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Showing 265 to 268 of 268 entries
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Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation.

Developmental cell

Campbell NR, Rao A, Hunter MV, Sznurkowska MK, Briker L, Zhang M, Baron M, Heilmann S, Deforet M, Kenny C, Ferretti LP, Huang TH, Perlee S, Garg M, Nsengimana J, Saini M, Montal E, Tagore M, Newton-Bishop J, Middleton MR, Corrie P, Adams DJ, Rabbie R, Aceto N, Levesque MP, Cornell RA, Yanai I, Xavier JB, White RM.
PMID: 34529939
Dev Cell. 2021 Oct 25;56(20):2808-2825.e10. doi: 10.1016/j.devcel.2021.08.018. Epub 2021 Sep 15.

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus invasive (INV) subpopulations that represent a "go or grow" trade-off; however, how these populations interact is poorly understood. Using a combination of zebrafish modeling and analysis of patient...

The Impact of Upcoming Treatments in Huntington's Disease: Resource Capacity Limitations and Access to Care Implications.

Journal of Huntington's disease

Guttman M, Pedrazzoli M, Ponomareva M, Pelletier M, Townson L, Mukelabai K, Levine A, Nordström AL, Reilmann R, Burgunder JM.
PMID: 33843690
J Huntingtons Dis. 2021;10(2):303-311. doi: 10.3233/JHD-200462.

BACKGROUND: The most advanced disease-modifying therapies (DMTs) in development for Huntington's disease (HD) require intrathecal (IT) administration, which may create or exacerbate bottlenecks in resource capacity.OBJECTIVE: To understand the readiness of healthcare systems for intrathecally administered HD DMTs in...

Controlling Catenation in Germanium(I) Chemistry through Hemilability.

Angewandte Chemie (International ed. in English)

Caise A, Griffin LP, Heilmann A, McManus C, Campos J, Aldridge S.
PMID: 33939867
Angew Chem Int Ed Engl. 2021 Jul 05;60(28):15606-15612. doi: 10.1002/anie.202104643. Epub 2021 Jun 09.

We present a novel approach for constructing chains of Group 14 metal atoms linked by unsupported metal-metal bonds that exploits hemilabile ligands to generate unsaturated metal sites. The formation/nature of catenated species (oligo-dimetallynes) can be controlled by the use...

IL-7 and IL-15 Levels Reflect the Degree of T Cell Depletion during Lymphopenia and Are Associated with an Expansion of Effector Memory T Cells after Pediatric Hematopoietic Stem Cell Transplantation.

Journal of immunology (Baltimore, Md. : 1950)

Kielsen K, Oostenbrink LVE, von Asmuth EGJ, Jansen-Hoogendijk AM, van Ostaijen-Ten Dam MM, Ifversen M, Heilmann C, Schilham MW, van Halteren AGS, Bredius RGM, Lankester AC, Jol-van der Zijde CM, van Tol MJD, Müller K.
PMID: 34108260
J Immunol. 2021 Jun 15;206(12):2828-2838. doi: 10.4049/jimmunol.2001077. Epub 2021 Jun 09.

Differentially and functionally distinct T cell subsets are involved in the development of complications after allogeneic hematopoietic stem cell transplantation (HSCT), but little is known about factors regulating their recovery after HSCT. In this study, we investigated associations between...

Showing 265 to 268 of 268 entries