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Showing 25 to 36 of 2902 entries
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Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.

Frontiers in behavioral neuroscience

Gan G, Preston-Campbell RN, Moeller SJ, Steinberg JL, Lane SD, Maloney T, Parvaz MA, Goldstein RZ, Alia-Klein N.
PMID: 27729852
Front Behav Neurosci. 2016 Sep 27;10:179. doi: 10.3389/fnbeh.2016.00179. eCollection 2016.

The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant...

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

ACS medicinal chemistry letters

Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, Buist N, Terebetski J, Kelly T, Bugianesi R, Priest BT, Dingley KH, Li X, Mitelman S, Salituro G, Trujillo ME, Pachanski M, Kirkland M, Powles MA, Eiermann GJ, Feng Y, Shang J, Howard AD, Ujjainwalla F, Sinz CJ, Debenham JS, Edmondson SD, Nargund RP, Hagmann WK, Li D.
PMID: 27994747
ACS Med Chem Lett. 2016 Oct 12;7(12):1107-1111. doi: 10.1021/acsmedchemlett.6b00314. eCollection 2016 Dec 08.

GPR142 has been identified as a potential glucose-stimulated insulin secretion (GSIS) target for the treatment of type 2 diabetes mellitus (T2DM). A class of triazole GPR142 agonists was discovered through a high throughput screen. The lead compound

Have radiographic progression rates in early rheumatoid arthritis changed? A systematic review and meta-analysis of long-term cohorts.

Rheumatology (Oxford, England)

Carpenter L, Nikiphorou E, Sharpe R, Norton S, Rennie K, Bunn F, Scott DL, Dixey J, Young A.
PMID: 26961746
Rheumatology (Oxford). 2016 Jun;55(6):1053-1065. doi: 10.1093/rheumatology/kew004. Epub 2016 Mar 08.

OBJECTIVE: To evaluate, firstly, all published data on baseline and annual progression rates of radiographic damage from all longitudinal observational cohorts, and secondly, the association of standard clinical and laboratory parameters with long-term radiographic joint damage.METHODS: A comprehensive search...

MORTALITY PLATEAUS AND THE EVOLUTION OF SENESCENCE: WHY ARE OLD-AGE MORTALITY RATES SO LOW?.

Evolution; international journal of organic evolution

Pletcher SD, Curtsinger JW.
PMID: 28568338
Evolution. 1998 Apr;52(2):454-464. doi: 10.1111/j.1558-5646.1998.tb01645.x.

Age-specific mortality rates level off far below 100% at advanced ages in experimental populations of Drosophila melanogaster and other organisms. This observation is inconsistent with the equilibrium predictions of both the antagonistic pleiotropy and mutation accumulation models of senescence,...

Relative judgment theory and the mediation of facial recognition: Implications for theories of eyewitness identification.

Cognitive research: principles and implications

McAdoo RM, Gronlund SD.
PMID: 28180162
Cogn Res Princ Implic. 2016;1(1):11. doi: 10.1186/s41235-016-0014-7. Epub 2016 Nov 05.

Many in the eyewitness identification community believe that sequential lineups are superior to simultaneous lineups because simultaneous lineups encourage inappropriate choosing due to promoting comparisons among choices (a relative judgment strategy), but sequential lineups reduce this propensity by inducing...

Earthquakes drive large-scale submarine canyon development and sediment supply to deep-ocean basins.

Science advances

Mountjoy JJ, Howarth JD, Orpin AR, Barnes PM, Bowden DA, Rowden AA, Schimel ACG, Holden C, Horgan HJ, Nodder SD, Patton JR, Lamarche G, Gerstenberger M, Micallef A, Pallentin A, Kane T.
PMID: 29546245
Sci Adv. 2018 Mar 14;4(3):eaar3748. doi: 10.1126/sciadv.aar3748. eCollection 2018 Mar.

