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A Systematic Approach for Post Hoc Subgroup Analyses With Applications in Clinical Case Studies.

Therapeutic innovation & regulatory science

Muysers C, Dmitrienko A, Kulmann H, Kirsch B, Lippert S, Schmelter T, Schulz A, Mentenich N, Schmitz H, Schaefers M, Meinhardt G, Keil T, Roll S.
PMID: 33301136
Ther Innov Regul Sci. 2020 May;54(3):507-518. doi: 10.1007/s43441-019-00082-6. Epub 2020 Jan 06.

BACKGROUND: The analysis of subgroups in clinical trials is essential to assess differences in treatment effects for distinct patient clusters, that is, to detect patients with greater treatment benefit or patients where the treatment seems to be ineffective.METHODS: The...

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Muysers C, Dmitrienko A, Kulmann H, et al. A Systematic Approach for Post Hoc Subgroup Analyses With Applications in Clinical Case Studies. Ther Innov Regul Sci. 2020;54(3):507-518doi: 10.1007/s43441-019-00082-6.
Muysers, C., Dmitrienko, A., Kulmann, H., Kirsch, B., Lippert, S., Schmelter, T., Schulz, A., Mentenich, N., Schmitz, H., Schaefers, M., Meinhardt, G., Keil, T., & Roll, S. (2020). A Systematic Approach for Post Hoc Subgroup Analyses With Applications in Clinical Case Studies. Therapeutic innovation & regulatory science, 54(3), 507-518. https://doi.org/10.1007/s43441-019-00082-6
Muysers, Christoph, et al. "A Systematic Approach for Post Hoc Subgroup Analyses With Applications in Clinical Case Studies." Therapeutic innovation & regulatory science vol. 54,3 (2020): 507-518. doi: https://doi.org/10.1007/s43441-019-00082-6
Muysers C, Dmitrienko A, Kulmann H, Kirsch B, Lippert S, Schmelter T, Schulz A, Mentenich N, Schmitz H, Schaefers M, Meinhardt G, Keil T, Roll S. A Systematic Approach for Post Hoc Subgroup Analyses With Applications in Clinical Case Studies. Ther Innov Regul Sci. 2020 May;54(3):507-518. doi: 10.1007/s43441-019-00082-6. Epub 2020 Jan 06. PMID: 33301136.
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Computational Psychiatry for Computers.

iScience

Schulz E, Dayan P.
PMID: 33294781
iScience. 2020 Nov 07;23(12):101772. doi: 10.1016/j.isci.2020.101772. eCollection 2020 Dec 18.

Computational psychiatry is a nascent field that attempts to use multi-level analyses of the underlying computational problems that we face in navigating a complex, uncertain and changing world to illuminate mental dysfunction and disease. Two particular foci of the...

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Schulz E, Dayan P. Computational Psychiatry for Computers. iScience. 2020;23(12):101772doi: 10.1016/j.isci.2020.101772.
Schulz, E., & Dayan, P. (2020). Computational Psychiatry for Computers. iScience, 23(12), 101772. https://doi.org/10.1016/j.isci.2020.101772
Schulz, Eric, and Dayan, Peter. "Computational Psychiatry for Computers." iScience vol. 23,12 (2020): 101772. doi: https://doi.org/10.1016/j.isci.2020.101772
Schulz E, Dayan P. Computational Psychiatry for Computers. iScience. 2020 Nov 07;23(12):101772. doi: 10.1016/j.isci.2020.101772. eCollection 2020 Dec 18. PMID: 33294781; PMCID: PMC7691174.
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[No title available]

ACS synthetic biology

Phaneuf PV, Zielinski DC, Yurkovich JT, Johnsen J, Szubin R, Yang L, Kim SH, Schulz S, Wu M, Dalldorf C, Ozdemir E, Lennen RM, Palsson BO, Feist AM.
PMID: 34762392
ACS Synth Biol. 2021 Dec 17;10(12):3379-3395. doi: 10.1021/acssynbio.1c00337. Epub 2021 Nov 11.

Microbes are being engineered for an increasingly large and diverse set of applications. However, the designing of microbial genomes remains challenging due to the general complexity of biological systems. Adaptive Laboratory Evolution (ALE) leverages nature's problem-solving processes to generate...

