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Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children.

Clinical and translational allergy

Schei K, Simpson MR, Øien T, Salamati S, Rudi K, Ødegård RA.
PMID: 34194728
Clin Transl Allergy. 2021 Jun 28;11(5):e12041. doi: 10.1002/clt2.12041. eCollection 2021 Jul.

BACKGROUND: The early gut microbiota has been proposed as an important link between environmental exposures and development of allergy-related diseases. Beyond the widely investigated associations between the gut bacterial microbiota, we investigated the involvement of early gut mycobiota and...

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Schei K, Simpson MR, Øien T, et al. Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children. Clin Transl Allergy. 2021;11(5):e12041doi: 10.1002/clt2.12041.
Schei, K., Simpson, M. R., Øien, T., Salamati, S., Rudi, K., & Ødegård, R. A. (2021). Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children. Clinical and translational allergy, 11(5), e12041. https://doi.org/10.1002/clt2.12041
Schei, Kasper, et al. "Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children." Clinical and translational allergy vol. 11,5 (2021): e12041. doi: https://doi.org/10.1002/clt2.12041
Schei K, Simpson MR, Øien T, Salamati S, Rudi K, Ødegård RA. Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children. Clin Transl Allergy. 2021 Jun 28;11(5):e12041. doi: 10.1002/clt2.12041. eCollection 2021 Jul. PMID: 34194728; PMCID: PMC8238386.
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Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.

Gut

Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K.
PMID: 35017199
Gut. 2022 Jan 11; doi: 10.1136/gutjnl-2021-326269. Epub 2022 Jan 11.

OBJECTIVE: This study is to investigate the role of gut dysbiosis in triggering inflammation in the brain and its contribution to Alzheimer's disease (AD) pathogenesis.DESIGN: We analysed the gut microbiota composition of 3×Tg mice in an age-dependent manner. We...

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Chen C, Liao J, Xia Y, et al. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022;doi: 10.1136/gutjnl-2021-326269.
Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022). Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut, . https://doi.org/10.1136/gutjnl-2021-326269
Chen, Chun, et al. "Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation." Gut vol. (2022). doi: https://doi.org/10.1136/gutjnl-2021-326269
Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022 Jan 11; doi: 10.1136/gutjnl-2021-326269. Epub 2022 Jan 11. PMID: 35017199.
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Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders.

Genome medicine

Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE.
PMID: 33874999
Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6.

BACKGROUND: With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype-phenotype correlations, with clinical characterization remaining a bottleneck for understanding...

Cite
Gillentine MA, Wang T, Hoekzema K, et al. Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Genome Med. 2021;13(1):63doi: 10.1186/s13073-021-00870-6.
Gillentine, M. A., Wang, T., Hoekzema, K., Rosenfeld, J., Liu, P., Guo, H., Kim, C. N., De Vries, B. B. A., Vissers, L. E. L. M., Nordenskjold, M., Kvarnung, M., Lindstrand, A., Nordgren, A., Gecz, J., Iascone, M., Cereda, A., Scatigno, A., Maitz, S., Zanni, G., Bertini, E., Zweier, C., Schuhmann, S., Wiesener, A., Pepper, M., Panjwani, H., Torti, E., Abid, F., Anselm, I., Srivastava, S., Atwal, P., Bacino, C. A., Bhat, G., Cobian, K., Bird, L. M., Friedman, J., Wright, M. S., Callewaert, B., Petit, F., Mathieu, S., Afenjar, A., Christensen, C. K., White, K. M., Elpeleg, O., Berger, I., Espineli, E. J., Fagerberg, C., Brasch-Andersen, C., Hansen, L. K., Feyma, T., Hughes, S., Thiffault, I., Sullivan, B., Yan, S., Keller, K., Keren, B., Mignot, C., Kooy, F., Meuwissen, M., Basinger, A., Kukolich, M., Philips, M., Ortega, L., Drummond-Borg, M., Lauridsen, M., Sorensen, K., Lehman, A., Lopez-Rangel, E., Levy, P., Lessel, D., Lotze, T., Madan-Khetarpal, S., Sebastian, J., Vento, J., Vats, D., Benman, L. M., Mckee, S., Mirzaa, G. M., Muss, C., Pappas, J., Peeters, H., Romano, C., Elia, M., Galesi, O., Simon, M. E. H., van Gassen, K. L. I., Simpson, K., Stratton, R., Syed, S., Thevenon, J., Palafoll, I. V., Vitobello, A., Bournez, M., Faivre, L., Xia, K., Earl, R. K., Nowakowski, T., Bernier, R. A., & Eichler, E. E. (2021). Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Genome medicine, 13(1), 63. https://doi.org/10.1186/s13073-021-00870-6
Gillentine, Madelyn A, et al. "Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders." Genome medicine vol. 13,1 (2021): 63. doi: https://doi.org/10.1186/s13073-021-00870-6
Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE. Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6. PMID: 33874999; PMCID: PMC8056596.
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Dimensional Affective Processing in BD.

