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Showing 4585 to 4596 of 4613 entries
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Daratumumab utilization and cost analysis among patients with multiple myeloma in a US community oncology setting.

Future oncology (London, England)

Gordan LN, Marks SM, Xue M, Nagovski N, Lambert JH, Smith RE.
PMID: 34709061
Future Oncol. 2022 Jan;18(3):301-309. doi: 10.2217/fon-2021-1072. Epub 2021 Oct 28.

No abstract available.

RETRACTED: A systematic review of the complications of contemporary total elbow arthroplasty.

Shoulder & elbow

Parker P, Furness ND, Evans JP, White WJ, Smith CD.
PMID: 34394729
Shoulder Elbow. 2019 Dec;11(6):NP2-NP9. doi: 10.1177/1758573219834934. Epub 2019 Mar 16.

No abstract available.

The root meristem is shaped by brassinosteroid control of cell geometry.

Nature plants

Fridman Y, Strauss S, Horev G, Ackerman-Lavert M, Reiner-Benaim A, Lane B, Smith RS, Savaldi-Goldstein S.
PMID: 34782771
Nat Plants. 2021 Nov;7(11):1475-1484. doi: 10.1038/s41477-021-01014-9. Epub 2021 Nov 15.

Growth extent and direction determine cell and whole-organ architecture. How they are spatio-temporally modulated to control size and shape is not well known. Here we tackled this question by studying the effect of brassinosteroid (BR) signalling on the structure...

Erratum to: Global translational landscape of the Candida albicans morphological transition.

G3 (Bethesda, Md.)

Mundodi V, Choudhary S, Smith AD, Kadosh D.
PMID: 33890619
G3 (Bethesda). 2021 Apr 23;11(3). doi: 10.1093/g3journal/jkab039.

No abstract available.

A proposed framework for the development and qualitative evaluation of West Nile virus models and their application to local public health decision-making.

PLoS neglected tropical diseases

Keyel AC, Gorris ME, Rochlin I, Uelmen JA, Chaves LF, Hamer GL, Moise IK, Shocket M, Kilpatrick AM, DeFelice NB, Davis JK, Little E, Irwin P, Tyre AJ, Helm Smith K, Fredregill CL, Elison Timm O, Holcomb KM, Wimberly MC, Ward MJ, Barker CM, Rhodes CG, Smith RL.
PMID: 34499656
PLoS Negl Trop Dis. 2021 Sep 09;15(9):e0009653. doi: 10.1371/journal.pntd.0009653. eCollection 2021 Sep.

West Nile virus (WNV) is a globally distributed mosquito-borne virus of great public health concern. The number of WNV human cases and mosquito infection patterns vary in space and time. Many statistical models have been developed to understand and...

Absolute and Dose-Adjusted Serum Concentrations of Clozapine in Patients Switching vs. Maintaining Treatment: An Observational Study of 1979 Patients.

CNS drugs

Kyllesø L, Smith RL, Karlstad Ø, Andreassen OA, Molden E.
PMID: 34417726
CNS Drugs. 2021 Sep;35(9):999-1008. doi: 10.1007/s40263-021-00847-4. Epub 2021 Aug 20.

BACKGROUND: Clozapine is an effective drug for the management of schizophrenia that has not responded to other agents, but some patients experience insufficient or adverse effects and discontinue treatment.OBJECTIVE: We investigated a potential association between clozapine serum concentrations and...

Chiral figure-eight molecular scaffold for fluorescent probe development.

Organic & biomolecular chemistry

Schreiber CL, Zhai C, Smith BD.
PMID: 33885576
Org Biomol Chem. 2021 Apr 14;19(14):3213-3219. doi: 10.1039/d1ob00306b. Epub 2021 Mar 24.

Targeted fluorescent molecular probes are useful for cell microscopy, diagnostics, and biological imaging. An emerging discovery paradigm is to screen libraries of fluorescent molecules and identify hit compounds with interesting targeting properties. However, a current limitation with this approach...

