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The need to shift pharmacogenetic research from candidate gene to genome-wide association studies.

Pharmacogenomics

Linskey DW, Linskey DC, McLeod HL, Luzum JA.
PMID: 34608812
Pharmacogenomics. 2021 Nov;22(17):1143-1150. doi: 10.2217/pgs-2021-0108. Epub 2021 Oct 05.

The primary research approach in pharmacogenetics has been candidate gene association studies (CGAS), but pharmacogenomic genome-wide association studies (GWAS) are becoming more common. We are now at a critical juncture when the results of those two research approaches, CGAS...

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Linskey DW, Linskey DC, McLeod HL, et al. The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. Pharmacogenomics. 2021;22(17):1143-1150doi: 10.2217/pgs-2021-0108.
Linskey, D. W., Linskey, D. C., McLeod, H. L., & Luzum, J. A. (2021). The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. Pharmacogenomics, 22(17), 1143-1150. https://doi.org/10.2217/pgs-2021-0108
Linskey, Derek W, et al. "The need to shift pharmacogenetic research from candidate gene to genome-wide association studies." Pharmacogenomics vol. 22,17 (2021): 1143-1150. doi: https://doi.org/10.2217/pgs-2021-0108
Linskey DW, Linskey DC, McLeod HL, Luzum JA. The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. Pharmacogenomics. 2021 Nov;22(17):1143-1150. doi: 10.2217/pgs-2021-0108. Epub 2021 Oct 05. PMID: 34608812; PMCID: PMC8738979.
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The need to shift pharmacogenetic research from candidate gene to genome-wide association studies.

Pharmacogenomics

Linskey DW, Linskey DC, McLeod HL, Luzum JA.
PMID: 34608812
Pharmacogenomics. 2021 Nov;22(17):1143-1150. doi: 10.2217/pgs-2021-0108. Epub 2021 Oct 05.

The primary research approach in pharmacogenetics has been candidate gene association studies (CGAS), but pharmacogenomic genome-wide association studies (GWAS) are becoming more common. We are now at a critical juncture when the results of those two research approaches, CGAS...

Cite
Linskey DW, Linskey DC, McLeod HL, et al. The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. Pharmacogenomics. 2021;22(17):1143-1150doi: 10.2217/pgs-2021-0108.
Linskey, D. W., Linskey, D. C., McLeod, H. L., & Luzum, J. A. (2021). The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. Pharmacogenomics, 22(17), 1143-1150. https://doi.org/10.2217/pgs-2021-0108
Linskey, Derek W, et al. "The need to shift pharmacogenetic research from candidate gene to genome-wide association studies." Pharmacogenomics vol. 22,17 (2021): 1143-1150. doi: https://doi.org/10.2217/pgs-2021-0108
Linskey DW, Linskey DC, McLeod HL, Luzum JA. The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. Pharmacogenomics. 2021 Nov;22(17):1143-1150. doi: 10.2217/pgs-2021-0108. Epub 2021 Oct 05. PMID: 34608812.
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Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).

Pharmacogenetics and genomics

Patel JN, Jiang C, Owzar K, Mulkey F, Luzum JA, Mamon HJ, Haller DG, Dragovich T, Alberts SR, Bjarnason G, Willet CG, Niedzwiecki D, Enzinger P, Ratain MJ, Fuchs C, McLeod HL.
PMID: 34149004
Pharmacogenet Genomics. 2021 Dec 01;31(9):215-220. doi: 10.1097/FPC.0000000000000442.

There is a lack of pharmacogenetic predictors of outcome in gastric cancer patients. The aim of this study was to assess previously identified candidate genes associated with 5-fluorouracil (5-FU), cisplatin, or epirubicin toxicity or response in a cohort of...

