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Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016).

Advanced healthcare materials

Othman BA, Greenwood C, Abuelela AF, Bharath AA, Chen S, Theodorou I, Douglas T, Uchida M, Ryan M, Merzaban JS, Porter AE.
PMID: 27275627
Adv Healthc Mater. 2016 Jun;5(11):1248. doi: 10.1002/adhm.201670053.

On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron...

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Othman BA, Greenwood C, Abuelela AF, et al. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Adv Healthc Mater. 2016;5(11):1248doi: 10.1002/adhm.201670053.
Othman, B. A., Greenwood, C., Abuelela, A. F., Bharath, A. A., Chen, S., Theodorou, I., Douglas, T., Uchida, M., Ryan, M., Merzaban, J. S., & Porter, A. E. (2016). Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Advanced healthcare materials, 5(11), 1248. https://doi.org/10.1002/adhm.201670053
Othman, Basmah A, et al. "Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016)." Advanced healthcare materials vol. 5,11 (2016): 1248. doi: https://doi.org/10.1002/adhm.201670053
Othman BA, Greenwood C, Abuelela AF, Bharath AA, Chen S, Theodorou I, Douglas T, Uchida M, Ryan M, Merzaban JS, Porter AE. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Adv Healthc Mater. 2016 Jun;5(11):1248. doi: 10.1002/adhm.201670053. PMID: 27275627.
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[The strategy how to restart heart transplantation in Japan from the viewpoint of cardiovascular surgeons].

Nihon Kyobu Shikkan Gakkai zasshi

Koyanagi H, Hachida M.
PMID: 8007480
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Dec;31:86-9.

Japan is still in the midst of confusion the ethical, social and legal standpoints of organ transplantation. We have paid attention and effort to negotiate and reorganize the heart transplantation environment. This paper discusses several problems concerning the criteria,...

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Koyanagi H, Hachida M. [The strategy how to restart heart transplantation in Japan from the viewpoint of cardiovascular surgeons]. Nihon Kyobu Shikkan Gakkai Zasshi. 1993;31:86-9
Koyanagi, H., & Hachida, M. (1993). [The strategy how to restart heart transplantation in Japan from the viewpoint of cardiovascular surgeons]. Nihon Kyobu Shikkan Gakkai zasshi, 3186-9.
Koyanagi, H, and Hachida, M. "[The strategy how to restart heart transplantation in Japan from the viewpoint of cardiovascular surgeons]." Nihon Kyobu Shikkan Gakkai zasshi vol. 31 (1993): 86-9.
Koyanagi H, Hachida M. [The strategy how to restart heart transplantation in Japan from the viewpoint of cardiovascular surgeons]. Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Dec;31:86-9. Japanese. PMID: 8007480.
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Reduction of Iron(III) Ion by Activated Carbon Fiber.

Journal of colloid and interface science

Uchida M, Shinohara O, Ito S, Kawasaki N, Nakamura T, Tanada S.
PMID: 10727346
J Colloid Interface Sci. 2000 Apr 15;224(2):347-350. doi: 10.1006/jcis.2000.6713.

The mechanisms of adsorption of iron(II) ion, iron(III) ion, and reduced iron(III) ion onto an activated carbon fiber and the ability of carbon fibers to reduce iron(III) ion were investigated on the basis of the amounts of iron ion...

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Uchida M, Shinohara O, Ito S, et al. Reduction of Iron(III) Ion by Activated Carbon Fiber. J Colloid Interface Sci. 2000;224(2):347-350doi: 10.1006/jcis.2000.6713.
Uchida, M., Shinohara, O., Ito, S., Kawasaki, N., Nakamura, T., & Tanada, S. (2000). Reduction of Iron(III) Ion by Activated Carbon Fiber. Journal of colloid and interface science, 224(2), 347-350. https://doi.org/10.1006/jcis.2000.6713
Uchida, et al. "Reduction of Iron(III) Ion by Activated Carbon Fiber." Journal of colloid and interface science vol. 224,2 (2000): 347-350. doi: https://doi.org/10.1006/jcis.2000.6713
Uchida M, Shinohara O, Ito S, Kawasaki N, Nakamura T, Tanada S. Reduction of Iron(III) Ion by Activated Carbon Fiber. J Colloid Interface Sci. 2000 Apr 15;224(2):347-350. doi: 10.1006/jcis.2000.6713. PMID: 10727346.
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Intramolecular Cyclizations of o-Acylbenzyllithiums. Formation of Benzocyclobuten-1-ol Derivatives and Their Thermal Isomerization.

The Journal of organic chemistry

Kobayashi K, Kawakita M, Uchida M, Nishimura K, Mannami T, Irisawa S, Morikawa O, Konishi H.
PMID: 11674481
J Org Chem. 1999 May 14;64(10):3557-3562. doi: 10.1021/jo982366o.

The formation of benzocyclobutenol derivatives by intramolecular cyclizations of o-acylbenzyllithiums is described. Treatment of o-(trialkylsilylmethyl)phenyl ketones with lithium diisopropylamide (LDA) followed by quenching of the resulting benzylic carbanions with chlorotrialkylsilane resulted in stereoselective formation of the corresponding 1-trialkylsiloxy-2-(trialkylsilyl)benzocyclobutenes in...