Tuning Proton Transfer Thermodynamics in SARS-Cov-2 Main Protease: Implications for Catalysis and Inhibitor Design.

ChemRxiv : the preprint server for chemistry

Zanetti-Polzi L, Smith MD, Chipot C, Gumbart JC, Lynch DL, Pavlova A, Smith JC, Daidone I.
PMID: 33200115
ChemRxiv. 2020 Nov 06; doi: 10.26434/chemrxiv.13200227.

In this comutational work a hybrid quantum mechanics/molecular mechanics approach, the MD-PMM approach, is used to investigate the proton transfer reaction the activates the catalytic activity of SARS-CoV-2 main protease. The proton transfer thermodynamics is investigated for the apo...

Supercomputer-Based Ensemble Docking Drug Discovery Pipeline with Application to Covid-19.

ChemRxiv : the preprint server for chemistry

Acharya A, Agarwal R, Baker M, Baudry J, Bhowmik D, Boehm S, Byler KG, Coates L, Chen SY, Cooper CJ, Demerdash O, Daidone I, Eblen JD, Ellingson S, Forli S, Glaser J, Gumbart JC, Gunnels J, Hernandez O, Irle S, Larkin J, Lawrence TJ, LeGrand S, Liu SH, Mitchell JC, Park G, Parks JM, Pavlova A, Petridis L, Poole D, Pouchard L, Ramanathan A, Rogers D, Santos-Martins D, Scheinberg A, Sedova A, Shen S, Smith JC, Smith MD, Soto C, Tsaris A, Thavappiragasam M, Tillack AF, Vermaas JV, Vuong VQ, Yin J, Yoo S, Zahran M, Zanetti-Polzi L.
PMID: 33200117
ChemRxiv. 2020 Jul 29; doi: 10.26434/chemrxiv.12725465.

We present a supercomputer-driven pipeline for in-silico drug discovery using enhanced sampling molecular dynamics (MD) and ensemble docking. We also describe preliminary results obtained for 23 systems involving eight protein targets of the proteome of SARS CoV-2. THe MD...

Review of investigations of premises housing animals that were linked to human outbreaks of cryptosporidiosis in England and Wales between 2009 and 2019.

The Veterinary record

Smith RP, Newton K, Rimdap E, Wight A, Robinson G, Chalmers RM.
PMID: 33870515
Vet Rec. 2021 Aug;189(4):e246. doi: 10.1002/vetr.246. Epub 2021 Apr 19.

BACKGROUND: Cryptosporidium can be an important human health risk, predominantly causing gastroenteritis. With increased public attendance at commercial and open farms, there is a need to improve the understanding of Cryptosporidium risk on premises that are visited by the...

Are Throat Pain and Otalgia Predictive of Perineural Invasion in Squamous Cell Carcinoma of the Oropharynx?.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Fahmy MD, Clegg D, Belcastro A, Smith BD, Eric Heidel R, Carlson ER, Hechler B.
PMID: 34606767
J Oral Maxillofac Surg. 2021 Sep 06; doi: 10.1016/j.joms.2021.08.265. Epub 2021 Sep 06.

PURPOSE: Head and neck cancer is often associated with pain and perineural invasion (PNI). The purpose of this study was to determine the association of pain complaints and the microscopic identification of PNI in patients with oropharyngeal squamous cell...

Multipopulational transcriptome analysis of post-weaned beef cattle at arrival further validates candidate biomarkers for predicting clinical bovine respiratory disease.

Scientific reports

Scott MA, Woolums AR, Swiderski CE, Perkins AD, Nanduri B, Smith DR, Karisch BB, Epperson WB, Blanton JR.
PMID: 34903778
Sci Rep. 2021 Dec 13;11(1):23877. doi: 10.1038/s41598-021-03355-z.

Bovine respiratory disease (BRD) remains the leading infectious disease in post-weaned beef cattle. The objective of this investigation was to contrast the at-arrival blood transcriptomes from cattle derived from two distinct populations that developed BRD in the 28 days...

Showing 4585 to 4596 of 4613 entries