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Phaneuf PV, Zielinski DC, Yurkovich JT, et al. . ACS Synth Biol. 2021;10(12):3379-3395doi: 10.1021/acssynbio.1c00337.
Phaneuf, P. V., Zielinski, D. C., Yurkovich, J. T., Johnsen, J., Szubin, R., Yang, L., Kim, S. H., Schulz, S., Wu, M., Dalldorf, C., Ozdemir, E., Lennen, R. M., Palsson, B. O., & Feist, A. M. (2021). . ACS synthetic biology, 10(12), 3379-3395. https://doi.org/10.1021/acssynbio.1c00337
Phaneuf, Patrick V, et al. "." ACS synthetic biology vol. 10,12 (2021): 3379-3395. doi: https://doi.org/10.1021/acssynbio.1c00337
Phaneuf PV, Zielinski DC, Yurkovich JT, Johnsen J, Szubin R, Yang L, Kim SH, Schulz S, Wu M, Dalldorf C, Ozdemir E, Lennen RM, Palsson BO, Feist AM. . ACS Synth Biol. 2021 Dec 17;10(12):3379-3395. doi: 10.1021/acssynbio.1c00337. Epub 2021 Nov 11. PMID: 34762392.
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Neuromuscular Scoliosis: Comorbidities and Complications.

Asian spine journal

Weissmann KA, Lafage V, Pitaque CB, Lafage R, Huaiquilaf CM, Ang B, Schulz RG.
PMID: 33355852
Asian Spine J. 2021 Dec;15(6):778-790. doi: 10.31616/asj.2020.0263. Epub 2020 Dec 28.

STUDY DESIGN: Single-center, retrospective cohort study conducted from 2013 to 2017.PURPOSE: To determine the risk factors for surgical complications in neuromuscular scoliosis based on known patient comorbidities.OVERVIEW OF LITERATURE: The concept of neuromuscular scoliosis includes a wide variety of...

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Weissmann KA, Lafage V, Pitaque CB, et al. Neuromuscular Scoliosis: Comorbidities and Complications. Asian Spine J. 2020;15(6):778-790doi: 10.31616/asj.2020.0263.
Weissmann, K. A., Lafage, V., Pitaque, C. B., Lafage, R., Huaiquilaf, C. M., Ang, B., & Schulz, R. G. (2021). Neuromuscular Scoliosis: Comorbidities and Complications. Asian spine journal, 15(6), 778-790. https://doi.org/10.31616/asj.2020.0263
Weissmann, Karen Andrea, et al. "Neuromuscular Scoliosis: Comorbidities and Complications." Asian spine journal vol. 15,6 (2021): 778-790. doi: https://doi.org/10.31616/asj.2020.0263
Weissmann KA, Lafage V, Pitaque CB, Lafage R, Huaiquilaf CM, Ang B, Schulz RG. Neuromuscular Scoliosis: Comorbidities and Complications. Asian Spine J. 2021 Dec;15(6):778-790. doi: 10.31616/asj.2020.0263. Epub 2020 Dec 28. PMID: 33355852.
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Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface.

Med (New York, N.Y.)

Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF.
PMID: 33969332
Med (N Y). 2021 May 14;2(5):591-610.e10. doi: 10.1016/j.medj.2021.04.016. Epub 2021 Apr 30.

BACKGROUND: Pregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and its potential effect on the developing fetus is not well understood.METHODS: We assessed placental histology, ACE2...

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Lu-Culligan A, Chavan AR, Vijayakumar P, et al. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med (N Y). 2021;2(5):591-610.e10doi: 10.1016/j.medj.2021.04.016.
Lu-Culligan, A., Chavan, A. R., Vijayakumar, P., Irshaid, L., Courchaine, E. M., Milano, K. M., Tang, Z., Pope, S. D., Song, E., Vogels, C. B. F., Lu-Culligan, W. J., Campbell, K. H., Casanovas-Massana, A., Bermejo, S., Toothaker, J. M., Lee, H. J., Liu, F., Schulz, W., Fournier, J., Muenker, M. C., Moore, A. J., Konnikova, L., Neugebauer, K. M., Ring, A., Grubaugh, N. D., Ko, A. I., Morotti, R., Guller, S., Kliman, H. J., Iwasaki, A., & Farhadian, S. F. (2021). Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med (New York, N.Y.), 2(5), 591-610.e10. https://doi.org/10.1016/j.medj.2021.04.016
Lu-Culligan, Alice, et al. "Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface." Med (New York, N.Y.) vol. 2,5 (2021): 591-610.e10. doi: https://doi.org/10.1016/j.medj.2021.04.016
Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med (N Y). 2021 May 14;2(5):591-610.e10. doi: 10.1016/j.medj.2021.04.016. Epub 2021 Apr 30. PMID: 33969332; PMCID: PMC8084634.
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The gene regulation knowledge commons: the action area of GREEKC.

