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Showing 73 to 84 of 100 entries
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Exploiting systems biology to investigate the gene modules and drugs in ovarian cancer: A hypothesis based on the weighted gene co-expression network analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Nomiri S, Karami H, Baradaran B, Javadrashid D, Derakhshani A, Nourbakhsh NS, Shadbad MA, Solimando AG, Tabrizi NJ, Brunetti O, Nasseri S, Racanelli V, Safarpour H, Silvestris N.
PMID: 34922114
Biomed Pharmacother. 2021 Dec 16;146:112537. doi: 10.1016/j.biopha.2021.112537. Epub 2021 Dec 16.

BACKGROUND: Ovarian cancer (OC) is one of the worrisome gynecological cancers worldwide. Given its considerable mortality rate, it is necessary to investigate its oncogenesis.METHODS: In this study, we used systems biology approaches to describe the key gene modules, hub...

Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories.

Frontiers in molecular neuroscience

Cuveillier C, Boulan B, Ravanello C, Denarier E, Deloulme JC, Gory-Fauré S, Delphin C, Bosc C, Arnal I, Andrieux A.
PMID: 34025352
Front Mol Neurosci. 2021 May 05;14:665693. doi: 10.3389/fnmol.2021.665693. eCollection 2021.

The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and activity, it was...

Arginase 1 (.

Journal of clinical medicine

Derakhshani A, Hemmat N, Asadzadeh Z, Ghaseminia M, Shadbad MA, Jadideslam G, Silvestris N, Racanelli V, Baradaran B.
PMID: 33806290
J Clin Med. 2021 Mar 04;10(5). doi: 10.3390/jcm10051051.

No abstract available.

Vaccination with Detoxified Leukocidin AB Reduces Bacterial Load in a Staphylococcus aureus Minipig Deep Surgical Wound Infection Model.

The Journal of infectious diseases

Fernandez J, Sanders H, Henn J, Wilson JM, Malone D, Buoninfante A, Willms M, Chan R, DuMont AL, McLahan C, Grubb K, Romanello A, van den Dobbelsteen G, Torres VJ, Poolman JT.
PMID: 33895843
J Infect Dis. 2021 Apr 25; doi: 10.1093/infdis/jiab219. Epub 2021 Apr 25.

Vaccines against Staphylococcus aureus have eluded researchers for over three decades while the burden of staphylococcal diseases has increased. Early vaccine attempts mainly used rodents to characterize preclinical efficacy, and all subsequently failed in human clinical efficacy trials. More...

Aerobic Exercise Training Attenuates Tumor Growth and Reduces Insulin Secretion in Walker 256 Tumor-Bearing Rats.

Frontiers in physiology

Moreira VM, da Silva Franco CC, Prates KV, Gomes RM, de Moraes AMP, Ribeiro TA, Martins IP, Previate C, Pavanello A, Matiusso CCI, Almeida DL, Francisco FA, Malta A, Tófolo LP, da Silva Silveira S, Saavedra LPJ, Machado K, da Silva PHO, Fabrício GS, Palma-Rigo K, de Souza HM, de Fátima Silva F, Biazi GR, Pereira TS, Vieira E, Miranda RA, de Oliveira JC, da Costa Lima LD, Rinaldi W, Ravanelli MI, de Freitas Mathias PC.
PMID: 29867528
Front Physiol. 2018 May 08;9:465. doi: 10.3389/fphys.2018.00465. eCollection 2018.

Aerobic exercise training can improve insulin sensitivity in many tissues; however, the relationship among exercise, insulin, and cancer cell growth is unclear. We tested the hypothesis that aerobic exercise training begun during adolescence can attenuate Walker 256 tumor growth...

Right Heart Changes Impact on Clinical Phenotype of Amyloid Cardiac Involvement: A Single Centre Study.

Life (Basel, Switzerland)

Cicco S, Solimando AG, Buono R, Susca N, Inglese G, Melaccio A, Prete M, Ria R, Racanelli V, Vacca A.
PMID: 33081052
Life (Basel). 2020 Oct 18;10(10). doi: 10.3390/life10100247.

Amyloidosis is due to deposition of an excessive amount of protein in many parenchymal tissues, including myocardium. The onset of cardiac Amyloidosis (CA) is an inauspicious prognostic factor, which can lead to sudden death. We retrospectively analyzed 135 patients...

