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Showing 541 to 550 of 550 entries
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A Multicentre, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of the S1P Receptor Agonist KRP203 in Patients with Moderately Active Refractory Ulcerative Colitis.

Inflammatory intestinal diseases

Radeke HH, Stein J, Van Assche G, Rogler G, Lakatos PL, Muellershausen F, Moulin P, Jarvis P, Colin L, Gergely P, Kruis W.
PMID: 33313070
Inflamm Intest Dis. 2020 Nov;5(4):180-190. doi: 10.1159/000509393. Epub 2020 Aug 21.

BACKGROUND AND AIMS: KRP203 is a potent oral agonist of the sphingosine-1-phosphate receptor subtype 1 that induces the sequestration of peripheral lymphocytes, thereby potentially reducing the number of activated lymphocytes circulating to the gastrointestinal tract.METHODS: We conducted a multicentre,...

Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes.

Stem cell reports

Ho BX, Yu H, Pang JKS, Hor JH, Liew LC, Szyniarowski P, Lim CYY, An O, Yang HH, Stewart CL, Chan WK, Ng SY, Soh BS.
PMID: 34767749
Stem Cell Reports. 2021 Nov 02; doi: 10.1016/j.stemcr.2021.10.009. Epub 2021 Nov 02.

The immature characteristics and metabolic phenotypes of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) restrict their applications for disease modeling, drug discovery, and cell-based therapy. Leveraging on the metabolic shifts from glycolysis to fatty acid oxidation as CMs mature, a...

Draft de novo Genome Assembly of the Elusive Jaguarundi, Puma yagouaroundi.

The Journal of heredity

Tamazian G, Dobrynin P, Zhuk A, Zhernakova DV, Perelman PL, Serdyukova NA, Graphodatsky AS, Komissarov A, Kliver S, Cherkasov N, Scott AF, Mohr DW, Koepfli KP, O'Brien SJ, Krasheninnikova K.
PMID: 34146095
J Hered. 2021 Nov 01;112(6):540-548. doi: 10.1093/jhered/esab036.

The Puma lineage within the family Felidae consists of 3 species that last shared a common ancestor around 4.9 million years ago. Whole-genome sequences of 2 species from the lineage were previously reported: the cheetah (Acinonyx jubatus) and the...

Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Sexton CE, Anstey KJ, Baldacci F, Barnum CJ, Barron AM, Blennow K, Brodaty H, Burnham S, Elahi FM, Götz J, Jeon YH, Koronyo-Hamaoui M, Landau SM, Lautenschlager NT, Laws SM, Lipnicki DM, Lu H, Masters CL, Moyle W, Nakamura A, Pasinetti GM, Rao N, Rowe C, Sachdev PS, Schofield PR, Sigurdsson EM, Smith K, Srikanth V, Szoeke C, Tansey MG, Whitmer R, Wilcock D, Wong TY, Bain LJ, Carrillo MC.
PMID: 34058063
Alzheimers Dement. 2021 May 31; doi: 10.1002/alz.12380. Epub 2021 May 31.

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes...

Source breakup dynamics in Au + Au collisions at sqrt[s(NN)]=200 GeV via three-dimensional two-pion source imaging.

