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The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia.

Frontiers in oncology

Annageldiyev C, Tan SF, Thakur S, Dhanyamraju PK, Ramisetti SR, Bhadauria P, Schick J, Zeng Z, Sharma V, Dunton W, Dovat S, Desai D, Zheng H, Feith DJ, Loughran TP, Amin S, Sharma AK, Claxton D, Sharma A.
PMID: 32296637
Front Oncol. 2020 Apr 01;10:393. doi: 10.3389/fonc.2020.00393. eCollection 2020.

Acute myeloid leukemia is a heterogeneous disease with a 5-year survival rate of 28.3%, and current treatment options constrained by dose-limiting toxicities. One of the key signaling pathways known to be frequently activated and dysregulated in AML is PI3K/AKT....

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Annageldiyev C, Tan SF, Thakur S, et al. The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia. Front Oncol. 2020;10:393doi: 10.3389/fonc.2020.00393.
Annageldiyev, C., Tan, S. F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., Schick, J., Zeng, Z., Sharma, V., Dunton, W., Dovat, S., Desai, D., Zheng, H., Feith, D. J., Loughran, T. P., Amin, S., Sharma, A. K., Claxton, D., & Sharma, A. (2020). The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia. Frontiers in oncology, 10393. https://doi.org/10.3389/fonc.2020.00393
Annageldiyev, Charyguly, et al. "The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia." Frontiers in oncology vol. 10 (2020): 393. doi: https://doi.org/10.3389/fonc.2020.00393
Annageldiyev C, Tan SF, Thakur S, Dhanyamraju PK, Ramisetti SR, Bhadauria P, Schick J, Zeng Z, Sharma V, Dunton W, Dovat S, Desai D, Zheng H, Feith DJ, Loughran TP, Amin S, Sharma AK, Claxton D, Sharma A. The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia. Front Oncol. 2020 Apr 01;10:393. doi: 10.3389/fonc.2020.00393. eCollection 2020. PMID: 32296637; PMCID: PMC7140985.
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Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.

EFSA journal. European Food Safety Authority

, Turck D, Bresson JL, Burlingame B, Dean T, Fairweather-Tait S, Heinonen M, Hirsch-Ernst KI, Mangelsdorf I, McArdle HJ, Naska A, Neuhäuser-Berthold M, Nowicka G, Pentieva K, Sanz Y, Sjödin A, Stern M, Tomé D, Van Loveren H, Vinceti M, Willatts P, Martin A, Strain JJ, Ciok J, Siani A.
PMID: 32625273
EFSA J. 2017 Jan 27;15(1):e04685. doi: 10.2903/j.efsa.2017.4685. eCollection 2017 Jan.

Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and...

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, Turck D, Bresson JL, et al. Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J. 2017;15(1):e04685doi: 10.2903/j.efsa.2017.4685.
, Turck, D., Bresson, J. L., Burlingame, B., Dean, T., Fairweather-Tait, S., Heinonen, M., Hirsch-Ernst, K. I., Mangelsdorf, I., McArdle, H. J., Naska, A., Neuhäuser-Berthold, M., Nowicka, G., Pentieva, K., Sanz, Y., Sjödin, A., Stern, M., Tomé, D., Van Loveren, H., Vinceti, M., Willatts, P., Martin, A., Strain, J. J., Ciok, J., & Siani, A. (2017). Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA journal. European Food Safety Authority, 15(1), e04685. https://doi.org/10.2903/j.efsa.2017.4685
, et al. "Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006." EFSA journal. European Food Safety Authority vol. 15,1 (2017): e04685. doi: https://doi.org/10.2903/j.efsa.2017.4685
, Turck D, Bresson JL, Burlingame B, Dean T, Fairweather-Tait S, Heinonen M, Hirsch-Ernst KI, Mangelsdorf I, McArdle HJ, Naska A, Neuhäuser-Berthold M, Nowicka G, Pentieva K, Sanz Y, Sjödin A, Stern M, Tomé D, Van Loveren H, Vinceti M, Willatts P, Martin A, Strain JJ, Ciok J, Siani A. Vitamin C and protection of DNA, proteins and lipids from oxidative damage: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA J. 2017 Jan 27;15(1):e04685. doi: 10.2903/j.efsa.2017.4685. eCollection 2017 Jan. PMID: 32625273; PMCID: PMC7010190.
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Food Fraud Prevention: Policy, Strategy, and Decision-Making - Implementation Steps for a Government Agency or Industry.