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Patel JN, Jiang C, Owzar K, et al. Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance). Pharmacogenet Genomics. 2021;31(9):215-220doi: 10.1097/FPC.0000000000000442.
Patel, J. N., Jiang, C., Owzar, K., Mulkey, F., Luzum, J. A., Mamon, H. J., Haller, D. G., Dragovich, T., Alberts, S. R., Bjarnason, G., Willet, C. G., Niedzwiecki, D., Enzinger, P., Ratain, M. J., Fuchs, C., & McLeod, H. L. (2021). Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance). Pharmacogenetics and genomics, 31(9), 215-220. https://doi.org/10.1097/FPC.0000000000000442
Patel, Jai N, et al. "Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance)." Pharmacogenetics and genomics vol. 31,9 (2021): 215-220. doi: https://doi.org/10.1097/FPC.0000000000000442
Patel JN, Jiang C, Owzar K, Mulkey F, Luzum JA, Mamon HJ, Haller DG, Dragovich T, Alberts SR, Bjarnason G, Willet CG, Niedzwiecki D, Enzinger P, Ratain MJ, Fuchs C, McLeod HL. Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance). Pharmacogenet Genomics. 2021 Dec 01;31(9):215-220. doi: 10.1097/FPC.0000000000000442. PMID: 34149004; PMCID: PMC8490297.
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Perceived Discrimination Among Surgical Residents at Academic Medical Centers.

The Journal of surgical research

Khubchandani JA, Atkinson RB, Ortega G, Reidy E, Mullen JT, Smink DS.
PMID: 34942508
J Surg Res. 2021 Dec 20;272:79-87. doi: 10.1016/j.jss.2021.10.029. Epub 2021 Dec 20.

BACKGROUND: Residents of color experience microaggressions in the work environment, are less likely to feel that they fit into their training programs, and feel less comfortable asking for help. Discrimination has been documented among surgical residents, but has not...

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Khubchandani JA, Atkinson RB, Ortega G, et al. Perceived Discrimination Among Surgical Residents at Academic Medical Centers. J Surg Res. 2021;272:79-87doi: 10.1016/j.jss.2021.10.029.
Khubchandani, J. A., Atkinson, R. B., Ortega, G., Reidy, E., Mullen, J. T., Smink, D. S. (2021). Perceived Discrimination Among Surgical Residents at Academic Medical Centers. The Journal of surgical research, 27279-87. https://doi.org/10.1016/j.jss.2021.10.029
Khubchandani, Jasmine A, et al. "Perceived Discrimination Among Surgical Residents at Academic Medical Centers." The Journal of surgical research vol. 272 (2021): 79-87. doi: https://doi.org/10.1016/j.jss.2021.10.029
Khubchandani JA, Atkinson RB, Ortega G, Reidy E, Mullen JT, Smink DS. Perceived Discrimination Among Surgical Residents at Academic Medical Centers. J Surg Res. 2021 Dec 20;272:79-87. doi: 10.1016/j.jss.2021.10.029. Epub 2021 Dec 20. PMID: 34942508.
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Assessment of anhedonia in psychological trauma: development of the Hedonic Deficit and Interference Scale.

European journal of psychotraumatology

Frewen PA, Dean JA, Lanius RA.
PMID: 22893833
Eur J Psychotraumatol. 2012;3. doi: 10.3402/ejpt.v3i0.8585. Epub 2012 Jan 11.

Symptoms of anhedonia, or deficits in the ability to experience positive affect, are increasingly recognized as an outcome of traumatic stress. Herein we demonstrate a phenomenon of "negative affective interference", specifically, negative affective responses to positive events, in association...

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Frewen PA, Dean JA, Lanius RA. Assessment of anhedonia in psychological trauma: development of the Hedonic Deficit and Interference Scale. Eur J Psychotraumatol. 2012;3doi: 10.3402/ejpt.v3i0.8585.
Frewen, P. A., Dean, J. A., & Lanius, R. A. (2012). Assessment of anhedonia in psychological trauma: development of the Hedonic Deficit and Interference Scale. European journal of psychotraumatology, 3. https://doi.org/10.3402/ejpt.v3i0.8585
Frewen, Paul A, et al. "Assessment of anhedonia in psychological trauma: development of the Hedonic Deficit and Interference Scale." European journal of psychotraumatology vol. 3 (2012). doi: https://doi.org/10.3402/ejpt.v3i0.8585
Frewen PA, Dean JA, Lanius RA. Assessment of anhedonia in psychological trauma: development of the Hedonic Deficit and Interference Scale. Eur J Psychotraumatol. 2012;3. doi: 10.3402/ejpt.v3i0.8585. Epub 2012 Jan 11. PMID: 22893833; PMCID: PMC3402111.
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Cardiac Arrest After Interscalene Block Before Arthroscopic Shoulder Surgery: A Case Report.

