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Showing 229 to 236 of 236 entries
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Sleep Characteristics of Highly Trained Wheelchair Rugby Athletes With and Without a Cervical Spinal Cord Injury During the Competitive Season.

Frontiers in sports and active living

Murphy CJ, Hartescu I, Roberts IE, Leicht CA, Goosey-Tolfrey VL.
PMID: 33997778
Front Sports Act Living. 2021 Apr 29;3:643233. doi: 10.3389/fspor.2021.643233. eCollection 2021.

Sleep behaviors although significantly relevant to exercise recovery are poorly characterized in Para-sport athletes. Therefore, the main aims of this study were to describe sleep quality and quantity of highly trained wheelchair rugby (WR) athletes during the competitive season,...

Healthy volunteers in first-in-human oncology drug development for small molecules.

British journal of clinical pharmacology

de Las Heras B, Bouyoucef-Cherchalli D, Reeve L, Reichl A, Mandarino D, Flach S, Vidal L, van Brummelen EMJ, Steeghs N.
PMID: 34558113
Br J Clin Pharmacol. 2021 Sep 23; doi: 10.1111/bcp.15092. Epub 2021 Sep 23.

This review provides tools to consider the inclusion of healthy volunteers (HVs) in first-in-human (FIH) oncology clinical trials with small molecules, including targeted and immunomodulatory agents, a strategy that was not envisioned with classic chemotherapy. To enable an FIH...

Uniting the Global Gastroenterology Community to Meet the Challenge of Climate Change and Non-Recyclable Waste.

Gastroenterology

Leddin D, Omary MB, Veitch A, Metz G, Amrani N, Aabakken L, Raja Ali RA, Alvares-Da-Silva MR, Armstrong D, Boyacioglu S, Chen Y, Elwakil R, Fock KM, Hamid SS, Makharia G, Macrae F, Malekzadeh R, Mulder CJ, Piscoya A, Perman ML, Sadeghi A, Sáenz R, Saurin JC, Butt AS, Wu K, Lee YY.
PMID: 34629165
Gastroenterology. 2021 Nov;161(5):1354-1360. doi: 10.1053/j.gastro.2021.08.001. Epub 2021 Oct 07.

No abstract available.

Elimination versus mitigation of SARS-CoV-2 in the presence of effective vaccines.

The Lancet. Global health

Oliu-Barton M, Pradelski BSR, Algan Y, Baker MG, Binagwaho A, Dore GJ, El-Mohandes A, Fontanet A, Peichl A, Priesemann V, Wolff GB, Yamey G, Lazarus JV.
PMID: 34739862
Lancet Glob Health. 2021 Nov 02; doi: 10.1016/S2214-109X(21)00494-0. Epub 2021 Nov 02.

There is increasing evidence that elimination strategies have resulted in better outcomes for public health, the economy, and civil liberties than have mitigation strategies throughout the first year of the COVID-19 pandemic. With vaccines that offer high protection against...

ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation.

Science signaling

Scheffler L, Feicht S, Babushku T, Kuhn LB, Ehrenberg S, Frankenberger S, Lehmann FM, Hobeika E, Jungnickel B, Baccarini M, Bornkamm GW, Strobl LJ, Zimber-Strobl U.
PMID: 33975980
Sci Signal. 2021 May 11;14(682). doi: 10.1126/scisignal.abc1648.

Members of the RAF family of serine-threonine kinases are intermediates in the mitogen-activated protein kinase and extracellular signal-regulated kinase (MAPK-ERK) signaling pathway, which controls key differentiation processes in B cells. By analyzing mice with B cell-specific deletion of

A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy.

Cancers

Krassnig S, Wohlrab C, Golob-Schwarzl N, Raicht A, Schatz C, Birkl-Toeglhofer AM, Skofler C, Gantenbein N, Leoni M, Asslaber M, Leber SL, Mahdy-Ali K, von Campe G, Mayer M, Borenich A, Weis S, Benesch M, Haybaeck J.
PMID: 33807050
Cancers (Basel). 2021 Mar 23;13(6). doi: 10.3390/cancers13061482.

Glioblastoma (GBM) is an utterly devastating cerebral neoplasm and current therapies only marginally improve patients' overall survival (OS). The PI3K/AKT/mTOR pathway participates in gliomagenesis through regulation of cell growth and proliferation. Since it is an upstream regulator of the...

Uniting the global gastroenterology community to meet the challenge of climate change and non-recyclable waste.

Gut

Leddin D, Omary MB, Veitch A, Metz G, Amrani N, Aabakken L, Raja Ali RA, Alvares-Da-Silva MR, Armstrong D, Boyacioglu S, Chen Y, Elwakil R, Fock KM, Hamid SS, Makharia G, Macrae F, Malekzadeh R, Mulder CJ, Piscoya A, Perman ML, Sadeghi A, Saenz R, Saurin JC, Butt AS, Wu K, Yeh Lee Y.
PMID: 34620696
Gut. 2021 Nov;70(11):2025-2029. doi: 10.1136/gutjnl-2021-325789.

No abstract available.

Resuming endoscopy during COVID-19 pandemic: ESGE, WEO and WGO Joint Cascade Guideline for Resource Limited Settings.

Endoscopy international open

Antonelli G, Karsensten JG, Bhat P, Ijoma U, Osuagwu C, Desalegn H, Abera H, Guy C, Vilmann P, Dinis-Ribeiro M, Ponchon T, Sabbagh LC, Pausawasdi N, Makharia G, Hassan C, Veitch A, Aabakken L, Ebigbo A.
PMID: 33816775
Endosc Int Open. 2021 Apr;9(4):E543-E551. doi: 10.1055/a-1400-9135. Epub 2021 Mar 17.

No abstract available.

Showing 229 to 236 of 236 entries