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Comparison of Successful and Unsuccessful Cases of New Drug Approvals Based on the International Council on Harmonization E5 Guidelines in Japan.

Clinical pharmacology in drug development

Asada R, Shimizu S, Nakamura H, Ono S, Yamaguchi T.
PMID: 33787062
Clin Pharmacol Drug Dev. 2021 May;10(5):434-439. doi: 10.1002/cpdd.942. Epub 2021 Mar 30.

No abstract available.

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Asada R, Shimizu S, Nakamura H, et al. Comparison of Successful and Unsuccessful Cases of New Drug Approvals Based on the International Council on Harmonization E5 Guidelines in Japan. Clin Pharmacol Drug Dev. 2021;10(5):434-439doi: 10.1002/cpdd.942.
Asada, R., Shimizu, S., Nakamura, H., Ono, S., & Yamaguchi, T. (2021). Comparison of Successful and Unsuccessful Cases of New Drug Approvals Based on the International Council on Harmonization E5 Guidelines in Japan. Clinical pharmacology in drug development, 10(5), 434-439. https://doi.org/10.1002/cpdd.942
Asada, Ryuta, et al. "Comparison of Successful and Unsuccessful Cases of New Drug Approvals Based on the International Council on Harmonization E5 Guidelines in Japan." Clinical pharmacology in drug development vol. 10,5 (2021): 434-439. doi: https://doi.org/10.1002/cpdd.942
Asada R, Shimizu S, Nakamura H, Ono S, Yamaguchi T. Comparison of Successful and Unsuccessful Cases of New Drug Approvals Based on the International Council on Harmonization E5 Guidelines in Japan. Clin Pharmacol Drug Dev. 2021 May;10(5):434-439. doi: 10.1002/cpdd.942. Epub 2021 Mar 30. PMID: 33787062.
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Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction.

Biomaterials

Takada T, Sasaki D, Matsuura K, Miura K, Sakamoto S, Goto H, Ohya T, Iida T, Homma J, Shimizu T, Hagiwara N.
PMID: 34979417
Biomaterials. 2021 Dec 30;281:121351. doi: 10.1016/j.biomaterials.2021.121351. Epub 2021 Dec 30.

Alignment, as seen in the native myocardium, is crucial for the fabrication of functional cardiac tissue. However, it remains unclear whether the control of cardiomyocyte alignment influences cardiac function and the underlying mechanisms. We fabricated aligned human cardiac tissue...

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Takada T, Sasaki D, Matsuura K, et al. Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction. Biomaterials. 2021;281:121351doi: 10.1016/j.biomaterials.2021.121351.
Takada, T., Sasaki, D., Matsuura, K., Miura, K., Sakamoto, S., Goto, H., Ohya, T., Iida, T., Homma, J., Shimizu, T., & Hagiwara, N. (2021). Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction. Biomaterials, 281121351. https://doi.org/10.1016/j.biomaterials.2021.121351
Takada, Takuma, et al. "Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction." Biomaterials vol. 281 (2021): 121351. doi: https://doi.org/10.1016/j.biomaterials.2021.121351
Takada T, Sasaki D, Matsuura K, Miura K, Sakamoto S, Goto H, Ohya T, Iida T, Homma J, Shimizu T, Hagiwara N. Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction. Biomaterials. 2021 Dec 30;281:121351. doi: 10.1016/j.biomaterials.2021.121351. Epub 2021 Dec 30. PMID: 34979417.
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Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracis.

mSystems

Furuta Y, Cheng C, Zorigt T, Paudel A, Izumi S, Tsujinouchi M, Shimizu T, Meijer WG, Higashi H.
PMID: 34282944
mSystems. 2021 Aug 31;6(4):e0029121. doi: 10.1128/mSystems.00291-21. Epub 2021 Jul 20.

AtxA, the master virulence regulator of Bacillus anthracis, regulates the expression of three toxins and genes for capsule formation that are required for the pathogenicity of B. anthracis. Recent transcriptome analyses showed that AtxA affects a large number of...

