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A path forward in the debate over health impacts of endocrine disrupting chemicals.

Environmental health : a global access science source

Zoeller RT, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN.
PMID: 25533907
Environ Health. 2014 Dec 22;13:118. doi: 10.1186/1476-069X-13-118.

Several recent publications reflect debate on the issue of "endocrine disrupting chemicals" (EDCs), indicating that two seemingly mutually exclusive perspectives are being articulated separately and independently. Considering this, a group of scientists with expertise in basic science, medicine and...

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Zoeller RT, Bergman Å, Becher G, et al. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014;13:118doi: 10.1186/1476-069X-13-118.
Zoeller, R. T., Bergman, �. �., Becher, G., Bjerregaard, P., Bornman, R., Brandt, I., Iguchi, T., Jobling, S., Kidd, K. A., Kortenkamp, A., Skakkebaek, N. E., Toppari, J., & Vandenberg, L. N. (2014). A path forward in the debate over health impacts of endocrine disrupting chemicals. Environmental health : a global access science source, 13118. https://doi.org/10.1186/1476-069X-13-118
Zoeller, R Thomas, et al. "A path forward in the debate over health impacts of endocrine disrupting chemicals." Environmental health : a global access science source vol. 13 (2014): 118. doi: https://doi.org/10.1186/1476-069X-13-118
Zoeller RT, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014 Dec 22;13:118. doi: 10.1186/1476-069X-13-118. PMID: 25533907; PMCID: PMC4298083.
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Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?.

Nature clinical practice. Urology

Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, Rorth M, Jorgensen N, Skakkebaek NE.
PMID: 17955048
Nat Clin Pract Urol. 2007 Dec;4(12):652-3. doi: 10.1038/ncpuro0964. Epub 2007 Oct 23.

No abstract available.

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Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, et al. Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?. Nat Clin Pract Urol. 2007;4(12):652-3doi: 10.1038/ncpuro0964.
Hoei-Hansen, C. E., Rajpert-De Meyts, E., Daugaard, G., Rorth, M., Jorgensen, N., & Skakkebaek, N. E. (2007). Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?. Nature clinical practice. Urology, 4(12), 652-3. https://doi.org/10.1038/ncpuro0964
Hoei-Hansen, Christina E, et al. "Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?." Nature clinical practice. Urology vol. 4,12 (2007): 652-3. doi: https://doi.org/10.1038/ncpuro0964
Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, Rorth M, Jorgensen N, Skakkebaek NE. Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?. Nat Clin Pract Urol. 2007 Dec;4(12):652-3. doi: 10.1038/ncpuro0964. Epub 2007 Oct 23. PMID: 17955048.
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The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age.

Frontiers in endocrinology

Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, McLachlan R, Newnham JP, Dickinson JE, Pennell CE, Norman RJ, Main KM.
PMID: 29922230
Front Endocrinol (Lausanne). 2018 Jun 04;9:288. doi: 10.3389/fendo.2018.00288. eCollection 2018.

Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenital distance in...

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Hart RJ, Frederiksen H, Doherty DA, et al. The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Front Endocrinol (Lausanne). 2018;9:288doi: 10.3389/fendo.2018.00288.
Hart, R. J., Frederiksen, H., Doherty, D. A., Keelan, J. A., Skakkebaek, N. E., Minaee, N. S., McLachlan, R., Newnham, J. P., Dickinson, J. E., Pennell, C. E., Norman, R. J., & Main, K. M. (2018). The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Frontiers in endocrinology, 9288. https://doi.org/10.3389/fendo.2018.00288
Hart, Roger J, et al. "The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age." Frontiers in endocrinology vol. 9 (2018): 288. doi: https://doi.org/10.3389/fendo.2018.00288
Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, McLachlan R, Newnham JP, Dickinson JE, Pennell CE, Norman RJ, Main KM. The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Front Endocrinol (Lausanne). 2018 Jun 04;9:288. doi: 10.3389/fendo.2018.00288. eCollection 2018. PMID: 29922230; PMCID: PMC5996240.
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CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT.

AACE clinical case reports

Monai E, Johansen A, Clasen-Linde E, Rajpert-De Meyts E, Skakkebæk NE, Main KM, Jørgensen A, Jensen RB.
PMID: 31967069
AACE Clin Case Rep. 2019 Aug 15;5(6):e352-e356. doi: 10.4158/ACCR-2019-0245. eCollection 2019.

