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Showing 1921 to 1931 of 1931 entries
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Late and very late relapsed acute lymphoblastic leukemia: clinical and molecular features, and treatment outcomes.

Blood cancer journal

Aldoss I, Pillai R, Yang D, Yang L, Arslan S, Mokhtari S, Malki MMA, Salhotra A, Shahani S, Ali H, Mei M, Artz A, Snyder D, Afkhami M, Armenian S, Stein A, Marcucci G, Forman SJ, Nakamura R, Pullarkat V.
PMID: 34215723
Blood Cancer J. 2021 Jul 02;11(7):125. doi: 10.1038/s41408-021-00516-1.

No abstract available.

Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma.

Cell reports. Medicine

Anagnostou V, Bruhm DC, Niknafs N, White JR, Shao XM, Sidhom JW, Stein J, Tsai HL, Wang H, Belcaid Z, Murray J, Balan A, Ferreira L, Ross-Macdonald P, Wind-Rotolo M, Baras AS, Taube J, Karchin R, Scharpf RB, Grasso C, Ribas A, Pardoll DM, Topalian SL, Velculescu VE.
PMID: 33294860
Cell Rep Med. 2020 Nov 17;1(8):100139. doi: 10.1016/j.xcrm.2020.100139. eCollection 2020 Nov 17.

In this study, we incorporate analyses of genome-wide sequence and structural alterations with pre- and on-therapy transcriptomic and T cell repertoire features in immunotherapy-naive melanoma patients treated with immune checkpoint blockade. Although tumor mutation burden is associated with improved...

Directional sound source modeling using the adjoint Euler equations in a finite-difference time-domain approach.

The Journal of the Acoustical Society of America

Stein L, Straube F, Weinzierl S, Lemke M.
PMID: 33261372
J Acoust Soc Am. 2020 Nov;148(5):3075. doi: 10.1121/10.0002425.

An adjoint-based approach for synthesizing complex sound sources by discrete, grid-based monopoles in finite-difference time-domain simulations is presented. Previously, Stein, Straube, Sesterhenn, Weinzierl, and Lemke [(2019). J. Acoust. Soc. Am. 146(3), 1774-1785] demonstrated that the approach allows one to...

Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma: Final Results of the PAPAGEMO Phase 2 Randomized Clinical Trial.

JAMA oncology

Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A.
PMID: 33355646
JAMA Oncol. 2021 Feb 01;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564.

IMPORTANCE: Pazopanib and gemcitabine have shown good tolerability, albeit modest single-agent activity in pretreated soft tissue sarcoma. A combined regimen to improve outcomes is required.OBJECTIVE: To determine the efficacy of gemcitabine and pazopanib compared with pazopanib alone.DESIGN, SETTING, AND...

[Quality of life for wearers of a suprapubic or transurethral bladder catheter as lifelong permanent care].

Der Urologe. Ausg. A

Wiedemann A, Gedding C, Heese M, Stein J, Manseck A, Kirschner-Hermanns R, Karstedt H, Schorn A, Wagner A, Moll V, Unger U, Eisenhardt A, Bannowsky A, Linné C, Wirz S, Brammen E, Heppner HJ.
PMID: 34605933
Urologe A. 2021 Oct 04; doi: 10.1007/s00120-021-01642-1. Epub 2021 Oct 04.

BACKGROUND: The insertion of a Foley catheter (FC) or a suprapubic catheter (SPC) in lifelong intent is an intervention with significant complications, comorbidities and impact on the further life that has not yet been analyzed.METHODOLOGY: The analysis was based...

SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis.

Cell reports

Portillo M, Eremenko E, Kaluski S, Garcia-Venzor A, Onn L, Stein D, Slobodnik Z, Zaretsky A, Ueberham U, Einav M, Brückner MK, Arendt T, Toiber D.
PMID: 33910019
Cell Rep. 2021 Apr 27;35(4):109035. doi: 10.1016/j.celrep.2021.109035.

Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegeneration. Here, we show that Tau hyper-acetylation at residue 174 increases its own nuclear presence and is...

Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study.

JAMA pediatrics

Villar J, Restrepo-Méndez MC, McGready R, Barros FC, Victora CG, Munim S, Papageorghiou AT, Ochieng R, Craik R, Barsosio HC, Berkley JA, Carvalho M, Fernandes M, Cheikh Ismail L, Lambert A, Norris SA, Ohuma EO, Stein A, Tshivuila-Matala COO, Zondervan KT, Winsey A, Nosten F, Uauy R, Bhutta ZA, Kennedy SH.
PMID: 33646288
JAMA Pediatr. 2021 May 01;175(5):483-493. doi: 10.1001/jamapediatrics.2020.6087.

IMPORTANCE: The etiologic complexities of preterm birth remain inadequately understood, which may impede the development of better preventative and treatment measures.OBJECTIVE: To examine the association between specific preterm-birth phenotypes and clinical, growth, and neurodevelopmental differences among preterm newborns compared...

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes.

Diabetes

Tong X, Stein R.
PMID: 34433630
Diabetes. 2021 Nov;70(11):2595-2607. doi: 10.2337/db21-0261. Epub 2021 Aug 25.

Free fatty acids (FFAs) are often stored in lipid droplet (LD) depots for eventual metabolic and/or synthetic use in many cell types, such a muscle, liver, and fat. In pancreatic islets, overt LD accumulation was detected in humans but...

A Brief Home-Based Parenting Intervention to Reduce Behavior Problems in Young Children: A Pragmatic Randomized Clinical Trial.

JAMA pediatrics

O'Farrelly C, Watt H, Babalis D, Bakermans-Kranenburg MJ, Barker B, Byford S, Ganguli P, Grimas E, Iles J, Mattock H, McGinley J, Phillips C, Ryan R, Scott S, Smith J, Stein A, Stevens E, van IJzendoorn MH, Warwick J, Ramchandani PG.
PMID: 33720329
JAMA Pediatr. 2021 Jun 01;175(6):567-576. doi: 10.1001/jamapediatrics.2020.6834.

IMPORTANCE: Behavior problems are one of the most common mental health disorders in childhood and can undermine children's health, education, and employment outcomes into adulthood. There are few effective interventions for early childhood.OBJECTIVE: To test the clinical effectiveness of...

Postoperative tonsil/adenoidectomy bleeding management in patients with diagnosed bleeding disorders.

Laryngoscope investigative otolaryngology

Pai K, Desai H, Stein D, Cole S.
PMID: 34401515
Laryngoscope Investig Otolaryngol. 2021 Jun 10;6(4):872-877. doi: 10.1002/lio2.589. eCollection 2021 Aug.

OBJECTIVE: Tonsil/adenoidectomy (T/A) is a commonly performed procedure with an average post-tonsillectomy bleed (PTB) rate between 3 and 5%. Patients with bleeding disorders (BDs) are believed to have an increased risk of PTB. We hypothesize that our medical management...

The four habits coding scheme: Validation of an instrument to assess clinicians' communication behavior.

Krupat E, Frankel R, Stein T, Irish J.
UIID-AD: 519
2006;62:38-45. doi: 10.1016/j.pec.2005.04.015.

Objective: To present preliminary evidence for the reliability and validity of the Four Habits Coding Scheme (4HCS), an instrument based on a teaching model used widely throughout Kaiser Permanente to improve clinicians' communication skills. Methods: One hundred videotaped primary...

Showing 1921 to 1931 of 1931 entries