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Showing 25 to 36 of 188 entries
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Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus.

Molecular therapy : the journal of the American Society of Gene Therapy

Vaidyanathan S, Baik R, Chen L, Bravo DT, Suarez CJ, Abazari SM, Salahudeen AA, Dudek AM, Teran CA, Davis TH, Lee CM, Bao G, Randell SH, Artandi SE, Wine JJ, Kuo CJ, Desai TJ, Nayak JV, Sellers ZM, Porteus MH.
PMID: 33794364
Mol Ther. 2021 Mar 29; doi: 10.1016/j.ymthe.2021.03.023. Epub 2021 Mar 29.

Cystic fibrosis (CF) is a monogenic disease caused by impaired production and/or function of the CF transmembrane conductance regulator (CFTR) protein. Although we have previously shown correction of the most common pathogenic mutation, there are many other pathogenic mutations...

Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium.

Scientific reports

Marozkina N, Smith L, Zhao Y, Zein J, Chmiel JF, Kim J, Kiselar J, Davis MD, Cunningham RS, Randell SH, Gaston B.
PMID: 34326365
Sci Rep. 2021 Jul 29;11(1):15498. doi: 10.1038/s41598-021-94782-5.

Endothelial hemoglobin (Hb)α regulates endothelial nitric oxide synthase (eNOS) biochemistry. We hypothesized that Hb could also be expressed and biochemically active in the ciliated human airway epithelium. Primary human airway epithelial cells, cultured at air-liquid interface (ALI), were obtained...

Chromatic perceptive field sizes measured at 10 degrees eccentricity along the horizontal and vertical meridians.

Journal of the Optical Society of America. A, Optics, image science, and vision

Volbrecht VJ, Clark CL, Nerger JL, Randell CE.
PMID: 19412234
J Opt Soc Am A Opt Image Sci Vis. 2009 May;26(5):1167-77. doi: 10.1364/josaa.26.001167.

The different hemifields in the retina are known to vary in photoreceptor density as well as in the number of photoreceptors converging onto one ganglion cell. The effect of these differences among the retinal hemifields at 10 degrees retinal...

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus.

Molecular therapy : the journal of the American Society of Gene Therapy

Vaidyanathan S, Baik R, Chen L, Bravo DT, Suarez CJ, Abazari SM, Salahudeen AA, Dudek AM, Teran CA, Davis TH, Lee CM, Bao G, Randell SH, Artandi SE, Wine JJ, Kuo CJ, Desai TJ, Nayak JV, Sellers ZM, Porteus MH.
PMID: 33794364
Mol Ther. 2022 Jan 05;30(1):223-237. doi: 10.1016/j.ymthe.2021.03.023. Epub 2021 Mar 29.

Cystic fibrosis (CF) is a monogenic disease caused by impaired production and/or function of the CF transmembrane conductance regulator (CFTR) protein. Although we have previously shown correction of the most common pathogenic mutation, there are many other pathogenic mutations...

Handheld Point-of-Care System for Rapid Detection of SARS-CoV-2 Extracted RNA in under 20 min.

ACS central science

Rodriguez-Manzano J, Malpartida-Cardenas K, Moser N, Pennisi I, Cavuto M, Miglietta L, Moniri A, Penn R, Satta G, Randell P, Davies F, Bolt F, Barclay W, Holmes A, Georgiou P.
PMID: 33649735
ACS Cent Sci. 2021 Feb 24;7(2):307-317. doi: 10.1021/acscentsci.0c01288. Epub 2021 Jan 13.

The COVID-19 pandemic is a global health emergency characterized by the high rate of transmission and ongoing increase of cases globally. Rapid point-of-care (PoC) diagnostics to detect the causative virus, SARS-CoV-2, are urgently needed to identify and isolate patients,...

Imaging human skin autograft integration with optical coherence tomography.