Although the global flux of sediment and carbon from land to the coastal ocean is well known, the volume of material that reaches the deep ocean-the ultimate sink-and the mechanisms by which it is transferred are poorly documented. Using...

Reply: Business Education for Plastic Surgeons: A Systematic Review, Development, and Implementation of a Business Principles Curriculum in a Residency Program.

Plastic and reconstructive surgery

Cooney CM, Frick K, Zarrabi B, Burce KK, Seal SM, Lifchez SD, Redett RJ, Dorafshar AH.
PMID: 29485602
Plast Reconstr Surg. 2018 Mar;141(3):463e-464e. doi: 10.1097/PRS.0000000000004158.

No abstract available.

DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions.

Synlett : accounts and rapid communications in synthetic organic chemistry

Reilly MK, Rychnovsky SD.
PMID: 24371372
Synlett. 2011 Oct 01;2011(16). doi: 10.1055/s-0030-1261218.

Diethanolamine complexed heterocyclic boronic acids (DABO boronates) are air-stable reagents that can be used directly in Suzuki-Miyaura reactions in the presence of water or a protic co-solvent. Interestingly, heterocyclic DABO boronates can be stored for extended periods of time...

Retinopathy and clinical outcomes in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia.

BMJ open diabetes research & care

Bello NA, Pfeffer MA, Skali H, McGill JB, Rossert J, Olson KA, Weinrauch L, Cooper ME, de Zeeuw D, Rossing P, McMurray JJ, Solomon SD.
PMID: 25452859
BMJ Open Diabetes Res Care. 2014 Apr 06;2(1):e000011. doi: 10.1136/bmjdrc-2013-000011. eCollection 2014.

OBJECTIVE: Retinopathy is an established microvascular complication of type 2 diabetes mellitus (T2DM), but its independent relationship with macrovascular and other microvascular complications is less well defined across the spectrum of kidney disease in T2DM. We examined the prognostic...

Two-dimensional aperture coding for magnetic sector mass spectrometry.

Journal of the American Society for Mass Spectrometry

Russell ZE, Chen EX, Amsden JJ, Wolter SD, Danell RM, Parker CB, Stoner BR, Gehm ME, Brady DJ, Glass JT.
PMID: 25510933
J Am Soc Mass Spectrom. 2015 Feb;26(2):248-56. doi: 10.1007/s13361-014-1051-4. Epub 2014 Dec 16.

In mass spectrometer design, there has been a historic belief that there exists a fundamental trade-off between instrument size, throughput, and resolution. When miniaturizing a traditional system, performance loss in either resolution or throughput would be expected. However, in...

Polynuclear lanthanide (Ln) complexes of a tri-functional hydrazone ligand--mononuclear (Dy), dinuclear (Yb, Tm), tetranuclear (Gd), and hexanuclear (Gd, Dy, Tb) examples.

Dalton transactions (Cambridge, England : 2003)

Anwar MU, Dawe LN, Tandon SS, Bunge SD, Thompson LK.
PMID: 23552191
Dalton Trans. 2013 Jun 07;42(21):7781-94. doi: 10.1039/c3dt32732a.

The lanthanide coordination chemistry of a tri-functional vanillin-hydrazone-oxime ligand reveals a variety of different products, depending on reaction conditions, with mono-nuclear (Dy), dinuclear (Yb, Tm), tetranuclear (Gd) and hexanuclear (Gd, Tb, Dy) examples. The Ln6 (Ln = Gd, Dy,...

The herbaceous landlord: integrating the effects of symbiont consortia within a single host.

PeerJ

Vandegrift R, Roy BA, Pfeifer-Meister L, Johnson BR, Bridgham SD.
PMID: 26557442
PeerJ. 2015 Nov 03;3:e1379. doi: 10.7717/peerj.1379. eCollection 2015.

Plants are typically infected by a consortium of internal fungal associates, including endophytes in their leaves, as well as arbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSE) in their roots. It is logical that these organisms will interact...

Showing 25 to 36 of 2902 entries