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Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice.

Frontiers in cellular neuroscience

Cibelli A, Veronica Lopez-Quintero S, Mccutcheon S, Scemes E, Spray DC, Stout RF, Suadicani SO, Thi MM, Urban-Maldonado M.
PMID: 33790744
Front Cell Neurosci. 2021 Mar 15;15:647109. doi: 10.3389/fncel.2021.647109. eCollection 2021.

We transduced mouse cortical astrocytes cultured from four litters of embryonic wildtype (WT) and connexin43 (Cx43) null mouse pups with lentiviral vector encoding hTERT and measured expression of astrocyte-specific markers up to passage 10 (p10). The immortalized cell lines...

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Cibelli A, Veronica Lopez-Quintero S, Mccutcheon S, et al. Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Front Cell Neurosci. 2021;15:647109doi: 10.3389/fncel.2021.647109.
Cibelli, A., Veronica Lopez-Quintero, S., Mccutcheon, S., Scemes, E., Spray, D. C., Stout, R. F., Suadicani, S. O., Thi, M. M., & Urban-Maldonado, M. (2021). Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Frontiers in cellular neuroscience, 15647109. https://doi.org/10.3389/fncel.2021.647109
Cibelli, Antonio, et al. "Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice." Frontiers in cellular neuroscience vol. 15 (2021): 647109. doi: https://doi.org/10.3389/fncel.2021.647109
Cibelli A, Veronica Lopez-Quintero S, Mccutcheon S, Scemes E, Spray DC, Stout RF, Suadicani SO, Thi MM, Urban-Maldonado M. Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Front Cell Neurosci. 2021 Mar 15;15:647109. doi: 10.3389/fncel.2021.647109. eCollection 2021. PMID: 33790744; PMCID: PMC8005635.
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Methylphenidate improves motor functions in children diagnosed with Hyperkinetic Disorder.

Behavioral and brain functions : BBF

Stray LL, Stray T, Iversen S, Ruud A, Ellertsen B.
PMID: 19439096
Behav Brain Funct. 2009 May 13;5:21. doi: 10.1186/1744-9081-5-21.

BACKGROUND: A previous study showed that a high percentage of children diagnosed with Hyperkinetic Disorder (HKD) displayed a consistent pattern of motor function problems. The purpose of this study was to investigate the effect of methylphenidate (MPH) on such...

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Stray LL, Stray T, Iversen S, et al. Methylphenidate improves motor functions in children diagnosed with Hyperkinetic Disorder. Behav Brain Funct. 2009;5:21doi: 10.1186/1744-9081-5-21.
Stray, L. L., Stray, T., Iversen, S., Ruud, A., & Ellertsen, B. (2009). Methylphenidate improves motor functions in children diagnosed with Hyperkinetic Disorder. Behavioral and brain functions : BBF, 521. https://doi.org/10.1186/1744-9081-5-21
Stray, Liv Larsen, et al. "Methylphenidate improves motor functions in children diagnosed with Hyperkinetic Disorder." Behavioral and brain functions : BBF vol. 5 (2009): 21. doi: https://doi.org/10.1186/1744-9081-5-21
Stray LL, Stray T, Iversen S, Ruud A, Ellertsen B. Methylphenidate improves motor functions in children diagnosed with Hyperkinetic Disorder. Behav Brain Funct. 2009 May 13;5:21. doi: 10.1186/1744-9081-5-21. PMID: 19439096; PMCID: PMC2686715.
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Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia.

The Journal of pediatrics

Rumpel J, Spray BJ, Chock VY, Kirkley MJ, Slagle CL, Frymoyer A, Cho SH, Gist KM, Blaszak R, Poindexter B, Courtney SE.
PMID: 34547334
J Pediatr. 2021 Sep 20; doi: 10.1016/j.jpeds.2021.08.090. Epub 2021 Sep 20.

OBJECTIVE: To evaluate the predictive performance of urine biomarkers for acute kidney injury (AKI) in neonates with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia.STUDY DESIGN: We performed a multicenter prospective observational study of 64 neonates. Urine specimens were obtained...

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Rumpel J, Spray BJ, Chock VY, et al. Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia. J Pediatr. 2021;doi: 10.1016/j.jpeds.2021.08.090.
Rumpel, J., Spray, B. J., Chock, V. Y., Kirkley, M. J., Slagle, C. L., Frymoyer, A., Cho, S. H., Gist, K. M., Blaszak, R., Poindexter, B., & Courtney, S. E. (2021). Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia. The Journal of pediatrics, . https://doi.org/10.1016/j.jpeds.2021.08.090
Rumpel, Jennifer, et al. "Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia." The Journal of pediatrics vol. (2021). doi: https://doi.org/10.1016/j.jpeds.2021.08.090
Rumpel J, Spray BJ, Chock VY, Kirkley MJ, Slagle CL, Frymoyer A, Cho SH, Gist KM, Blaszak R, Poindexter B, Courtney SE. Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia. J Pediatr. 2021 Sep 20; doi: 10.1016/j.jpeds.2021.08.090. Epub 2021 Sep 20. PMID: 34547334.
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Situating household management of children's asthma in the context of social, economic, and environmental injustice.