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Furuta Y, Cheng C, Zorigt T, et al. Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracis. mSystems. 2021;6(4):e0029121doi: 10.1128/mSystems.00291-21.
Furuta, Y., Cheng, C., Zorigt, T., Paudel, A., Izumi, S., Tsujinouchi, M., Shimizu, T., Meijer, W. G., & Higashi, H. (2021). Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracis. mSystems, 6(4), e0029121. https://doi.org/10.1128/mSystems.00291-21
Furuta, Yoshikazu, et al. "Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracis." mSystems vol. 6,4 (2021): e0029121. doi: https://doi.org/10.1128/mSystems.00291-21
Furuta Y, Cheng C, Zorigt T, Paudel A, Izumi S, Tsujinouchi M, Shimizu T, Meijer WG, Higashi H. Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracis. mSystems. 2021 Aug 31;6(4):e0029121. doi: 10.1128/mSystems.00291-21. Epub 2021 Jul 20. PMID: 34282944; PMCID: PMC8407390.
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Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.

Nature

Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K.
PMID: 34823256
Nature. 2021 Nov 25; doi: 10.1038/s41586-021-04266-9. Epub 2021 Nov 25.

During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to...

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Saito A, Irie T, Suzuki R, et al. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature. 2021;doi: 10.1038/s41586-021-04266-9.
Saito, A., Irie, T., Suzuki, R., Maemura, T., Nasser, H., Uriu, K., Kosugi, Y., Shirakawa, K., Sadamasu, K., Kimura, I., Ito, J., Wu, J., Iwatsuki-Horimoto, K., Ito, M., Yamayoshi, S., Loeber, S., Tsuda, M., Wang, L., Ozono, S., Butlertanaka, E. P., Tanaka, Y. L., Shimizu, R., Shimizu, K., Yoshimatsu, K., Kawabata, R., Sakaguchi, T., Tokunaga, K., Yoshida, I., Asakura, H., Nagashima, M., Kazuma, Y., Nomura, R., Horisawa, Y., Yoshimura, K., Takaori-Kondo, A., Imai, M., Tanaka, S., Nakagawa, S., Ikeda, T., Fukuhara, T., Kawaoka, Y., & Sato, K. (2021). Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature, . https://doi.org/10.1038/s41586-021-04266-9
Saito, Akatsuki, et al. "Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation." Nature vol. (2021). doi: https://doi.org/10.1038/s41586-021-04266-9
Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature. 2021 Nov 25; doi: 10.1038/s41586-021-04266-9. Epub 2021 Nov 25. PMID: 34823256.
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A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation.

CEN case reports

Hayashi S, Ohashi N, Goto D, Isomura N, Isobe S, Fujikura T, Fujigaki Y, Shimizu A, Ito H, Yasuda H.
PMID: 33721266
CEN Case Rep. 2021 Nov;10(4):476-482. doi: 10.1007/s13730-021-00592-z. Epub 2021 Mar 15.

Preeclampsia and superimposed preeclampsia usually develop after 20 weeks of gestation. We report a case of a 35-year-old Japanese woman who developed hypertensive disorders of pregnancy (HDP) before 20 weeks of gestation. She presented with hypertension and proteinuria at...

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Hayashi S, Ohashi N, Goto D, et al. A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation. CEN Case Rep. 2021;10(4):476-482doi: 10.1007/s13730-021-00592-z.
Hayashi, S., Ohashi, N., Goto, D., Isomura, N., Isobe, S., Fujikura, T., Fujigaki, Y., Shimizu, A., Ito, H., & Yasuda, H. (2021). A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation. CEN case reports, 10(4), 476-482. https://doi.org/10.1007/s13730-021-00592-z
Hayashi, Saki, et al. "A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation." CEN case reports vol. 10,4 (2021): 476-482. doi: https://doi.org/10.1007/s13730-021-00592-z
Hayashi S, Ohashi N, Goto D, Isomura N, Isobe S, Fujikura T, Fujigaki Y, Shimizu A, Ito H, Yasuda H. A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation. CEN Case Rep. 2021 Nov;10(4):476-482. doi: 10.1007/s13730-021-00592-z. Epub 2021 Mar 15. PMID: 33721266; PMCID: PMC8494829.
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Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Tazawa H, Suzuki T, Saito A, Ishikawa A, Komo T, Sada H, Shimada N, Hadano N, Onoe T, Sudo T, Shimizu Y, Kuraoka K, Tashiro H.
PMID: 34379296
J Gastrointest Surg. 2021 Aug 11; doi: 10.1007/s11605-021-05101-2. Epub 2021 Aug 11.

