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Showing 1213 to 1220 of 1220 entries
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Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder.

mSystems

Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K.
PMID: 33293403
mSystems. 2020 Dec 08;5(6). doi: 10.1128/mSystems.00797-20.

Gut dysbiosis has been repeatedly reported in Parkinson's disease (PD) but only once in idiopathic rapid-eye-movement sleep behavior disorder (iRBD) from Germany. Abnormal aggregation of α-synuclein fibrils causing PD possibly starts from the intestine, although this is still currently...

Construction of .

Oncology letters

Takahashi N, Higa A, Hiyama G, Tamura H, Hoshi H, Dobashi Y, Katahira K, Ishihara H, Takagi K, Goda K, Okabe N, Muto S, Suzuki H, Shimomura K, Watanabe S, Takagi M.
PMID: 33841567
Oncol Lett. 2021 May;21(5):406. doi: 10.3892/ol.2021.12667. Epub 2021 Mar 22.

An

Neutrophil-to-lymphocyte ratio is associated with sensitivity to platinum-based chemotherapy and prognosis in patients with advanced serous ovarian carcinoma.

Molecular and clinical oncology

Fukuda T, Kawanishi M, Awazu Y, Nanno S, Shimomura M, Inoue Y, Matsubara H, Yamauchi M, Kasai M, Hashiguchi Y, Ichimura T, Yasui T, Sumi T.
PMID: 34476101
Mol Clin Oncol. 2021 Oct;15(4):217. doi: 10.3892/mco.2021.2381. Epub 2021 Aug 25.

The role of the neutrophil-to-lymphocyte ratio (NLR) in predicting sensitivity to chemotherapy and prognosis has attracted great interest in several types of cancer. In the present study, the correlation between pre-chemotherapy NLR and sensitivity to platinum-based chemotherapy and prognosis...

Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3.

The Journal of biological chemistry

Hirazawa K, Tateyama M, Kubo Y, Shimomura T.
PMID: 34800436
J Biol Chem. 2021 Nov 18;297(6):101425. doi: 10.1016/j.jbc.2021.101425. Epub 2021 Nov 18.

The two-pore channels (TPCs) are voltage-gated cation channels consisting of single polypeptides with two repeats of a canonical 6-transmembrane unit. TPCs are known to be regulated by various physiological signals such as membrane voltage and phosphoinositide (PI). The fourth...

Long-term survival after esophagectomy with distal pancreatectomy for locally advanced esophageal cancer with pancreatic invasion: a case report.

Surgical case reports

Kaneko Y, Hisakura K, Ogawa K, Akashi Y, Ohara Y, Owada Y, Enomoto T, Furuya K, Moue S, Doi M, Takahashi K, Shimomura O, Hashimoto S, Sakamoto N, Maruyama T, Oda T.
PMID: 34905130
Surg Case Rep. 2021 Dec 14;7(1):254. doi: 10.1186/s40792-021-01338-w.

BACKGROUND: The treatment for the locally advanced esophageal cancer invading adjacent organs is controversial. We performed a radical surgery for a patient suffering from lower esophageal cancer with pancreatic invasion, and led to long-term survival.CASE PRESENTATION: A 62-year-old man...

Hematologic complications with age in Shwachman-Diamond syndrome.

Blood advances

Furutani E, Liu S, Galvin A, Steltz S, Malsch MM, Loveless SK, Mount L, Larson JH, Queenan K, Bertuch AA, Fleming MD, Gansner JM, Geddis AE, Hanna R, Keel SB, Lau BW, Lipton JM, Lorsbach R, Nakano TA, Vlachos A, Wang WC, Davies SM, Weller E, Myers KC, Shimamura A.
PMID: 34758064
Blood Adv. 2022 Jan 11;6(1):297-306. doi: 10.1182/bloodadvances.2021005539.

Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure syndrome with leukemia predisposition. An understanding of the hematologic complications of SDS with age could guide clinical management, but data are limited for this rare disease. We conducted a cohort...

Translation, reliability, and validity of Japanese version of the Respiratory Distress Observation Scale.

PloS one

Sakuramoto H, Hatozaki C, Unoki T, Aikawa G, Kobayashi S, Okamoto S, Shimomura S, Kawasaki A, Fukui M.
PMID: 34379672
PLoS One. 2021 Aug 11;16(8):e0255991. doi: 10.1371/journal.pone.0255991. eCollection 2021.

Dyspnea is a common, distressing symptom of cardiopulmonary and neuromuscular diseases and is defined as "a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity." However, Japanese intensive care units (ICUs) do not...

SLC25A38 congenital sideroblastic anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature.

Human mutation

Heeney MM, Berhe S, Campagna DR, Oved JH, Kurre P, Shaw PJ, Teo J, Shanap MA, Hassab HM, Glader BE, Shah S, Yoshimi A, Ameri A, Antin JH, Boudreaux J, Briones M, Dickerson KE, Fernandez CV, Farah R, Hasle H, Keel SB, Olson TS, Powers JM, Rose MJ, Shimamura A, Bottomley SS, Fleming MD.
PMID: 34298585
Hum Mutat. 2021 Nov;42(11):1367-1383. doi: 10.1002/humu.24267. Epub 2021 Aug 05.

The congenital sideroblastic anemias (CSAs) are a heterogeneous group of inherited disorders of erythropoiesis characterized by pathologic deposits of iron in the mitochondria of developing erythroblasts. Mutations in the mitochondrial glycine carrier SLC25A38 cause the most common recessive form...

Showing 1213 to 1220 of 1220 entries