The Journal of asthma : official journal of the Association for the Care of Asthma

Hunleth J, Spray J, Ruiz S, Maki J, Fedele DA, Prabhakaran S, Forsyth RB, Sykes C, Crepps K, Shepperd J, Bowen D, Waters EA.
PMID: 33107771
J Asthma. 2020 Oct 27;1-9. doi: 10.1080/02770903.2020.1837159. Epub 2020 Oct 27.

BACKGROUND: Structural determinants of health are social, economic, and environmental forces that generate unequal opportunities for resources and unequally distribute exposure to risk. For example, economic constraint, racial discrimination and segregation, and environmental injustice shape population-level asthma prevalence and...

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Hunleth J, Spray J, Ruiz S, et al. Situating household management of children's asthma in the context of social, economic, and environmental injustice. J Asthma. 2020;1-9doi: 10.1080/02770903.2020.1837159.
Hunleth, J., Spray, J., Ruiz, S., Maki, J., Fedele, D. A., Prabhakaran, S., Forsyth, R. B., Sykes, C., Crepps, K., Shepperd, J., Bowen, D., & Waters, E. A. (2020). Situating household management of children's asthma in the context of social, economic, and environmental injustice. The Journal of asthma : official journal of the Association for the Care of Asthma, 1-9. https://doi.org/10.1080/02770903.2020.1837159
Hunleth, Jean, et al. "Situating household management of children's asthma in the context of social, economic, and environmental injustice." The Journal of asthma : official journal of the Association for the Care of Asthma vol. (2020): 1-9. doi: https://doi.org/10.1080/02770903.2020.1837159
Hunleth J, Spray J, Ruiz S, Maki J, Fedele DA, Prabhakaran S, Forsyth RB, Sykes C, Crepps K, Shepperd J, Bowen D, Waters EA. Situating household management of children's asthma in the context of social, economic, and environmental injustice. J Asthma. 2020 Oct 27;1-9. doi: 10.1080/02770903.2020.1837159. Epub 2020 Oct 27. PMID: 33107771; PMCID: PMC8076336.
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Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction.

Heart (British Cardiac Society)

Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil SER, Gaskin D, Bakogiannis C, Sopova K, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall AJ, Stellos K, Stamatelopoulos K, Spyridopoulos I.
PMID: 34544804
Heart. 2021 Dec;107(23):1881-1888. doi: 10.1136/heartjnl-2021-319225. Epub 2021 Sep 20.

BACKGROUND AND AIM: Although the diagnostic usefulness of high-sensitivity cardiac troponin T (hs-cTnT) is well established in ST-segment elevation myocardial infarction (STEMI), its prognostic relevance in risk stratification of patients with STEMI remains obscure. This study sought to determine...

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Coelho-Lima J, Georgiopoulos G, Ahmed J, et al. Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart. 2021;107(23):1881-1888doi: 10.1136/heartjnl-2021-319225.
Coelho-Lima, J., Georgiopoulos, G., Ahmed, J., Adil, S. E. R., Gaskin, D., Bakogiannis, C., Sopova, K., Ahmed, F., Ahmed, H., Spray, L., Richardson, G., Bagnall, A. J., Stellos, K., Stamatelopoulos, K., & Spyridopoulos, I. (2021). Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart (British Cardiac Society), 107(23), 1881-1888. https://doi.org/10.1136/heartjnl-2021-319225
Coelho-Lima, Jose, et al. "Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction." Heart (British Cardiac Society) vol. 107,23 (2021): 1881-1888. doi: https://doi.org/10.1136/heartjnl-2021-319225
Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil SER, Gaskin D, Bakogiannis C, Sopova K, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall AJ, Stellos K, Stamatelopoulos K, Spyridopoulos I. Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart. 2021 Dec;107(23):1881-1888. doi: 10.1136/heartjnl-2021-319225. Epub 2021 Sep 20. PMID: 34544804.
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Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability.

Scientific reports

Cibelli A, Stout R, Timmermann A, de Menezes L, Guo P, Maass K, Seifert G, Steinhäuser C, Spray DC, Scemes E.
PMID: 34934080
Sci Rep. 2021 Dec 21;11(1):24334. doi: 10.1038/s41598-021-03694-x.

