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Showing 301 to 307 of 307 entries
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Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis.

European heart journal

Momi S, Falcinelli E, Petito E, Ciarrocca Taranta G, Ossoli A, Gresele P.
PMID: 34529782
Eur Heart J. 2021 Sep 16; doi: 10.1093/eurheartj/ehab631. Epub 2021 Sep 16.

AIMS : Platelets participate in atherogenesis with mechanisms not yet fully clarified. Vascular wall MMP-2 is involved in the arterial remodelling accompanying atherosclerosis. Platelets contain and release MMP-2 but no informations are available on its role in atherosclerotic lesion...

Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli-Berg F, Virgintino D, Solito E.
PMID: 34939700
FASEB J. 2022 Jan;36(1):e22107. doi: 10.1096/fj.202101297R.

Mounting evidence has linked the metabolic disease to neurovascular disorders and cognitive decline. Using a murine model of a high-fat high-sugar diet mimicking obesity-induced type 2 diabetes mellitus (T2DM) in humans, we show that pro-inflammatory mediators and altered immune...

Role of multiparametric ultrasound in testicular focal lesions and diffuse pathology evaluation, with particular regard to elastography: Review of literature.

Andrology

Cantisani V, Di Leo N, Bertolotto M, Fresilli D, Granata A, Polti G, Polito E, Pacini P, Guiban O, Del Gaudio G, Dolcetti V, DʼAndrea V, Di Pierro GB, Verrengia M, Drudi FM, Catalano C.
PMID: 34114745
Andrology. 2021 Sep;9(5):1356-1368. doi: 10.1111/andr.13067. Epub 2021 Jun 21.

BACKGROUND: Ultrasound is the main requested technique for the assessment of traumatic, vascular, neoplastic, and inflammatory testicular pathology. Moreover, the role of ultrasound has broadened over the years along with the introduction of new techniques, such as contrast enhanced...

Human Papillomavirus‒Positive and ‒Negative Vulvar Squamous Cell Carcinoma Are Biologically but Not Clinically Distinct.

The Journal of investigative dermatology

Kolitz E, Lucas E, Hosler GA, Kim J, Hammer S, Lewis C, Xu L, Day AT, Mauskar M, Lea JS, Wang RC.
PMID: 34756880
J Invest Dermatol. 2021 Oct 28; doi: 10.1016/j.jid.2021.10.009. Epub 2021 Oct 28.

Vulvar squamous cell carcinoma pathogenesis is traditionally defined by the presence or absence of human papillomavirus (HPV), but the definition of these groups and their molecular characteristics remain ambiguous across studies. In this study, we present a retrospective cohort...

Cognitive impairment and type 2 diabetes mellitus: Focus of SGLT2 inhibitors treatment.

Pharmacological research

Rizzo MR, Di Meo I, Polito R, Auriemma MC, Gambardella A, di Mauro G, Capuano A, Paolisso G.
PMID: 35017046
Pharmacol Res. 2022 Jan 10;176:106062. doi: 10.1016/j.phrs.2022.106062. Epub 2022 Jan 10.

Gliflozins are a novel class of oral anti-diabetic drugs, acting as inhibitors of sodium-glucose co-transporters (SGLTs) through the proximal convoluted tubules (PCT) and intestinal epithelium. The sodium-glucose co-transporters 2 (SGLT2) are mainly expressed in S1 and S2 segments of...

Xanthine oxidoreductase: A leading actor in cardiovascular disease drama.

Redox biology

Polito L, Bortolotti M, Battelli MG, Bolognesi A.
PMID: 34844041
Redox Biol. 2021 Nov 24;48:102195. doi: 10.1016/j.redox.2021.102195. Epub 2021 Nov 24.

Cardiovascular diseases (CVD) are the leading cause of global mortality and their pathogenesis lies mainly in the atherosclerotic process. There are close connections linking oxidative stress and inflammation to endothelial dysfunction, atherosclerosis and, consequently, to CVD. This review focuses...

How Would the Authors Treat Their Own Temporary Left Ventricular Failure With Mechanical Circulatory Support?.

Journal of cardiothoracic and vascular anesthesia

Loforte A, Comentale G, Botta L, Gliozzi G, Cavalli GG, Mariani C, Pilato E, Suarez SM, Pacini D.
PMID: 34785126
J Cardiothorac Vasc Anesth. 2021 Oct 21; doi: 10.1053/j.jvca.2021.10.020. Epub 2021 Oct 21.

In the last 20 years, mechanical circulatory supports (MCS) have overturned completely the outcomes and the clinical recovery of patients with isolated acute left ventricle failure (iALVF). This usually occurs more frequently than right-sided heart failure or biventricular dysfunction,...

Showing 301 to 307 of 307 entries