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Showing 577 to 584 of 584 entries
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Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids.

Stem cell reports

Fligor CM, Lavekar SS, Harkin J, Shields PK, VanderWall KB, Huang KC, Gomes C, Meyer JS, Sirayi M.
PMID: 34115986
Stem Cell Reports. 2021 Sep 14;16(9):2228-2241. doi: 10.1016/j.stemcr.2021.05.009. Epub 2021 Jun 10.

The development of the visual system involves the coordination of spatial and temporal events to specify the organization of varied cell types, including the elongation of axons from retinal ganglion cells (RGCs) to post-synaptic targets in the brain. Retinal...

Recurrent .

Journal of medical genetics

Tan NB, Pagnamenta AT, Ferla MP, Gadian J, Chung BH, Chan MC, Fung JL, Cook E, Guter S, Boschann F, Heinen A, Schallner J, Mignot C, Keren B, Whalen S, Sarret C, Mittag D, Demmer L, Stapleton R, Saida K, Matsumoto N, Miyake N, Sheffer R, Mor-Shaked H, Barnett CP, Byrne AB, Scott HS, Kraus A, Cappuccio G, Brunetti-Pierri N, Iorio R, Di Dato F, Pais LS, Yeung A, Tan TY, Taylor JC, Christodoulou J, White SM.
PMID: 34183358
J Med Genet. 2021 Jun 28; doi: 10.1136/jmedgenet-2020-107462. Epub 2021 Jun 28.

PURPOSE: Binding proteins (G-proteins) mediate signalling pathways involved in diverse cellular functions and comprise Gα and Gβγ units. Human diseases have been reported for all five Gβ proteins. A METHODS: We discovered a RESULTS: We identified 12 unrelated individuals...

Emergence of Clinical Clostridioides difficile Isolates With Decreased Susceptibility to Vancomycin.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Darkoh C, Keita K, Odo C, Oyaro M, Brown EL, Arias CA, Hanson BM, DuPont HL.
PMID: 35016207
Clin Infect Dis. 2022 Jan 07;74(1):120-126. doi: 10.1093/cid/ciaa912.

BACKGROUND: Clostridioides difficile infection (CDI) is a leading cause of hospital-associated antibiotic-related diarrhea and deaths worldwide. Vancomycin is one of the few antibiotics recommended for both nonsevere and severe CDI cases. We sought to determine whether vancomycin nonsusceptible C....

Efficient detection of copy-number variations using exome data: Batch- and sex-based analyses.

Human mutation

Uchiyama Y, Yamaguchi D, Iwama K, Miyatake S, Hamanaka K, Tsuchida N, Aoi H, Azuma Y, Itai T, Saida K, Fukuda H, Sekiguchi F, Sakaguchi T, Lei M, Ohori S, Sakamoto M, Kato M, Koike T, Takahashi Y, Tanda K, Hyodo Y, Honjo RS, Bertola DR, Kim CA, Goto M, Okazaki T, Yamada H, Maegaki Y, Osaka H, Ngu LH, Siew CG, Teik KW, Akasaka M, Doi H, Tanaka F, Goto T, Guo L, Ikegawa S, Haginoya K, Haniffa M, Hiraishi N, Hiraki Y, Ikemoto S, Daida A, Hamano SI, Miura M, Ishiyama A, Kawano O, Kondo A, Matsumoto H, Okamoto N, Okanishi T, Oyoshi Y, Takeshita E, Suzuki T, Ogawa Y, Handa H, Miyazono Y, Koshimizu E, Fujita A, Takata A, Miyake N, Mizuguchi T, Matsumoto N.
PMID: 33131168
Hum Mutat. 2021 Jan;42(1):50-65. doi: 10.1002/humu.24129. Epub 2020 Nov 11.

Many algorithms to detect copy number variations (CNVs) using exome sequencing (ES) data have been reported and evaluated on their sensitivity and specificity, reproducibility, and precision. However, operational optimization of such algorithms for a better performance has not been...

Porphyromonas gingivalis lipopolysaccharide induces interleukin-6 and c-c motif chemokine ligand 2 expression in cultured hCMEC/D3 human brain microvascular endothelial cells.

Gerodontology

Sato N, Matsumoto T, Kawaguchi S, Seya K, Matsumiya T, Ding J, Aizawa T, Imaizumi T.
PMID: 33599317
Gerodontology. 2021 Feb 18; doi: 10.1111/ger.12545. Epub 2021 Feb 18.

OBJECTIVE: This paper describes the effect of Porphyromonas gingivalis (P gingivalis) lipopolysaccharide (LPS) on the expression of interleukin-6 (IL-6) and C-C motif chemokine ligand 2 (CCL2) in cultured hCMEC/D3 human brain microvascular endothelial cells.BACKGROUND: P gingivalis is one of...

Neuronal intranuclear inclusion disease presenting with an MELAS-like episode in chronic polyneuropathy.

Neurology. Genetics

Ishihara T, Okamoto T, Saida K, Saitoh Y, Oda S, Sano T, Yoshida T, Morita Y, Fujita A, Fukuda H, Miyake N, Mizuguchi T, Saito Y, Sekijima Y, Matsumoto N, Takahashi Y.
PMID: 33324757
Neurol Genet. 2020 Nov 19;6(6):e531. doi: 10.1212/NXG.0000000000000531. eCollection 2020 Dec.

No abstract available.

Current international trends in the treatment of multiple sclerosis in children-Impact of the COVID-19 pandemic.

Multiple sclerosis and related disorders

Sandesjö F, Wassmer E, Deiva K, Amato MP, Chitnis T, Hemingway C, Krupp L, Pohl D, Rostasy K, Waubant E, Banwell B, Wickström R.
PMID: 34624643
Mult Scler Relat Disord. 2021 Sep 27;56:103277. doi: 10.1016/j.msard.2021.103277. Epub 2021 Sep 27.

BACKGROUND: Only recently has the first disease-modifying therapy been approved for children with multiple sclerosis (MS) and practice patterns including substantial off-label use have evolved. Understanding attitudes towards treatment of paediatric MS and whether this has changed due to...

New aspects of HSC mobilization for better therapeutic outcomes.

Cellular & molecular immunology

Patra AK.
PMID: 34158632
Cell Mol Immunol. 2021 Dec;18(12):2583-2585. doi: 10.1038/s41423-021-00723-7. Epub 2021 Jun 22.

No abstract available.

Showing 577 to 584 of 584 entries