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Showing 25 to 36 of 132 entries
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Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation Study.

Cardiovascular endocrinology

Khaliq A, Johnson BD, Anderson RD, Bavry AA, Cooper-DeHoff RM, Handberg EM, Bairey Merz CN, Nicholls SJ, Nissen S, Pepine CJ.
PMID: 26665010
Cardiovasc Endocrinol. 2015 Jun;4(2):45-52. doi: 10.1097/XCE.0000000000000049.

OBJECTIVE: In women, metabolic syndrome (MetS) is associated with higher risk of ischemic heart disease-related adverse outcomes versus individual components. We examined the relationship of MetS to subclinical coronary atherosclerosis.METHODS: Women (RESULTS: Detailed IVUS measurements were available in 87...

A multiplexed ion-exchange membrane-based miRNA (MIX·miR) detection platform for rapid diagnosis of myocardial infarction.

Lab on a chip

Ren X, Ellis BW, Ronan G, Blood SR, DeShetler C, Senapati S, March KL, Handberg E, Anderson D, Pepine C, Chang HC, Zorlutuna P.
PMID: 34546237
Lab Chip. 2021 Oct 12;21(20):3876-3887. doi: 10.1039/d1lc00685a.

Micro RNAs (miRNAs) have shown great potential as rapid and discriminating biomarkers for acute myocardial infarction (AMI) diagnosis. We have developed a multiplexed ion-exchange membrane-based miRNA (MIX·miR) preconcentration/sensing amplification-free platform for quantifying in parallel a panel of miRNAs, including...

Peak Systolic Blood Pressure During the Exercise Test: Reference Values by Sex and Age and Association With Mortality.

Hypertension (Dallas, Tex. : 1979)

Assaf Y, Barout A, Alhamid A, Al-Mouakeh A, Barillas-Lara MI, Fortin-Gamero S, Bonikowske AR, Pepine CJ, Allison TG.
PMID: 33866799
Hypertension. 2021 Jun;77(6):1906-1914. doi: 10.1161/HYPERTENSIONAHA.120.16570. Epub 2021 Apr 19.

[Figure: see text].

Erratum to "Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era" AmJMed, 133(11); 1254-1261.

The American journal of medicine

Massoomi MR, Anderson RD, Ahmed MM, Dasa O, George P, Miles WM, Aranda JM, Pepine CJ.
PMID: 33461734
Am J Med. 2021 Apr;134(4):555. doi: 10.1016/j.amjmed.2021.01.001. Epub 2021 Jan 09.

No abstract available.

Efficacy of Ranolazine for Treatment of Coronary Microvascular Dysfunction-A Systematic Review and Meta-analysis of Randomized Trials.

CJC open

Kofler T, Hess S, Moccetti F, Pepine CJ, Attinger A, Wolfrum M, Toggweiler S, Kobza R, Cuculi F, Bossard M.
PMID: 33458636
CJC Open. 2020 Sep 11;3(1):101-108. doi: 10.1016/j.cjco.2020.09.005. eCollection 2021 Jan.

BACKGROUND: Coronary microvascular dysfunction (CMD) is a common cause of angina and exercise intolerance in patients without obstructive coronary artery disease. The efficacy of ranolazine, a late sodium channel blocker, in patients with symptomatic obstructive coronary artery disease is...

Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial).

The American journal of cardiology

Keeley EC, Li HJ, Cogle CR, Handberg EM, Merz CNB, Pepine CJ.
PMID: 34728061
Am J Cardiol. 2021 Oct 30; doi: 10.1016/j.amjcard.2021.09.015. Epub 2021 Oct 30.

Resolvins and maresins, members of the specialized proresolving mediator (SPM) family, are omega-3 fatty acid-derived lipid mediators that attenuate inflammation. We hypothesized that they play a role in the pathophysiology of coronary microvascular dysfunction (CMD) in women with ischemia...

Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE).

International journal of cardiology. Heart & vasculature

Jones E, Delia Johnson B, Shaw LJ, Bakir M, Wei J, Mehta PK, Minissian M, Pepine CJ, Reis SE, Kelsey SF, Handberg E, Bittner V, Sopko G, Noel Bairey Merz C.
PMID: 32226820
Int J Cardiol Heart Vasc. 2020 Mar 24;27:100502. doi: 10.1016/j.ijcha.2020.100502. eCollection 2020 Apr.