OBJECTIVE: Prader-Willi syndrome (PWS) is a rare genetic neuroendocrine disorder characterized by hypotonia, obesity, short stature, and mental retardation. Incomplete or delayed pubertal development as well as premature adrenarche are usually found in PWS, whereas central precocious puberty is...

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Monai E, Johansen A, Clasen-Linde E, et al. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT. AACE Clin Case Rep. 2019;5(6):e352-e356doi: 10.4158/ACCR-2019-0245.
Monai, E., Johansen, A., Clasen-Linde, E., Rajpert-De Meyts, E., Skakkebæk, N. E., Main, K. M., Jørgensen, A., & Jensen, R. B. (2019). CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT. AACE clinical case reports, 5(6), e352-e356. https://doi.org/10.4158/ACCR-2019-0245
Monai, Elena, et al. "CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT." AACE clinical case reports vol. 5,6 (2019): e352-e356. doi: https://doi.org/10.4158/ACCR-2019-0245
Monai E, Johansen A, Clasen-Linde E, Rajpert-De Meyts E, Skakkebæk NE, Main KM, Jørgensen A, Jensen RB. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT. AACE Clin Case Rep. 2019 Aug 15;5(6):e352-e356. doi: 10.4158/ACCR-2019-0245. eCollection 2019. PMID: 31967069; PMCID: PMC6873836.
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Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden.

International archives of occupational and environmental health

Corbin S, Togawa K, Schüz J, Le Cornet C, Fervers B, Feychting M, Wiebert P, Hansen J, Dalton SO, Kjærheim K, Nordby KC, Østrem RS, Skakkebæk NE, Uuksulainen S, Pukkala E, Olsson A.
PMID: 34853884
Int Arch Occup Environ Health. 2021 Dec 01; doi: 10.1007/s00420-021-01818-4. Epub 2021 Dec 01.

OBJECTIVE: We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring.METHODS: NORD-TEST, a registry-based case-control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages...

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Corbin S, Togawa K, Schüz J, et al. Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. Int Arch Occup Environ Health. 2021;doi: 10.1007/s00420-021-01818-4.
Corbin, S., Togawa, K., Schüz, J., Le Cornet, C., Fervers, B., Feychting, M., Wiebert, P., Hansen, J., Dalton, S. O., Kjærheim, K., Nordby, K. C., Østrem, R. S., Skakkebæk, N. E., Uuksulainen, S., Pukkala, E., & Olsson, A. (2021). Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. International archives of occupational and environmental health, . https://doi.org/10.1007/s00420-021-01818-4
Corbin, Sara, et al. "Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden." International archives of occupational and environmental health vol. (2021). doi: https://doi.org/10.1007/s00420-021-01818-4
Corbin S, Togawa K, Schüz J, Le Cornet C, Fervers B, Feychting M, Wiebert P, Hansen J, Dalton SO, Kjærheim K, Nordby KC, Østrem RS, Skakkebæk NE, Uuksulainen S, Pukkala E, Olsson A. Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. Int Arch Occup Environ Health. 2021 Dec 01; doi: 10.1007/s00420-021-01818-4. Epub 2021 Dec 01. PMID: 34853884.
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Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis.

The Journal of clinical endocrinology and metabolism

Bräuner EV, Lim YH, Koch T, Uldbjerg CS, Gregersen LS, Pedersen MK, Frederiksen H, Petersen JH, Coull BA, Andersson AM, Hickey M, Skakkebæk NE, Hauser R, Juul A.
PMID: 34270734
J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4834-e4860. doi: 10.1210/clinem/dgab523.

The incidence of many hormone-dependent diseases, including testicular cancer, has sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs)...

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Bräuner EV, Lim YH, Koch T, et al. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. 2021;106(12):e4834-e4860doi: 10.1210/clinem/dgab523.
Bräuner, E. V., Lim, Y. H., Koch, T., Uldbjerg, C. S., Gregersen, L. S., Pedersen, M. K., Frederiksen, H., Petersen, J. H., Coull, B. A., Andersson, A. M., Hickey, M., Skakkebæk, N. E., Hauser, R., & Juul, A. (2021). Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis. The Journal of clinical endocrinology and metabolism, 106(12), e4834-e4860. https://doi.org/10.1210/clinem/dgab523
Bräuner, Elvira V, et al. "Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis." The Journal of clinical endocrinology and metabolism vol. 106,12 (2021): e4834-e4860. doi: https://doi.org/10.1210/clinem/dgab523
Bräuner EV, Lim YH, Koch T, Uldbjerg CS, Gregersen LS, Pedersen MK, Frederiksen H, Petersen JH, Coull BA, Andersson AM, Hickey M, Skakkebæk NE, Hauser R, Juul A. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4834-e4860. doi: 10.1210/clinem/dgab523. PMID: 34270734.
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Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis.

