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Showing 541 to 543 of 543 entries
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Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP.

Diabetologia

Hiller H, Yang C, Beachy DE, Kusmartseva I, Candelario-Jalil E, Posgai AL, Nick HS, Schatz D, Atkinson MA, Wasserfall CH.
PMID: 34274990
Diabetologia. 2021 Oct;64(10):2279-2291. doi: 10.1007/s00125-021-05501-8. Epub 2021 Jul 17.

AIMS/HYPOTHESIS: Normal cellular prion protein (PrPMETHODS: In order to evaluate localisation and trafficking of PrPRESULTS: In non-diabetic and type 1 diabetic pancreases (the latter displaying both insulin-positive [INS(+)] and -negative [INS(-)] islets), we found PrPCONCLUSIONS/INTERPRETATION: As the first study...

A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy.

Cancers

Krassnig S, Wohlrab C, Golob-Schwarzl N, Raicht A, Schatz C, Birkl-Toeglhofer AM, Skofler C, Gantenbein N, Leoni M, Asslaber M, Leber SL, Mahdy-Ali K, von Campe G, Mayer M, Borenich A, Weis S, Benesch M, Haybaeck J.
PMID: 33807050
Cancers (Basel). 2021 Mar 23;13(6). doi: 10.3390/cancers13061482.

Glioblastoma (GBM) is an utterly devastating cerebral neoplasm and current therapies only marginally improve patients' overall survival (OS). The PI3K/AKT/mTOR pathway participates in gliomagenesis through regulation of cell growth and proliferation. Since it is an upstream regulator of the...

How Physician Workforce Shortages Are Hampering the Response to the Opioid Crisis.

Psychiatric services (Washington, D.C.)

McNeely J, Schatz D, Olfson M, Appleton N, Williams AR.
PMID: 34521210
Psychiatr Serv. 2021 Sep 15;appips202000565. doi: 10.1176/appi.ps.202000565. Epub 2021 Sep 15.

The United States is experiencing an unprecedented opioid crisis, with a record of about 93,000 opioid-involved overdose deaths in 2020, which requires rapid and substantial scaling up of access to effective treatment for opioid use disorder. Only 18% of...

Showing 541 to 543 of 543 entries