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Showing 13 to 24 of 122 entries
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Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination.

Cancers

Giraud J, Bouriez D, Seeneevassen L, Rousseau B, Sifré E, Giese A, Mégraud F, Lehours P, Dubus P, Gronnier C, Varon C.
PMID: 31010193
Cancers (Basel). 2019 Apr 19;11(4). doi: 10.3390/cancers11040560.

Gastric cancer is the third leading cause of cancer mortality worldwide. Cancer stem cells (CSC) are at the origin of tumor initiation, chemoresistance, and the formation of metastases. However, there is a lack of mouse models enabling the study...

Cartilage-targeting ultrasmall lipid-polymer hybrid nanoparticles for the prevention of cartilage degradation.

Bioengineering & translational medicine

Ai X, Duan Y, Zhang Q, Sun D, Fang RH, Liu-Bryan R, Gao W, Zhang L.
PMID: 33532587
Bioeng Transl Med. 2020 Sep 10;6(1):e10187. doi: 10.1002/btm2.10187. eCollection 2021 Jan.

Current drug delivery approaches for the treatment of cartilage disorders such as osteoarthritis (OA) remain inadequate to achieve sufficient drug penetration and retention in the dense cartilage matrix. Herein, we synthesize sub-30 nm lipid-polymer hybrid nanoparticles functionalized with collagen-targeting...

Perkalite as an innovative filler for isotactic polypropylene-based nanocomposites.

Journal of nanoscience and nanotechnology

Marega C, Causin V, Marigo A, Ferrara G, Tonnaer H.
PMID: 19438024
J Nanosci Nanotechnol. 2009 Apr;9(4):2704-14. doi: 10.1166/jnn.2009.dk01.

Perkalite, an organically modified synthetic layered double hydroxide, was used as a filler in the preparation of nanocomposites based on isotactic polypropylene. The polymorphism of the polymer matrix was investigated, finding that Perkalite favors beta phase in certain conditions...

Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy.

Leukemia

Johnson DT, Zhou J, Kroll AV, Fang RH, Yan M, Xiao C, Chen X, Kline J, Zhang L, Zhang DE.
PMID: 34845316
Leukemia. 2021 Nov 29; doi: 10.1038/s41375-021-01432-w. Epub 2021 Nov 29.

Cancer vaccines are promising treatments to prevent relapse after chemotherapy in acute myeloid leukemia (AML) patients, particularly for those who cannot tolerate intensive consolidation therapies. Here, we report the development of an AML cell membrane-coated nanoparticle (AMCNP) vaccine platform,...

Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs.

Science advances

Park JH, Jiang Y, Zhou J, Gong H, Mohapatra A, Heo J, Gao W, Fang RH, Zhang L.
PMID: 34134990
Sci Adv. 2021 Jun 16;7(25). doi: 10.1126/sciadv.abf7820. Print 2021 Jun.

As numerous diseases are associated with increased local inflammation, directing drugs to the inflamed sites can be a powerful therapeutic strategy. One of the common characteristics of inflamed endothelial cells is the up-regulation of vascular cell adhesion molecule-1 (VCAM-1)....

Evaluation of a programming algorithm for deep brain stimulation in dystonia used in a double-blind, sham-controlled multicenter study.

Neurological research and practice

Steigerwald F, Kirsch AD, Kühn AA, Kupsch A, Mueller J, Eisner W, Deuschl G, Falk D, Schnitzler A, Skogseid IM, Vollmer-Haase J, Ip CW, Tronnier V, Vesper J, Naumann M, Volkmann J.
PMID: 33324891
Neurol Res Pract. 2019 Sep 24;1:25. doi: 10.1186/s42466-019-0032-2. eCollection 2019.

BACKGROUND: Programming deep brain stimulation in dystonia is difficult because of the delayed benefits and absence of evidence-based guidelines. Therefore, we evaluated the efficacy of a programming algorithm applied in a double-blind, sham-controlled multicenter study of pallidal deep brain...

CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells.

