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A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry .

Journal of medicinal chemistry

Adam C, Bray TL, Pérez-López AM, Tan EH, Rubio-Ruiz B, Baillache DJ, Houston DR, Salji MJ, Leung HY, Unciti-Broceta A.
PMID: 34979089
J Med Chem. 2022 Jan 13;65(1):552-561. doi: 10.1021/acs.jmedchem.1c01733. Epub 2022 Jan 03.

5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and dose-limiting toxicities, diverse 5-FU prodrugs have...

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Adam C, Bray TL, Pérez-López AM, et al. A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry . J Med Chem. 2022;65(1):552-561doi: 10.1021/acs.jmedchem.1c01733.
Adam, C., Bray, T. L., Pérez-López, A. M., Tan, E. H., Rubio-Ruiz, B., Baillache, D. J., Houston, D. R., Salji, M. J., Leung, H. Y., & Unciti-Broceta, A. (2022). A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry . Journal of medicinal chemistry, 65(1), 552-561. https://doi.org/10.1021/acs.jmedchem.1c01733
Adam, Catherine, et al. "A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry ." Journal of medicinal chemistry vol. 65,1 (2022): 552-561. doi: https://doi.org/10.1021/acs.jmedchem.1c01733
Adam C, Bray TL, Pérez-López AM, Tan EH, Rubio-Ruiz B, Baillache DJ, Houston DR, Salji MJ, Leung HY, Unciti-Broceta A. A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry . J Med Chem. 2022 Jan 13;65(1):552-561. doi: 10.1021/acs.jmedchem.1c01733. Epub 2022 Jan 03. PMID: 34979089.
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Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements.

Comparative medicine

Gilberto DB, Michener MS, Smith BE, Szczerba PJ, Holahan MA, Gray TL, Motzel SL.
PMID: 34903315
Comp Med. 2021 Dec 13; doi: 10.30802/AALAS-CM-21-000060. Epub 2021 Dec 13.

More than 20 y ago, we developed an animal model for chronic and continuous collection of cerebrospinal fluid (CSF) from conscious rhesus macaques. Since our previous publication in 2003, we have successfully implanted 168 rhesus macaquesusing this approach. Our...

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Gilberto DB, Michener MS, Smith BE, et al. Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements. Comp Med. 2021;doi: 10.30802/AALAS-CM-21-000060.
Gilberto, D. B., Michener, M. S., Smith, B. E., Szczerba, P. J., Holahan, M. A., Gray, T. L., & Motzel, S. L. (2021). Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements. Comparative medicine, . https://doi.org/10.30802/AALAS-CM-21-000060
Gilberto, David B, et al. "Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements." Comparative medicine vol. (2021). doi: https://doi.org/10.30802/AALAS-CM-21-000060
Gilberto DB, Michener MS, Smith BE, Szczerba PJ, Holahan MA, Gray TL, Motzel SL. Chronic Collection of Cerebrospinal Fluid from Rhesus Macaques (Macaca mulatta) with Cisterna Magna Ports: Update on Refinements. Comp Med. 2021 Dec 13; doi: 10.30802/AALAS-CM-21-000060. Epub 2021 Dec 13. PMID: 34903315.
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Showing 133 to 134 of 134 entries