The neurovascular unit (NVU) consists of cells intrinsic to the vessel wall, the endothelial cells and pericytes, and astrocyte endfeet that surround the vessel but are separated from it by basement membrane. Endothelial cells are primarily responsible for creating...

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Cibelli A, Stout R, Timmermann A, et al. Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability. Sci Rep. 2021;11(1):24334doi: 10.1038/s41598-021-03694-x.
Cibelli, A., Stout, R., Timmermann, A., de Menezes, L., Guo, P., Maass, K., Seifert, G., Steinhäuser, C., Spray, D. C., & Scemes, E. (2021). Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability. Scientific reports, 11(1), 24334. https://doi.org/10.1038/s41598-021-03694-x
Cibelli, Antonio, et al. "Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability." Scientific reports vol. 11,1 (2021): 24334. doi: https://doi.org/10.1038/s41598-021-03694-x
Cibelli A, Stout R, Timmermann A, de Menezes L, Guo P, Maass K, Seifert G, Steinhäuser C, Spray DC, Scemes E. Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability. Sci Rep. 2021 Dec 21;11(1):24334. doi: 10.1038/s41598-021-03694-x. PMID: 34934080.
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The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway.

Proceedings of the National Academy of Sciences of the United States of America

Spray CR, Kobayashi M, Suzuki Y, Phinney BO, Gaskin P, MacMillan J.
PMID: 11607708
Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10515-8. doi: 10.1073/pnas.93.19.10515.

In plants, gibberellin (GA)-responding mutants have been used as tools to identify the genes that control specific steps in the GA-biosynthetic pathway. They have also been used to determine which native GAs are active per se, i.e., further metabolism...

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Spray CR, Kobayashi M, Suzuki Y, et al. The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway. Proc Natl Acad Sci U S A. 1996;93(19):10515-8doi: 10.1073/pnas.93.19.10515.
Spray, C. R., Kobayashi, M., Suzuki, Y., Phinney, B. O., Gaskin, P., & MacMillan, J. (1996). The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America, 93(19), 10515-8. https://doi.org/10.1073/pnas.93.19.10515
Spray, C R, et al. "The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway." Proceedings of the National Academy of Sciences of the United States of America vol. 93,19 (1996): 10515-8. doi: https://doi.org/10.1073/pnas.93.19.10515
Spray CR, Kobayashi M, Suzuki Y, Phinney BO, Gaskin P, MacMillan J. The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10515-8. doi: 10.1073/pnas.93.19.10515. PMID: 11607708; PMCID: PMC38417.
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The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana.

Plant physiology

Kobayashi M, Gaskin P, Spray CR, Phinney BO, MacMillan J.
PMID: 12232414
Plant Physiol. 1994 Dec;106(4):1367-1372. doi: 10.1104/pp.106.4.1367.

The purpose of this study was to demonstrate the metabolism of gibberellin A20 (GA20) to gibberellin A1 (GA1) by tall and mutant shoots of rice (Oryza sativa L.) and Arabidopsis thaliana (L.) Heynh. The data show that the tall...

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Kobayashi M, Gaskin P, Spray CR, et al. The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana. Plant Physiol. 1994;106(4):1367-1372doi: 10.1104/pp.106.4.1367.
Kobayashi, M., Gaskin, P., Spray, C. R., Phinney, B. O., & MacMillan, J. (1994). The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana. Plant physiology, 106(4), 1367-1372. https://doi.org/10.1104/pp.106.4.1367
Kobayashi, M., et al. "The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana." Plant physiology vol. 106,4 (1994): 1367-1372. doi: https://doi.org/10.1104/pp.106.4.1367
Kobayashi M, Gaskin P, Spray CR, Phinney BO, MacMillan J. The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana. Plant Physiol. 1994 Dec;106(4):1367-1372. doi: 10.1104/pp.106.4.1367. PMID: 12232414; PMCID: PMC159674.
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Case of Laceration of the Cervix Uteri, Consequent on Passive Labour.

The London medical and physical journal

Aspray T.
PMID: 30494394
Lond Med Phys J. 1822 May;47(279):372-374.

No abstract available.

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Aspray T. Case of Laceration of the Cervix Uteri, Consequent on Passive Labour. Lond Med Phys J. 1822;47(279):372-374
Aspray, T. (1822). Case of Laceration of the Cervix Uteri, Consequent on Passive Labour. The London medical and physical journal, 47(279), 372-374.
Aspray, Thomas. "Case of Laceration of the Cervix Uteri, Consequent on Passive Labour." The London medical and physical journal vol. 47,279 (1822): 372-374.
Aspray T. Case of Laceration of the Cervix Uteri, Consequent on Passive Labour. Lond Med Phys J. 1822 May;47(279):372-374. PMID: 30494394; PMCID: PMC5629481.
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Vitamin D prescribing in older people in the UK depends on postcode.

