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Showing 25 to 36 of 189 entries
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A novel immuno-oncology algorithm measuring tumor microenvironment to predict response to immunotherapies.

Heliyon

Nielsen TJ, Ring BZ, Seitz RS, Hout DR, Schweitzer BL.
PMID: 33748492
Heliyon. 2021 Mar 09;7(3):e06438. doi: 10.1016/j.heliyon.2021.e06438. eCollection 2021 Mar.

Immune checkpoint inhibitor (ICI) therapies can improve clinical outcomes for patients with solid tumors, but relatively few patients respond. Because ICI therapies support an adaptive immune response, patients with an active tumor microenvironment (TME) may be more likely to...

Mind-Body Therapies From Traditional Chinese Medicine: Evidence Map.

Frontiers in public health

Fogaça LZ, Portella CFS, Ghelman R, Abdala CVM, Schveitzer MC.
PMID: 34988045
Front Public Health. 2021 Dec 10;9:659075. doi: 10.3389/fpubh.2021.659075. eCollection 2021.

No abstract available.

Trends in Clinical Severity of Hospitalized Patients With Coronavirus Disease 2019-Premier Hospital Dataset, April 2020-April 2021.

Open forum infectious diseases

Whitfield GP, Harris AM, Kadri SS, Warner S, Bamrah Morris S, Giovanni JE, Rogers-Brown JS, Hinckley AF, Kompaniyets L, Sircar KD, Yusuf HR, Koumans EH, Schweitzer BK.
PMID: 34988259
Open Forum Infect Dis. 2021 Nov 30;9(1):ofab599. doi: 10.1093/ofid/ofab599. eCollection 2022 Jan.

BACKGROUND: Clinical severity of coronavirus disease 2019 (COVID-19) may vary over time; trends in clinical severity at admission during the pandemic among hospitalized patients in the United States have been incompletely described, so a historical record of severity over...

The Conversational Circumplex: Identifying, prioritizing, and pursuing informational and relational motives in conversation.

Current opinion in psychology

Yeomans M, Schweitzer ME, Brooks AW.
PMID: 34826713
Curr Opin Psychol. 2021 Oct 11;44:293-302. doi: 10.1016/j.copsyc.2021.10.001. Epub 2021 Oct 11.

The meaning of success in conversation depends on people's goals. Often, individuals pursue multiple goals simultaneously, such as establishing shared understanding, making a favorable impression, having fun, or persuading a conversation partner. In this article, we introduce a novel...

Mindful eating for overweight and obese women in Brazil: An exploratory mixed-methods pilot study.

Nutrition and health

Salvo V, Sanudo A, Kristeller J, Schveitzer MC, Martins P, Favarato ML, Demarzo M.
PMID: 34913753
Nutr Health. 2021 Dec 16;2601060211052794. doi: 10.1177/02601060211052794. Epub 2021 Dec 16.

No abstract available.

A Task-dependent Investigation on Dose and Texture in CT Image Reconstruction.

IEEE transactions on radiation and plasma medical sciences

Gao Y, Liang Z, Zhang H, Yang J, Ferretti J, Bilfinger T, Yaddanapudi K, Schweitzer M, Bhattacharji P, Moore W.
PMID: 33907724
IEEE Trans Radiat Plasma Med Sci. 2020 Jul;4(4):441-449. doi: 10.1109/trpms.2019.2957459. Epub 2019 Dec 04.

Localizing and characterizing clinically-significant lung nodules, a potential precursor to lung cancer, at the lowest achievable radiation dose is demanded to minimize the stochastic radiation effects from x-ray computed tomography (CT). A minimal dose level is heavily dependent on...

Deep Time Paleoproteomics: Looking Forward.

Journal of proteome research

Schroeter ER, Cleland TP, Schweitzer MH.
PMID: 34918935
J Proteome Res. 2021 Dec 17; doi: 10.1021/acs.jproteome.1c00755. Epub 2021 Dec 17.

The goal of paleoproteomics is to characterize proteins from specimens that have been subjected to the degrading and obscuring effects of time, thus obtaining biological information about tissues or organisms both unobservable in the present and unobtainable through morphological...

Multicenter Technical Validation of 30 Rapid Antigen Tests for the Detection of SARS-CoV-2 (VALIDATE).

Microorganisms

Greub G, Caruana G, Schweitzer M, Imperiali M, Muigg V, Risch M, Croxatto A, Opota O, Heller S, Albertos Torres D, Tritten ML, Leuzinger K, Hirsch HH, Lienhard R, Egli A.
PMID: 34946190
Microorganisms. 2021 Dec 15;9(12). doi: 10.3390/microorganisms9122589.

During COVID19 pandemic, SARS-CoV-2 rapid antigen tests (RATs) were marketed with minimal or no performance data. We aimed at closing this gap by determining technical sensitivities and specificities of 30 RATs prior to market release. We developed a standardized...

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance.

Microorganisms

Mari A, Roloff T, Stange M, Søgaard KK, Asllanaj E, Tauriello G, Alexander LT, Schweitzer M, Leuzinger K, Gensch A, Martinez AE, Bielicki J, Pargger H, Siegemund M, Nickel CH, Bingisser R, Osthoff M, Bassetti S, Sendi P, Battegay M, Marzolini C, Seth-Smith HMB, Schwede T, Hirsch HH, Egli A.
PMID: 34069681
Microorganisms. 2021 May 19;9(5). doi: 10.3390/microorganisms9051094.

A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by

The importance of imaging - Perspectives from redeployment.

Clinical imaging

Atallah J, Shah S, Toy D, Dodelzon K, Schweitzer AD.
PMID: 33099069
Clin Imaging. 2021 Jan;69:380-383. doi: 10.1016/j.clinimag.2020.10.022. Epub 2020 Oct 13.

As the coronavirus disease 2019 (COVID-19) pandemic strains the healthcare system, radiology residents across the United States have become a vital part of the redeployed workforce. Through a series of four cases of COVID-19 patients encountered on the wards,...

Increased Adipose Tissue Fibrogenesis, Not Impaired Expandability, Is Associated With Nonalcoholic Fatty Liver Disease.

Hepatology (Baltimore, Md.)

Beals JW, Smith GI, Shankaran M, Fuchs A, Schweitzer GG, Yoshino J, Field T, Matthews M, Nyangau E, Morozov D, Mittendorfer B, Hellerstein MK, Klein S.
PMID: 33743554
Hepatology. 2021 Sep;74(3):1287-1299. doi: 10.1002/hep.31822. Epub 2021 Jun 22.

BACKGROUND AND AIMS: It is proposed that impaired expansion of subcutaneous adipose tissue (SAT) and an increase in adipose tissue (AT) fibrosis causes ectopic lipid accumulation, insulin resistance (IR), and metabolically unhealthy obesity. We therefore evaluated whether a decrease...

Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.

JCI insight

Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN.
PMID: 33986192
JCI Insight. 2021 May 10;6(9). doi: 10.1172/jci.insight.134340.

Lipin 1 is a bifunctional protein that is a transcriptional regulator and has phosphatidic acid (PA) phosphohydrolase activity, which dephosphorylates PA to generate diacylglycerol. Human lipin 1 mutations lead to episodic rhabdomyolysis, and some affected patients exhibit cardiac abnormalities,...

Showing 25 to 36 of 189 entries