Chimia

Spink J, Fortin ND, Moyer DC, Miao H, Wu Y.
PMID: 27198808
Chimia (Aarau). 2016;70(5):320-8. doi: 10.2533/chimia.2016.320.

This paper addresses the role of governments, industry, academics, and non-governmental organizations in Food Fraud prevention. Before providing strategic concepts for governments and authorities, definitions of Food Fraud are reviewed and discussed. Next there is a review of Food...

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Spink J, Fortin ND, Moyer DC, et al. Food Fraud Prevention: Policy, Strategy, and Decision-Making - Implementation Steps for a Government Agency or Industry. Chimia (Aarau). 2016;70(5):320-8doi: 10.2533/chimia.2016.320.
Spink, J., Fortin, N. D., Moyer, D. C., Miao, H., & Wu, Y. (2016). Food Fraud Prevention: Policy, Strategy, and Decision-Making - Implementation Steps for a Government Agency or Industry. Chimia, 70(5), 320-8. https://doi.org/10.2533/chimia.2016.320
Spink, John, et al. "Food Fraud Prevention: Policy, Strategy, and Decision-Making - Implementation Steps for a Government Agency or Industry." Chimia vol. 70,5 (2016): 320-8. doi: https://doi.org/10.2533/chimia.2016.320
Spink J, Fortin ND, Moyer DC, Miao H, Wu Y. Food Fraud Prevention: Policy, Strategy, and Decision-Making - Implementation Steps for a Government Agency or Industry. Chimia (Aarau). 2016;70(5):320-8. doi: 10.2533/chimia.2016.320. PMID: 27198808.
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A Post-pleistocene Calibrated Mutation Rate from Insect Museum Specimens.

PLoS currents

Ney G, Frederick K, Schul J.
PMID: 30116653
PLoS Curr. 2018 Jul 13;10. doi: 10.1371/currents.tol.aba557de56be881793261f7e1565cf35.

Quantifying the age of recent species divergence events can be challenging in the absence of calibration points within many groups. The katydid species

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Ney G, Frederick K, Schul J. A Post-pleistocene Calibrated Mutation Rate from Insect Museum Specimens. PLoS Curr. 2018;10doi: 10.1371/currents.tol.aba557de56be881793261f7e1565cf35.
Ney, G., Frederick, K., & Schul, J. (2018). A Post-pleistocene Calibrated Mutation Rate from Insect Museum Specimens. PLoS currents, 10. https://doi.org/10.1371/currents.tol.aba557de56be881793261f7e1565cf35
Ney, Gideon, et al. "A Post-pleistocene Calibrated Mutation Rate from Insect Museum Specimens." PLoS currents vol. 10 (2018). doi: https://doi.org/10.1371/currents.tol.aba557de56be881793261f7e1565cf35
Ney G, Frederick K, Schul J. A Post-pleistocene Calibrated Mutation Rate from Insect Museum Specimens. PLoS Curr. 2018 Jul 13;10. doi: 10.1371/currents.tol.aba557de56be881793261f7e1565cf35. PMID: 30116653; PMCID: PMC6072552.
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Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes.

Dalton transactions (Cambridge, England : 2003)

Cullinane C, Deacon GB, Drago PR, Erven AP, Junk PC, Luu J, Meyer G, Schmitz S, Ott I, Schur J, Webster LK, Klein A.
PMID: 29340396
Dalton Trans. 2018 Feb 06;47(6):1918-1932. doi: 10.1039/c7dt04615d.

