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Showing 1681 to 1689 of 1689 entries
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Antioxidant Enzymes and Heat Shock Protein Genes from .

Insects

Miao ZQ, Tu YQ, Guo PY, He W, Jing TX, Wang JJ, Wei DD.
PMID: 33261171
Insects. 2020 Nov 27;11(12). doi: 10.3390/insects11120839.

Psocids are a new risk for global food security and safety because they are significant worldwide pests of stored products. Among these psocids,

Analysis of mRNA Expression and DNA Methylation Datasets According to the Genomic Distribution of CpG Sites in Osteoarthritis.

Frontiers in genetics

Yi P, Xu X, Yao J, Qiu B.
PMID: 33936160
Front Genet. 2021 Apr 15;12:618803. doi: 10.3389/fgene.2021.618803. eCollection 2021.

Objectives Transcriptional changes in cartilage can impact function by causing degradation such as that which occurs during the development of osteoarthritis (OA). Epigenetic regulation may be a key factor leading to transcriptional changes in OA. In this study, we...

LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.

Redox biology

Wei WS, Wang N, Deng MH, Dong P, Liu JY, Xiang Z, Li XD, Li ZY, Liu ZH, Peng YL, Li Z, Jiang LJ, Yao K, Ye YL, Lu WH, Zhang ZL, Zhou FJ, Liu ZW, Xie D, Yu CP.
PMID: 34864630
Redox Biol. 2021 Nov 27;48:102201. doi: 10.1016/j.redox.2021.102201. Epub 2021 Nov 27.

Reactive oxygen species (ROS) which are continuously generated mainly by mitochondria, have been proved to play an important role in the stress signaling of cancer cells. Moreover, pentatricopeptide repeat (PPR) proteins have been suggested to take part in mitochondrial...

Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration.

Bioactive materials

Fan L, Guan P, Xiao C, Wen H, Wang Q, Liu C, Luo Y, Ma L, Tan G, Yu P, Zhou L, Ning C.
PMID: 33665507
Bioact Mater. 2021 Feb 15;6(9):2754-2766. doi: 10.1016/j.bioactmat.2021.02.005. eCollection 2021 Sep.

The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property. Bone marrow stem cells (BMSCs) derived exosomes (Exos) contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions. Herein, we...

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.

European journal of medicinal chemistry

Yeh TK, Song JS, Chang PW, Yu JC, Chang CH, Liao FY, Tien YW, Kuppusamy R, Li AS, Chen CH, Chen CW, Lin LM, Chang HH, Huang CH, Yao JY, Wu MH, Peng YH, Hsueh CC, Hsiao WC, Chen PH, Lin CY, Hsieh SH, Shih C, Hung MS, Wu SY, Kuo CC, Ueng SH.
PMID: 34929581
Eur J Med Chem. 2021 Dec 08;229:114043. doi: 10.1016/j.ejmech.2021.114043. Epub 2021 Dec 08.

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular...

AICAR suppresses cell proliferation and synergizes with decitabine in myelodysplastic syndrome via DNA damage induction.

Biotechnology letters

Liu J, Liang L, Li X, Peng YL, Zhang J, Wang XL, Liu J, Nie L.
PMID: 33788127
Biotechnol Lett. 2021 Jun;43(6):1131-1142. doi: 10.1007/s10529-021-03112-2. Epub 2021 Mar 31.

OBJECTIVE: To investigate the efficacy and safety of the AMPK activator AICAR alone or in combination with decitabine on myelodysplastic syndromes (MDS).RESULTS: p-AMPK (Thr172) expression was lower in MDS samples than in healthy donors. AMPK agonist AICAR inhibited the...

The clinical significance of transcription factor WD repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma and its potential molecular mechanism.

Pathology, research and practice

Wu JY, Lan XL, Yan DM, Fang YY, Peng YX, Liang FF, Jiang L, Huang SN, Mo M, Lin CX, Niu YT, Wu XW, Wei ZX.
PMID: 34999279
Pathol Res Pract. 2021 Dec 23;230:153751. doi: 10.1016/j.prp.2021.153751. Epub 2021 Dec 23.

BACKGROUND: Currently, high expression of WD repeat and HMG-box DNA binding protein 1 (WDHD1) has been found in a variety of tumors; but there is no research has been conducted concerning the expression of WDHD1 in laryngeal squamous cell...

Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated .

Frontiers in physiology

Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GM.
PMID: 34322038
Front Physiol. 2021 Jul 12;12:701995. doi: 10.3389/fphys.2021.701995. eCollection 2021.

Obstructive sleep apnea (OSA) is a common breathing disorder affecting a significant percentage of the adult population. OSA is an independent risk factor for cardiovascular disease (CVD); however, the underlying mechanisms are not completely understood. Since the severity of...

Mitochondrial targeted rhodium(III) complexes: Synthesis, characterized and antitumor mechanism investigation.

Journal of inorganic biochemistry

Peng YB, Tao C, Tan CP, Zhao P.
PMID: 33684684
J Inorg Biochem. 2021 May;218:111400. doi: 10.1016/j.jinorgbio.2021.111400. Epub 2021 Feb 25.

Recently, rhodium complexes have received intensive attentions due to their tunable chemical and biological properties as well as attractive antitumor activity. In this work, two imidazole triphenylamino rhodium complexes [Rh(ppy)

Showing 1681 to 1689 of 1689 entries