Physical review letters

Afanasiev S, Aidala C, Ajitanand NN, Akiba Y, Alexander J, Al-Jamel A, Aoki K, Aphecetche L, Armendariz R, Aronson SH, Averbeck R, Awes TC, Azmoun B, Babintsev V, Baldisseri A, Barish KN, Barnes PD, Bassalleck B, Bathe S, Batsouli S, Baublis V, Bauer F, Bazilevsky A, Belikov S, Bennett R, Berdnikov Y, Bjorndal MT, Boissevain JG, Borel H, Boyle K, Brooks ML, Brown DS, Bucher D, Buesching H, Bumazhnov V, Bunce G, Burward-Hoy JM, Butsyk S, Campbell S, Chai JS, Chernichenko S, Chiba J, Chi CY, Chiu M, Choi IJ, Chujo T, Chung P, Cianciolo V, Cleven CR, Cobigo Y, Cole BA, Comets MP, Constantin P, Csanád M, Csörgo T, Dahms T, Das K, David G, Delagrange H, Denisov A, d'Enterria D, Deshpande A, Desmond EJ, Dietzsch O, Dion A, Drachenberg JL, Drapier O, Drees A, Dubey AK, Durum A, Dzhordzhadze V, Efremenko YV, Egdemir J, Enokizono A, En'yo H, Espagnon B, Esumi S, Fields DE, Fleuret F, Fokin SL, Forestier B, Fraenkel Z, Frantz JE, Franz A, Frawley AD, Fukao Y, Fung SY, Gadrat S, Gastineau F, Germain M, Glenn A, Gonin M, Gosset J, Goto Y, Granier de Cassagnac R, Grau N, Greene SV, Grosse Perdekamp M, Gunji T, Gustafsson HA, Hachiya T, Henni AH, Haggerty JS, Hagiwara MN, Hamagaki H, Harada H, Hartouni EP, Haruna K, Harvey M, Haslum E, Hasuko K, Hayano R, Heffner M, Hemmick TK, Heuser JM, He X, Hiejima H, Hill JC, Hobbs R, Holmes M, Holzmann W, Homma K, Hong B, Horaguchi T, Hur MG, Ichihara T, Imai K, Inaba M, Isenhower D, Isenhower L, Ishihara M, Isobe T, Issah M, Isupov A, Jacak BV, Jia J, Jin J, Jinnouchi O, Johnson BM, Joo KS, Jouan D, Kajihara F, Kametani S, Kamihara N, Kaneta M, Kang JH, Kawagishi T, Kazantsev AV, Kelly S, Khanzadeev A, Kim DJ, Kim E, Kim YS, Kinney E, Kiss A, Kistenev E, Kiyomichi A, Klein-Boesing C, Kochenda L, Kochetkov V, Komkov B, Konno M, Kotchetkov D, Kozlov A, Kroon PJ, Kunde GJ, Kurihara N, Kurita K, Kweon MJ, Kwon Y, Kyle GS, Lacey R, Lajoie JG, Lebedev A, Le Bornec Y, Leckey S, Lee DM, Lee MK, Leitch MJ, Leite MA, Lim H, Litvinenko A, Liu MX, Li XH, Maguire CF, Makdisi YI, Malakhov A, Malik MD, Manko VI, Masui H, Matathias F, McCain MC, McGaughey PL, Miake Y, Miller TE, Milov A, Mioduszewski S, Mishra GC, Mitchell JT, Morrison DP, Moss JM, Moukhanova TV, Mukhopadhyay D, Murata J, Nagamiya S, Nagata Y, Nagle JL, Naglis M, Nakamura T, Newby J, Nguyen M, Norman BE, Nyanin AS, Nystrand J, O'Brien E, Ogilvie CA, Ohnishi H, Ojha ID, Okada H, Okada K, Omiwade OO, Oskarsson A, Otterlund I, Ozawa K, Pal D, Palounek AP, Pantuev V, Papavassiliou V, Park J, Park WJ, Pate SF, Pei H, Peng JC, Pereira H, Peresedov V, Peressounko DY, Pinkenburg C, Pisani RP, Purschke ML, Purwar AK, Qu H, Rak J, Ravinovich I, Read KF, Reuter M, Reygers K, Riabov V, Riabov Y, Roche G, Romana A, Rosati M, Rosendahl SS, Rosnet P, Rukoyatkin P, Rykov VL, Ryu SS, Sahlmueller B, Saito N, Sakaguchi T, Sakai S, Samsonov V, Sato HD, Sato S, Sawada S, Semenov V, Seto R, Sharma D, Shea TK, Shein I, Shibata TA, Shigaki K, Shimomura M, Shohjoh T, Shoji K, Sickles A, Silva CL, Silvermyr D, Sim KS, Singh CP, Singh V, Skutnik S, Smith WC, Soldatov A, Soltz RA, Sondheim WE, Sorensen SP, Sourikova IV, Staley F, Stankus PW, Stenlund E, Stepanov M, Ster A, Stoll SP, Sugitate T, Suire C, Sullivan JP, Sziklai J, Tabaru T, Takagi S, Takagui EM, Taketani A, Tanaka KH, Tanaka Y, Tanida K, Tannenbaum MJ, Taranenko A, Tarján P, Thomas TL, Togawa M, Tojo J, Torii H, Towell RS, Tram VN, Tserruya I, Tsuchimoto Y, Tuli SK, Tydesjö H, Tyurin N, Vale C, Valle H, van Hecke HW, Velkovska J, Vertesi R, Vinogradov AA, Vznuzdaev E, Wagner M, Wang XR, Watanabe Y, Wessels J, White SN, Willis N, Winter D, Woody CL, Wysocki M, Xie W, Yanovich A, Yokkaichi S, Young GR, Younus I, Yushmanov IE, Zajc WA, Zaudtke O, Zhang C, Zimányi J, Zolin L.
PMID: 18643489
Phys Rev Lett. 2008 Jun 13;100(23):232301. doi: 10.1103/PhysRevLett.100.232301. Epub 2008 Jun 13.