Theranostics

Campbell GR, Zhuang J, Zhang G, Landa I, Kubiatowicz LJ, Dehaini D, Fang RH, Zhang L, Spector SA.
PMID: 34522224
Theranostics. 2021 Aug 25;11(18):9009-9021. doi: 10.7150/thno.59728. eCollection 2021.

HIV-1 is a major global health challenge. The development of an effective vaccine and a therapeutic cure are top priorities. The creation of vaccines that focus an antibody response toward a particular epitope of a protein has shown promise,...

Binuclear C^C* Cyclometalated Platinum(II) NHC Complexes with Bridging Amidinate Ligands.

Angewandte Chemie (International ed. in English)

Leopold H, Tenne M, Tronnier A, Metz S, Münster I, Wagenblast G, Strassner T.
PMID: 27860097
Angew Chem Int Ed Engl. 2016 Dec 19;55(51):15779-15782. doi: 10.1002/anie.201607075. Epub 2016 Nov 18.

Binuclear C^C* cyclometalated NHC platinum(II) compounds with bridging amidinate ligands were synthesized to evaluate their photophysical properties. Their three-dimensional structures were determined by a combination of 2D NMR experiments, mass spectrometry, DFT calculations, and solid-state structure analysis. The bridging...

In vitro testing to assess the UVA protection performance of sun care products.

International journal of cosmetic science

, Gers-Barlag H, Klette E, Bimczok R, Springob C, Finkel P, Rudolph T, Gonzenbach HU, Schneider PH, Kockott D, Heinrich U, Tronnier H, Bernklau R, Johncock W, Langner R, Driller HJ, Westenfelder H.
PMID: 18503434
Int J Cosmet Sci. 2001 Feb;23(1):3-14. doi: 10.1046/j.1467-2494.2001.00048.x.

The UVA protection delivered by sunscreens is an issue of increasing importance due to the increasing knowledge about UVA-induced skin damage. In Europe there is no officially accepted method available to determine the degree of UVA protection. Therefore, the...

CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells.

Theranostics

Campbell GR, Zhuang J, Zhang G, Landa I, Kubiatowicz LJ, Dehaini D, Fang RH, Zhang L, Spector SA.
PMID: 34522224
Theranostics. 2021 Aug 25;11(18):9009-9021. doi: 10.7150/thno.59728. eCollection 2021.

HIV-1 is a major global health challenge. The development of an effective vaccine and a therapeutic cure are top priorities. The creation of vaccines that focus an antibody response toward a particular epitope of a protein has shown promise,...

Pallidal stimulation: an alternative to pallidotomy?.

Neurosurgical focus

Tronnier VM, Fogel W, Kronenbuerger M, Steinvorth S.
PMID: 15096016
Neurosurg Focus. 1997 Mar 15;2(3):e10. doi: 10.3171/foc.1997.2.5.10.

A resurgence of interest in the surgical treatment of Parkinson's disease (PD) came with the rediscovery of posteroventral pallidotomy by Laitinen in 1985. Laitinen's procedure improved most symptoms in drug-resistant PD, which engendered wide interest in the neurosurgical community....

S2k-Leitlinie Basalzellkarzinom der Haut - Teil 1: Epidemiologie, Genetik und Diagnostik.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

Lang BM, Balermpas P, Bauer A, Blum A, Brölsch GF, Dirschka T, Follmann M, Frank J, Frerich B, Fritz K, Hauschild A, Heindl LM, Howaldt HP, Ihrler S, Kakkassery V, Klumpp B, Krause-Bergmann A, Löser C, Meissner M, Sachse MM, Schlaak M, Schön MP, Tischendorf L, Tronnier M, Vordermark D, Welzel J, Weichenthal M, Wiegand S, Kaufmann R, Grabbe S.
PMID: 30615280
J Dtsch Dermatol Ges. 2019 Jan;17(1):94-104. doi: 10.1111/ddg.13733_g.

No abstract available.

Showing 13 to 24 of 122 entries