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Showing 25 to 33 of 33 entries
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Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity.

International journal of obesity (2005)

Azmi S, Ferdousi M, Liu Y, Adam S, Iqbal Z, Dhage S, Ponirakis G, Siahmansur T, Marshall A, Petropoulos I, Kalteniece A, Ho JH, Syed A, Gibson JM, Ammori BJ, Durrington PN, Malik RA, Soran H.
PMID: 33504933
Int J Obes (Lond). 2021 Mar;45(3):631-638. doi: 10.1038/s41366-020-00727-9. Epub 2021 Jan 27.

INTRODUCTION: Subjects with obesity have metabolic risk factors for nerve fibre damage. Because bariatric surgery improves these risk factors we have assessed whether this can ameliorate nerve fibre damage.METHODS: Twenty-six obese subjects without diabetes (age: 46.23 ± 8.6, BMI:...

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Azmi S, Ferdousi M, Liu Y, et al. Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity. Int J Obes (Lond). 2021;45(3):631-638doi: 10.1038/s41366-020-00727-9.
Azmi, S., Ferdousi, M., Liu, Y., Adam, S., Iqbal, Z., Dhage, S., Ponirakis, G., Siahmansur, T., Marshall, A., Petropoulos, I., Kalteniece, A., Ho, J. H., Syed, A., Gibson, J. M., Ammori, B. J., Durrington, P. N., Malik, R. A., & Soran, H. (2021). Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity. International journal of obesity (2005), 45(3), 631-638. https://doi.org/10.1038/s41366-020-00727-9
Azmi, Shazli, et al. "Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity." International journal of obesity (2005) vol. 45,3 (2021): 631-638. doi: https://doi.org/10.1038/s41366-020-00727-9
Azmi S, Ferdousi M, Liu Y, Adam S, Iqbal Z, Dhage S, Ponirakis G, Siahmansur T, Marshall A, Petropoulos I, Kalteniece A, Ho JH, Syed A, Gibson JM, Ammori BJ, Durrington PN, Malik RA, Soran H. Bariatric surgery leads to an improvement in small nerve fibre damage in subjects with obesity. Int J Obes (Lond). 2021 Mar;45(3):631-638. doi: 10.1038/s41366-020-00727-9. Epub 2021 Jan 27. PMID: 33504933.
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Optimal glycaemic and blood pressure but not lipid targets are related to a lower prevalence of diabetic microvascular complications.

Diabetes & metabolic syndrome

Bashir M, Elhadd T, Dabbous Z, Gul W, Salameh O, Siddiqui M, Al-Muhannadi H, Petropoulos I, Khan A, Ponirakis G, Malik RA.
PMID: 34390975
Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102241. doi: 10.1016/j.dsx.2021.102241. Epub 2021 Aug 08.

BACKGROUND: Diabetic microvascular complications are a major cause of morbidity and are related to glycaemic control and cardiovascular risk factors.AIMS: We sought to determine the association of microvascular complications in relation to control of glycemia, blood pressure and lipids...

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Bashir M, Elhadd T, Dabbous Z, et al. Optimal glycaemic and blood pressure but not lipid targets are related to a lower prevalence of diabetic microvascular complications. Diabetes Metab Syndr. 2021;15(5):102241doi: 10.1016/j.dsx.2021.102241.
Bashir, M., Elhadd, T., Dabbous, Z., Gul, W., Salameh, O., Siddiqui, M., Al-Muhannadi, H., Petropoulos, I., Khan, A., Ponirakis, G., & Malik, R. A. (2021). Optimal glycaemic and blood pressure but not lipid targets are related to a lower prevalence of diabetic microvascular complications. Diabetes & metabolic syndrome, 15(5), 102241. https://doi.org/10.1016/j.dsx.2021.102241
Bashir, Mohammad, et al. "Optimal glycaemic and blood pressure but not lipid targets are related to a lower prevalence of diabetic microvascular complications." Diabetes & metabolic syndrome vol. 15,5 (2021): 102241. doi: https://doi.org/10.1016/j.dsx.2021.102241
Bashir M, Elhadd T, Dabbous Z, Gul W, Salameh O, Siddiqui M, Al-Muhannadi H, Petropoulos I, Khan A, Ponirakis G, Malik RA. Optimal glycaemic and blood pressure but not lipid targets are related to a lower prevalence of diabetic microvascular complications. Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102241. doi: 10.1016/j.dsx.2021.102241. Epub 2021 Aug 08. PMID: 34390975.
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Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia.

