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Showing 2473 to 2484 of 2484 entries
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Sex differences in serum levels of 5α-androstane-3β, 17β-diol, and androstenediol in the young adults: A liquid chromatography-tandem mass spectrometry study.

PloS one

Tanabe H, Mutai H, Sasayama D, Sasamoto H, Miyashiro Y, Sugiyama N, Washizuka S.
PMID: 34910781
PLoS One. 2021 Dec 15;16(12):e0261440. doi: 10.1371/journal.pone.0261440. eCollection 2021.

Animal experiments have consistently shown that estrogen receptor β (ERβ)-selective ligands have antidepressant and anxiolytic effects. In humans, endogenous ligands for ERβ include 5α-androstane-3β, 17β-diol (3βAdiol) and androstenediol (Δ5-diol). We determined, for the first time, the exact serum levels...

Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model.

Cell chemical biology

Malinee M, Pandian GN, Sugiyama H.
PMID: 34520746
Cell Chem Biol. 2021 Sep 11; doi: 10.1016/j.chembiol.2021.08.001. Epub 2021 Sep 11.

Considering the potential of combinatorial therapies in overcoming existing limitations of cancer immunotherapy, there is an increasing need to identify small-molecule modulators of immune cells capable of augmenting the effect of programmed cell death protein 1 (PD-1) blockade, leading...

Improved performance of the SH test as an in vitro skin sensitization test with a new predictive model and decision tree.

Journal of applied toxicology : JAT

Imai N, Takeyoshi M, Aizawa S, Tsurumaki M, Kurosawa M, Toyoda A, Sugiyama M, Kasahara K, Ogata S, Omori T, Hirota M.
PMID: 34927266
J Appl Toxicol. 2021 Dec 19; doi: 10.1002/jat.4275. Epub 2021 Dec 19.

Demands for the elimination and replacement of animal experiments for cosmetic safety assessment have increased in recent years. Evaluation of skin sensitization, however, is a critical issue in cosmetic safety assessment. The SH test is an in vitro skin...

Characteristic Signal Behaviors for Water-in-Oil and Oil-in-Water Emulsions Measured by Resonance-Enhanced Multiphoton Ionization Time-of-Flight Mass Spectrometry.

ACS omega

Sugiyama T, Iwata M, Ueyama T, Uchimura T.
PMID: 33324839
ACS Omega. 2020 Nov 25;5(48):31289-31294. doi: 10.1021/acsomega.0c04734. eCollection 2020 Dec 08.

Resonance-enhanced multiphoton ionization time-of-flight mass spectrometry (REMPI-TOFMS) was used to study the characteristic signal behaviors obtained from two types of emulsions: water-in-oil (W/O) and oil-in-water (O/W). All emulsions were prepared using phase inversion emulsification, i.e., a solution for an...

The Outcome and CT Findings of Low-Dose Intensity Modulated Radiation Therapy with SQAP in a Cat with Thymoma.

Veterinary sciences

Kutara K, Mochizuki Y, Ohnishi A, Mitsui I, Kanda T, Sugiyama A, Maeta N, Kobayashi K, Shimizu Y, Okamura Y, Asanuma T.
PMID: 33327647
Vet Sci. 2020 Dec 14;7(4). doi: 10.3390/vetsci7040203.

A 9-year-old male intact domestic cat weighing 4.6 kg was referred for tachypnea. A large mass was visible in computed tomography (CT) scans of the thoracic cavity. A histopathological evaluation of the mass was consistent with thymoma. The cat...

Determinants of visual-functional mismatches as assessed by coronary angiography and quantitative flow ratio.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Sugiyama T, Kanno Y, Hamaya R, Kanaji Y, Hoshino M, Murai T, Lee T, Yonetsu T, Sasano T, Kakuta T.
PMID: 33197120
Catheter Cardiovasc Interv. 2021 Nov 15;98(6):1047-1056. doi: 10.1002/ccd.29388. Epub 2020 Nov 16.

OBJECTIVE: We aimed to evaluate the determinants of visual-functional mismatches between quantitative coronary angiography (QCA) and the quantitative flow ratio (QFR).BACKGROUND: The fractional flow reserve (FFR) has been established as a method to estimate the functional stenosis severity of...

Association between influenza and the incidence rate of new-onset type 1 diabetes in Japan.

Journal of diabetes investigation

Nishioka Y, Noda T, Okada S, Myojin T, Kubo S, Higashino T, Nakajima H, Sugiyama T, Ishii H, Imamura T.
PMID: 33660948
J Diabetes Investig. 2021 Oct;12(10):1797-1804. doi: 10.1111/jdi.13540. Epub 2021 Apr 03.

