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A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study.

Alzheimer's & dementia (New York, N. Y.)

Villemagne VL, Rowe CC, Barnham KJ, Cherny R, Woodward M, Bozinosvski S, Salvado O, Bourgeat P, Perez K, Fowler C, Rembach A, Maruff P, Ritchie C, Tanzi R, Masters CL.
PMID: 29201996
Alzheimers Dement (N Y). 2017 Nov 09;3(4):622-635. doi: 10.1016/j.trci.2017.10.001. eCollection 2017 Nov.

INTRODUCTION: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT2, Prana Biotechnology]) for targeting amyloid β (Aβ) in Alzheimer's disease (AD). In an earlier phase IIa, 3 month trial, PBT2 lowered cerebrospinal fluid Aβ by 13%...

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Villemagne VL, Rowe CC, Barnham KJ, et al. A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study. Alzheimers Dement (N Y). 2017;3(4):622-635doi: 10.1016/j.trci.2017.10.001.
Villemagne, V. L., Rowe, C. C., Barnham, K. J., Cherny, R., Woodward, M., Bozinosvski, S., Salvado, O., Bourgeat, P., Perez, K., Fowler, C., Rembach, A., Maruff, P., Ritchie, C., Tanzi, R., & Masters, C. L. (2017). A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study. Alzheimer's & dementia (New York, N. Y.), 3(4), 622-635. https://doi.org/10.1016/j.trci.2017.10.001
Villemagne, Victor L, et al. "A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study." Alzheimer's & dementia (New York, N. Y.) vol. 3,4 (2017): 622-635. doi: https://doi.org/10.1016/j.trci.2017.10.001
Villemagne VL, Rowe CC, Barnham KJ, Cherny R, Woodward M, Bozinosvski S, Salvado O, Bourgeat P, Perez K, Fowler C, Rembach A, Maruff P, Ritchie C, Tanzi R, Masters CL. A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study. Alzheimers Dement (N Y). 2017 Nov 09;3(4):622-635. doi: 10.1016/j.trci.2017.10.001. eCollection 2017 Nov. PMID: 29201996; PMCID: PMC5702880.
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Supraventricular Tachycardia in a Patient with Repaired Congenital Heart Disease.

Cardiac electrophysiology clinics

Tanel RE.
PMID: 28770756
Card Electrophysiol Clin. 2010 Jun;2(2):231-234. doi: 10.1016/j.ccep.2010.01.009.

This case illustrates the difficulty in diagnosing atrial tachycardia in a patient who had a Mustard procedure for transposition of great arteries. Identification of atrial arrhythmias, even when they occur at physiologic ventricular rates, is important, because these patients...

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Tanel RE. Supraventricular Tachycardia in a Patient with Repaired Congenital Heart Disease. Card Electrophysiol Clin. 2010;2(2):231-234doi: 10.1016/j.ccep.2010.01.009.
Tanel, R. E. (2010). Supraventricular Tachycardia in a Patient with Repaired Congenital Heart Disease. Cardiac electrophysiology clinics, 2(2), 231-234. https://doi.org/10.1016/j.ccep.2010.01.009
Tanel, Ronn E. "Supraventricular Tachycardia in a Patient with Repaired Congenital Heart Disease." Cardiac electrophysiology clinics vol. 2,2 (2010): 231-234. doi: https://doi.org/10.1016/j.ccep.2010.01.009
Tanel RE. Supraventricular Tachycardia in a Patient with Repaired Congenital Heart Disease. Card Electrophysiol Clin. 2010 Jun;2(2):231-234. doi: 10.1016/j.ccep.2010.01.009. PMID: 28770756.
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The Biological Metallic versus Metallic Solution in Treating Periprosthetic Femoral Fractures: Outcome Assessment.

Advances in medicine

Carta S, Fortina M, Riva A, Meccariello L, Manzi E, Di Giovanni A, Ferrata P.
PMID: 27990462
Adv Med. 2016;2016:2918735. doi: 10.1155/2016/2918735. Epub 2016 Nov 20.

No abstract available.

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Carta S, Fortina M, Riva A, et al. The Biological Metallic versus Metallic Solution in Treating Periprosthetic Femoral Fractures: Outcome Assessment. Adv Med. 2016;2016:2918735doi: 10.1155/2016/2918735.
Carta, S., Fortina, M., Riva, A., Meccariello, L., Manzi, E., Di Giovanni, A., & Ferrata, P. (2016). The Biological Metallic versus Metallic Solution in Treating Periprosthetic Femoral Fractures: Outcome Assessment. Advances in medicine, 20162918735. https://doi.org/10.1155/2016/2918735
Carta, Serafino, et al. "The Biological Metallic versus Metallic Solution in Treating Periprosthetic Femoral Fractures: Outcome Assessment." Advances in medicine vol. 2016 (2016): 2918735. doi: https://doi.org/10.1155/2016/2918735
Carta S, Fortina M, Riva A, Meccariello L, Manzi E, Di Giovanni A, Ferrata P. The Biological Metallic versus Metallic Solution in Treating Periprosthetic Femoral Fractures: Outcome Assessment. Adv Med. 2016;2016:2918735. doi: 10.1155/2016/2918735. Epub 2016 Nov 20. PMID: 27990462; PMCID: PMC5136380.
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Topic: Experimental Surgery.

