403. eCollection 2020.

Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it has been found in fibrotic regions...

Showing 25 to 36 of 201 entries