New organometallic complexes [M(dppe)(R)

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Cullinane C, Deacon GB, Drago PR, et al. Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes. Dalton Trans. 2018;47(6):1918-1932doi: 10.1039/c7dt04615d.
Cullinane, C., Deacon, G. B., Drago, P. R., Erven, A. P., Junk, P. C., Luu, J., Meyer, G., Schmitz, S., Ott, I., Schur, J., Webster, L. K., & Klein, A. (2018). Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes. Dalton transactions (Cambridge, England : 2003), 47(6), 1918-1932. https://doi.org/10.1039/c7dt04615d
Cullinane, Carleen, et al. "Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes." Dalton transactions (Cambridge, England : 2003) vol. 47,6 (2018): 1918-1932. doi: https://doi.org/10.1039/c7dt04615d
Cullinane C, Deacon GB, Drago PR, Erven AP, Junk PC, Luu J, Meyer G, Schmitz S, Ott I, Schur J, Webster LK, Klein A. Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes. Dalton Trans. 2018 Feb 06;47(6):1918-1932. doi: 10.1039/c7dt04615d. PMID: 29340396.
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Focusing of High-Brightness Electron Beams with Active-Plasma Lenses.

Physical review letters

Pompili R, Anania MP, Bellaveglia M, Biagioni A, Bini S, Bisesto F, Brentegani E, Cardelli F, Castorina G, Chiadroni E, Cianchi A, Coiro O, Costa G, Croia M, Di Giovenale D, Ferrario M, Filippi F, Giribono A, Lollo V, Marocchino A, Marongiu M, Martinelli V, Mostacci A, Pellegrini D, Piersanti L, Di Pirro G, Romeo S, Rossi AR, Scifo J, Shpakov V, Stella A, Vaccarezza C, Villa F, Zigler A.
PMID: 30411933
Phys Rev Lett. 2018 Oct 26;121(17):174801. doi: 10.1103/PhysRevLett.121.174801.

Plasma-based technology promises a tremendous reduction in size of accelerators used for research, medical, and industrial applications, making it possible to develop tabletop machines accessible for a broader scientific community. By overcoming current limits of conventional accelerators and pushing...

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Pompili R, Anania MP, Bellaveglia M, et al. Focusing of High-Brightness Electron Beams with Active-Plasma Lenses. Phys Rev Lett. 2018;121(17):174801doi: 10.1103/PhysRevLett.121.174801.
Pompili, R., Anania, M. P., Bellaveglia, M., Biagioni, A., Bini, S., Bisesto, F., Brentegani, E., Cardelli, F., Castorina, G., Chiadroni, E., Cianchi, A., Coiro, O., Costa, G., Croia, M., Di Giovenale, D., Ferrario, M., Filippi, F., Giribono, A., Lollo, V., Marocchino, A., Marongiu, M., Martinelli, V., Mostacci, A., Pellegrini, D., Piersanti, L., Di Pirro, G., Romeo, S., Rossi, A. R., Scifo, J., Shpakov, V., Stella, A., Vaccarezza, C., Villa, F., & Zigler, A. (2018). Focusing of High-Brightness Electron Beams with Active-Plasma Lenses. Physical review letters, 121(17), 174801. https://doi.org/10.1103/PhysRevLett.121.174801
Pompili, R, et al. "Focusing of High-Brightness Electron Beams with Active-Plasma Lenses." Physical review letters vol. 121,17 (2018): 174801. doi: https://doi.org/10.1103/PhysRevLett.121.174801
Pompili R, Anania MP, Bellaveglia M, Biagioni A, Bini S, Bisesto F, Brentegani E, Cardelli F, Castorina G, Chiadroni E, Cianchi A, Coiro O, Costa G, Croia M, Di Giovenale D, Ferrario M, Filippi F, Giribono A, Lollo V, Marocchino A, Marongiu M, Martinelli V, Mostacci A, Pellegrini D, Piersanti L, Di Pirro G, Romeo S, Rossi AR, Scifo J, Shpakov V, Stella A, Vaccarezza C, Villa F, Zigler A. Focusing of High-Brightness Electron Beams with Active-Plasma Lenses. Phys Rev Lett. 2018 Oct 26;121(17):174801. doi: 10.1103/PhysRevLett.121.174801. PMID: 30411933.
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Laser ablation- and plasma etching-based patterning of graphene on silicon-on-insulator waveguides.

