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Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.

JAMA oncology

Mangum DS, Meyer JA, Mason CC, Shams S, Maese LD, Gardiner JD, Downie JM, Pei D, Cheng C, Gleason A, Luo M, Pui CH, Aplenc R, Hunger SP, Loh M, Greaves M, Trede N, Raetz E, Frazer JK, Mullighan CG, Engel ME, Miles RR, Rabin KR, Schiffman JD.
PMID: 34410295
JAMA Oncol. 2021 Oct 01;7(10):1521-1528. doi: 10.1001/jamaoncol.2021.2723.

IMPORTANCE: Alterations in the IKZF1 gene drive B-cell acute lymphoblastic leukemia (B-ALL) but are not routinely used to stratify patients by risk because of inconsistent associations with outcomes. We describe a novel deletion in 22q11.22 that was consistently associated...

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Mangum DS, Meyer JA, Mason CC, et al. Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia. JAMA Oncol. 2021;7(10):1521-1528doi: 10.1001/jamaoncol.2021.2723.
Mangum, D. S., Meyer, J. A., Mason, C. C., Shams, S., Maese, L. D., Gardiner, J. D., Downie, J. M., Pei, D., Cheng, C., Gleason, A., Luo, M., Pui, C. H., Aplenc, R., Hunger, S. P., Loh, M., Greaves, M., Trede, N., Raetz, E., Frazer, J. K., Mullighan, C. G., Engel, M. E., Miles, R. R., Rabin, K. R., & Schiffman, J. D. (2021). Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia. JAMA oncology, 7(10), 1521-1528. https://doi.org/10.1001/jamaoncol.2021.2723
Mangum, David Spencer, et al. "Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia." JAMA oncology vol. 7,10 (2021): 1521-1528. doi: https://doi.org/10.1001/jamaoncol.2021.2723
Mangum DS, Meyer JA, Mason CC, Shams S, Maese LD, Gardiner JD, Downie JM, Pei D, Cheng C, Gleason A, Luo M, Pui CH, Aplenc R, Hunger SP, Loh M, Greaves M, Trede N, Raetz E, Frazer JK, Mullighan CG, Engel ME, Miles RR, Rabin KR, Schiffman JD. Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia. JAMA Oncol. 2021 Oct 01;7(10):1521-1528. doi: 10.1001/jamaoncol.2021.2723. PMID: 34410295; PMCID: PMC8377604.
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Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects.

Scientific reports

Shuryak I, Brenner DJ, Blattnig SR, Shukitt-Hale B, Rabin BM.
PMID: 33893378
Sci Rep. 2021 Apr 23;11(1):8845. doi: 10.1038/s41598-021-88486-z.

Radiation-induced cognitive dysfunction is increasingly recognized as an important risk for human exploration of distant planets. Mechanistically-motivated mathematical modeling helps to interpret and quantify this phenomenon. Here we considered two general mechanisms of ionizing radiation-induced damage: targeted effects (TE),...

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Shuryak I, Brenner DJ, Blattnig SR, et al. Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects. Sci Rep. 2021;11(1):8845doi: 10.1038/s41598-021-88486-z.
Shuryak, I., Brenner, D. J., Blattnig, S. R., Shukitt-Hale, B., & Rabin, B. M. (2021). Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects. Scientific reports, 11(1), 8845. https://doi.org/10.1038/s41598-021-88486-z
Shuryak, Igor, et al. "Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects." Scientific reports vol. 11,1 (2021): 8845. doi: https://doi.org/10.1038/s41598-021-88486-z
Shuryak I, Brenner DJ, Blattnig SR, Shukitt-Hale B, Rabin BM. Modeling space radiation induced cognitive dysfunction using targeted and non-targeted effects. Sci Rep. 2021 Apr 23;11(1):8845. doi: 10.1038/s41598-021-88486-z. PMID: 33893378; PMCID: PMC8065206.
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Showing 109 to 110 of 110 entries