Quantitative imaging in medicine and surgery

Deegan AJ, Lu J, Sharma R, Mandell SP, Wang RK.
PMID: 33532277
Quant Imaging Med Surg. 2021 Feb;11(2):784-796. doi: 10.21037/qims-20-750.

BACKGROUND: Skin autografting is a common clinical procedure for reconstructive surgery. Despite its widespread use, very few studies have been conducted to non-invasively evaluate and monitor the vascular and structural features of skin grafts. This study, therefore, aims to...

ERROR REDUCTION IN TRAUMA CARE: LESSONS FROM AN ANONYMIZED, NATIONAL, MULTICENTER MORTALITY REPORTING SYSTEM.

The journal of trauma and acute care surgery

Hamad DM, Mandell SP, Stewart RM, Patel B, Guttman MP, Williams P, Thomas A, Jerath A, Bulger EM, Nathens AB.
PMID: 34840270
J Trauma Acute Care Surg. 2021 Nov 29; doi: 10.1097/TA.0000000000003485. Epub 2021 Nov 29.

BACKGROUND: Twenty years ago, the landmark report To Err is Human, illustrated the importance of system-level solutions, in contrast to person-level interventions, to assure patient safety. Yet rates of preventable deaths, particularly in trauma care, have not materially changed....

The Clinic and the .

Cleveland Clinic journal of medicine

Mandell BF.
PMID: 33384304
Cleve Clin J Med. 2021 Jan 01;88(1):6-8. doi: 10.3949/ccjm.88b.01021.

No abstract available.

The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study.

The Journal of infection

Boshier FAT, Venturini C, Stirrup O, Guerra-Assunção JA, Alcolea-Medina A, Becket AH, Byott M, Charalampous T, Filipe ADS, Frampton D, Glaysher S, Khan T, Kulasegara-Shylini R, Kele B, Monahan IM, Mollett G, Parker M, Pelosi E, Randell P, Roy S, Taylor JF, Weller SJ, Wilson-Davies E, Wade P, Williams R, Copas AJ, Cutino-Moguel T, Freemantle N, Hayward AC, Holmes A, Hughes J, Mahungu TW, Nebbia G, Nastouli E, Partridge DG, Pope CF, Price JR, Robson SC, Saeed K, Shin GY, de Silva TI, Snell LB, Thomson EC, Witney AA, Breuer J.
PMID: 34610391
J Infect. 2021 Dec;83(6):693-700. doi: 10.1016/j.jinf.2021.09.022. Epub 2021 Oct 02.

OBJECTIVES: Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals.METHODS: We collected viral sequences and epidemiological data of patients...

Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections.

Research square

Esther CR, Kimura KS, Mikami Y, Edwards CE, Das SR, Freeman MH, Strickland BA, Brown HM, Wessinger BC, Gupta VC, Von Wahlde K, Sheng Q, Huang LC, Bacon DR, Kimple AJ, Ceppe AS, Kato T, Pickles RJ, Randell SH, Baric RS, Turner JH, Boucher RC.
PMID: 34013253
Res Sq. 2021 May 14; doi: 10.21203/rs.3.rs-500168/v1.

The nose is the portal for SARS-CoV-2 infection, suggesting the nose as a target for topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson's Baby Shampoo (J&J) was tested as a topical virucidal agent in SARS-CoV-2 infected subjects....

Heightening awareness of blistering disorders.

Cleveland Clinic journal of medicine

Mandell BF.
PMID: 34078612
Cleve Clin J Med. 2021 Jun 02;88(6):308-309. doi: 10.3949/ccjm.88b.06021.

No abstract available.

Author Correction: A role for Biofoundries in rapid development and validation of automated SARS-CoV-2 clinical diagnostics.

Nature communications

Crone MA, Priestman M, Ciechonska M, Jensen K, Sharp DJ, Anand A, Randell P, Storch M, Freemont PS.
PMID: 32943631
Nat Commun. 2020 Sep 17;11(1):4793. doi: 10.1038/s41467-020-18720-1.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Showing 25 to 36 of 188 entries