Scientific reports

Nielsen JE, Rolland AD, Meyts ER, Janfelt C, Jørgensen A, Winge SB, Kristensen DM, Juul A, Chalmel F, Jégou B, Skakkebaek NE.
PMID: 31965051
Sci Rep. 2020 Jan 22;10(1):1267. doi: 10.1038/s41598-020-58153-w.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Nielsen JE, Rolland AD, Meyts ER, et al. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis. Sci Rep. 2020;10(1):1267doi: 10.1038/s41598-020-58153-w.
Nielsen, J. E., Rolland, A. D., Meyts, E. R., Janfelt, C., Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, A., Chalmel, F., Jégou, B., & Skakkebaek, N. E. (2020). Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis. Scientific reports, 10(1), 1267. https://doi.org/10.1038/s41598-020-58153-w
Nielsen, John E, et al. "Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis." Scientific reports vol. 10,1 (2020): 1267. doi: https://doi.org/10.1038/s41598-020-58153-w
Nielsen JE, Rolland AD, Meyts ER, Janfelt C, Jørgensen A, Winge SB, Kristensen DM, Juul A, Chalmel F, Jégou B, Skakkebaek NE. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis. Sci Rep. 2020 Jan 22;10(1):1267. doi: 10.1038/s41598-020-58153-w. PMID: 31965051; PMCID: PMC6974603.
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Paracetamol use during pregnancy - a call for precautionary action.

Nature reviews. Endocrinology

Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM.
PMID: 34556849
Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA...

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Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021;17(12):757-766doi: 10.1038/s41574-021-00553-7.
Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C. G., Andrade, A. M., Olsen, J., Jensen, R. H., Mitchell, R. T., Skakkebaek, N. E., Jégou, B., & Kristensen, D. M. (2021). Paracetamol use during pregnancy - a call for precautionary action. Nature reviews. Endocrinology, 17(12), 757-766. https://doi.org/10.1038/s41574-021-00553-7
Bauer, Ann Z, et al. "Paracetamol use during pregnancy - a call for precautionary action." Nature reviews. Endocrinology vol. 17,12 (2021): 757-766. doi: https://doi.org/10.1038/s41574-021-00553-7
Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23. PMID: 34556849; PMCID: PMC8580820.
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Polygenic susceptibility to testicular cancer: implications for personalised health care.

British journal of cancer

Litchfield K, Mitchell JS, Shipley J, Huddart R, Rajpert-De Meyts E, Skakkebæk NE, Houlston RS, Turnbull C.
PMID: 27228286
Br J Cancer. 2016 Jun 14;114(12):e22. doi: 10.1038/bjc.2016.136. Epub 2016 May 26.

No abstract available.

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Litchfield K, Mitchell JS, Shipley J, et al. Polygenic susceptibility to testicular cancer: implications for personalised health care. Br J Cancer. 2016;114(12):e22doi: 10.1038/bjc.2016.136.
Litchfield, K., Mitchell, J. S., Shipley, J., Huddart, R., Rajpert-De Meyts, E., Skakkebæk, N. E., Houlston, R. S., & Turnbull, C. (2016). Polygenic susceptibility to testicular cancer: implications for personalised health care. British journal of cancer, 114(12), e22. https://doi.org/10.1038/bjc.2016.136
Litchfield, Kevin, et al. "Polygenic susceptibility to testicular cancer: implications for personalised health care." British journal of cancer vol. 114,12 (2016): e22. doi: https://doi.org/10.1038/bjc.2016.136
Litchfield K, Mitchell JS, Shipley J, Huddart R, Rajpert-De Meyts E, Skakkebæk NE, Houlston RS, Turnbull C. Polygenic susceptibility to testicular cancer: implications for personalised health care. Br J Cancer. 2016 Jun 14;114(12):e22. doi: 10.1038/bjc.2016.136. Epub 2016 May 26. PMID: 27228286; PMCID: PMC4984465.
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Early detection of testicular cancer: An introduction.