Hernia : the journal of hernias and abdominal wall surgery

Ceci F, Mattia S, Manzi E, D'Amore L, Gossetti F, Negro P.
PMID: 26518807
Hernia. 2015 Apr;19:S219. doi: 10.1007/BF03355356.

No abstract available.

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Ceci F, Mattia S, Manzi E, et al. Topic: Experimental Surgery. Hernia. 2015;19:S219doi: 10.1007/BF03355356.
Ceci, F., Mattia, S., Manzi, E., D'Amore, L., Gossetti, F., & Negro, P. (2015). Topic: Experimental Surgery. Hernia : the journal of hernias and abdominal wall surgery, 19S219. https://doi.org/10.1007/BF03355356
Ceci, F, et al. "Topic: Experimental Surgery." Hernia : the journal of hernias and abdominal wall surgery vol. 19 (2015): S219. doi: https://doi.org/10.1007/BF03355356
Ceci F, Mattia S, Manzi E, D'Amore L, Gossetti F, Negro P. Topic: Experimental Surgery. Hernia. 2015 Apr;19:S219. doi: 10.1007/BF03355356. PMID: 26518807.
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Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study.

BMC obesity

Negash S, Agyemang C, Matsha TE, Peer N, Erasmus RT, Kengne AP.
PMID: 28725448
BMC Obes. 2017 Jul 17;4:29. doi: 10.1186/s40608-017-0165-1. eCollection 2017.

BACKGROUND: Factors influencing the increasing prevalence of overweight/obesity among children and adolescents in sub-Saharan Africa remain unclear. We assessed the prevalence and determinants of overweight and obesity and effects on cardio-metabolic profile in school learners in the Western Cape,...

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Negash S, Agyemang C, Matsha TE, et al. Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study. BMC Obes. 2017;4:29doi: 10.1186/s40608-017-0165-1.
Negash, S., Agyemang, C., Matsha, T. E., Peer, N., Erasmus, R. T., & Kengne, A. P. (2017). Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study. BMC obesity, 429. https://doi.org/10.1186/s40608-017-0165-1
Negash, Sarah, et al. "Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study." BMC obesity vol. 4 (2017): 29. doi: https://doi.org/10.1186/s40608-017-0165-1
Negash S, Agyemang C, Matsha TE, Peer N, Erasmus RT, Kengne AP. Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study. BMC Obes. 2017 Jul 17;4:29. doi: 10.1186/s40608-017-0165-1. eCollection 2017. PMID: 28725448; PMCID: PMC5514529.
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Propensity of .

Toxics

Mudumbi JBN, Daso AP, Okonkwo OJ, Ntwampe SKO, Matsha TE, Mekuto L, Itoba-Tombo EF, Adetunji AT, Sibali LL.
PMID: 30934572
Toxics. 2019 Mar 25;7(1). doi: 10.3390/toxics7010018.

It has been extensively demonstrated that plants accumulate organic substances emanating from various sources, including soil and water. This fact suggests the potentiality of contamination of certain vital bioresources, such as medicinal plants, by persistent contaminants, such as perfluorooctanoic...

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Mudumbi JBN, Daso AP, Okonkwo OJ, et al. Propensity of . Toxics. 2019;7(1)doi: 10.3390/toxics7010018.
Mudumbi, J. B. N., Daso, A. P., Okonkwo, O. J., Ntwampe, S. K. O., Matsha, T. E., Mekuto, L., Itoba-Tombo, E. F., Adetunji, A. T., & Sibali, L. L. (2019). Propensity of . Toxics, 7(1), . https://doi.org/10.3390/toxics7010018
Mudumbi, John Baptist Nzukizi, et al. "Propensity of ." Toxics vol. 7,1 (2019). doi: https://doi.org/10.3390/toxics7010018
Mudumbi JBN, Daso AP, Okonkwo OJ, Ntwampe SKO, Matsha TE, Mekuto L, Itoba-Tombo EF, Adetunji AT, Sibali LL. Propensity of . Toxics. 2019 Mar 25;7(1). doi: 10.3390/toxics7010018. PMID: 30934572; PMCID: PMC6468628.
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Molecular evidence of .

