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Showing 49 to 60 of 3879 entries
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A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling.

Scientific reports

Li D, Chang X, Connolly JJ, Tian L, Liu Y, Bhoj EJ, Robinson N, Abrams D, Li YR, Bradfield JP, Kim CE, Li J, Wang F, Snyder J, Lemma M, Hou C, Wei Z, Guo Y, Qiu H, Mentch FD, Thomas KA, Chiavacci RM, Cone R, Li B, Sleiman PA, Hakonarson H.
PMID: 28630421
Sci Rep. 2017 Jun 19;7(1):3847. doi: 10.1038/s41598-017-01674-8.

We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell...

Simulating Ideal Assistive Devices to Reduce the Metabolic Cost of Running.

PloS one

Uchida TK, Seth A, Pouya S, Dembia CL, Hicks JL, Delp SL.
PMID: 27656901
PLoS One. 2016 Sep 22;11(9):e0163417. doi: 10.1371/journal.pone.0163417. eCollection 2016.

Tools have been used for millions of years to augment the capabilities of the human body, allowing us to accomplish tasks that would otherwise be difficult or impossible. Powered exoskeletons and other assistive devices are sophisticated modern tools that...

A report of two deep-seated noncutaneous penile tumors: more than meets the eye.

Radiology case reports

Thomas K, Spiess P, Caracciolo JT.
PMID: 29484058
Radiol Case Rep. 2017 Aug 12;12(4):726-730. doi: 10.1016/j.radcr.2017.07.012. eCollection 2017 Dec.

Penile cancer is an uncommon primary genitourinary malignancy, the vast majority representing superficial squamous cell carcinomas. However, less common skin cancers, secondary malignancies, mesenchymal neoplasms, and hematopoietic tumors do affect the penis. Medical history, atypical presentation, and deep epicenter...

High-throughput screening of inorganic compounds for the discovery of novel dielectric and optical materials.

Scientific data

Petousis I, Mrdjenovich D, Ballouz E, Liu M, Winston D, Chen W, Graf T, Schladt TD, Persson KA, Prinz FB.
PMID: 28140408
Sci Data. 2017 Jan 31;4:160134. doi: 10.1038/sdata.2016.134.

Dielectrics are an important class of materials that are ubiquitous in modern electronic applications. Even though their properties are important for the performance of devices, the number of compounds with known dielectric constant is on the order of a...

Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia.

Oncotarget

Zhou J, He L, Pang Z, Appelman HD, Kuick R, Beer DG, Li M, Wang TD.
PMID: 29152066
Oncotarget. 2017 Aug 01;8(50):87095-87106. doi: 10.18632/oncotarget.19764. eCollection 2017 Oct 20.

The incidence of esophageal adenocarcinoma (EAC) is rising rapidly, and early detection within the precursor state of Barrett's esophagus (BE) is challenged by flat premalignant lesions that are difficult detect with conventional endoscopic surveillance. Overexpression of cell surface fibroblast...

Identification of non-regulated polycyclic aromatic compounds and other markers of urban pollution in road tunnel particulate matter.

Journal of hazardous materials

Grung M, Kringstad A, Bæk K, Allan IJ, Thomas KV, Meland S, Ranneklev SB.
PMID: 27233209
J Hazard Mater. 2017 Feb 05;323:36-44. doi: 10.1016/j.jhazmat.2016.05.036. Epub 2016 May 12.

A combination of silicone rubber extraction and non-target and suspect screening by gas chromatography coupled to high-resolution time-of flight mass spectrometry was used for the identification of compounds in particulate matter (PM). Tunnel PM is a proxy for local...

Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles.

ACS medicinal chemistry letters

Houck JD, Dawson TK, Kennedy AJ, Kharel Y, Naimon ND, Field SD, Lynch KR, Macdonald TL.
PMID: 27190598
ACS Med Chem Lett. 2016 Mar 01;7(5):487-92. doi: 10.1021/acsmedchemlett.6b00002. eCollection 2016 May 12.

Sphingosine 1-phosphate (S1P) is a potent growth-signaling lipid that has been implicated in cancer progression, inflammation, sickle cell disease, and fibrosis. Two sphingosine kinases (SphK1 and 2) are the source of S1P; thus, inhibitors of the SphKs have potential...

Performance Evaluation of Small Animal PET Scanners With Different System Designs.

IEEE transactions on nuclear science

Li X, Alessio AM, Burnett TH, Lewellen TK, Miyaoka R.
PMID: 24273335
IEEE Trans Nucl Sci. 2013 Jun;60(3). doi: 10.1109/TNS.2013.2246797.

This study evaluated the image quality metrics of small animal PET scanners based upon measured single detector module positioning performance. A semi-analytical approach was developed to study PET scanner performance in the scenario of multiple realizations. Positron range blurring,...

Investments, time preferences and public transfers paid to women.

Economic development and cultural change

Rubalcava L, Teruel G, Thomas D.
PMID: 25926705
Econ Dev Cult Change. 2009 Apr;57(3):507-538. doi: 10.1086/596617.

The literature suggests men and women may have different preferences. This paper exploits a social experiment in which women in treatment households were given a large public cash transfer (PROGRESA). In an effort to disentangle the effect of additional...

Evidence Summarized in Attorneys' Closing Arguments Predicts Acquittals in Criminal Trials of Child Sexual Abuse.

Child maltreatment

Stolzenberg SN, Lyon TD.
PMID: 24920247
Child Maltreat. 2014 May;19(2):119-129. doi: 10.1177/1077559514539388. Epub 2014 Jun 11.

Evidence summarized in attorney's closing arguments of criminal child sexual abuse cases (N = 189) was coded to predict acquittal rates. Ten variables were significant bivariate predictors; five variables significant at p < .01 were entered into a multivariate...

Taxane-cisplatin-fluorouracil as induction chemotherapy for advanced head and neck cancer: a meta-analysis of the 5-year efficacy and safety.

SpringerPlus

Qian X, Ma C, Hoffmann TK, Kaufmann AM, Albers AE.
PMID: 25977896
Springerplus. 2015 May 01;4:208. doi: 10.1186/s40064-015-0988-5. eCollection 2015.

BACKGROUND: The objective of this study was to compare the efficacy and safety of taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) with cisplatin plus fluorouracil (PF) regimen by a meta-analysis of data retrieved from the literature.METHODS: Seven randomized...

Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production.

International journal for parasitology. Drugs and drug resistance

Chapman HD, Jeffers TK.
PMID: 25516830
Int J Parasitol Drugs Drug Resist. 2014 Oct 25;4(3):214-7. doi: 10.1016/j.ijpddr.2014.10.002. eCollection 2014 Dec.

Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by protozoa of the...

Showing 49 to 60 of 3879 entries