Biochimica et biophysica acta. Gene regulatory mechanisms

Kuiper M, Bonello J, Fernández-Breis JT, Bucher P, Futschik ME, Gaudet P, Kulakovskiy IV, Licata L, Logie C, Lovering RC, Makeev VJ, Orchard S, Panni S, Perfetto L, Sant D, Schulz S, Vercruysse S, Zerbino DR, Lægreid A.
PMID: 34757206
Biochim Biophys Acta Gene Regul Mech. 2021 Oct 30;1865(1):194768. doi: 10.1016/j.bbagrm.2021.194768. Epub 2021 Oct 30.

As computational modeling becomes more essential to analyze and understand biological regulatory mechanisms, governance of the many databases and knowledge bases that support this domain is crucial to guarantee reliability and interoperability of resources. To address this, the COST...

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Kuiper M, Bonello J, Fernández-Breis JT, et al. The gene regulation knowledge commons: the action area of GREEKC. Biochim Biophys Acta Gene Regul Mech. 2021;1865(1):194768doi: 10.1016/j.bbagrm.2021.194768.
Kuiper, M., Bonello, J., Fernández-Breis, J. T., Bucher, P., Futschik, M. E., Gaudet, P., Kulakovskiy, I. V., Licata, L., Logie, C., Lovering, R. C., Makeev, V. J., Orchard, S., Panni, S., Perfetto, L., Sant, D., Schulz, S., Vercruysse, S., Zerbino, D. R., Lægreid, A. (2021). The gene regulation knowledge commons: the action area of GREEKC. Biochimica et biophysica acta. Gene regulatory mechanisms, 1865(1), 194768. https://doi.org/10.1016/j.bbagrm.2021.194768
Kuiper, Martin, et al. "The gene regulation knowledge commons: the action area of GREEKC." Biochimica et biophysica acta. Gene regulatory mechanisms vol. 1865,1 (2021): 194768. doi: https://doi.org/10.1016/j.bbagrm.2021.194768
Kuiper M, Bonello J, Fernández-Breis JT, Bucher P, Futschik ME, Gaudet P, Kulakovskiy IV, Licata L, Logie C, Lovering RC, Makeev VJ, Orchard S, Panni S, Perfetto L, Sant D, Schulz S, Vercruysse S, Zerbino DR, Lægreid A. The gene regulation knowledge commons: the action area of GREEKC. Biochim Biophys Acta Gene Regul Mech. 2021 Oct 30;1865(1):194768. doi: 10.1016/j.bbagrm.2021.194768. Epub 2021 Oct 30. PMID: 34757206.
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MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening.

Molecular therapy. Nucleic acids

Schellinger IN, Wagenhäuser M, Chodisetti G, Mattern K, Dannert A, Petzold A, Jakubizka-Smorag J, Emrich F, Haunschild J, Schuster A, Schwob E, Schulz K, Maegdefessel L, Spin JM, Stumvoll M, Hasenfuß G, Tsao PS, Raaz U.
PMID: 33767915
Mol Ther Nucleic Acids. 2021 Feb 24;24:188-199. doi: 10.1016/j.omtn.2021.02.021. eCollection 2021 Jun 04.

Patients with type 2 diabetes (T2D) are threatened by excessive cardiovascular morbidity and mortality. While accelerated arterial stiffening may represent a critical mechanistic factor driving cardiovascular risk in T2D, specific therapies to contain the underlying diabetic arterial remodeling have...

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Schellinger IN, Wagenhäuser M, Chodisetti G, et al. MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Mol Ther Nucleic Acids. 2021;24:188-199doi: 10.1016/j.omtn.2021.02.021.
Schellinger, I. N., Wagenhäuser, M., Chodisetti, G., Mattern, K., Dannert, A., Petzold, A., Jakubizka-Smorag, J., Emrich, F., Haunschild, J., Schuster, A., Schwob, E., Schulz, K., Maegdefessel, L., Spin, J. M., Stumvoll, M., Hasenfuß, G., Tsao, P. S., & Raaz, U. (2021). MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Molecular therapy. Nucleic acids, 24188-199. https://doi.org/10.1016/j.omtn.2021.02.021
Schellinger, Isabel N, et al. "MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening." Molecular therapy. Nucleic acids vol. 24 (2021): 188-199. doi: https://doi.org/10.1016/j.omtn.2021.02.021
Schellinger IN, Wagenhäuser M, Chodisetti G, Mattern K, Dannert A, Petzold A, Jakubizka-Smorag J, Emrich F, Haunschild J, Schuster A, Schwob E, Schulz K, Maegdefessel L, Spin JM, Stumvoll M, Hasenfuß G, Tsao PS, Raaz U. MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Mol Ther Nucleic Acids. 2021 Feb 24;24:188-199. doi: 10.1016/j.omtn.2021.02.021. eCollection 2021 Jun 04. PMID: 33767915; PMCID: PMC7957025.
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Thermodynamic profile of mutual subunit control in a heteromeric receptor.