Maturitas

Hill TR, Aspray TJ.
PMID: 28209237
Maturitas. 2017 May;99:109-113. doi: 10.1016/j.maturitas.2017.01.010. Epub 2017 Jan 25.

No abstract available.

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Hill TR, Aspray TJ. Vitamin D prescribing in older people in the UK depends on postcode. Maturitas. 2017;99:109-113doi: 10.1016/j.maturitas.2017.01.010.
Hill, T. R., & Aspray, T. J. (2017). Vitamin D prescribing in older people in the UK depends on postcode. Maturitas, 99109-113. https://doi.org/10.1016/j.maturitas.2017.01.010
Hill, Thomas R, and Aspray, Terry J. "Vitamin D prescribing in older people in the UK depends on postcode." Maturitas vol. 99 (2017): 109-113. doi: https://doi.org/10.1016/j.maturitas.2017.01.010
Hill TR, Aspray TJ. Vitamin D prescribing in older people in the UK depends on postcode. Maturitas. 2017 May;99:109-113. doi: 10.1016/j.maturitas.2017.01.010. Epub 2017 Jan 25. PMID: 28209237.
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Adenosine 5'-triphosphate (ATP) receptors induce intracellular calcium changes in mouse leydig cells.

Endocrine

Pérez-Armendariz EM, Nadal A, Fuentes E, Spray DC.
PMID: 21153280
Endocrine. 1996 Jun;4(3):239-47. doi: 10.1007/BF02738690.

Cytoplasmic calcium ([Ca(2+)](i)) changes evoked by adenosine 5(1)-triphosphate (ATP) were recorded in cultured individual Leydig cells within 10-18 h after cell dispersion. [Ca(2+)](i) was monitored using Fura-2AM loaded cells with a digital ratio imaging system. Five micromolars ATP induced...

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Pérez-Armendariz EM, Nadal A, Fuentes E, et al. Adenosine 5'-triphosphate (ATP) receptors induce intracellular calcium changes in mouse leydig cells. Endocrine. 1996;4(3):239-47doi: 10.1007/BF02738690.
Pérez-Armendariz, E. M., Nadal, A., Fuentes, E., & Spray, D. C. (1996). Adenosine 5'-triphosphate (ATP) receptors induce intracellular calcium changes in mouse leydig cells. Endocrine, 4(3), 239-47. https://doi.org/10.1007/BF02738690
Pérez-Armendariz, E M, et al. "Adenosine 5'-triphosphate (ATP) receptors induce intracellular calcium changes in mouse leydig cells." Endocrine vol. 4,3 (1996): 239-47. doi: https://doi.org/10.1007/BF02738690
Pérez-Armendariz EM, Nadal A, Fuentes E, Spray DC. Adenosine 5'-triphosphate (ATP) receptors induce intracellular calcium changes in mouse leydig cells. Endocrine. 1996 Jun;4(3):239-47. doi: 10.1007/BF02738690. PMID: 21153280.
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Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L.

Plant physiology

Fujioka S, Yamane H, Spray CR, Phinney BO, Gaskin P, Macmillan J, Takahashi N.
PMID: 16667678
Plant Physiol. 1990 Sep;94(1):127-31. doi: 10.1104/pp.94.1.127.

[17-(13)C,(3)H]-Labeled gibberellin A(20) (GA(20)), GA(5), and GA(1) were fed to homozygous normal (+/+), heterozygous dominant dwarf (D8/+), and homozygous dominant dwarf (D8/D8) seedlings of Zea mays L. (maize). (13)C-Labeled GA(29), GA(8), GA(5), GA(1), and 3-epi-GA(1), as well as unmetabolized...

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Fujioka S, Yamane H, Spray CR, et al. Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant Physiol. 1990;94(1):127-31doi: 10.1104/pp.94.1.127.
Fujioka, S., Yamane, H., Spray, C. R., Phinney, B. O., Gaskin, P., Macmillan, J., & Takahashi, N. (1990). Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant physiology, 94(1), 127-31. https://doi.org/10.1104/pp.94.1.127
Fujioka, S, et al. "Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L." Plant physiology vol. 94,1 (1990): 127-31. doi: https://doi.org/10.1104/pp.94.1.127
Fujioka S, Yamane H, Spray CR, Phinney BO, Gaskin P, Macmillan J, Takahashi N. Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant Physiol. 1990 Sep;94(1):127-31. doi: 10.1104/pp.94.1.127. PMID: 16667678; PMCID: PMC1077200.
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