A millikelvin scanning tunneling microscope in ultra-high vacuum with adiabatic demagnetization refrigeration.

The Review of scientific instruments

Esat T, Borgens P, Yang X, Coenen P, Cherepanov V, Raccanelli A, Tautz FS, Temirov R.
PMID: 34243501
Rev Sci Instrum. 2021 Jun 01;92(6):063701. doi: 10.1063/5.0050532.

We present the design and performance of an ultra-high vacuum scanning tunneling microscope (STM) that uses adiabatic demagnetization of electron magnetic moments for controlling its operating temperature ranging between 30 mK and 1 K with an accuracy of up...

The Role of V-Domain Ig Suppressor of T Cell Activation (VISTA) in Cancer Therapy: Lessons Learned and the Road Ahead.

Frontiers in immunology

Hosseinkhani N, Derakhshani A, Shadbad MA, Argentiero A, Racanelli V, Kazemi T, Mokhtarzadeh A, Brunetti O, Silvestris N, Baradaran B.
PMID: 34093577
Front Immunol. 2021 May 19;12:676181. doi: 10.3389/fimmu.2021.676181. eCollection 2021.

Immune checkpoints (ICs) have pivotal roles in regulating immune responses. The inhibitory ICs in the tumor microenvironment (TME) have been implicated in the immune evasion of tumoral cells. Therefore, identifying and targeting these inhibitory ICs might be critical for...

Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats.

Frontiers in endocrinology

Franco CCDS, Previate C, Trombini AB, Miranda RA, Barella LF, Saavedra LPJ, de Oliveira JC, Prates KV, Tófolo LP, Ribeiro TA, Pavanello A, Malta A, Martins IP, Moreira VM, Matiusso CCI, Francisco FA, Alves VS, de Moraes AMP, de Sant Anna JR, de Castro Prado MAA, Gomes RM, Vieira E, de Freitas Mathias PC.
PMID: 34149616
Front Endocrinol (Lausanne). 2021 Jun 04;12:660793. doi: 10.3389/fendo.2021.660793. eCollection 2021.

Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases. This study aimed to test whether metformin could improve ANS function in obese...

Low-intensity and moderate exercise training improves autonomic nervous system activity imbalanced by postnatal early overfeeding in rats.

Journal of the International Society of Sports Nutrition

Rinaldi W, Gomes RM, Scomparin DX, Grassiolli S, Ribeiro TA, Fabricio GS, Barella LF, Pavanello A, Trombini AB, Mathias PC, de Oliveira JC.
PMID: 24914402
J Int Soc Sports Nutr. 2014 Jun 02;11:25. doi: 10.1186/1550-2783-11-25. eCollection 2014.

BACKGROUND: Postnatal early overfeeding and physical inactivity are serious risk factors for obesity. Physical activity enhances energy expenditure and consumes fat stocks, thereby decreasing body weight (bw). This study aimed to examine whether low-intensity and moderate exercise training in...

Identification and monitoring of Copy Number Variants (CNV) in monoclonal gammopathy.

Cancer biology & therapy

Sallustio F, Curci C, Solimando AG, Leone P, Pontrelli P, Gesualdo L, Vacca A, Racanelli V, Gallone A.
PMID: 34288806
Cancer Biol Ther. 2021 Jun 03;22(5):404-412. doi: 10.1080/15384047.2021.1946458. Epub 2021 Jul 21.

Monoclonal gammopathy of undetermined significance (MGUS) represents the pre-clinical stage of Multiple Myeloma (MM) with the 5% of MGUS progresses to MM. Although the progression from MGUS to MM has not been completely characterized, it is possible to monitor...

Validity and reliability of the Spanish version of the diagnostic assessment for the severely handicapped (DASH-II).

Research in developmental disabilities

Vargas-Vargas C, Rafanell A, Montalvo D, Estarlich M, Pomarol-Clotet E, Sarró S.
PMID: 25462514
Res Dev Disabil. 2015 Jan;36:537-542. doi: 10.1016/j.ridd.2014.10.034. Epub 2014 Nov 14.

BACKGROUND AND OBJECTIVES: The DASH-II scale is a specific instrument for measuring psychopathological symptoms in people with severe and profound intellectual disability (ID). The aim of the study is the validation of the Spanish version, evaluating its reliability and...

Showing 73 to 84 of 100 entries