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Showing 13 to 24 of 84 entries
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PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism.

Molecular oncology

Simula L, Antonucci Y, Scarpelli G, Cancila V, Colamatteo A, Manni S, De Angelis B, Quintarelli C, Procaccini C, Matarese G, Tripodo C, Campello S.
PMID: 34535949
Mol Oncol. 2022 Jan;16(1):188-205. doi: 10.1002/1878-0261.13103. Epub 2021 Oct 14.

Programmed cell death-1 (PD-1) signaling downregulates the T-cell response, promoting an exhausted state in tumor-infiltrating T cells, through mostly unveiled molecular mechanisms. Dynamin-related protein-1 (Drp1)-dependent mitochondrial fission plays a crucial role in sustaining T-cell motility, proliferation, survival, and glycolytic...

Extramedullary femoral alignment system in total knee arthroplasty: Accuracy in relation of severity and different types of varus.

Journal of orthopaedics

Aquili A, Canè PP, Fravisini M, Farinelli L, Procaccini R, Gigante AP.
PMID: 33679033
J Orthop. 2021 Feb 12;24:86-90. doi: 10.1016/j.jor.2021.02.007. eCollection 2021.

OBJECTIVES: We assessed the accuracy of an extramedullary guide system for femoral component alignment in TKA.METHODS: We retrospectively analysed 87 total knee arthroplasties using a newly developed extramedullary guide system.RESULTS: Correct postoperative coronal plane femoral component, with deviation from...

Effects of Resveratrol on p66Shc phosphorylation in cultured prostate cells.

Translational medicine @ UniSa

Conte A, Procaccini C, Iannelli P, Kisslinger A, De Amicis F, Pierantoni GM, Mancini FP, Matarese G, Tramontano D.
PMID: 27042433
Transl Med UniSa. 2016 Jan 31;13:47-58. eCollection 2015 Dec.

There is increasing evidence that diet plays a crucial role in age-related diseases and cancer. Oxidative stress is a conceivable link between diet and diseases, thus food antioxidants, counteracting the damage caused by oxidation, are potential tools for fight...

Neuropeptides in inflammatory bowel disease: an update.

Inflammatory bowel diseases

Reinshagen M, Egger B, Procaccino F, Eysselein VE.
PMID: 23282877
Inflamm Bowel Dis. 1997;3(4):303-13.

SUMMARY: : Extrinsic and intrinsic neurons of the gut contain multiple neuropeptides, which through complex interactions modulate mucosal defense, inflammation, and repair in response to injury. Initial changes of the neurovascular peptidergic system may represent normal protective mechanisms against...

Angular stable plate versus reverse shoulder arthroplasty for proximal humeral fractures in elderly patient.

Musculoskeletal surgery

Luciani P, Procaccini R, Rotini M, Pettinari F, Gigante A.
PMID: 32504451
Musculoskelet Surg. 2020 Jun 05; doi: 10.1007/s12306-020-00669-5. Epub 2020 Jun 05.

BACKGROUND: Treatment of complex proximal humeral fractures in the elderly is a challenge and reverse shoulder arthroplasty (RTSA) is now an important alternative to open reduction internal fixation (ORIF) with angular stable plate. The purpose of this study is...

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects.

Dentistry journal

Mascitti M, Coccia E, Vignini A, Aquilanti L, Santarelli A, Salvolini E, Sabbatinelli J, Mazzanti L, Procaccini M, Rappelli G.
PMID: 31159381
Dent J (Basel). 2019 Jun 01;7(2). doi: 10.3390/dj7020060.

The aim of this study was to compare the oral health status and salivary antioxidant system between patients diagnosed with anorexia nervosa (AN) and healthy controls. A total of 25 female AN patients and 25 matched healthy controls were...

An Overview on Current Non-invasive Diagnostic Devices in Oral Oncology.

Frontiers in physiology

Mascitti M, Orsini G, Tosco V, Monterubbianesi R, Balercia A, Putignano A, Procaccini M, Santarelli A.
PMID: 30410451
Front Physiol. 2018 Oct 25;9:1510. doi: 10.3389/fphys.2018.01510. eCollection 2018.

Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy, and despite advances in cancer therapies, the overall 5-year survival rate has remained below 50% over the past decades. OSCC is typically preceded by potentially malignant...

Diagnostic Impact of Radiological Findings and Extracellular Vesicles: Are We Close to Radiovesicolomics?.

Biology

Serafini FL, Lanuti P, Delli Pizzi A, Procaccini L, Villani M, Taraschi AL, Pascucci L, Mincuzzi E, Izzi J, Chiacchiaretta P, Buca D, Catitti G, Bologna G, Simeone P, Pieragostino D, Caulo M.
PMID: 34943180
Biology (Basel). 2021 Dec 03;10(12). doi: 10.3390/biology10121265.

Currently, several pathologies have corresponding and specific diagnostic and therapeutic branches of interest focused on early and correct detection, as well as the best therapeutic approach. Radiology never ceases to develop newer technologies in order to give patients a...

CD8.

Cell death & disease

Feizi N, Focaccetti C, Pacella I, Tucci G, Rossi A, Costanza M, Pedotti R, Sidney J, Sette A, La Rocca C, Procaccini C, Matarese G, Barnaba V, Piconese S.
PMID: 34716313
Cell Death Dis. 2021 Oct 29;12(11):1026. doi: 10.1038/s41419-021-04310-6.

The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8

CD4.

Frontiers in cell and developmental biology

Di Silvestre D, Garavelli S, Procaccini C, Prattichizzo F, Passignani G, De Rosa V, Mauri P, Matarese G, de Candia P.
PMID: 34778265
Front Cell Dev Biol. 2021 Oct 27;9:753884. doi: 10.3389/fcell.2021.753884. eCollection 2021.

MicroRNAs (miRNAs), small non-coding molecules targeting messenger RNAs and inhibiting protein translation, modulate key biological processes, including cell growth and development, energy utilization, and homeostasis. In particular, miRNAs control the differentiation, survival, and activation of CD4

Predictors of complications in initially haemodynamically stable patients admitted in a modern coronary care unit.

Journal of cardiovascular medicine (Hagerstown, Md.)

Campanile A, Ciccarelli M, Galasso G, Dell'Aquila F, Procaccini V, Vigorito F, Vecchione C, Ravera A.
PMID: 34076603
J Cardiovasc Med (Hagerstown). 2021 Jul 01;22(7):553-559. doi: 10.2459/JCM.0000000000001173.

AIMS: Resource optimization in the intensive cardiac care unit (ICCU) is, nowadays, of great importance because of the increasing number of acute cardiovascular patients requiring high-intensity level-of-care. Because of natural limits in ICCU bed availability, understanding, which patients will...

Thermo-priming increases heat-stress tolerance in seedlings of the Mediterranean seagrass P. oceanica.

Marine pollution bulletin

Pazzaglia J, Badalamenti F, Bernardeau-Esteller J, Ruiz JM, Giacalone VM, Procaccini G, Marín-Guirao L.
PMID: 34864463
Mar Pollut Bull. 2021 Dec 02;174:113164. doi: 10.1016/j.marpolbul.2021.113164. Epub 2021 Dec 02.

Seawater warming and increased incidence of marine heatwaves (MHW) are threatening the integrity of coastal marine habitats including seagrasses, which are particularly vulnerable to climate changes. Novel stress tolerance-enhancing strategies, including thermo-priming, have been extensively applied in terrestrial plants...

Showing 13 to 24 of 84 entries