Frontiers in neuroscience

Ponirakis G, Elsotouhy A, Al Hamad H, Vattoth S, Petropoulos IN, Khan A, Gad H, Al-Khayat F, Chandran M, Ramadan M, Elorrabi M, Gadelseed M, Tosino R, Gawhale PV, Alobaidi M, Khan S, Manikoth P, Abdelrahim YHM, Thodi N, Almuhannadi H, Al-Mohannadi S, AlMarri F, Qazi M, Own A, Mahfoud ZR, Shuaib A, Malik RA.
PMID: 34234643
Front Neurosci. 2021 Jun 21;15:690896. doi: 10.3389/fnins.2021.690896. eCollection 2021.

INTRODUCTION: This study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia.METHODS: Subjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal...

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Ponirakis G, Elsotouhy A, Al Hamad H, et al. Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia. Front Neurosci. 2021;15:690896doi: 10.3389/fnins.2021.690896.
Ponirakis, G., Elsotouhy, A., Al Hamad, H., Vattoth, S., Petropoulos, I. N., Khan, A., Gad, H., Al-Khayat, F., Chandran, M., Ramadan, M., Elorrabi, M., Gadelseed, M., Tosino, R., Gawhale, P. V., Alobaidi, M., Khan, S., Manikoth, P., Abdelrahim, Y. H. M., Thodi, N., Almuhannadi, H., Al-Mohannadi, S., AlMarri, F., Qazi, M., Own, A., Mahfoud, Z. R., Shuaib, A., & Malik, R. A. (2021). Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia. Frontiers in neuroscience, 15690896. https://doi.org/10.3389/fnins.2021.690896
Ponirakis, Georgios, et al. "Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia." Frontiers in neuroscience vol. 15 (2021): 690896. doi: https://doi.org/10.3389/fnins.2021.690896
Ponirakis G, Elsotouhy A, Al Hamad H, Vattoth S, Petropoulos IN, Khan A, Gad H, Al-Khayat F, Chandran M, Ramadan M, Elorrabi M, Gadelseed M, Tosino R, Gawhale PV, Alobaidi M, Khan S, Manikoth P, Abdelrahim YHM, Thodi N, Almuhannadi H, Al-Mohannadi S, AlMarri F, Qazi M, Own A, Mahfoud ZR, Shuaib A, Malik RA. Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia. Front Neurosci. 2021 Jun 21;15:690896. doi: 10.3389/fnins.2021.690896. eCollection 2021. PMID: 34234643; PMCID: PMC8257078.
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Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis.

Journal of diabetes investigation

Gad H, Petropoulos IN, Khan A, Ponirakis G, MacDonald R, Alam U, Malik RA.
PMID: 34351711
J Diabetes Investig. 2021 Aug 05; doi: 10.1111/jdi.13643. Epub 2021 Aug 05.

INTRODUCTION: Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging technique that identifies corneal nerve fiber damage. Small studies suggest that CCM could be used to assess patients with diabetic peripheral neuropathy (DPN).AIM: To undertake a systematic review...

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Gad H, Petropoulos IN, Khan A, et al. Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis. J Diabetes Investig. 2021;doi: 10.1111/jdi.13643.
Gad, H., Petropoulos, I. N., Khan, A., Ponirakis, G., MacDonald, R., Alam, U., & Malik, R. A. (2021). Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis. Journal of diabetes investigation, . https://doi.org/10.1111/jdi.13643
Gad, Hoda, et al. "Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis." Journal of diabetes investigation vol. (2021). doi: https://doi.org/10.1111/jdi.13643
Gad H, Petropoulos IN, Khan A, Ponirakis G, MacDonald R, Alam U, Malik RA. Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis. J Diabetes Investig. 2021 Aug 05; doi: 10.1111/jdi.13643. Epub 2021 Aug 05. PMID: 34351711.
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Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis.

Journal of diabetes investigation

Gad H, Petropoulos IN, Khan A, Ponirakis G, MacDonald R, Alam U, Malik RA.
PMID: 34351711
J Diabetes Investig. 2022 Jan;13(1):134-147. doi: 10.1111/jdi.13643. Epub 2021 Aug 27.

INTRODUCTION: Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging technique that identifies corneal nerve fiber damage. Small studies suggest that CCM could be used to assess patients with diabetic peripheral neuropathy (DPN).AIM: To undertake a systematic review...