International journal of andrology

Skakkebaek NE.
PMID: 29112239
Int J Androl. 1981 Mar;4:11-13. doi: 10.1111/j.1365-2605.1981.tb00644.x.

No abstract available.

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Skakkebaek NE. Early detection of testicular cancer: An introduction. Int J Androl. 1981;4:11-13doi: 10.1111/j.1365-2605.1981.tb00644.x.
Skakkebaek, N. E. (1981). Early detection of testicular cancer: An introduction. International journal of andrology, 411-13. https://doi.org/10.1111/j.1365-2605.1981.tb00644.x
Skakkebaek, Niels E. "Early detection of testicular cancer: An introduction." International journal of andrology vol. 4 (1981): 11-13. doi: https://doi.org/10.1111/j.1365-2605.1981.tb00644.x
Skakkebaek NE. Early detection of testicular cancer: An introduction. Int J Androl. 1981 Mar;4:11-13. doi: 10.1111/j.1365-2605.1981.tb00644.x. PMID: 29112239.
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Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory.

International journal of andrology

Skakkebaek NE, Berthelsen JG.
PMID: 29112252
Int J Androl. 1981 Mar;4:26-33. doi: 10.1111/j.1365-2605.1981.tb00647.x.

The hypothesis is proposed that seminomas and non-seminomas are histogenetically closely related and both types of germ cell tumours may originate from a common precursor cell: namely the germ cell showing the carcinoma-in-situ pattern. However, it is suggested that...

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Skakkebaek NE, Berthelsen JG. Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. Int J Androl. 1981;4:26-33doi: 10.1111/j.1365-2605.1981.tb00647.x.
Skakkebaek, N. E., & Berthelsen, J. G. (1981). Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. International journal of andrology, 426-33. https://doi.org/10.1111/j.1365-2605.1981.tb00647.x
Skakkebaek, Niels E, and Berthelsen, Jørgen G. "Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory." International journal of andrology vol. 4 (1981): 26-33. doi: https://doi.org/10.1111/j.1365-2605.1981.tb00647.x
Skakkebaek NE, Berthelsen JG. Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. Int J Androl. 1981 Mar;4:26-33. doi: 10.1111/j.1365-2605.1981.tb00647.x. PMID: 29112252.
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Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer.

Frontiers in endocrinology

Edsgärd D, Dalgaard MD, Weinhold N, Wesolowska-Andersen A, Rajpert-De Meyts E, Ottesen AM, Juul A, Skakkebæk NE, Skøt Jensen T, Gupta R, Leffers H, Brunak S.
PMID: 23372565
Front Endocrinol (Lausanne). 2013 Jan 29;4:2. doi: 10.3389/fendo.2013.00002. eCollection 2013.

Testicular germ cell cancer (TGCC) is one of the most heritable forms of cancer. Previous genome-wide association studies have focused on single nucleotide polymorphisms, largely ignoring the influence of copy number variants (CNVs). Here we present a genome-wide study...

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Edsgärd D, Dalgaard MD, Weinhold N, et al. Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. Front Endocrinol (Lausanne). 2013;4:2doi: 10.3389/fendo.2013.00002.
Edsgärd, D., Dalgaard, M. D., Weinhold, N., Wesolowska-Andersen, A., Rajpert-De Meyts, E., Ottesen, A. M., Juul, A., Skakkebæk, N. E., Skøt Jensen, T., Gupta, R., Leffers, H., & Brunak, S. (2013). Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. Frontiers in endocrinology, 42. https://doi.org/10.3389/fendo.2013.00002
Edsgärd, Daniel, et al. "Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer." Frontiers in endocrinology vol. 4 (2013): 2. doi: https://doi.org/10.3389/fendo.2013.00002
Edsgärd D, Dalgaard MD, Weinhold N, Wesolowska-Andersen A, Rajpert-De Meyts E, Ottesen AM, Juul A, Skakkebæk NE, Skøt Jensen T, Gupta R, Leffers H, Brunak S. Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. Front Endocrinol (Lausanne). 2013 Jan 29;4:2. doi: 10.3389/fendo.2013.00002. eCollection 2013. PMID: 23372565; PMCID: PMC3557397.
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