Proceedings of the National Academy of Sciences of the United States of America

Schirmeyer J, Hummert S, Eick T, Schulz E, Schwabe T, Ehrlich G, Kukaj T, Wiegand M, Sattler C, Schmauder R, Zimmer T, Kosmalla N, Münch J, Bonus M, Gohlke H, Benndorf K.
PMID: 34301910
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30). doi: 10.1073/pnas.2100469118.

Cyclic nucleotide-gated (CNG) ion channels of olfactory neurons are tetrameric membrane receptors that are composed of two A2 subunits, one A4 subunit, and one B1b subunit. Each subunit carries a cyclic nucleotide-binding domain in the carboxyl terminus, and the...

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Schirmeyer J, Hummert S, Eick T, et al. Thermodynamic profile of mutual subunit control in a heteromeric receptor. Proc Natl Acad Sci U S A. 2021;118(30)doi: 10.1073/pnas.2100469118.
Schirmeyer, J., Hummert, S., Eick, T., Schulz, E., Schwabe, T., Ehrlich, G., Kukaj, T., Wiegand, M., Sattler, C., Schmauder, R., Zimmer, T., Kosmalla, N., Münch, J., Bonus, M., Gohlke, H., & Benndorf, K. (2021). Thermodynamic profile of mutual subunit control in a heteromeric receptor. Proceedings of the National Academy of Sciences of the United States of America, 118(30), . https://doi.org/10.1073/pnas.2100469118
Schirmeyer, Jana, et al. "Thermodynamic profile of mutual subunit control in a heteromeric receptor." Proceedings of the National Academy of Sciences of the United States of America vol. 118,30 (2021). doi: https://doi.org/10.1073/pnas.2100469118
Schirmeyer J, Hummert S, Eick T, Schulz E, Schwabe T, Ehrlich G, Kukaj T, Wiegand M, Sattler C, Schmauder R, Zimmer T, Kosmalla N, Münch J, Bonus M, Gohlke H, Benndorf K. Thermodynamic profile of mutual subunit control in a heteromeric receptor. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30). doi: 10.1073/pnas.2100469118. PMID: 34301910; PMCID: PMC8325370.
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A Persistent Phosphanyl-Substituted Thioketyl Radical Anion.

Angewandte Chemie (International ed. in English)

Szych LS, Pilopp Y, Bresien J, Villinger A, Rabeah J, Schulz A.
PMID: 34843637
Angew Chem Int Ed Engl. 2021 Nov 29;e202114792. doi: 10.1002/anie.202114792. Epub 2021 Nov 29.

Alkali metal salts, M

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Szych LS, Pilopp Y, Bresien J, et al. A Persistent Phosphanyl-Substituted Thioketyl Radical Anion. Angew Chem Int Ed Engl. 2021;e202114792doi: 10.1002/anie.202114792.
Szych, L. S., Pilopp, Y., Bresien, J., Villinger, A., Rabeah, J., & Schulz, A. (2021). A Persistent Phosphanyl-Substituted Thioketyl Radical Anion. Angewandte Chemie (International ed. in English), e202114792. https://doi.org/10.1002/anie.202114792
Szych, Lilian Sophie, et al. "A Persistent Phosphanyl-Substituted Thioketyl Radical Anion." Angewandte Chemie (International ed. in English) vol. (2021): e202114792. doi: https://doi.org/10.1002/anie.202114792
Szych LS, Pilopp Y, Bresien J, Villinger A, Rabeah J, Schulz A. A Persistent Phosphanyl-Substituted Thioketyl Radical Anion. Angew Chem Int Ed Engl. 2021 Nov 29;e202114792. doi: 10.1002/anie.202114792. Epub 2021 Nov 29. PMID: 34843637.
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Showing 2857 to 2865 of 2865 entries