AIM: This study aimed to determine whether there is an association between influenza and new-onset type 1 diabetes.MATERIALS AND METHODS: This population-based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check-ups...

Incidence and risk factors of acute encephalopathy with biphasic seizures in febrile status epilepticus.

Brain & development

Ichinose F, Nakamura T, Kira R, Furuno K, Ishii S, Takamura K, Hashiguchi M, Inoue T, Senju A, Ichimiya Y, Sakakibara T, Sugiyama N, Naitou T, Higuchi N, Togawa M, Torii KI, Toda S, Iwamatsu H, Sato T, Tsurui S, Tanaka H, Motobayashi M, Abe A, Kawaguchi A, Matsuo M.
PMID: 34362595
Brain Dev. 2022 Jan;44(1):36-43. doi: 10.1016/j.braindev.2021.07.004. Epub 2021 Aug 03.

OBJECTIVE: To clarify the incidence and risk factors of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) in pediatric patients with febrile status epilepticus (FSE).METHODS: We retrospectively surveyed patients with FSE (≥20 min and ≥40 min) who...

Japanese Project for Telepsychiatry Evaluation during COVID-19: Treatment Comparison Trial (J-PROTECT): Rationale, design, and methodology.

Contemporary clinical trials

Kishimoto T, Kinoshita S, Bun S, Sato Y, Kitazawa M, Kikuchi T, Sado M, Takamiya A, Mimura M, Nakamae T, Abe Y, Kanazawa T, Kawabata Y, Tomita H, Abe K, Hishimoto A, Asami T, Suda A, Watanabe Y, Amagai T, Sakuma K, Kida H, Funayama M, Kimura H, Sato A, Fujiwara S, Nagao K, Sugiyama N, Takamiya M, Kodama H, Azekawa T.
PMID: 34653648
Contemp Clin Trials. 2021 Dec;111:106596. doi: 10.1016/j.cct.2021.106596. Epub 2021 Oct 13.

INTRODUCTION: The COVID-19 pandemic has had a profound impact on the mental health of people around the world. Anxiety related to infection, stress and stigma caused by the forced changes in daily life have reportedly increased the incidence and...

Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia.

Cancers

Fujioka Y, Sugiyama D, Matsumura I, Minami Y, Miura M, Atsuta Y, Ohtake S, Kiyoi H, Miyazaki Y, Nishikawa H, Takahashi N.
PMID: 34885012
Cancers (Basel). 2021 Nov 24;13(23). doi: 10.3390/cancers13235904.

Treatment-free remission (TFR) has become a therapeutic goal in chronic myeloid leukemia (CML), and approximately half of the patients with chronic phase-CML (CML-CP) with deep molecular remission (DMR) by tyrosine-kinase inhibitors (TKIs) have achieved TFR. However, the mechanism of...

Direct platelet adhesion potentiates group 2 innate lymphoid cell functions.

Allergy

Orimo K, Tamari M, Takeda T, Kubo T, Rückert B, Motomura K, Sugiyama H, Yamada A, Saito K, Arae K, Kuriyama M, Hara M, Soyka MB, Ikutani M, Yamaguchi S, Morimoto N, Nakabayashi K, Hata K, Matsuda A, Akdis CA, Sudo K, Saito H, Nakae S, Tamaoki J, Tagaya E, Matsumoto K, Morita H.
PMID: 34402091
Allergy. 2021 Aug 17; doi: 10.1111/all.15057. Epub 2021 Aug 17.

BACKGROUND: Platelets are thought to be involved in the pathophysiology of asthma, presumably through direct adhesion to inflammatory cells, including group 2 innate lymphoid cells (ILC2s). Here, we tried to elucidate the effects of platelet adhesion to ILC2s in...

Clinical utility of 1-month postpartum random plasma glucose and glycated hemoglobin combined with pre-pregnancy body mass index for detecting postpartum glucose intolerance in Japanese women with gestational diabetes.

Journal of diabetes investigation

Sugiyama K, Saisho Y, Kasuga Y, Ochiai D, Itoh H.
PMID: 34109761
J Diabetes Investig. 2021 Dec;12(12):2242-2246. doi: 10.1111/jdi.13612. Epub 2021 Jul 28.

During the coronavirus disease 2019 pandemic, the Japanese Society of Diabetes and Pregnancy proposed the use of random plasma glucose and glycated hemoglobin measured 1 month after delivery combined with pre-pregnancy body mass index to detect postpartum glucose intolerance...

Showing 2473 to 2484 of 2484 entries