JMM case reports

Ciceri G, Gori M, Bianchi S, Corrado G, Panisi P, Papa A, Tanzi E, Pontello M.
PMID: 29114396
JMM Case Rep. 2017 Sep 18;4(9):e005115. doi: 10.1099/jmmcr.0.005115. eCollection 2017 Sep.

No abstract available.

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Ciceri G, Gori M, Bianchi S, et al. Molecular evidence of . JMM Case Rep. 2017;4(9):e005115doi: 10.1099/jmmcr.0.005115.
Ciceri, G., Gori, M., Bianchi, S., Corrado, G., Panisi, P., Papa, A., Tanzi, E., & Pontello, M. (2017). Molecular evidence of . JMM case reports, 4(9), e005115. https://doi.org/10.1099/jmmcr.0.005115
Ciceri, Giulia, et al. "Molecular evidence of ." JMM case reports vol. 4,9 (2017): e005115. doi: https://doi.org/10.1099/jmmcr.0.005115
Ciceri G, Gori M, Bianchi S, Corrado G, Panisi P, Papa A, Tanzi E, Pontello M. Molecular evidence of . JMM Case Rep. 2017 Sep 18;4(9):e005115. doi: 10.1099/jmmcr.0.005115. eCollection 2017 Sep. PMID: 29114396; PMCID: PMC5643003.
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The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants.

Chemical science

Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C.
PMID: 28989646
Chem Sci. 2017 Sep 01;8(9):6155-6164. doi: 10.1039/c7sc01787a. Epub 2017 Jun 22.

The biological fate of amyloid beta (Aβ) species is a fundamental question in Alzheimer's disease (AD) pathogenesis. The competition between clearance and aggregation of Aβs is critical for the onset of AD. Copper has been widely considered to be...

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Yang J, Zhang X, Zhu Y, et al. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chem Sci. 2017;8(9):6155-6164doi: 10.1039/c7sc01787a.
Yang, J., Zhang, X., Zhu, Y., Lenczowski, E., Tian, Y., Yang, J., Zhang, C., Hardt, M., Qiao, C., Tanzi, R. E., Moore, A., Ye, H., & Ran, C. (2017). The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chemical science, 8(9), 6155-6164. https://doi.org/10.1039/c7sc01787a
Yang, Jing, et al. "The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants." Chemical science vol. 8,9 (2017): 6155-6164. doi: https://doi.org/10.1039/c7sc01787a
Yang J, Zhang X, Zhu Y, Lenczowski E, Tian Y, Yang J, Zhang C, Hardt M, Qiao C, Tanzi RE, Moore A, Ye H, Ran C. The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chem Sci. 2017 Sep 01;8(9):6155-6164. doi: 10.1039/c7sc01787a. Epub 2017 Jun 22. PMID: 28989646; PMCID: PMC5627602.
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Decreased Trunk Rotation at Foot Contact in Professional Baseball Pitchers With Prior Conservatively Managed SLAP Tears: A Propensity Score-Matched Analysis.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Manzi JE, Kunze KN, Meza B, Trauger N, Quan T, Rauck RC, Carr JB, Dines JS.
PMID: 34785298
Arthroscopy. 2021 Nov 14; doi: 10.1016/j.arthro.2021.11.009. Epub 2021 Nov 14.

PURPOSE: To compare kinematic and kinetic parameters between a cohort of fully recovered professional pitchers with prior shoulder injury treated conservatively and a cohort with no prior shoulder injury.METHODS: Twenty-six fully recovered professional baseball pitchers with a history of...

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Manzi JE, Kunze KN, Meza B, et al. Decreased Trunk Rotation at Foot Contact in Professional Baseball Pitchers With Prior Conservatively Managed SLAP Tears: A Propensity Score-Matched Analysis. Arthroscopy. 2021;doi: 10.1016/j.arthro.2021.11.009.
Manzi, J. E., Kunze, K. N., Meza, B., Trauger, N., Quan, T., Rauck, R. C., Carr, J. B., & Dines, J. S. (2021). Decreased Trunk Rotation at Foot Contact in Professional Baseball Pitchers With Prior Conservatively Managed SLAP Tears: A Propensity Score-Matched Analysis. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, . https://doi.org/10.1016/j.arthro.2021.11.009
Manzi, Joseph E, et al. "Decreased Trunk Rotation at Foot Contact in Professional Baseball Pitchers With Prior Conservatively Managed SLAP Tears: A Propensity Score-Matched Analysis." Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association vol. (2021). doi: https://doi.org/10.1016/j.arthro.2021.11.009
Manzi JE, Kunze KN, Meza B, Trauger N, Quan T, Rauck RC, Carr JB, Dines JS. Decreased Trunk Rotation at Foot Contact in Professional Baseball Pitchers With Prior Conservatively Managed SLAP Tears: A Propensity Score-Matched Analysis. Arthroscopy. 2021 Nov 14; doi: 10.1016/j.arthro.2021.11.009. Epub 2021 Nov 14. PMID: 34785298.
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Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing.