Optics express

Van Erps J, Ciuk T, Pasternak I, Krajewska A, Strupinski W, Van Put S, Van Steenberge G, Baert K, Terryn H, Thienpont H, Vermeulen N.
PMID: 26480176
Opt Express. 2015 Oct 05;23(20):26639-50. doi: 10.1364/OE.23.026639.

We present a new approach to remove monolayer graphene transferred on top of a silicon-on-insulator (SOI) photonic integrated chip. Femtosecond laser ablation is used for the first time to remove graphene from SOI waveguides, whereas oxygen plasma etching through...

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Van Erps J, Ciuk T, Pasternak I, et al. Laser ablation- and plasma etching-based patterning of graphene on silicon-on-insulator waveguides. Opt Express. 2015;23(20):26639-50doi: 10.1364/OE.23.026639.
Van Erps, J., Ciuk, T., Pasternak, I., Krajewska, A., Strupinski, W., Van Put, S., Van Steenberge, G., Baert, K., Terryn, H., Thienpont, H., & Vermeulen, N. (2015). Laser ablation- and plasma etching-based patterning of graphene on silicon-on-insulator waveguides. Optics express, 23(20), 26639-50. https://doi.org/10.1364/OE.23.026639
Van Erps, Jürgen, et al. "Laser ablation- and plasma etching-based patterning of graphene on silicon-on-insulator waveguides." Optics express vol. 23,20 (2015): 26639-50. doi: https://doi.org/10.1364/OE.23.026639
Van Erps J, Ciuk T, Pasternak I, Krajewska A, Strupinski W, Van Put S, Van Steenberge G, Baert K, Terryn H, Thienpont H, Vermeulen N. Laser ablation- and plasma etching-based patterning of graphene on silicon-on-insulator waveguides. Opt Express. 2015 Oct 05;23(20):26639-50. doi: 10.1364/OE.23.026639. PMID: 26480176.
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Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage.

Frontiers in immunology

Lang R, Schick J.
PMID: 29312343
Front Immunol. 2017 Dec 22;8:1864. doi: 10.3389/fimmu.2017.01864. eCollection 2017.

Successful immune control of

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Lang R, Schick J. Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage. Front Immunol. 2017;8:1864doi: 10.3389/fimmu.2017.01864.
Lang, R., & Schick, J. (2017). Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage. Frontiers in immunology, 81864. https://doi.org/10.3389/fimmu.2017.01864
Lang, Roland, and Schick, Judith. "Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage." Frontiers in immunology vol. 8 (2017): 1864. doi: https://doi.org/10.3389/fimmu.2017.01864
Lang R, Schick J. Review: Impact of Helminth Infection on Antimycobacterial Immunity-A Focus on the Macrophage. Front Immunol. 2017 Dec 22;8:1864. doi: 10.3389/fimmu.2017.01864. eCollection 2017. PMID: 29312343; PMCID: PMC5743664.
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Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds.

The journal of physical chemistry. A

Chatgilialoglu C, Mozziconacci O, Tamba M, Bobrowski K, Kciuk G, Bertrand MP, Gastaldi S, Timokhin VI.
PMID: 22724535
J Phys Chem A. 2012 Jul 26;116(29):7623-8. doi: 10.1021/jp304863y. Epub 2012 Jul 12.

The reactions of α-hydroxyl and α-alkoxyl alkyl radicals with methanesulfonyl chloride (MeSO(2)Cl) have been studied by pulse radiolysis at room temperature. The alkyl radicals were produced by ionizing radiation of N(2)O-saturated aqueous solution containing methanol, ethanol, isopropanol, or tetrahydrofuran....

