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Showing 2161 to 2169 of 2169 entries
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Facilitating an International Research Experience Focused on Applied Nanotechnology and Surface Chemistry for American Undergraduate Students Collaborating with Mentors at a German Educational and Research Institution.

Journal of chemical education

Wilson C, Hirtz M, Levkin PA, Sutlief AL, Holmes AE.
PMID: 33911314
J Chem Educ. 2019 Nov 12;96(11):2441-2449. doi: 10.1021/acs.jchemed.9b00146. Epub 2019 Oct 03.

The "International Research Experience for Students (IRES)" at Doane University (DU) located in Crete, Nebraska, exposed undergraduate science, technology, engineering, and mathematics (STEM) students to international research at the Karlsruhe Institute of Technology (KIT) in Germany. The international collaboration...

The Association of Mitochondrial Copy Number With Sarcopenia in Adult Survivors of Childhood Cancer.

Journal of the National Cancer Institute

McCastlain K, Howell CR, Welsh CE, Wang Z, Wilson CL, Mulder HL, Easton J, Mertens AC, Zhang J, Yasui Y, Hudson MM, Robison LL, Kundu M, Ness KK.
PMID: 33871611
J Natl Cancer Inst. 2021 Nov 02;113(11):1570-1580. doi: 10.1093/jnci/djab084.

BACKGROUND: Adult childhood cancer survivors are at risk for frailty, including low muscle mass and weakness (sarcopenia). Using peripheral blood mitochondrial DNA copy number (mtDNAcn) as a proxy for functional mitochondria, this study describes cross-sectional associations between mtDNAcn and...

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Genome medicine

Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ, Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, Redline S.
PMID: 34446064
Genome Med. 2021 Aug 26;13(1):136. doi: 10.1186/s13073-021-00917-8.

BACKGROUND: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing.METHODS:...

Cancer-specific outcomes for prostate cancer patients who had prebiopsy prostate MRI.

Urologic oncology

Li J, Patil D, Sanda MG, Filson CP.
PMID: 34353711
Urol Oncol. 2021 Aug 02; doi: 10.1016/j.urolonc.2021.07.013. Epub 2021 Aug 02.

PURPOSE: We characterized population-level cancer-specific outcomes for prostate cancer patients based on use of prebiopsy prostate MRI.METHODS: Using SEER-Medicare claims, we identified men diagnosed with localized prostate cancer from 2010-2015 and prostate-specific antigen (PSA) < 20 ng/mL. Primary exposure...

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Journal of medicinal chemistry

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, Parai MK, Acharya A, Tamaki F, Scullion P, Epemolu O, Riley J, Stojanovski L, Lopez-Román EM, Torres-Gómez PA, Toledo AM, Guijarro-Lopez L, Camino I, Engelhart CA, Schnappinger D, Massoudi LM, Lenaerts A, Robertson GT, Walpole C, Matthews D, Floyd D, Sacchettini JC, Read KD, Encinas L, Bates RH, Green SR, Wyatt PG.
PMID: 34910486
J Med Chem. 2022 Jan 13;65(1):409-423. doi: 10.1021/acs.jmedchem.1c01586. Epub 2021 Dec 15.

With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to current treatments. Benzofuran

Single-shot interferometric measurement of cavitation bubble dynamics.

Optics letters

Wilson BG, Fan Z, Sreedasyam R, Botvinick EL, Venugopalan V.
PMID: 33720199
Opt Lett. 2021 Mar 15;46(6):1409-1412. doi: 10.1364/OL.416923.

We demonstrate an interferometric method to provide direct, single-shot measurements of cavitation bubble dynamics with nanoscale spatial and temporal resolution with results that closely match theoretical predictions. Implementation of this method reduces the need for expensive and complex ultra-high...

Progression of Frailty in Survivors of Childhood Cancer: A St. Jude Lifetime Cohort Report.

Journal of the National Cancer Institute

Delaney A, Howell CR, Krull KR, Brinkman TM, Armstrong GT, Chemaitilly W, Wilson CL, Mulrooney DA, Wang Z, Lanctot JQ, Johnson RE, Krull MR, Partin RE, Shelton KC, Srivastava DK, Robison LL, Hudson MM, Ness KK.
PMID: 33720359
J Natl Cancer Inst. 2021 Oct 01;113(10):1415-1421. doi: 10.1093/jnci/djab033.

BACKGROUND: Some adult survivors of childhood cancers develop frailty at higher rates than expected based on their chronological age. This study examined the incidence of frailty among survivors at 10 or more years after diagnosis, frailty prevalence 5 years...

A chromosome-anchored genome assembly for Lake Trout (Salvelinus namaycush).

Molecular ecology resources

Smith SR, Normandeau E, Djambazian H, Nawarathna PM, Berube P, Muir AM, Ragoussis J, Penney CM, Scribner KT, Luikart G, Wilson CC, Bernatchez L.
PMID: 34351050
Mol Ecol Resour. 2021 Aug 05; doi: 10.1111/1755-0998.13483. Epub 2021 Aug 05.

Here, we present an annotated, chromosome-anchored, genome assembly for Lake Trout (Salvelinus namaycush) - a highly diverse salmonid species of notable conservation concern and an excellent model for research on adaptation and speciation. We leveraged Pacific Biosciences long-read sequencing,...

Alternate Reality Games as an Informal Learning Tool for Generating STEM Engagement among Underrepresented Youth: a Qualitative Evaluation of the Source.

Gilliam M, Jagoda P, Fabiyi C, Lyman P, Wilson C, Hill B, Bouris A.
UIID-AD: 4186
2017;295-308. doi: 10.1007/s10956-016-9679-4.

This project developed and studied The Source, an alternate reality game (ARG) designed to foster interest and knowledge related to science, technology, engineering, and math (STEM) among youth from populations underrepresented in STEM fields. ARGs are multiplayer games that...

Showing 2161 to 2169 of 2169 entries