Psychiatry research

Migó M, Simpson K, Peters A, Ellard KK, Chou T, Nierenberg AA, Dougherty DD, Deckersbach T.
PMID: 34896848
Psychiatry Res. 2021 Nov 30;307:114304. doi: 10.1016/j.psychres.2021.114304. Epub 2021 Nov 30.

Bipolar Disorder (BD) involves altered neural affective processing, but studies comparing BD patients to controls have yielded inconsistent results. This might relate to substantial variability in the nature and severity of mood symptoms among individuals with BD. Hence, we...

Cite
Migó M, Simpson K, Peters A, et al. Dimensional Affective Processing in BD. Psychiatry Res. 2021;307:114304doi: 10.1016/j.psychres.2021.114304.
Migó, M., Simpson, K., Peters, A., Ellard, K. K., Chou, T., Nierenberg, A. A., Dougherty, D. D., & Deckersbach, T. (2021). Dimensional Affective Processing in BD. Psychiatry research, 307114304. https://doi.org/10.1016/j.psychres.2021.114304
Migó, Marta, et al. "Dimensional Affective Processing in BD." Psychiatry research vol. 307 (2021): 114304. doi: https://doi.org/10.1016/j.psychres.2021.114304
Migó M, Simpson K, Peters A, Ellard KK, Chou T, Nierenberg AA, Dougherty DD, Deckersbach T. Dimensional Affective Processing in BD. Psychiatry Res. 2021 Nov 30;307:114304. doi: 10.1016/j.psychres.2021.114304. Epub 2021 Nov 30. PMID: 34896848.
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Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders.

Genome medicine

Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE.
PMID: 33874999
Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6.

BACKGROUND: With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype-phenotype correlations, with clinical characterization remaining a bottleneck for understanding...

Cite
Gillentine MA, Wang T, Hoekzema K, et al. Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Genome Med. 2021;13(1):63doi: 10.1186/s13073-021-00870-6.
Gillentine, M. A., Wang, T., Hoekzema, K., Rosenfeld, J., Liu, P., Guo, H., Kim, C. N., De Vries, B. B. A., Vissers, L. E. L. M., Nordenskjold, M., Kvarnung, M., Lindstrand, A., Nordgren, A., Gecz, J., Iascone, M., Cereda, A., Scatigno, A., Maitz, S., Zanni, G., Bertini, E., Zweier, C., Schuhmann, S., Wiesener, A., Pepper, M., Panjwani, H., Torti, E., Abid, F., Anselm, I., Srivastava, S., Atwal, P., Bacino, C. A., Bhat, G., Cobian, K., Bird, L. M., Friedman, J., Wright, M. S., Callewaert, B., Petit, F., Mathieu, S., Afenjar, A., Christensen, C. K., White, K. M., Elpeleg, O., Berger, I., Espineli, E. J., Fagerberg, C., Brasch-Andersen, C., Hansen, L. K., Feyma, T., Hughes, S., Thiffault, I., Sullivan, B., Yan, S., Keller, K., Keren, B., Mignot, C., Kooy, F., Meuwissen, M., Basinger, A., Kukolich, M., Philips, M., Ortega, L., Drummond-Borg, M., Lauridsen, M., Sorensen, K., Lehman, A., Lopez-Rangel, E., Levy, P., Lessel, D., Lotze, T., Madan-Khetarpal, S., Sebastian, J., Vento, J., Vats, D., Benman, L. M., Mckee, S., Mirzaa, G. M., Muss, C., Pappas, J., Peeters, H., Romano, C., Elia, M., Galesi, O., Simon, M. E. H., van Gassen, K. L. I., Simpson, K., Stratton, R., Syed, S., Thevenon, J., Palafoll, I. V., Vitobello, A., Bournez, M., Faivre, L., Xia, K., Earl, R. K., Nowakowski, T., Bernier, R. A., & Eichler, E. E. (2021). Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Genome medicine, 13(1), 63. https://doi.org/10.1186/s13073-021-00870-6
Gillentine, Madelyn A, et al. "Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders." Genome medicine vol. 13,1 (2021): 63. doi: https://doi.org/10.1186/s13073-021-00870-6
Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE. Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6. PMID: 33874999; PMCID: PMC8056596.
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Dimensional Affective Processing in BD.

