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Showing 169 to 172 of 172 entries
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Improved estimates of strength and stiffness in pathologic vertebrae with bone metastases using CT-derived bone density compared with radiographic bone lesion quality classification.

Journal of neurosurgery. Spine

Alkalay RN, Groff MW, Stadelmann MA, Buck FM, Hoppe S, Theumann N, Mektar U, Davis RB, Hackney DB.
PMID: 34479191
J Neurosurg Spine. 2021 Sep 03;36(1):113-124. doi: 10.3171/2021.2.SPINE202027. Print 2022 Jan 01.

OBJECTIVE: The aim of this study was to compare the ability of 1) CT-derived bone lesion quality (classification of vertebral bone metastases [BM]) and 2) computed CT-measured volumetric bone mineral density (vBMD) for evaluating the strength and stiffness of...

Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency.

The Journal of allergy and clinical immunology

Blom M, Zetterström RH, Stray-Pedersen A, Gilmour K, Gennery AR, Puck JM, van der Burg M.
PMID: 34537207
J Allergy Clin Immunol. 2021 Sep 16; doi: 10.1016/j.jaci.2021.08.026. Epub 2021 Sep 16.

BACKGROUND: Public health newborn screening (NBS) programs continuously evolve, taking advantage of international shared learning. NBS for severe combined immunodeficiency (SCID) has recently been introduced in many countries. However, comparison of screening outcomes has been hampered by use of...

A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.

Cell reports

Geisler CE, Ghimire S, Bruggink SM, Miller KE, Weninger SN, Kronenfeld JM, Yoshino J, Klein S, Duca FA, Renquist BJ.
PMID: 34192532
Cell Rep. 2021 Jun 29;35(13):109301. doi: 10.1016/j.celrep.2021.109301.

Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production...

microPublication biology

Vrailas-Mortimer AD, Aggarwal N, Ahmed NN, Alberts IM, Alhawasli M, Aljerdi IA, Allen BM, Alnajar AM, Anderson MA, Armstong R, Avery CC, Avila EJ, Baker TN, Basardeh S, Bates NA, Beidas FN, Bosler AC, Brewer DM, Buenaventura RS, Burrell NJ, Cabrera-Lopez AP, Cervantes-Gonzalez AB, Cezar RP, Coronel J, Croslyn C, Damery KR, Diaz-Alavez L, Dixit NP, Duarte DL, Emke AR, English K, Eshun AA, Esterly SR, Estrada AJ, Feng M, Freund MM, Garcia N, Ghotra CS, Ghyasi H, Hale CS, Hulsman L, Jamerson L, Jones AK, Kuczynski M, Lacey-Kennedy TN, Lee MJ, Mahjoub T, Mersinger MC, Muckerheide AD, Myers DW, Nielsen K, Nosowicz PJ, Nunez JA, Ortiz AC, Patel TT, Perry NN, Poser WSA, Puga DM, Quam C, Quintana-Lopez P, Rennerfeldt P, Reyes NM, Rines IG, Roberts C, Robinson DB, Rossa KM, Ruhlmann GJ, Schmidt J, Sherwood JR, Shonoda DH, Soellner H, Torrez JC, Velide M, Weinzapfel Z, Ward AC, Bieser KL, Merkle JA, Stamm JC, Tillett RL, Kagey JD.
PMID: 33474526
MicroPubl Biol. 2021 Jan 18;2021. doi: 10.17912/micropub.biology.000359.

Genetic screens have been used to identify genes involved in the regulation of different biological processes. We identified growth mutants in a Flp/FRT screen using the

Showing 169 to 172 of 172 entries