A three-dimensional correlation function obtained from midrapidity, low p(T), pion pairs in central Au+Au collisions at sqrt[s(NN)]=200 GeV is studied. The extracted model-independent source function indicates a long range tail in the directions of the pion pair transverse momentum...

Minimum 10-Year Clinical Outcomes After Arthroscopic 270° Labral Repair in Traumatic Shoulder Instability Involving Anterior, Inferior, and Posterior Labral Injury.

The American journal of sports medicine

Berthold DP, LeVasseur MR, Muench LN, Mancini MR, Uyeki CL, Lee J, Beitzel K, Imhoff AB, Arciero RA, Scheiderer B, Siebenlist S, Mazzocca AD.
PMID: 34723684
Am J Sports Med. 2021 Dec;49(14):3937-3944. doi: 10.1177/03635465211053632. Epub 2021 Nov 01.

BACKGROUND: Current literature reports highly satisfactory short- and midterm clinical outcomes in patients with arthroscopic 270° labral tear repairs. However, data remain limited on long-term clinical outcomes and complication and redislocation rates in patients with traumatic shoulder instability involving...

Analysis of the reasons for screening failure in phase I clinical trials in China: a retrospective study of the clinical trials screening process.

Annals of translational medicine

Li B, Zhang Q, Liu Y, Zhang X, Cheng D, Li A, Chen Y, Zhu X, Su Y, Zhou H.
PMID: 34790770
Ann Transl Med. 2021 Oct;9(20):1564. doi: 10.21037/atm-21-5010.

BACKGROUND: To analyze the main reasons for screening failure in the screening process of healthy subjects in phase I clinical trials and coping strategies.METHODS: We retrospectively collected data from the screening process of 1,640 healthy subjects in 12 phase...

Geographic variations in lipid-lowering therapy utilization, LDL-C levels, and proportion retrospectively meeting the ACC/AHA very high-risk criteria in a real-world population of patients with major atherosclerotic cardiovascular disease events in the United States.

American journal of preventive cardiology

Baum SJ, Rane PB, Nunna S, Habib M, Philip K, Sun K, Wang X, Wade RL.
PMID: 34327500
Am J Prev Cardiol. 2021 Mar 30;6:100177. doi: 10.1016/j.ajpc.2021.100177. eCollection 2021 Jun.

OBJECTIVE: We assessed national- and state-level geographic variations among patients with a history of ≥1 major atherosclerotic cardiovascular disease (ASCVD) event in: (1) the proportion of patients with retrospectively identified 2018 American College of Cardiology/American Heart Association guideline very...

Learning deficit in cognitively normal APOE ε4 carriers with LOW β-amyloid.

Alzheimer's & dementia (Amsterdam, Netherlands)

Lim YY, Baker JE, Mills A, Bruns L, Fowler C, Fripp J, Rainey-Smith SR, Ames D, Masters CL, Maruff P.
PMID: 33748392
Alzheimers Dement (Amst). 2021 Mar 16;13(1):e12136. doi: 10.1002/dad2.12136. eCollection 2021.

INTRODUCTION: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ-) apolipoprotein E (METHODS: Aβ- CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A...

Silencing of the .

Frontiers in molecular biosciences

Gan Y, Cao C, Li A, Song H, Kuang G, Ma B, Zhang Q, Zhang Q.
PMID: 33816562
Front Mol Biosci. 2021 Mar 16;8:655126. doi: 10.3389/fmolb.2021.655126. eCollection 2021.

To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with clinicopathological features and prognosis of...

Showing 541 to 550 of 550 entries