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Potentiation by methyl isobutyl ketone of the cholestasis induced in rats by a manganese-bilirubin combination or manganese alone.

Vézina M, Plaa GL.
PMID: 3424376
Toxicol Appl Pharmacol. 1987 Dec;91(3):477-83. doi: 10.1016/0041-008x(87)90069-x.

Haloalkane-induced hepatonecrogenesis can be potentiated by the prior administration of methyl isobutyl ketone (MIBK). In a previous study, MIBK was shown to potentiate the cholestasis induced by taurolithocholate in rats. We investigated the possibility that this ketone could potentiate...

The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.

Rice AJ, Plaa GL.
PMID: 4975608
Toxicol Appl Pharmacol. 1969 Jan;14(1):151-62. doi: 10.1016/0041-008x(69)90175-6.

No abstract available.

Dose and time relationships in manganese-bilirubin cholestasis.

de Lamirande E, Plaa GL.
PMID: 494277
Toxicol Appl Pharmacol. 1979 Jun 30;49(2):257-63. doi: 10.1016/0041-008x(79)90249-7.

No abstract available.

Role of manganese, bilirubin and sulfobromophthalein in manganese-bilirubin cholestasis in rats.

Lamirande ED, Plaa GL.
PMID: 674234
Proc Soc Exp Biol Med. 1978 Jun;158(2):283-7. doi: 10.3181/00379727-158-40189.

No abstract available.

Potentiation of chloroform-induced hepatotoxicity by methyl isobutyl ketone and two metabolites.

Vézina M, Kobusch AB, du Souich P, Greselin E, Plaa GL.
PMID: 2390735
Can J Physiol Pharmacol. 1990 Aug;68(8):1055-61. doi: 10.1139/y90-159.

The hepatonecrogenic properties of chloroform (CHCl3) can be modified by the administration of various chemicals. The ability of methyl isobutyl ketone (MIBK) and its two major metabolites, 4-methyl-2-pentanol (4MPOL) and 4-hydroxymethyl isobutyl ketone (4-OHMIBK) to potentiate the liver injury...

Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.

Dahlström-King L, Couture J, Lamoureux C, Vaillancourt T, Plaa GL.
PMID: 2361581
Fundam Appl Toxicol. 1990 May;14(4):833-41.

The aim was to determine if isolated suspended hepatocytes could differentiate between the effects of four chlorinated hydrocarbons that are hepatotoxic in vivo and four that are not. Membrane integrity was assessed by measuring alanine aminotransferase (ALT) release after...

Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.

Hanasono GK, Witschi H, Plaa GL.
PMID: 1166087
Proc Soc Exp Biol Med. 1975 Sep;149(4):903-7. doi: 10.3181/00379727-149-38924.

Alloxan diabetes enhances the hepatotoxic response of male rats to chloroform and 1, 1, 2-trichloroethane, but not to trichloroethylene nor 1, 1, 1-trichloroethane. Insulin treatment partially protects the animals against the alloxan-induced enhancement of chloroform hepatotoxicity. Alloxan diabetes also...

Effect of hypothermia on carbon tetrachloride-induced changes in hepatic ultrastructure.

Kurstak C, Côté G, Plaa GL.
PMID: 4127055
Toxicol Appl Pharmacol. 1973 Sep;26(1):14-28. doi: 10.1016/0041-008x(73)90081-1.

No abstract available.

The effects of cycloheximide, actinomycin D, and ethionine on the biliary excretion of labelled alpha-naphthylisothiocyanate in rats.

Skelton FS, Witschi H, Plaa GL.
PMID: 1183536
Exp Mol Pathol. 1975 Oct;23(2):171-80. doi: 10.1016/0014-4800(75)90015-5.

No abstract available.

Simultaneous high-performance liquid chromatographic analysis of hippuric acid and ortho-, meta-, and para-methylhippuric acids in urine.

Tardif R, Brodeur J, Plaa GL.
PMID: 2607759
J Anal Toxicol. 1989 Nov-Dec;13(6):313-6. doi: 10.1093/jat/13.6.313.

A high-performance liquid chromatographic assay for the simultaneous analysis of hippuric and methylhippuric acids in urine is described. Compounds are first extracted from acidified urines after addition of o-methylbenzoylalanine (internal standard), using methyl-t-butyl ether. The organic phase is evaporated...

Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene.

Dionne S, Russo P, Tuchweber B, Plaa GL, Yousef IM.
PMID: 2074731
Liver. 1990 Dec;10(6):336-42. doi: 10.1111/j.1600-0676.1990.tb00478.x.

The transport of cholic acid (CA) and chenodeoxycholic acid (CDC) and their influence on bile formation was investigated in rats treated with bromobenzene (BZ), a toxicant which selectively destroys zone 3 of the hepatic acinus. The necrosis equals 27-31%...

Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone.

Hewitt WR, Plaa GL.
PMID: 6836608
Toxicol Lett. 1983 Apr;16(1):145-52. doi: 10.1016/0378-4274(83)90023-1.

The ability of acetone to potentiate the toxicity of 1,1-dichloroethylene (DCE) in male rats was investigated. A biphasic potentiation of DCE-induced hepatotoxicity was observed; low doses (5 and 10 mmol/kg, p.o.) of acetone were active, whereas higher doses (15...

Showing 13 to 24 of 204 entries