JBJS case connector

Scott JA, Schuett D, Hauff N.
PMID: 34398845
JBJS Case Connect. 2021 Aug 16;11(3). doi: 10.2106/JBJS.CC.21.00079.

CASE: A 42-year-old previously healthy woman developed profound hypotension, bradycardia, and asystolic cardiac arrest requiring cardiopulmonary resuscitation after an interscalene block before being placed in the beach-chair position for shoulder arthroscopy.CONCLUSION: Activation of the Bezold-Jarisch reflex, a vagally mediated...

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Scott JA, Schuett D, Hauff N. Cardiac Arrest After Interscalene Block Before Arthroscopic Shoulder Surgery: A Case Report. JBJS Case Connect. 2021;11(3)doi: 10.2106/JBJS.CC.21.00079.
Scott, J. A., Schuett, D., & Hauff, N. (2021). Cardiac Arrest After Interscalene Block Before Arthroscopic Shoulder Surgery: A Case Report. JBJS case connector, 11(3), . https://doi.org/10.2106/JBJS.CC.21.00079
Scott, Jasmine A, et al. "Cardiac Arrest After Interscalene Block Before Arthroscopic Shoulder Surgery: A Case Report." JBJS case connector vol. 11,3 (2021). doi: https://doi.org/10.2106/JBJS.CC.21.00079
Scott JA, Schuett D, Hauff N. Cardiac Arrest After Interscalene Block Before Arthroscopic Shoulder Surgery: A Case Report. JBJS Case Connect. 2021 Aug 16;11(3). doi: 10.2106/JBJS.CC.21.00079. PMID: 34398845.
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Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1.

Translational oncology

McQuerry JA, Chen J, Chang JT, Bild AH.
PMID: 34298440
Transl Oncol. 2021 Oct;14(10):101181. doi: 10.1016/j.tranon.2021.101181. Epub 2021 Jul 20.

Effective cancer chemotherapy treatment requires both therapy delivery and retention by malignant cells. Cancer cell overexpression of the multidrug transmembrane transporter gene ABCB1 (MDR1, multi-drug resistance protein 1) thwarts therapy retention, leading to a drug-resistant phenotype. We explored the...

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McQuerry JA, Chen J, Chang JT, et al. Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1. Transl Oncol. 2021;14(10):101181doi: 10.1016/j.tranon.2021.101181.
McQuerry, J. A., Chen, J., Chang, J. T., & Bild, A. H. (2021). Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1. Translational oncology, 14(10), 101181. https://doi.org/10.1016/j.tranon.2021.101181
McQuerry, Jasmine A, et al. "Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1." Translational oncology vol. 14,10 (2021): 101181. doi: https://doi.org/10.1016/j.tranon.2021.101181
McQuerry JA, Chen J, Chang JT, Bild AH. Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1. Transl Oncol. 2021 Oct;14(10):101181. doi: 10.1016/j.tranon.2021.101181. Epub 2021 Jul 20. PMID: 34298440; PMCID: PMC8322466.
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Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation.

Redox biology

Ferreira JJ, Cassina A, Irigoyen P, Ford M, Pietroroia S, Peramsetty N, Radi R, Santi CM, Sapiro R.
PMID: 34753004
Redox Biol. 2021 Nov 01;48:102176. doi: 10.1016/j.redox.2021.102176. Epub 2021 Nov 01.

To fertilize an oocyte, sperm must undergo several biochemical and functional changes known as capacitation. A key event in capacitation is calcium influx through the cation channel of sperm (CatSper). However, the molecular mechanisms of capacitation downstream of this...