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Chatgilialoglu C, Mozziconacci O, Tamba M, et al. Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds. J Phys Chem A. 2012;116(29):7623-8doi: 10.1021/jp304863y.
Chatgilialoglu, C., Mozziconacci, O., Tamba, M., Bobrowski, K., Kciuk, G., Bertrand, M. P., Gastaldi, S., & Timokhin, V. I. (2012). Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds. The journal of physical chemistry. A, 116(29), 7623-8. https://doi.org/10.1021/jp304863y
Chatgilialoglu, Chryssostomos, et al. "Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds." The journal of physical chemistry. A vol. 116,29 (2012): 7623-8. doi: https://doi.org/10.1021/jp304863y
Chatgilialoglu C, Mozziconacci O, Tamba M, Bobrowski K, Kciuk G, Bertrand MP, Gastaldi S, Timokhin VI. Kinetic studies on the formation of sulfonyl radicals and their addition to carbon-carbon multiple bonds. J Phys Chem A. 2012 Jul 26;116(29):7623-8. doi: 10.1021/jp304863y. Epub 2012 Jul 12. PMID: 22724535.
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CT scans: bad habit or necessity?.

Inflammatory bowel diseases

Sauk J.
PMID: 22275340
Inflamm Bowel Dis. 2012 Sep;18(9):1797-8. doi: 10.1002/ibd.22894. Epub 2012 Jan 24.

No abstract available.

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Sauk J. CT scans: bad habit or necessity?. Inflamm Bowel Dis. 2012;18(9):1797-8doi: 10.1002/ibd.22894.
Sauk, J. (2012). CT scans: bad habit or necessity?. Inflammatory bowel diseases, 18(9), 1797-8. https://doi.org/10.1002/ibd.22894
Sauk, Jenny. "CT scans: bad habit or necessity?." Inflammatory bowel diseases vol. 18,9 (2012): 1797-8. doi: https://doi.org/10.1002/ibd.22894
Sauk J. CT scans: bad habit or necessity?. Inflamm Bowel Dis. 2012 Sep;18(9):1797-8. doi: 10.1002/ibd.22894. Epub 2012 Jan 24. PMID: 22275340.
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Specific differences in sound production and pattern recognition in tettigoniids.

Behavioural processes

Jatho M, Schul J, Stiedl O, Kalmring K.
PMID: 24924941
Behav Processes. 1994 Apr;31(2):293-300. doi: 10.1016/0376-6357(94)90014-0.

A brief comparative description of the stridulatory songs of nine different tettigoniid species is given to introduce a set of four parameters (phase of sound production during opening and closing movement of the wings, syllable repetition mode, syllable similarity,...

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Jatho M, Schul J, Stiedl O, et al. Specific differences in sound production and pattern recognition in tettigoniids. Behav Processes. 1994;31(2):293-300doi: 10.1016/0376-6357(94)90014-0.
Jatho, M., Schul, J., Stiedl, O., & Kalmring, K. (1994). Specific differences in sound production and pattern recognition in tettigoniids. Behavioural processes, 31(2), 293-300. https://doi.org/10.1016/0376-6357(94)90014-0
Jatho, M, et al. "Specific differences in sound production and pattern recognition in tettigoniids." Behavioural processes vol. 31,2 (1994): 293-300. doi: https://doi.org/10.1016/0376-6357(94)90014-0
Jatho M, Schul J, Stiedl O, Kalmring K. Specific differences in sound production and pattern recognition in tettigoniids. Behav Processes. 1994 Apr;31(2):293-300. doi: 10.1016/0376-6357(94)90014-0. PMID: 24924941.
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Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders.

Current topics in medicinal chemistry

Miller E, Morel A, Saso L, Saluk J.
PMID: 25547102
Curr Top Med Chem. 2014 Dec 29; Epub 2014 Dec 29.

Neurodegeneration is the hallmark of many chronic progressive neurogical disorders characterized by specific clinical, morphological and biochemical features. Central nervous system is very sensitive to oxidative stress, which is considered as a key factor of neurodegenerative disorders. Therefore, many...

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Miller E, Morel A, Saso L, et al. Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders. Curr Top Med Chem. 2014;
Miller, E., Morel, A., Saso, L., & Saluk, J. (2014). Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders. Current topics in medicinal chemistry, .
Miller, Elżbieta, et al. "Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders." Current topics in medicinal chemistry vol. (2014).
Miller E, Morel A, Saso L, Saluk J. Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders. Curr Top Med Chem. 2014 Dec 29; Epub 2014 Dec 29. PMID: 25547102.
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