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Showing 1093 to 1096 of 1096 entries
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Ultrasound to identify systemic lupus erythematosus patients with musculoskeletal symptoms who respond best to therapy: the US Evaluation For mUsculoskeletal Lupus longitudinal multicentre study.

Rheumatology (Oxford, England)

Mahmoud K, Zayat AS, Yusof MYM, Dutton K, Teh LS, Yee CS, D'Cruz D, Ng N, Isenberg D, Ciurtin C, Conaghan PG, Emery P, Edwards CJ, Hensor EMA, Vital EM.
PMID: 33792659
Rheumatology (Oxford). 2021 Nov 03;60(11):5194-5204. doi: 10.1093/rheumatology/keab288.

OBJECTIVES: To determine whether SLE patients with inflammatory joint symptoms and US synovitis/tenosyovitis achieve better clinical responses to glucocorticoids compared with patients with normal scans. Secondary objectives included identification of clinical features predicting US synovitis/tenosynovitis.METHODS: In a longitudinal multicentre...

Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast.

Genetics

Garge RK, Cha HJ, Lee C, Gollihar JD, Kachroo AH, Wallingford JB, Marcotte EM.
PMID: 34849907
Genetics. 2021 Aug 26;219(1). doi: 10.1093/genetics/iyab101.

Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dissociating vascular endothelial cells in...

Faecal immunochemical test for patients with 'high-risk' bowel symptoms: a large prospective cohort study and updated literature review.

British journal of cancer

Laszlo HE, Seward E, Ayling RM, Lake J, Malhi A, Stephens C, Pritchard-Jones K, Chung D, Hackshaw A, Machesney M.
PMID: 34903843
Br J Cancer. 2021 Dec 13; doi: 10.1038/s41416-021-01653-x. Epub 2021 Dec 13.

BACKGROUND: We evaluated whether faecal immunochemical testing (FIT) can rule out colorectal cancer (CRC) among patients presenting with 'high-risk' symptoms requiring definitive investigation.METHODS: Three thousand five hundred and ninety-six symptomatic patients referred to the standard urgent CRC pathway were...

Recognition of the antigen-presenting molecule MR1 by a Vδ3.

Proceedings of the National Academy of Sciences of the United States of America

Rice MT, von Borstel A, Chevour P, Awad W, Howson LJ, Littler DR, Gherardin NA, Le Nours J, Giles EM, Berry R, Godfrey DI, Davey MS, Rossjohn J, Gully BS.
PMID: 34845016
Proc Natl Acad Sci U S A. 2021 Dec 07;118(49). doi: 10.1073/pnas.2110288118.

Unlike conventional αβ T cells, γδ T cells typically recognize nonpeptide ligands independently of major histocompatibility complex (MHC) restriction. Accordingly, the γδ T cell receptor (TCR) can potentially recognize a wide array of ligands; however, few ligands have been...

Showing 1093 to 1096 of 1096 entries