BACKGROUND: Women frequently present with symptoms not typical of angina (NTA) making ischemic heart disease recognition, diagnosis and treatment challenging. We compared mortality in women with obstructive coronary artery disease (CAD) with NTA vs typical angina (TA).METHODS: We studied...

Depression phenotype identified by using single nucleotide exact amplicon sequence variants of the human gut microbiome.

Molecular psychiatry

Stevens BR, Roesch L, Thiago P, Russell JT, Pepine CJ, Holbert RC, Raizada MK, Triplett EW.
PMID: 31988436
Mol Psychiatry. 2021 Aug;26(8):4277-4287. doi: 10.1038/s41380-020-0652-5. Epub 2020 Jan 27.

Single nucleotide exact amplicon sequence variants (ASV) of the human gut microbiome were used to evaluate if individuals with a depression phenotype (DEPR) could be identified from healthy reference subjects (NODEP). Microbial DNA in stool samples obtained from 40...

First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients.

JACC. Basic to translational science

Traverse JH, Henry TD, Dib N, Patel AN, Pepine C, Schaer GL, DeQuach JA, Kinsey AM, Chamberlin P, Christman KL.
PMID: 31709316
JACC Basic Transl Sci. 2019 Sep 11;4(6):659-669. doi: 10.1016/j.jacbts.2019.07.012. eCollection 2019 Oct.

This study evaluated the safety and feasibility of transendocardial injections of VentriGel, a cardiac extracellular matrix hydrogel, in early and late post-myocardial infarction (MI) patients with left ventricular (LV) dysfunction. VentriGel was delivered in 15 patients with moderate LV...

Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis.

Lancet (London, England)

Nazarzadeh M, Bidel Z, Canoy D, Copland E, Wamil M, Majert J, Smith Byrne K, Sundström J, Teo K, Davis BR, Chalmers J, Pepine CJ, Dehghan A, Bennett DA, Smith GD, Rahimi K.
PMID: 34774144
Lancet. 2021 Nov 13;398(10313):1803-1810. doi: 10.1016/S0140-6736(21)01920-6.

BACKGROUND: Blood pressure lowering is an established strategy for preventing microvascular and macrovascular complications of diabetes, but its role in the prevention of diabetes itself is unclear. We aimed to examine this question using individual participant data from major...

Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease among Women with Suspected Ischemia: The Women's Ischemia Syndrome Evaluation.

Heart and mind (Mumbai, India)

Emami AS, Bairey Merz CN, Eastwood JA, Pepine CJ, Handberg EM, Bittner V, Mehta PK, Krantz DS, Vaccarino V, Eteiba W, Cornell CE, Rutledge T.
PMID: 34966880
Heart Mind (Mumbai). 2021 Oct-Dec;5(4):112-118. doi: 10.4103/hm.hm_34_21. Epub 2021 Nov 30.

BACKGROUND: Depression is an established predictor of coronary artery disease (CAD) progression and mortality. "Somatic" symptoms of depression such as fatigue and sleep impairment overlap with symptoms of CAD and independently predict CAD events. Differentiating between "somatic" and "cognitive"...

Sensitized by a sea slug: Site-specific short-term and general long-term sensitization in Aplysia following Navanax attack.

Neurobiology of learning and memory

Pepino C, Rakovski C, Gutierrez C, Rodriguez A, Tillett S, Berriman C, Mason M, Ingalls AW, Emshwiler R, Scher SC, Zachary V, Lee L, Johnson S, Olsen K, Wright WG.
PMID: 34748927
Neurobiol Learn Mem. 2022 Jan;187:107542. doi: 10.1016/j.nlm.2021.107542. Epub 2021 Nov 05.

Neurobiological studies of the model species, Aplysia californica (Mollusca, Gastropoda, Euopisthobranchia), have helped advance our knowledge of the neural bases of different forms of learning, including sensitization, a non-associative increase in withdrawal behaviors in response to mild innocuous stimuli....

Showing 25 to 36 of 132 entries