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Showing 1429 to 1438 of 1438 entries
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Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma.

Nature communications

Zoumpoulidou G, Alvarez-Mendoza C, Mancusi C, Ahmed RM, Denman M, Steele CD, Tarabichi M, Roy E, Davies LR, Manji J, Cristalli C, Scotlandi K, Pillay N, Strauss SJ, Mittnacht S.
PMID: 34862364
Nat Commun. 2021 Dec 03;12(1):7064. doi: 10.1038/s41467-021-27291-8.

Loss-of-function mutations in the RB1 tumour suppressor are key drivers in cancer, including osteosarcoma. RB1 loss-of-function compromises genome-maintenance and hence could yield vulnerability to therapeutics targeting such processes. Here we demonstrate selective hypersensitivity to clinically-approved inhibitors of Poly-ADP-Polymerase1,2 inhibitors...

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

Science advances

Kurth I, Yamaguchi N, Andreu-Agullo C, Tian HS, Sridhar S, Takeda S, Gonsalves FC, Loo JM, Barlas A, Manova-Todorova K, Busby R, Bendell JC, Strauss J, Fakih M, McRee AJ, Hendifar AE, Rosen LS, Cercek A, Wasserman R, Szarek M, Spector SL, Raza S, Tavazoie MF, Tavazoie SF.
PMID: 34613776
Sci Adv. 2021 Oct 08;7(41):eabi7511. doi: 10.1126/sciadv.abi7511. Epub 2021 Oct 06.

[Figure: see text].

Reply to "A limitation regarding the association between intranasal corticosteroid use and better COVID-19 outcomes: Nasal symptoms matter".

The journal of allergy and clinical immunology. In practice

Strauss R, Attaway AH, Zein JG.
PMID: 35000738
J Allergy Clin Immunol Pract. 2022 Jan;10(1):355-356. doi: 10.1016/j.jaip.2021.10.062.

No abstract available.

Reply to "A limitation regarding the association between intranasal corticosteroid use and better COVID-19 outcomes: Nasal symptoms matter".

The journal of allergy and clinical immunology. In practice

Strauss R, Attaway AH, Zein JG.
PMID: 35000738
J Allergy Clin Immunol Pract. 2022 Jan;10(1):355-356. doi: 10.1016/j.jaip.2021.10.062.

No abstract available.

The root meristem is shaped by brassinosteroid control of cell geometry.

Nature plants

Fridman Y, Strauss S, Horev G, Ackerman-Lavert M, Reiner-Benaim A, Lane B, Smith RS, Savaldi-Goldstein S.
PMID: 34782771
Nat Plants. 2021 Nov;7(11):1475-1484. doi: 10.1038/s41477-021-01014-9. Epub 2021 Nov 15.

Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally modulated to control size and shape is not well known. Here we tackled this question by studying the effect of brassinosteroid (BR) signalling on the structure...

Association of Logic's hip hop song "1-800-273-8255" with Lifeline calls and suicides in the United States: interrupted time series analysis.

BMJ (Clinical research ed.)

Niederkrotenthaler T, Tran US, Gould M, Sinyor M, Sumner S, Strauss MJ, Voracek M, Till B, Murphy S, Gonzalez F, Spittal MJ, Draper J.
PMID: 34903528
BMJ. 2021 Dec 13;375:e067726. doi: 10.1136/bmj-2021-067726.

OBJECTIVE: To assess changes in daily call volumes to the US National Suicide Prevention Lifeline and in suicides during periods of wide scale public attention to the song "1-800-273-8255" by American hip hop artist Logic.DESIGN: Time series analysis.SETTING: United...

Multiplexed direct detection of barcoded protein reporters on a nanopore array.

Nature biotechnology

Cardozo N, Zhang K, Doroschak K, Nguyen A, Siddiqui Z, Bogard N, Strauss K, Ceze L, Nivala J.
PMID: 34385692
Nat Biotechnol. 2021 Aug 12; doi: 10.1038/s41587-021-01002-6. Epub 2021 Aug 12.

Detection of specific proteins using nanopores is currently challenging. To address this challenge, we developed a collection of over twenty nanopore-addressable protein tags engineered as reporters (NanoporeTERs, or NTERs). NTERs are constructed with a secretion tag, folded domain and...

Reducing stress and promoting well-being in healthcare workers using mindfulness-based cognitive therapy for life.

International journal of clinical and health psychology : IJCHP

Strauss C, Gu J, Montero-Marin J, Whittington A, Chapman C, Kuyken W.
PMID: 33680001
Int J Clin Health Psychol. 2021 May-Aug;21(2):100227. doi: 10.1016/j.ijchp.2021.100227. Epub 2021 Feb 18.

Healthcare workers play a critical role in the health of a nation, yet rates of healthcare worker stress are disproportionately high. We evaluated whether mindfulness-based cognitive therapy for life (MBCT-L), could reduce stress in healthcare workers and target a...

Is clinician-supported use of a mindfulness smartphone app a feasible treatment for depression? A mixed-methods feasibility study.

Internet interventions

Strauss C, Dunkeld C, Cavanagh K.
PMID: 34401372
Internet Interv. 2021 Jun 05;25:100413. doi: 10.1016/j.invent.2021.100413. eCollection 2021 Sep.

Depression is the leading cause of disability globally and has serious consequences for the individual, their family and for society. Effective, accessible and affordable treatments are urgently needed. In-person group-based mindfulness-based interventions are an effective treatment for depression, but...

The Impact of Nursing Students' Cultural Diversity on the Intention and Attitudes Toward the Use of Information Technology.

Gonen A, Sharon D, Lev-Ari L, Strauss E, Segev R.
UIID-AD: 4370
2016;302-10. doi: 10.1177/1043659615581558.

This research highlights the evidences that: The greater the threat, the lower the attitude toward information technology is, and the greater the sense of challenge, the greater self-efficacy is. Innovativeness was found to be a behavioral intention predictor in...

Showing 1429 to 1438 of 1438 entries