Psychiatry research

Migó M, Simpson K, Peters A, Ellard KK, Chou T, Nierenberg AA, Dougherty DD, Deckersbach T.
PMID: 34896848
Psychiatry Res. 2021 Nov 30;307:114304. doi: 10.1016/j.psychres.2021.114304. Epub 2021 Nov 30.

Bipolar Disorder (BD) involves altered neural affective processing, but studies comparing BD patients to controls have yielded inconsistent results. This might relate to substantial variability in the nature and severity of mood symptoms among individuals with BD. Hence, we...

Cite
Migó M, Simpson K, Peters A, et al. Dimensional Affective Processing in BD. Psychiatry Res. 2021;307:114304doi: 10.1016/j.psychres.2021.114304.
Migó, M., Simpson, K., Peters, A., Ellard, K. K., Chou, T., Nierenberg, A. A., Dougherty, D. D., & Deckersbach, T. (2021). Dimensional Affective Processing in BD. Psychiatry research, 307114304. https://doi.org/10.1016/j.psychres.2021.114304
Migó, Marta, et al. "Dimensional Affective Processing in BD." Psychiatry research vol. 307 (2021): 114304. doi: https://doi.org/10.1016/j.psychres.2021.114304
Migó M, Simpson K, Peters A, Ellard KK, Chou T, Nierenberg AA, Dougherty DD, Deckersbach T. Dimensional Affective Processing in BD. Psychiatry Res. 2021 Nov 30;307:114304. doi: 10.1016/j.psychres.2021.114304. Epub 2021 Nov 30. PMID: 34896848.
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Heterogeneous outcomes of liver disease after heart transplantation for a failed Fontan procedure.

Pediatric transplantation

Ybarra AM, Khanna G, Turmelle YP, Stoll J, Castleberry CD, Scheel J, Ballweg JA, Ameduri R, Kimberling M, Makil E, Birnbaum BF, Exil V, Canter CE, Simpson KE.
PMID: 34296503
Pediatr Transplant. 2021 Dec;25(8):e14094. doi: 10.1111/petr.14094. Epub 2021 Jul 22.

BACKGROUND: Fontan-associated liver disease (FALD) uniformly affects patients with long-term Fontan physiology. The effect of isolated heart transplant (HT) on the course of FALD post-HT is not well understood.METHODS: We evaluated serial liver imaging pre- and post-HT to assess...

Cite
Ybarra AM, Khanna G, Turmelle YP, et al. Heterogeneous outcomes of liver disease after heart transplantation for a failed Fontan procedure. Pediatr Transplant. 2021;25(8):e14094doi: 10.1111/petr.14094.
Ybarra, A. M., Khanna, G., Turmelle, Y. P., Stoll, J., Castleberry, C. D., Scheel, J., Ballweg, J. A., Ameduri, R., Kimberling, M., Makil, E., Birnbaum, B. F., Exil, V., Canter, C. E., & Simpson, K. E. (2021). Heterogeneous outcomes of liver disease after heart transplantation for a failed Fontan procedure. Pediatric transplantation, 25(8), e14094. https://doi.org/10.1111/petr.14094
Ybarra, Aecha M, et al. "Heterogeneous outcomes of liver disease after heart transplantation for a failed Fontan procedure." Pediatric transplantation vol. 25,8 (2021): e14094. doi: https://doi.org/10.1111/petr.14094
Ybarra AM, Khanna G, Turmelle YP, Stoll J, Castleberry CD, Scheel J, Ballweg JA, Ameduri R, Kimberling M, Makil E, Birnbaum BF, Exil V, Canter CE, Simpson KE. Heterogeneous outcomes of liver disease after heart transplantation for a failed Fontan procedure. Pediatr Transplant. 2021 Dec;25(8):e14094. doi: 10.1111/petr.14094. Epub 2021 Jul 22. PMID: 34296503.
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