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Showing 25 to 36 of 52 entries
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Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study.

Clinical cancer research : an official journal of the American Association for Cancer Research

Delaidelli A, Dunham C, Santi M, Negri GL, Triscott J, Zheludkova O, Golanov A, Ryzhova M, Okonechnikov K, Schrimpf D, Stichel D, Ellison DW, von Deimling A, Kool M, Pfister SM, Ramaswamy V, Korshunov A, Taylor MD, Sorensen PH.
PMID: 34702771
Clin Cancer Res. 2021 Oct 26; doi: 10.1158/1078-0432.CCR-21-2057. Epub 2021 Oct 26.

PURPOSE: International consensus and the 2021 WHO classification recognize eight molecular subgroups among non-WNT/non-SHH (Group 3/4) medulloblastoma, representing approximately 60% of tumors. However, very few clinical centers worldwide possess the technical capabilities to determine DNA methylation profiles or other...

Systemic delivery of a DUX4-targeting antisense oligonucleotide to treat facioscapulohumeral muscular dystrophy.

Molecular therapy. Nucleic acids

Bouwman LF, den Hamer B, van den Heuvel A, Franken M, Jackson M, Dwyer CA, Tapscott SJ, Rigo F, van der Maarel SM, de Greef JC.
PMID: 34729250
Mol Ther Nucleic Acids. 2021 Sep 27;26:813-827. doi: 10.1016/j.omtn.2021.09.010. eCollection 2021 Dec 03.

Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent skeletal muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by inappropriate expression of the transcription factor DUX4, which activates different myotoxic pathways. At the moment there...

Use of Telehealth in Mental Health (MH) Services During and After COVID-19.

Community mental health journal

Molfenter T, Heitkamp T, Murphy AA, Tapscott S, Behlman S, Cody OJ.
PMID: 34165695
Community Ment Health J. 2021 Oct;57(7):1244-1251. doi: 10.1007/s10597-021-00861-2. Epub 2021 Jun 24.

COVID-19 social distancing guidelines caused a rapid transition to telephone and video technologies for the delivery of mental health (MH) services. The study examined: (a) adoption of these technologies across the MH service continuum; (b) acceptance of these technologies;...

A proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression.

Scientific reports

Goossens R, Tihaya MS, van den Heuvel A, Tabot-Ndip K, Willemsen IM, Tapscott SJ, González-Prieto R, Chang JG, Vertegaal ACO, Balog J, van der Maarel SM.
PMID: 34880314
Sci Rep. 2021 Dec 08;11(1):23642. doi: 10.1038/s41598-021-03030-3.

Structural Maintenance of Chromosomes Hinge Domain Containing 1 (SMCHD1) is a chromatin repressor, which is mutated in > 95% of Facioscapulohumeral dystrophy (FSHD) type 2 cases. In FSHD2, SMCHD1 mutations ultimately result in the presence of the cleavage stage...

Pbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish.

Biology open

Yao Z, Farr GH, Tapscott SJ, Maves L.
PMID: 23789105
Biol Open. 2013 Apr 08;2(6):546-55. doi: 10.1242/bio.20133921. Print 2013 Jun 15.

The basic helix-loop-helix factor Myod initiates skeletal muscle differentiation by directly and sequentially activating sets of muscle differentiation genes, including those encoding muscle contractile proteins. We hypothesize that Pbx homeodomain proteins direct Myod to a subset of its transcriptional...

Testing the Predictive Validity and Construct of Pathological Video Game Use.

Behavioral sciences (Basel, Switzerland)

Groves CL, Gentile D, Tapscott RL, Lynch PJ.
PMID: 26694472
Behav Sci (Basel). 2015 Dec 15;5(4):602-25. doi: 10.3390/bs5040602.

Three studies assessed the construct of pathological video game use and tested its predictive validity. Replicating previous research, Study 1 produced evidence of convergent validity in 8th and 9th graders (N = 607) classified as pathological gamers. Study 2...

Port-site complications after pediatric urologic robotic surgery.

Journal of robotic surgery

Tapscott A, Kim SS, White S, Graves R, Kraft K, Casale P.
PMID: 27638377
J Robot Surg. 2009 Oct;3(3):187. doi: 10.1007/s11701-009-0160-8. Epub 2009 Oct 06.

The incidence of port-site hernia development after adult laparoscopic surgery is reported to be between 0.1% and 3.0%. There are no published reports concerning hernia incidence or related factors after pediatric urologic laparoscopic interventions. We present our experience with...

Safety and Efficacy of Collagenase Clostridium histolyticum in the Treatment of Acute Phase Peyronie's Disease: A Multi-institutional Analysis.

Urology

Nguyen HMT, Yousif A, Chung A, Virasoro R, Tapscott A, Ziegelmann M, Trost L, Gelbard M, Hellstrom WJG.
PMID: 32777367
Urology. 2020 Nov;145:147-151. doi: 10.1016/j.urology.2020.07.048. Epub 2020 Aug 07.

OBJECTIVE: To study, in a multi-institutional setting, the efficacy/safety outcomes in acute phase Peyronie's disease (PD) of multiple high-volume centers employing CCH to treat PD, which is defined as the abnormal formation of fibrous plaque(s) in the tunica albuginea...

Detection of Astrovirus, Rotavirus C, and Hepatitis E Viral RNA in Adult and Juvenile Farmed Mink (.

Frontiers in veterinary science

Xie XT, Macdonald RE, Tapscott B, Nagy E, Turner PV.
PMID: 29974054
Front Vet Sci. 2018 Jun 19;5:132. doi: 10.3389/fvets.2018.00132. eCollection 2018.

Mink astrovirus (MiAstV) is known to play a major role in mink pre-weaning diarrhea, and rotavirus and hepatitis E virus (HEV) are both considered potentially zoonotic agents. These viruses are not monitored in commercial mink, and the role of...

Randomized Trial of a Mobile Personal Health Record for Behavioral Health Homes.

Psychiatric services (Washington, D.C.)

Druss BG, Li J, Tapscott S, Lally CA.
PMID: 32362226
Psychiatr Serv. 2020 Aug 01;71(8):803-809. doi: 10.1176/appi.ps.201900381. Epub 2020 May 04.

OBJECTIVE: Behavioral health homes, which provide onsite primary medical care in mental health clinics, face challenges in integrating information across multiple health records. This study tested whether a mobile personal health record application improved quality of medical care for...

The Impact of Context on Affective Norms: A Case of Study With Suspense.

Frontiers in psychology

Delatorre P, Salguero A, León C, Tapscott A.
PMID: 31543851
Front Psychol. 2019 Aug 30;10:1988. doi: 10.3389/fpsyg.2019.01988. eCollection 2019.

The emotional response to a stimulus is typically measured in three variables called valence, arousal and dominance. Based on such dimensions, Bradley and Lang (1999) published the Affective Norms for English Words (ANEW), a corpus of affective ratings for...

Morphology of the Greater Trochanter: An Assessment of Anatomic Variation and Canal Overhang.

Arthroplasty today

Horberg JV, Tapscott DC, Kurcz BP, O'Rourke RJ, Mikesell TA, Owen TM, Allan DG.
PMID: 32875012
Arthroplast Today. 2020 Aug 22;6(4):644-649. doi: 10.1016/j.artd.2020.07.020. eCollection 2020 Dec.

BACKGROUND: Varus malposition is a risk of early failure in total hip arthroplasty. The degree to which the tip of the greater trochanter (GT) overhangs the canal can increase this risk. Although we know proximal femoral anatomy is variable,...

Showing 25 to 36 of 52 entries