Cite
Gad H, Petropoulos IN, Khan A, et al. Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis. J Diabetes Investig. 2021;13(1):134-147doi: 10.1111/jdi.13643.
Gad, H., Petropoulos, I. N., Khan, A., Ponirakis, G., MacDonald, R., Alam, U., & Malik, R. A. (2022). Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis. Journal of diabetes investigation, 13(1), 134-147. https://doi.org/10.1111/jdi.13643
Gad, Hoda, et al. "Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis." Journal of diabetes investigation vol. 13,1 (2022): 134-147. doi: https://doi.org/10.1111/jdi.13643
Gad H, Petropoulos IN, Khan A, Ponirakis G, MacDonald R, Alam U, Malik RA. Corneal confocal microscopy for the diagnosis of diabetic peripheral neuropathy: A systematic review and meta-analysis. J Diabetes Investig. 2022 Jan;13(1):134-147. doi: 10.1111/jdi.13643. Epub 2021 Aug 27. PMID: 34351711.
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Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy.

Neurobiology of disease

Marquez A, Guernsey LS, Frizzi KE, Cundiff M, Constantino I, Muttalib N, Arenas F, Zhou X, Lim SH, Ferdousi M, Ponirakis G, Silverdale M, Kobylecki C, Jones M, Marshall A, Malik RA, Jolivalt CG.
PMID: 33482356
Neurobiol Dis. 2021 Apr;151:105273. doi: 10.1016/j.nbd.2021.105273. Epub 2021 Jan 19.

Pathological hyperphosphorylated tau is a key feature of Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Using transgenic mice overexpressing human non-mutated tau (htau mice), we assessed the contribution of tau to peripheral and central neurodegeneration. Indices of peripheral small...

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Marquez A, Guernsey LS, Frizzi KE, et al. Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy. Neurobiol Dis. 2021;151:105273doi: 10.1016/j.nbd.2021.105273.
Marquez, A., Guernsey, L. S., Frizzi, K. E., Cundiff, M., Constantino, I., Muttalib, N., Arenas, F., Zhou, X., Lim, S. H., Ferdousi, M., Ponirakis, G., Silverdale, M., Kobylecki, C., Jones, M., Marshall, A., Malik, R. A., & Jolivalt, C. G. (2021). Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy. Neurobiology of disease, 151105273. https://doi.org/10.1016/j.nbd.2021.105273
Marquez, Alexandra, et al. "Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy." Neurobiology of disease vol. 151 (2021): 105273. doi: https://doi.org/10.1016/j.nbd.2021.105273
Marquez A, Guernsey LS, Frizzi KE, Cundiff M, Constantino I, Muttalib N, Arenas F, Zhou X, Lim SH, Ferdousi M, Ponirakis G, Silverdale M, Kobylecki C, Jones M, Marshall A, Malik RA, Jolivalt CG. Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy. Neurobiol Dis. 2021 Apr;151:105273. doi: 10.1016/j.nbd.2021.105273. Epub 2021 Jan 19. PMID: 33482356; PMCID: PMC7925437.
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Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis.

Scientific reports

Petropoulos IN, Fitzgerald KC, Oakley J, Ponirakis G, Khan A, Gad H, George P, Deleu D, Canibano BG, Akhtar N, Shuaib A, Own A, Malik T, Russakoff DB, Mankowski JL, Misra SL, McGhee CNJ, Calabresi P, Saidha S, Kamran S, Malik RA.
PMID: 34737384
Sci Rep. 2021 Nov 04;11(1):21688. doi: 10.1038/s41598-021-01226-1.

Axonal loss is the main determinant of disease progression in multiple sclerosis (MS). This study aimed to assess the utility of corneal confocal microscopy (CCM) in detecting corneal axonal loss in different courses of MS. The results were confirmed...

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Petropoulos IN, Fitzgerald KC, Oakley J, et al. Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis. Sci Rep. 2021;11(1):21688doi: 10.1038/s41598-021-01226-1.
Petropoulos, I. N., Fitzgerald, K. C., Oakley, J., Ponirakis, G., Khan, A., Gad, H., George, P., Deleu, D., Canibano, B. G., Akhtar, N., Shuaib, A., Own, A., Malik, T., Russakoff, D. B., Mankowski, J. L., Misra, S. L., McGhee, C. N. J., Calabresi, P., Saidha, S., Kamran, S., & Malik, R. A. (2021). Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis. Scientific reports, 11(1), 21688. https://doi.org/10.1038/s41598-021-01226-1
Petropoulos, Ioannis N, et al. "Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis." Scientific reports vol. 11,1 (2021): 21688. doi: https://doi.org/10.1038/s41598-021-01226-1
Petropoulos IN, Fitzgerald KC, Oakley J, Ponirakis G, Khan A, Gad H, George P, Deleu D, Canibano BG, Akhtar N, Shuaib A, Own A, Malik T, Russakoff DB, Mankowski JL, Misra SL, McGhee CNJ, Calabresi P, Saidha S, Kamran S, Malik RA. Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis. Sci Rep. 2021 Nov 04;11(1):21688. doi: 10.1038/s41598-021-01226-1. PMID: 34737384; PMCID: PMC8568943.
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Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control.

