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Showing 217 to 225 of 225 entries
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Assessment of pesticide induced inhibition of Apis mellifera (honeybee) acetylcholinesterase by means of N-doped carbon dots/BSA nanocomposite modified electrochemical biosensor.

Bioelectrochemistry (Amsterdam, Netherlands)

Bilal S, Sami AJ, Hayat A, Fayyaz Ur Rehman M.
PMID: 34801807
Bioelectrochemistry. 2021 Nov 13;144:107999. doi: 10.1016/j.bioelechem.2021.107999. Epub 2021 Nov 13.

This work describes the development and optimization of an electrochemical method to evaluate pesticide induced inhibition of honey bee (Apis mellifera) acetylcholinesterase (AChE) by means of acetylcholinesterase biosensor. The inhibition assay was based on the detection of changes in...

Comparative pathology, molecular pathogenicity, immunological features, and genetic characterization of three highly pathogenic human coronaviruses (MERS-CoV, SARS-CoV, and SARS-CoV-2).

European review for medical and pharmacological sciences

Rabaan AA, Mutair AA, Alawi ZA, Alhumaid S, Mohaini MA, Aldali J, Tirupathi R, Sule AA, Koritala T, Adhikari R, Bilal M, Dhawan M, Mohapatra RK, Tiwari R, Sami SA, Mitra S, Pandey MK, Harapan H, Emran TB, Dhama K.
PMID: 34859882
Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):7162-7184. doi: 10.26355/eurrev_202111_27270.

The last two decades have witnessed the emergence of three deadly coronaviruses (CoVs) in humans: severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are still no...

Assessment of pesticide induced inhibition of Apis mellifera (honeybee) acetylcholinesterase by means of N-doped carbon dots/BSA nanocomposite modified electrochemical biosensor.

Bioelectrochemistry (Amsterdam, Netherlands)

Bilal S, Sami AJ, Hayat A, Fayyaz Ur Rehman M.
PMID: 34801807
Bioelectrochemistry. 2021 Nov 13;144:107999. doi: 10.1016/j.bioelechem.2021.107999. Epub 2021 Nov 13.

This work describes the development and optimization of an electrochemical method to evaluate pesticide induced inhibition of honey bee (Apis mellifera) acetylcholinesterase (AChE) by means of acetylcholinesterase biosensor. The inhibition assay was based on the detection of changes in...

Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children's Oncology Group study.

Haematologica

Hoff FW, Van Dijk AD, Qiu Y, Hu CW, Ries RE, Ligeralde A, Jenkins GN, Gerbing RB, Gamis AS, Aplenc R, Kolb EA, Alonzo TA, Meshinchi S, Qutub AA, De Bont ESJM, Horton TM, Kornblau SM.
PMID: 35021602
Haematologica. 2022 Jan 13; doi: 10.3324/haematol.2021.279672. Epub 2022 Jan 13.

Pediatric acute myeloid leukemia (AML) remains a fatal disease for at least 30% of patients, stressing the need for improved therapies and better risk stratification. As proteins are the unifying feature of (epi)genetic and environmental alterations, and are often...

Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks.

Molecular psychiatry

Roussy M, Luna R, Duong L, Corrigan B, Gulli RA, Nogueira R, Moreno-Bote R, Sachs AJ, Palaniyappan L, Martinez-Trujillo JC.
PMID: 33981008
Mol Psychiatry. 2021 Nov;26(11):6688-6703. doi: 10.1038/s41380-021-01082-5. Epub 2021 May 12.

Ketamine is a dissociative anesthetic drug, which has more recently emerged as a rapid-acting antidepressant. When acutely administered at subanesthetic doses, ketamine causes cognitive deficits like those observed in patients with schizophrenia, including impaired working memory. Although these effects...

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling.

British journal of cancer

Hamis SJ, Kapelyukh Y, McLaren A, Henderson CJ, Roland Wolf C, Chaplain MAJ.
PMID: 34621046
Br J Cancer. 2021 Nov;125(11):1552-1560. doi: 10.1038/s41416-021-01565-w. Epub 2021 Oct 07.

BACKGROUND: Simultaneous inhibition of multiple components of the BRAF-MEK-ERK cascade (vertical inhibition) has become a standard of care for treating BRAF-mutant melanoma. However, the molecular mechanism of how vertical inhibition synergistically suppresses intracellular ERK activity, and consequently cell proliferation,...

MYOD1 as a prognostic indicator in rhabdomyosarcoma.

Pediatric blood & cancer

Ahmed AA, Habeebu S, Farooqi MS, Gamis AS, Gonzalez E, Flatt T, Sherman A, Surrey L, Arnold MA, Conces M, Koo S, Dioufa N, Barr FG, Tsokos MG.
PMID: 33913590
Pediatr Blood Cancer. 2021 Sep;68(9):e29085. doi: 10.1002/pbc.29085. Epub 2021 Apr 29.

BACKGROUND/OBJECTIVES: Rhabdomyosarcoma (RMS) is characterized by the expression of the myogenic regulatory protein MYOD1. Histologic types include alveolar, embryonal (ERMS), and spindle cell sclerosing RMS (SRMS). SRMS harbors MYOD1 mutations in a subset of adult cases in association with...

Outcomes of intensification of induction chemotherapy for children with high-risk acute myeloid leukemia: A report from the Children's Oncology Group.

Pediatric blood & cancer

Elgarten CW, Wood AC, Li Y, Alonzo TA, Brodersen LE, Gerbing RB, Getz KD, Huang YV, Loken M, Meshinchi S, Pollard JA, Sung L, Woods WG, Kolb EA, Gamis AS, Aplenc R.
PMID: 34596937
Pediatr Blood Cancer. 2021 Dec;68(12):e29281. doi: 10.1002/pbc.29281. Epub 2021 Oct 01.

BACKGROUND: High-risk pediatric acute myeloid leukemia confers a poor prognosis, and alternative strategies are needed to improve outcomes. We hypothesized that intensifying induction on the AAML1031 clinical trial would improve outcomes compared to the predecessor trial AAML0531.METHODS: Patients on...

Racial Diversity Among American Cardiologists: Implications for the Past, Present, and Future.

Circulation

Johnson AE, Talabi MB, Bonifacino E, Culyba AJ, Davis EM, Davis PK, De Castro LM, Essien UR, Maria Gonzaga A, Hogan MV, James AJ, Jonassaint CR, Jonassaint NL, Matheo L, Nance MA, Napoé GS, Olafiranye O, Owusu-Ansah S, Pierson-Brown TN, Conrad Smith AJ, Suber TL, Torres O, Tripp R, Ufomata E, Wilson JD, South-Paul JE.
PMID: 34125564
Circulation. 2021 Jun 15;143(24):2395-2405. doi: 10.1161/CIRCULATIONAHA.121.053566. Epub 2021 Jun 14.

In the United States, race-based disparities in cardiovascular disease care have proven to be pervasive, deadly, and expensive. African American/Black, Hispanic/Latinx, and Native/Indigenous American individuals are at an increased risk of cardiovascular disease and are less likely to receive...

Showing 217 to 225 of 225 entries