BACKGROUND: Transmembrane serine protease 4 (TMPRSS4) belongs to the family of type II transmembrane serine proteases that are known to be upregulated in many malignant tumors. However, there is a paucity of studies documenting the clinical impact and biological...

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Tazawa H, Suzuki T, Saito A, et al. Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer. J Gastrointest Surg. 2021;doi: 10.1007/s11605-021-05101-2.
Tazawa, H., Suzuki, T., Saito, A., Ishikawa, A., Komo, T., Sada, H., Shimada, N., Hadano, N., Onoe, T., Sudo, T., Shimizu, Y., Kuraoka, K., & Tashiro, H. (2021). Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, . https://doi.org/10.1007/s11605-021-05101-2
Tazawa, Hirofumi, et al. "Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract vol. (2021). doi: https://doi.org/10.1007/s11605-021-05101-2
Tazawa H, Suzuki T, Saito A, Ishikawa A, Komo T, Sada H, Shimada N, Hadano N, Onoe T, Sudo T, Shimizu Y, Kuraoka K, Tashiro H. Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer. J Gastrointest Surg. 2021 Aug 11; doi: 10.1007/s11605-021-05101-2. Epub 2021 Aug 11. PMID: 34379296.
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Hemoglobin and adult height loss among Japanese workers: A retrospective study.

PloS one

Shimizu Y, Hayakawa H, Takada M, Okada T, Kiyama M.
PMID: 34403451
PLoS One. 2021 Aug 17;16(8):e0256281. doi: 10.1371/journal.pone.0256281. eCollection 2021.

Height loss starting in middle age is reported to be associated with increased all-cause and cardiovascular mortality later in life. However, the mechanisms underlying this association are unclear. Hypoxia and oxidative stress, which are known causes of cardiovascular disease,...

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Shimizu Y, Hayakawa H, Takada M, et al. Hemoglobin and adult height loss among Japanese workers: A retrospective study. PLoS One. 2021;16(8):e0256281doi: 10.1371/journal.pone.0256281.
Shimizu, Y., Hayakawa, H., Takada, M., Okada, T., & Kiyama, M. (2021). Hemoglobin and adult height loss among Japanese workers: A retrospective study. PloS one, 16(8), e0256281. https://doi.org/10.1371/journal.pone.0256281
Shimizu, Yuji, et al. "Hemoglobin and adult height loss among Japanese workers: A retrospective study." PloS one vol. 16,8 (2021): e0256281. doi: https://doi.org/10.1371/journal.pone.0256281
Shimizu Y, Hayakawa H, Takada M, Okada T, Kiyama M. Hemoglobin and adult height loss among Japanese workers: A retrospective study. PLoS One. 2021 Aug 17;16(8):e0256281. doi: 10.1371/journal.pone.0256281. eCollection 2021. PMID: 34403451; PMCID: PMC8370608.
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Characteristics of physicians engaged in basic science: a questionnaire survey of physicians in basic science departments of a medical school in Japan.

Yamazaki Y, Uka T, Shimizu H, Miyahira A, Sakai T, Marui E.
UIID-AD: 2926
2012;228:75-82.

The number of physicians engaged in basic science and teaching is sharply decreasing in Japan. To alleviate this shortage, central government has increased the quota of medical students entering the field. This study aimed to determine the characteristics of...

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Yamazaki Y, Uka T, Shimizu H, et al. Characteristics of physicians engaged in basic science: a questionnaire survey of physicians in basic science departments of a medical school in Japan. 2012;228:75-82
Yamazaki, Y., Uka, T., Shimizu, H., Miyahira, A., Sakai, T., & Marui, E. (2012). Characteristics of physicians engaged in basic science: a questionnaire survey of physicians in basic science departments of a medical school in Japan. 22875-82.
Yamazaki, Y, et al. "Characteristics of physicians engaged in basic science: a questionnaire survey of physicians in basic science departments of a medical school in Japan." vol. 228 (2012): 75-82.
Yamazaki Y, Uka T, Shimizu H, Miyahira A, Sakai T, Marui E. Characteristics of physicians engaged in basic science: a questionnaire survey of physicians in basic science departments of a medical school in Japan. 2012;228:75-82. UIID-AD: 2926.
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Showing 6013 to 6020 of 6020 entries