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Showing 2461 to 2472 of 2484 entries
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Body Muscle-to-Fat Ratio, Rather Than Fat-to-Muscle Ratio, Significantly Correlates With Measured Insulin Resistance in Patients With Type 2 Diabetes Mellitus.

Journal of clinical medicine research

Kurinami N, Sugiyama S, Yoshida A, Hieshima K, Miyamoto F, Kajiwara K, Jinnouch K, Jinnouchi T, Nomura M, Jinnouchi H.
PMID: 34394781
J Clin Med Res. 2021 Jul;13(7):387-391. doi: 10.14740/jocmr4401. Epub 2021 Jul 28.

BACKGROUND: Insulin resistance (IR) assessment is important in treating type 2 diabetes mellitus (T2DM). We thus compared body muscle-to-fat ratio (BMFR) and fat-to-muscle ratio (FMR) values against M/I values as clinical index of IR.METHODS: Subject included 118 untreated T2DM...

Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens.

International journal of molecular sciences

Nakazawa Y, Petrova RS, Sugiyama Y, Nagai N, Tamura H, Donaldson PJ.
PMID: 34884463
Int J Mol Sci. 2021 Nov 23;22(23). doi: 10.3390/ijms222312658.

Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity. Here, we...

Assessment of appropriate body mass index cut-off points for long-term mortality among ST-elevation myocardial infarction survivors in Asian population using machine learning algorithm.

Heart and vessels

Yoshioka N, Takagi K, Tanaka A, Morita Y, Yoshida R, Nagai H, Kanzaki Y, Watanabe N, Yamauchi R, Komeyama S, Sugiyama H, Shimojo K, Imaoka T, Sakamoto G, Ohi T, Goto H, Ishii H, Morishima I, Murohara T.
PMID: 34365566
Heart Vessels. 2021 Aug 07; doi: 10.1007/s00380-021-01916-w. Epub 2021 Aug 07.

Low body mass index (BMI) is a predictor of adverse events in patients with ST-elevated myocardial infarction (STEMI) in Western countries. Because the average BMI of Asians is significantly lower than that of the Western population, the appropriate cut-off...

Effects of Repeated Intracordal Glucocorticoid Injection on the Histology and Gene Expression of Rat Vocal Folds.

Journal of voice : official journal of the Voice Foundation

Hashimoto K, Kaneko M, Kinoshita S, Ozawa S, Mukudai S, Sugiyama Y, Hirano S.
PMID: 34284926
J Voice. 2021 Jul 17; doi: 10.1016/j.jvoice.2021.06.013. Epub 2021 Jul 17.

OBJECTIVES: Local injection of glucocorticoids (GCs) into the vocal folds has been used for treating the vocal fold lesions. While the positive effects on vocal fold nodules, polyps, or scarring have been clinically reported, some concern remains around the...

Distinct contributions of partial and full EMT to breast cancer malignancy.

Developmental cell

Lüönd F, Sugiyama N, Bill R, Bornes L, Hager C, Tang F, Santacroce N, Beisel C, Ivanek R, Bürglin T, Tiede S, van Rheenen J, Christofori G.
PMID: 34847378
Dev Cell. 2021 Dec 06;56(23):3203-3221.e11. doi: 10.1016/j.devcel.2021.11.006. Epub 2021 Nov 29.

Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-differentiation where cancer cells transit between various stages of an EMT continuum, including epithelial, partial EMT, and mesenchymal cell states. We have employed Tamoxifen-inducible dual recombinase lineage tracing systems...

Two plasmid modules for introducing the auxin-inducible degron into the fission yeast .

microPublication biology

Song X, Xu R, Sugiyama T.
PMID: 34423281
MicroPubl Biol. 2021 Aug 18;2021. doi: 10.17912/micropub.biology.000442. eCollection 2021.

Targeted protein degradation is a powerful approach to study and inhibit protein function

Correction: Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan.

