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Showing 25 to 36 of 176 entries
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The D-score: a metric for interpreting the early development of infants and toddlers across global settings.

BMJ global health

Weber AM, Rubio-Codina M, Walker SP, van Buuren S, Eekhout I, Grantham-McGregor SM, Araujo MC, Chang SM, Fernald LC, Hamadani JD, Hanlon C, Karam SM, Lozoff B, Ratsifandrihamanana L, Richter L, Black MM.
PMID: 31803508
BMJ Glob Health. 2019 Nov 19;4(6):e001724. doi: 10.1136/bmjgh-2019-001724. eCollection 2019.

INTRODUCTION: Early childhood development can be described by an underlying latent construct. Global comparisons of children's development are hindered by the lack of a validated metric that is comparable across cultures and contexts, especially for children under age 3...

Profiling of Protein Degraders in Cultures of Human Gut Microbiota.

Frontiers in microbiology

Amaretti A, Gozzoli C, Simone M, Raimondi S, Righini L, Pérez-Brocal V, García-López R, Moya A, Rossi M.
PMID: 31803157
Front Microbiol. 2019 Nov 15;10:2614. doi: 10.3389/fmicb.2019.02614. eCollection 2019.

Unabsorbed proteins reach the colon and are fermented by the microbiota, yielding a variety of harmful metabolites. In the present study, a 16S rRNA gene survey identified the bacterial taxa flourishing in 11 batch fermentations with proteins and peptones...

An Embodied Tutoring System for Literal vs. Metaphorical Concepts.

Frontiers in psychology

Sionti M, Schack T, Aloimonos Y.
PMID: 30546328
Front Psychol. 2018 Nov 28;9:2254. doi: 10.3389/fpsyg.2018.02254. eCollection 2018.

In this paper we combine motion captured data with linguistic notions (preliminary study) in a game-like tutoring system (study 1), in order to help elementary school students to better differentiate literal from metaphorical uses of motion verbs, based on...

Feasibility of narrative exposure therapy in an outpatient day treatment programme for refugees: improvement in symptoms and global functioning.

European journal of psychotraumatology

de la Rie SM, Smid GE, van der Aa N, van Est LAC, Bisseling E, Boelen PA.
PMID: 33029303
Eur J Psychotraumatol. 2020 Jun 16;11(1):1759983. doi: 10.1080/20008198.2020.1759983.

BACKGROUND:  Refugees are at high risk for developing post-traumatic stress disorder (PTSD). Narrative exposure therapy (NET) is an evidence-based treatment of PTSD, designed for patients exposed to (multiple) traumatic events and recommended for patients with culturally diverse backgrounds. In...

Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis.

European journal of cancer (Oxford, England : 1990)

Goldinger SM, Buder-Bakhaya K, Lo SN, Forschner A, McKean M, Zimmer L, Khoo C, Dummer R, Eroglu Z, Buchbinder EI, Ascierto PA, Gutzmer R, Rozeman EA, Hoeller C, Johnson DB, Gesierich A, Kölblinger P, Bennannoune N, Cohen JV, Kähler KC, Wilson MA, Cebon J, Atkinson V, Smith JL, Michielin O, Long GV, Hassel JC, Weide B, Haydu LE, Schadendorf D, McArthur G, Ott PA, Blank C, Robert C, Sullivan R, Hauschild A, Carlino MS, Garbe C, Davies MA, Menzies AM.
PMID: 34952480
Eur J Cancer. 2021 Dec 21;162:22-33. doi: 10.1016/j.ejca.2021.11.022. Epub 2021 Dec 21.

INTRODUCTION: Despite remarkably improved outcomes with immune checkpoint inhibition, many patients with metastatic melanoma will eventually require further therapy. Chemotherapy has limited activity when used first-line but can alter the tumour microenvironment and does improve efficacy when used in...

The Interaction between Reactive Peritoneal Mesothelial Cells and Tumor Cells via Extracellular Vesicles Facilitates Colorectal Cancer Dissemination.