Pulmonology

Dourado VZ, Nishiaka RK, Simões MSMP, Lauria VT, Tanni SE, Godoy I, Gagliardi ART, Romiti M, Arantes RL.
PMID: 33958319
Pulmonology. 2021 Nov-Dec;27(6):500-508. doi: 10.1016/j.pulmoe.2021.03.006. Epub 2021 May 04.

BACKGROUND: The six-minute walk test (6MWT) distance could facilitate the assessment of cardiorespiratory fitness (CRF) in clinical practice as recommended. We aimed to develop a CRF classification using the 6MWT distance in asymptomatic adults considering the treadmill maximum oxygen...

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Dourado VZ, Nishiaka RK, Simões MSMP, et al. Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing. Pulmonology. 2021;27(6):500-508doi: 10.1016/j.pulmoe.2021.03.006.
Dourado, V. Z., Nishiaka, R. K., Simões, M. S. M. P., Lauria, V. T., Tanni, S. E., Godoy, I., Gagliardi, A. R. T., Romiti, M., & Arantes, R. L. (2021). Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing. Pulmonology, 27(6), 500-508. https://doi.org/10.1016/j.pulmoe.2021.03.006
Dourado, V Z, et al. "Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing." Pulmonology vol. 27,6 (2021): 500-508. doi: https://doi.org/10.1016/j.pulmoe.2021.03.006
Dourado VZ, Nishiaka RK, Simões MSMP, Lauria VT, Tanni SE, Godoy I, Gagliardi ART, Romiti M, Arantes RL. Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing. Pulmonology. 2021 Nov-Dec;27(6):500-508. doi: 10.1016/j.pulmoe.2021.03.006. Epub 2021 May 04. PMID: 33958319.
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Author Correction: Exercise hormone irisin is a critical regulator of cognitive function.

Nature metabolism

Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD.
PMID: 34621079
Nat Metab. 2021 Oct;3(10):1432. doi: 10.1038/s42255-021-00476-7.

No abstract available.

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Islam MR, Valaris S, Young MF, et al. Author Correction: Exercise hormone irisin is a critical regulator of cognitive function. Nat Metab. 2021;3(10):1432doi: 10.1038/s42255-021-00476-7.
Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., Christie, B. R., Schmider, A. B., Soberman, R. J., Besnard, A., Jedrychowski, M. P., Kim, H., Tu, H., Kim, E., Choi, S. H., Tanzi, R. E., Spiegelman, B. M., & Wrann, C. D. (2021). Author Correction: Exercise hormone irisin is a critical regulator of cognitive function. Nature metabolism, 3(10), 1432. https://doi.org/10.1038/s42255-021-00476-7
Islam, Mohammad R, et al. "Author Correction: Exercise hormone irisin is a critical regulator of cognitive function." Nature metabolism vol. 3,10 (2021): 1432. doi: https://doi.org/10.1038/s42255-021-00476-7
Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD. Author Correction: Exercise hormone irisin is a critical regulator of cognitive function. Nat Metab. 2021 Oct;3(10):1432. doi: 10.1038/s42255-021-00476-7. PMID: 34621079.
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Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review.

BMJ open

Glaab E, Rauschenberger A, Banzi R, Gerardi C, Garcia P, Demotes J.
PMID: 34873011
BMJ Open. 2021 Dec 06;11(12):e053674. doi: 10.1136/bmjopen-2021-053674.

OBJECTIVE: To review biomarker discovery studies using omics data for patient stratification which led to clinically validated FDA-cleared tests or laboratory developed tests, in order to identify common characteristics and derive recommendations for future biomarker projects.DESIGN: Scoping review.METHODS: We...

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Glaab E, Rauschenberger A, Banzi R, et al. Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review. BMJ Open. 2021;11(12):e053674doi: 10.1136/bmjopen-2021-053674.
Glaab, E., Rauschenberger, A., Banzi, R., Gerardi, C., Garcia, P., & Demotes, J. (2021). Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review. BMJ open, 11(12), e053674. https://doi.org/10.1136/bmjopen-2021-053674
Glaab, Enrico, et al. "Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review." BMJ open vol. 11,12 (2021): e053674. doi: https://doi.org/10.1136/bmjopen-2021-053674
Glaab E, Rauschenberger A, Banzi R, Gerardi C, Garcia P, Demotes J. Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review. BMJ Open. 2021 Dec 06;11(12):e053674. doi: 10.1136/bmjopen-2021-053674. PMID: 34873011; PMCID: PMC8650485.
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