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Showing 13 to 24 of 182 entries
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Ubiquitin Lys 63 chains - second-most abundant, but poorly understood in plants.

Frontiers in plant science

Tomanov K, Luschnig C, Bachmair A.
PMID: 24550925
Front Plant Sci. 2014 Jan 31;5:15. doi: 10.3389/fpls.2014.00015. eCollection 2014.

Covalent attachment of the small modifier ubiquitin to Lys ε-amino groups of proteins is surprisingly diverse. Once attached to a substrate, ubiquitin is itself frequently modified by ubiquitin, to form chains. All seven Lys residues of ubiquitin, as well...

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

Beilstein journal of organic chemistry

Koopmanschap G, Ruijter E, Orru RV.
PMID: 24605172
Beilstein J Org Chem. 2014 Mar 04;10:544-98. doi: 10.3762/bjoc.10.50. eCollection 2014.

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs...

Strategy for bone metastases treatment in patients with impending cord compression or vertebral fractures: a pilot study.

World journal of nuclear medicine

Rasulova N, Lyubshin V, Djalalov F, Kim KH, Nazirova L, Ormanov N, Arybzhanov D.
PMID: 22034578
World J Nucl Med. 2011 Jan;10(1):14-9. doi: 10.4103/1450-1147.82114.

Impending spinal cord compression and vertebral fractures are considered contraindications for radionuclide bone pain palliation therapy. However, most of the patients with widespread bone metastases already have weakened vertebral segments that may be broken. Therefore, local field external-beam radiotherapy...

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade.

The Journal of organic chemistry

Collet JW, Ackermans K, Lambregts J, Maes BUW, Orru RVA, Ruijter E.
PMID: 29260564
J Org Chem. 2018 Jan 19;83(2):854-861. doi: 10.1021/acs.joc.7b02844. Epub 2018 Jan 02.

We developed a one-pot, two-stage synthetic route to substituted 4-aminoquinolines involving an imidoylative Sonogashira coupling followed by acid-mediated cyclization. This three-component reaction affords pharmaceutically valuable 4-aminoquinolines in a one-pot procedure from readily available starting materials. The reaction tolerates various...

Expression and Purification of the .

Bio-protocol

Tomanov K, Bachmair A.
PMID: 29085855
Bio Protoc. 2015 Aug 05;5(15). doi: 10.21769/BioProtoc.1544.

The proteins PIAL1 (At1g08910) and PIAL2 (At5g41580) are members of the recently discovered group of plant E4 SUMO ligases. This protocol allows quick and simple expression of the recombinant proteins in

Improved identification of the solution space of aerosol microphysical properties derived from the inversion of profiles of lidar optical data, part 1: theory.

Applied optics

Kolgotin A, Müller D, Chemyakin E, Romanov A.
PMID: 27958480
Appl Opt. 2016 Dec 01;55(34):9839-9849. doi: 10.1364/AO.55.009839.

Multiwavelength Raman/high spectral resolution lidars that measure backscatter coefficients at 355, 532, and 1064 nm and extinction coefficients at 355 and 532 nm can be used for the retrieval of particle microphysical parameters, such as effective and mean radius,...

Comparative Study of the Structure, Composition, and Electrocatalytic Performance of Hydrogen Evolution in MoS.

Nanomaterials (Basel, Switzerland)

Fominski V, Demin M, Fominski D, Romanov R, Goikhman A, Maksimova K.
PMID: 31991546
Nanomaterials (Basel). 2020 Jan 24;10(2). doi: 10.3390/nano10020201.

Systematic and in-depth studies of the structure, composition, and efficiency of hydrogen evolution reactions (HERs) on MoS

Evaluation of D-isomer of .

Asia Oceania journal of nuclear medicine & biology

Hirai N, Watabe T, Nagamori S, Wiriyasermkul P, Tanaka Y, Romanov V, Naka S, Kanai Y, Liu Y, Tani N, Sakai T, Tatsumi M, Shimosegawa E, Kanai Y, Hatazawa J.
PMID: 32714997
Asia Ocean J Nucl Med Biol. 2020;8(2):102-108. doi: 10.22038/AOJNMB.2020.47399.1321.

OBJECTIVES: L-4-borono-2-METHODS: HEK293-LAT1 and HEK293-LAT2 cells were tested for [RESULTS: In contrast to L-FBPA, which inhibited substrate uptake in both HEK293-LAT1 and -LAT2 cells, D-FBPA showed no inhibitory effect on both cells, suggesting low transporter selectivity of D-[CONCLUSION: This...

Synthesis of Secondary Amides from Thiocarbamates.

Organic letters

Mampuys P, Ruijter E, Orru RVA, Maes BUW.
PMID: 29975068
Org Lett. 2018 Jul 20;20(14):4235-4239. doi: 10.1021/acs.orglett.8b01654. Epub 2018 Jul 05.

The synthesis of secondary amides from readily accessible and bench-stable substituted S-phenyl thiocarbamates and Grignard reactants is reported. Oxidative workup allows recycling of the thiolate leaving group as diphenyl disulfide. Diphenyl disulfide can be transformed into S-phenyl benzenethiosulfonate, a...

The association between the renin-angiotensin system and the hypothalamic-pituitary-adrenal axis in anxiety disorders: A systematic review of animal studies.

Psychoneuroendocrinology

Balthazar L, Lages YVM, Romano VC, Landeira-Fernandez J, Krahe TE.
PMID: 34329905
Psychoneuroendocrinology. 2021 Oct;132:105354. doi: 10.1016/j.psyneuen.2021.105354. Epub 2021 Jul 09.

Anxiety is characterized as the emotional response in anticipation of a future threat. This hypervigilant state comprehends a cascade of neuroendocrine and physiological processes, involving the renin-angiotensin system (RAS) and hypothalamic-pituitary-adrenal axis (HPA). Excessive and chronic anxiety may ultimately...

Return of the Quaaludes? Prolonged agitated delirium after intentional ingestion of the methaqualone analog SL-164 - a case report.

Substance abuse

Romanek K, Fels H, Dame T, Skopp G, Musshoff F, Eiglmeier H, Eyer F.
PMID: 33760714
Subst Abus. 2021;42(4):503-505. doi: 10.1080/08897077.2021.1903648. Epub 2021 Mar 24.

No abstract available.

Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058.

Journal of biomolecular structure & dynamics

Chirgadze YN, Battaile KP, Likhachev IV, Balabaev NK, Gordon RD, Romanov V, Lin A, Karisch R, Lam R, Ruzanov M, Brazhnikov EV, Pai EF, Neel BG, Chirgadze NY.
PMID: 34705594
J Biomol Struct Dyn. 2021 Oct 27;1-10. doi: 10.1080/07391102.2021.1994879. Epub 2021 Oct 27.

Protein tyrosine phosphatases constitute a family of cytosolic and receptor-like signal transducing enzymes that catalyze the hydrolysis of phospho-tyrosine residues of phosphorylated proteins. PTP1B, encoded by

Showing 13 to 24 of 182 entries