Journal of diabetes investigation

Ponirakis G, Abdul-Ghani MA, Jayyousi A, Zirie MA, Al-Mohannadi S, Almuhannadi H, Petropoulos IN, Khan A, Gad H, Migahid O, Megahed A, Qazi M, AlMarri F, Al-Khayat F, Mahfoud Z, DeFronzo R, Malik RA.
PMID: 34002953
J Diabetes Investig. 2021 Nov;12(11):2002-2009. doi: 10.1111/jdi.13582. Epub 2021 Jun 19.

AIMS/INTRODUCTION: This study aimed to investigate whether insulin resistance (IR) in individuals with type 2 diabetes undergoing intensive glycemic control determines the extent of improvement in neuropathy.MATERIALS AND METHODS: This was an exploratory substudy of an open-label, randomized controlled...

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Ponirakis G, Abdul-Ghani MA, Jayyousi A, et al. Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control. J Diabetes Investig. 2021;12(11):2002-2009doi: 10.1111/jdi.13582.
Ponirakis, G., Abdul-Ghani, M. A., Jayyousi, A., Zirie, M. A., Al-Mohannadi, S., Almuhannadi, H., Petropoulos, I. N., Khan, A., Gad, H., Migahid, O., Megahed, A., Qazi, M., AlMarri, F., Al-Khayat, F., Mahfoud, Z., DeFronzo, R., & Malik, R. A. (2021). Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control. Journal of diabetes investigation, 12(11), 2002-2009. https://doi.org/10.1111/jdi.13582
Ponirakis, Georgios, et al. "Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control." Journal of diabetes investigation vol. 12,11 (2021): 2002-2009. doi: https://doi.org/10.1111/jdi.13582
Ponirakis G, Abdul-Ghani MA, Jayyousi A, Zirie MA, Al-Mohannadi S, Almuhannadi H, Petropoulos IN, Khan A, Gad H, Migahid O, Megahed A, Qazi M, AlMarri F, Al-Khayat F, Mahfoud Z, DeFronzo R, Malik RA. Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control. J Diabetes Investig. 2021 Nov;12(11):2002-2009. doi: 10.1111/jdi.13582. Epub 2021 Jun 19. PMID: 34002953; PMCID: PMC8565403.
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Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke.

Scientific reports

Khan A, Menon A, Akhtar N, Kamran S, Muhammad A, Ponirakis G, Gad H, Petropoulos IN, Wadiwala F, Babu B, Narangoli AM, Bermejo PG, Al Hamad H, Ramadan M, Woodruff P, Santos M, Saqqur M, Shuaib A, Malik RA.
PMID: 34611233
Sci Rep. 2021 Oct 05;11(1):19718. doi: 10.1038/s41598-021-99131-0.

In patients with acute ischemic stroke, pial collaterals play a key role in limiting neurological disability by maintaining blood flow to ischemic penumbra. We hypothesized that patient with poor pial collaterals will have greater corneal nerve and endothelial cell...

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Khan A, Menon A, Akhtar N, et al. Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke. Sci Rep. 2021;11(1):19718doi: 10.1038/s41598-021-99131-0.
Khan, A., Menon, A., Akhtar, N., Kamran, S., Muhammad, A., Ponirakis, G., Gad, H., Petropoulos, I. N., Wadiwala, F., Babu, B., Narangoli, A. M., Bermejo, P. G., Al Hamad, H., Ramadan, M., Woodruff, P., Santos, M., Saqqur, M., Shuaib, A., & Malik, R. A. (2021). Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke. Scientific reports, 11(1), 19718. https://doi.org/10.1038/s41598-021-99131-0
Khan, Adnan, et al. "Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke." Scientific reports vol. 11,1 (2021): 19718. doi: https://doi.org/10.1038/s41598-021-99131-0
Khan A, Menon A, Akhtar N, Kamran S, Muhammad A, Ponirakis G, Gad H, Petropoulos IN, Wadiwala F, Babu B, Narangoli AM, Bermejo PG, Al Hamad H, Ramadan M, Woodruff P, Santos M, Saqqur M, Shuaib A, Malik RA. Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke. Sci Rep. 2021 Oct 05;11(1):19718. doi: 10.1038/s41598-021-99131-0. PMID: 34611233; PMCID: PMC8492683.
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