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Showing 13 to 24 of 28 entries
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Commentary: Back to the future: Failed mitral valve bioprosthesis in the setting of mitral annular calcification.

JTCVS techniques

Parchment N, Brescia AA, Ailawadi G.
PMID: 34977735
JTCVS Tech. 2021 Aug 06;10:269-270. doi: 10.1016/j.xjtc.2021.08.007. eCollection 2021 Dec.

No abstract available.

Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Takebe N, Naqash AR, O'Sullivan Coyne G, Kummar S, Do K, Bruns A, Juwara L, Zlott J, Rubinstein L, Piekarz R, Sharon E, Streicher H, Mittra A, Miller SB, Ji J, Wilsker D, Kinders RJ, Parchment RE, Chen L, Chang TC, Das B, Mugundu G, Doroshow JH, Chen AP.
PMID: 33863809
Clin Cancer Res. 2021 Jul 15;27(14):3834-3844. doi: 10.1158/1078-0432.CCR-21-0329. Epub 2021 Apr 16.

PURPOSE: The Wee1 kinase inhibitor adavosertib abrogates cell-cycle arrest, leading to cell death. Prior testing of twice-daily adavosertib in patients with advanced solid tumors determined the recommended phase II dose (RPh2D). Here, we report results for once-daily adavosertib.PATIENTS AND...

The association between self-Esteem, stigma, and mental health among South African youth living with HIV: the need for integrated HIV care services.

AIDS care

Small LA, Huynh AK, Parchment TM.
PMID: 34839770
AIDS Care. 2022 Jan;34(1):86-94. doi: 10.1080/09540121.2021.2002253. Epub 2021 Nov 27.

Treatment among pYLHIV focuses on their physical health. However, they also experience depression and anxiety, compounded by developmental challenges and the stress of managing a chronic illness. However, limited services are available to help pYLHIV manage the emotional stressors...

ATR inhibition reverses the resistance of homologous recombination deficient MGMT.

Oncotarget

El Touny LH, Hose C, Connelly J, Harris E, Monks A, Dull AB, Wilsker DF, Hollingshead MG, Gottholm-Ahalt M, Alcoser SY, Mullendore ME, Parchment RE, Doroshow JH, Teicher BA, Rapisarda A.
PMID: 34676045
Oncotarget. 2021 Oct 12;12(21):2114-2130. doi: 10.18632/oncotarget.28090. eCollection 2021 Oct 12.

The therapeutic efficacy of temozolomide (TMZ) is hindered by inherent and acquired resistance. Biomarkers such as MGMT expression and MMR proficiency are used as predictors of response. However, not all MGMT

The association between self-Esteem, stigma, and mental health among South African youth living with HIV: the need for integrated HIV care services.

AIDS care

Small LA, Huynh AK, Parchment TM.
PMID: 34839770
AIDS Care. 2022 Jan;34(1):86-94. doi: 10.1080/09540121.2021.2002253. Epub 2021 Nov 27.

Treatment among pYLHIV focuses on their physical health. However, they also experience depression and anxiety, compounded by developmental challenges and the stress of managing a chronic illness. However, limited services are available to help pYLHIV manage the emotional stressors...

Cell surface (Amsterdam, Netherlands)

Upadhya R, Lam WC, Hole CR, Parchment D, Lee CK, Specht CA, Levitz SM, Lodge JK.
PMID: 34712865
Cell Surf. 2021 Oct 15;7:100066. doi: 10.1016/j.tcsw.2021.100066. eCollection 2021 Dec.

Chitosan, a deacetylated form of chitin, is required for the virulence of

Familial and Contextual Influences on Children's Prosocial Behavior: South African Caregivers as Adult Protective Shields in Enhancing Child Mental Health.

Global social welfare : research, policy & practice

Parchment TM, Small L, Osuji H, McKay M, Bhana A.
PMID: 28401033
Glob Soc Welf. 2016 Mar;3(1):1-10. doi: 10.1007/s40609-016-0042-8. Epub 2016 Feb 04.

BACKGROUND: The mental health of children is too frequently overlooked in resource scarce low and middle-income countries. South Africa represents one of many country contexts struggling to meet the mental health needs of large numbers of young people. Family...

Topoisomerase I inhibitors and drug resistance.

Cytotechnology

Parchment RE, Pessina A.
PMID: 19002789
Cytotechnology. 1998 Sep;27(1):149-64. doi: 10.1023/A:1008008719699.

DNA topoisomerase I is a nuclear enzyme which catalyzes the conversion of the DNA topology by introducing single-strand breaks into the DNA molecule. This enzyme represents a novel and distinct molecule target for cancer therapy by antitopoisomerase drugs belonging...

Cell surface (Amsterdam, Netherlands)

Upadhya R, Lam WC, Hole CR, Parchment D, Lee CK, Specht CA, Levitz SM, Lodge JK.
PMID: 34712865
Cell Surf. 2021 Oct 15;7:100066. doi: 10.1016/j.tcsw.2021.100066. eCollection 2021 Dec.

Chitosan, a deacetylated form of chitin, is required for the virulence of

Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors.

Investigational new drugs

Kummar S, Srivastava AK, Navas T, Cecchi F, Lee YH, Bottaro DP, Park SR, Do KT, Jeong W, Johnson BC, Voth AR, Rubinstein L, Wright JJ, Parchment RE, Doroshow JH, Chen AP.
PMID: 34180036
Invest New Drugs. 2021 Dec;39(6):1577-1586. doi: 10.1007/s10637-021-01138-x. Epub 2021 Jun 28.

The vascular endothelial growth factor (VEGF)/VEGFR and hepatocyte growth factor (HGF)/c-MET signaling pathways act synergistically to promote angiogenesis. Studies indicate VEGF inhibition leads to increased levels of phosphorylated c-MET, bypassing VEGF-mediated angiogenesis and leading to chemoresistance. We conducted a...

Perceived Benefits of a Multiple Family Group for Children with Behavior Problems and their Families.

Social work with groups

Acri MC, Hamovitch EK, Lambert K, Galler M, Parchment TM, Bornheimer LA.
PMID: 31827309
Soc Work Groups. 2019;42(3):197-212. doi: 10.1080/01609513.2019.1567437. Epub 2019 Feb 04.

Multiple family groups (MFG) have shown to have promising results for children with behavioral difficulties. The 4Rs and 2Ss is a curriculum-based multiple family group model for families of children with disruptive behavior disorders, who live in poverty-impacted communities....

Beyond Ti.

ACS nano

Han M, Shuck CE, Rakhmanov R, Parchment D, Anasori B, Koo CM, Friedman G, Gogotsi Y.
PMID: 32163265
ACS Nano. 2020 Apr 28;14(4):5008-5016. doi: 10.1021/acsnano.0c01312. Epub 2020 Mar 17.

New ultrathin and multifunctional electromagnetic interference (EMI) shielding materials are required for protecting electronics against electromagnetic pollution in the fifth-generation networks and Internet of Things era. Micrometer-thin Ti

Showing 13 to 24 of 28 entries