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Ferreira JJ, Cassina A, Irigoyen P, et al. Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation. Redox Biol. 2021;48:102176doi: 10.1016/j.redox.2021.102176.
Ferreira, J. J., Cassina, A., Irigoyen, P., Ford, M., Pietroroia, S., Peramsetty, N., Radi, R., Santi, C. M., & Sapiro, R. (2021). Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation. Redox biology, 48102176. https://doi.org/10.1016/j.redox.2021.102176
Ferreira, Juan J, et al. "Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation." Redox biology vol. 48 (2021): 102176. doi: https://doi.org/10.1016/j.redox.2021.102176
Ferreira JJ, Cassina A, Irigoyen P, Ford M, Pietroroia S, Peramsetty N, Radi R, Santi CM, Sapiro R. Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation. Redox Biol. 2021 Nov 01;48:102176. doi: 10.1016/j.redox.2021.102176. Epub 2021 Nov 01. PMID: 34753004; PMCID: PMC8585656.
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Snot what you think: Mucus or myxoid matrix with epithelioid cells and bubbly cytoplasm?.

Cytopathology : official journal of the British Society for Clinical Cytology

Ludwig K, Biancotti R, Alessandrini L, Fassina A.
PMID: 34318538
Cytopathology. 2022 Jan;33(1):149-152. doi: 10.1111/cyt.13036. Epub 2021 Oct 12.

A case of progressive nasal obstruction in a 63 year old man is described. FNA cytology yielded dominant myxoid matrix with charateristic epithelioid cells, round nuclei with nucleoli, and eosinophilic, granular or vacuolated cytoplasm to allow a diagnosis tto...

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Ludwig K, Biancotti R, Alessandrini L, et al. Snot what you think: Mucus or myxoid matrix with epithelioid cells and bubbly cytoplasm?. Cytopathology. 2021;33(1):149-152doi: 10.1111/cyt.13036.
Ludwig, K., Biancotti, R., Alessandrini, L., & Fassina, A. (2022). Snot what you think: Mucus or myxoid matrix with epithelioid cells and bubbly cytoplasm?. Cytopathology : official journal of the British Society for Clinical Cytology, 33(1), 149-152. https://doi.org/10.1111/cyt.13036
Ludwig, Kathrin, et al. "Snot what you think: Mucus or myxoid matrix with epithelioid cells and bubbly cytoplasm?." Cytopathology : official journal of the British Society for Clinical Cytology vol. 33,1 (2022): 149-152. doi: https://doi.org/10.1111/cyt.13036
Ludwig K, Biancotti R, Alessandrini L, Fassina A. Snot what you think: Mucus or myxoid matrix with epithelioid cells and bubbly cytoplasm?. Cytopathology. 2022 Jan;33(1):149-152. doi: 10.1111/cyt.13036. Epub 2021 Oct 12. PMID: 34318538.
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Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Gordhandas SB, Kahn R, Sassine D, Aviki EM, Baltich Nelson B, Catchings A, Liu YL, Lakhman Y, Abu-Rustum NR, Park KJ, Mueller JJ.
PMID: 34903560
Int J Gynecol Cancer. 2021 Dec 13; doi: 10.1136/ijgc-2021-002997. Epub 2021 Dec 13.

OBJECTIVES: To perform a systematic review of gastric-type adenocarcinoma of the cervix and lobular endocervical glandular hyperplasia (a possible precursor lesion) in Peutz-Jeghers syndrome, and to analyze data from the literature, along with our institutional experience, to determine recommendations...

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Gordhandas SB, Kahn R, Sassine D, et al. Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines. Int J Gynecol Cancer. 2021;doi: 10.1136/ijgc-2021-002997.
Gordhandas, S. B., Kahn, R., Sassine, D., Aviki, E. M., Baltich Nelson, B., Catchings, A., Liu, Y. L., Lakhman, Y., Abu-Rustum, N. R., Park, K. J., & Mueller, J. J. (2021). Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, . https://doi.org/10.1136/ijgc-2021-002997
Gordhandas, Sushmita B, et al. "Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society vol. (2021). doi: https://doi.org/10.1136/ijgc-2021-002997
Gordhandas SB, Kahn R, Sassine D, Aviki EM, Baltich Nelson B, Catchings A, Liu YL, Lakhman Y, Abu-Rustum NR, Park KJ, Mueller JJ. Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines. Int J Gynecol Cancer. 2021 Dec 13; doi: 10.1136/ijgc-2021-002997. Epub 2021 Dec 13. PMID: 34903560.
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Showing 265 to 274 of 274 entries