PloS one

Shibutami E, Ishii R, Harada S, Kurihara A, Kuwabara K, Kato S, Iida M, Akiyama M, Sugiyama D, Hirayama A, Sato A, Amano K, Sugimoto M, Soga T, Tomita M, Takebayashi T.
PMID: 33886678
PLoS One. 2021 Apr 22;16(4):e0250864. doi: 10.1371/journal.pone.0250864. eCollection 2021.

[This corrects the article DOI: 10.1371/journal.pone.0246456.].

The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death.

Pharmacological reports : PR

Ota A, Tajima M, Mori K, Sugiyama E, Sato VH, Sato H.
PMID: 33864630
Pharmacol Rep. 2021 Jun;73(3):847-857. doi: 10.1007/s43440-021-00260-0. Epub 2021 Apr 17.

BACKGROUND: Silver is a transition metal that is known to be less toxic than platinum. However, only few studies have reported the anticancer effects of some silver complexes and their possibility as an alternative to platinum complex. This study...

Improvement in Brachial Endothelial Vasomotor Function and Brachial-Ankle Pulse Wave Velocity Reduces the Residual Risk for Cardiovascular Events after Optimal Medical Treatment in Patients with Coronary Artery Disease.

Journal of atherosclerosis and thrombosis

Nakamura T, Uematsu M, Horikoshi T, Yoshizaki T, Kobayashi T, Saito Y, Watanabe Y, Nakamura K, Obata JE, Kugiyama K.
PMID: 33229855
J Atheroscler Thromb. 2021 Nov 01;28(11):1133-1144. doi: 10.5551/jat.57562. Epub 2020 Nov 20.

AIM: To examine whether improvement in flow-mediated endothelium-dependent dilatation (FMD) of the brachial artery and brachial-ankle pulse wave velocity (baPWV) has an additive effect on achieving optimal goals of traditional risk factors to reduce cardiovascular risk in patients with...

Inhibitory effects of somatostatin analogue in bleomycin-induced pulmonary fibrosis.

Experimental lung research

Hosono T, Bando M, Mizushina Y, Sata M, Hagiwara K, Sugiyama Y.
PMID: 33899633
Exp Lung Res. 2021 May-Aug;47(6):280-288. doi: 10.1080/01902148.2021.1916650. Epub 2021 Apr 24.

BACKGROUND AND OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease. An increased expression of somatostatin receptor subtype 2 in patients with IPF was identified and lung fibroblasts expressed somatostatin receptors METHODS: C57BL/6 mice received a...

Author Correction: Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model.

Scientific reports

Kashiwagi Y, Aburaya S, Sugiyama N, Narukawa Y, Sakamoto Y, Takahashi M, Uemura H, Yamashita R, Tominaga S, Hayashi S, Nozaki T, Yamada S, Izumi Y, Kashiwagi A, Bamba T, Ishihama Y, Murakami S.
PMID: 34608253
Sci Rep. 2021 Oct 04;11(1):20016. doi: 10.1038/s41598-021-99556-7.

No abstract available.

Low tumor cell content predicts favorable prognosis in germinoma patients.

Neuro-oncology advances

Takami H, Satomi K, Fukuoka K, Fukushima S, Matsushita Y, Yamasaki K, Nakamura T, Tanaka S, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Nakamura H, Sugiyama K, Tamura K, Maehara T, Nakada M, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kanemura Y, Kobayashi K, Nagane M, Kurozumi K, Yoshimoto K, Matsuda M, Matsumura A, Hirose Y, Tokuyama T, Kumabe T, Narita Y, Shibui S, Nakazato Y, Nishikawa R, Matsutani M, Ichimura K.
PMID: 34549182
Neurooncol Adv. 2021 Aug 10;3(1):vdab110. doi: 10.1093/noajnl/vdab110. eCollection 2021.

BACKGROUND: Germinoma preferentially occurs in pediatric and young adult age groups. Although they are responsive to treatment with chemotherapy and radiation, the treatment may cause long-term sequelae in their later lives. Here, we searched for clinical and histopathological features...

Showing 2461 to 2472 of 2484 entries