Cancers

Serratì S, Porcelli L, Fragassi F, Garofoli M, Di Fonte R, Fucci L, Iacobazzi RM, Palazzo A, Margheri F, Cristiani G, Albano A, De Luca R, Altomare DF, Simone M, Azzariti A.
PMID: 34065529
Cancers (Basel). 2021 May 20;13(10). doi: 10.3390/cancers13102505.

Advanced colorectal cancer (CRC) is highly metastatic and often results in peritoneal dissemination. The extracellular vesicles (EVs) released by cancer cells in the microenvironment are important mediators of tumor metastasis. We investigated the contribution of EV-mediated interaction between peritoneal...

Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential.

Biotechnology progress

Luo H, Li Y, Robbins D, Wang SC, Xi G, Cox M, Nicholson SM, Wei C, Pabst TM, Wang WK.
PMID: 33373106
Biotechnol Prog. 2021 May;37(3):e3119. doi: 10.1002/btpr.3119. Epub 2021 Jan 06.

Process-related impurities (PRIs) derived from manufacturing process should be minimized in final drug product. ICH Q3A provides a regulatory road map for PRIs but excludes biologic drugs like monoclonal antibodies (mAbs) that contain biological PRIs (e.g. host cell proteins...

Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity.

The EMBO journal

Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, Wilting SM, Ohtani N, Jager A, Demaria M.
PMID: 34985783
EMBO J. 2022 Jan 05;e108946. doi: 10.15252/embj.2021108946. Epub 2022 Jan 05.

Cellular senescence is a state of stable growth arrest and a desired outcome of tumor suppressive interventions. Treatment with many anti-cancer drugs can cause premature senescence of non-malignant cells. These therapy-induced senescent cells can have pro-tumorigenic and pro-disease functions...

Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis.

European journal of cancer (Oxford, England : 1990)

Goldinger SM, Buder-Bakhaya K, Lo SN, Forschner A, McKean M, Zimmer L, Khoo C, Dummer R, Eroglu Z, Buchbinder EI, Ascierto PA, Gutzmer R, Rozeman EA, Hoeller C, Johnson DB, Gesierich A, Kölblinger P, Bennannoune N, Cohen JV, Kähler KC, Wilson MA, Cebon J, Atkinson V, Smith JL, Michielin O, Long GV, Hassel JC, Weide B, Haydu LE, Schadendorf D, McArthur G, Ott PA, Blank C, Robert C, Sullivan R, Hauschild A, Carlino MS, Garbe C, Davies MA, Menzies AM.
PMID: 34952480
Eur J Cancer. 2021 Dec 21;162:22-33. doi: 10.1016/j.ejca.2021.11.022. Epub 2021 Dec 21.

INTRODUCTION: Despite remarkably improved outcomes with immune checkpoint inhibition, many patients with metastatic melanoma will eventually require further therapy. Chemotherapy has limited activity when used first-line but can alter the tumour microenvironment and does improve efficacy when used in...

Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.

Frontiers in aging neuroscience

den Hoedt S, Crivelli SM, Leijten FPJ, Losen M, Stevens JAA, Mané-Damas M, de Vries HE, Walter J, Mirzaian M, Sijbrands EJG, Aerts JMFG, Verhoeven AJM, Martinez-Martinez P, Mulder MT.
PMID: 34776936
Front Aging Neurosci. 2021 Oct 27;13:765252. doi: 10.3389/fnagi.2021.765252. eCollection 2021.

Apolipoprotein ε4 (

[Ethics and health professions].

Boletin de la Asociacion Medica de Puerto Rico

Sifontes JE.
PMID: 6932875
Bol Asoc Med P R. 1980 Jul;72(7):376-9.

No abstract available.

Frontiers in neurology

Simone M, Trabacca A, Panzeri E, Losito L, Citterio A, Bassi MT.
PMID: 30581417
Front Neurol. 2018 Dec 07;9:1078. doi: 10.3389/fneur.2018.01078. eCollection 2018.

This paper describes the clinical evolution and the novel genetic findings in a

Showing 25 to 36 of 176 entries