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Kobayashi K, Kawakita M, Uchida M, et al. Intramolecular Cyclizations of o-Acylbenzyllithiums. Formation of Benzocyclobuten-1-ol Derivatives and Their Thermal Isomerization. J Org Chem. 1999;64(10):3557-3562doi: 10.1021/jo982366o.
Kobayashi, K., Kawakita, M., Uchida, M., Nishimura, K., Mannami, T., Irisawa, S., Morikawa, O., & Konishi, H. (1999). Intramolecular Cyclizations of o-Acylbenzyllithiums. Formation of Benzocyclobuten-1-ol Derivatives and Their Thermal Isomerization. The Journal of organic chemistry, 64(10), 3557-3562. https://doi.org/10.1021/jo982366o
Kobayashi, Kazuhiro, et al. "Intramolecular Cyclizations of o-Acylbenzyllithiums. Formation of Benzocyclobuten-1-ol Derivatives and Their Thermal Isomerization." The Journal of organic chemistry vol. 64,10 (1999): 3557-3562. doi: https://doi.org/10.1021/jo982366o
Kobayashi K, Kawakita M, Uchida M, Nishimura K, Mannami T, Irisawa S, Morikawa O, Konishi H. Intramolecular Cyclizations of o-Acylbenzyllithiums. Formation of Benzocyclobuten-1-ol Derivatives and Their Thermal Isomerization. J Org Chem. 1999 May 14;64(10):3557-3562. doi: 10.1021/jo982366o. PMID: 11674481.
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Effects on Metal Binding of Circular NH- - -O=C Intramolecular Hydrogen Bonding in Hydrophilic Pseudocavities of p-tert-Butylcalix[4]arenes Carrying Amino Acid Moieties.

The Journal of organic chemistry

Nomura E, Takagaki M, Nakaoka C, Uchida M, Taniguchi H.
PMID: 11674414
J Org Chem. 1999 Apr 30;64(9):3151-3156. doi: 10.1021/jo982251k.

Calix[4]arenes bearing amino acid moieties were prepared by the reaction of carboxyl-protected amino acids with the acid chlorides of O-carboxymethylcalix[4]arenes. The binding ability toward metal ions was estimated by solvent extraction. These calixarenes showed selective extraction capability toward Na(+)...

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Nomura E, Takagaki M, Nakaoka C, et al. Effects on Metal Binding of Circular NH- - -O=C Intramolecular Hydrogen Bonding in Hydrophilic Pseudocavities of p-tert-Butylcalix[4]arenes Carrying Amino Acid Moieties. J Org Chem. 1999;64(9):3151-3156doi: 10.1021/jo982251k.
Nomura, E., Takagaki, M., Nakaoka, C., Uchida, M., & Taniguchi, H. (1999). Effects on Metal Binding of Circular NH- - -O=C Intramolecular Hydrogen Bonding in Hydrophilic Pseudocavities of p-tert-Butylcalix[4]arenes Carrying Amino Acid Moieties. The Journal of organic chemistry, 64(9), 3151-3156. https://doi.org/10.1021/jo982251k
Nomura, Eisaku, et al. "Effects on Metal Binding of Circular NH- - -O=C Intramolecular Hydrogen Bonding in Hydrophilic Pseudocavities of p-tert-Butylcalix[4]arenes Carrying Amino Acid Moieties." The Journal of organic chemistry vol. 64,9 (1999): 3151-3156. doi: https://doi.org/10.1021/jo982251k
Nomura E, Takagaki M, Nakaoka C, Uchida M, Taniguchi H. Effects on Metal Binding of Circular NH- - -O=C Intramolecular Hydrogen Bonding in Hydrophilic Pseudocavities of p-tert-Butylcalix[4]arenes Carrying Amino Acid Moieties. J Org Chem. 1999 Apr 30;64(9):3151-3156. doi: 10.1021/jo982251k. PMID: 11674414.
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A solvent used for antiepileptic drugs increases serum and brain zonisamide concentrations in seizure-susceptible el mice.

Epilepsy & behavior : E&B

Nagatomo I, Akasaki Y, Hashiguchi W, Tominaga M, Uchida M, Takigawa M.
PMID: 12609213
Epilepsy Behav. 2001 Aug;2(4):357-62. doi: 10.1006/ebeh.2001.0224.

Effects of a solvent mixture commonly used to dissolve antiepileptic drugs on the anticonvulsive effect as well as serum and brain concentrations of zonisamide (ZNS), a sulfonamide derivative, were investigated. The solvent mixture consisted of propylene glycol (PG, 40%)...

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Nagatomo I, Akasaki Y, Hashiguchi W, et al. A solvent used for antiepileptic drugs increases serum and brain zonisamide concentrations in seizure-susceptible el mice. Epilepsy Behav. 2001;2(4):357-62doi: 10.1006/ebeh.2001.0224.
Nagatomo, I., Akasaki, Y., Hashiguchi, W., Tominaga, M., Uchida, M., & Takigawa, M. (2001). A solvent used for antiepileptic drugs increases serum and brain zonisamide concentrations in seizure-susceptible el mice. Epilepsy & behavior : E&B, 2(4), 357-62. https://doi.org/10.1006/ebeh.2001.0224
Nagatomo, I, et al. "A solvent used for antiepileptic drugs increases serum and brain zonisamide concentrations in seizure-susceptible el mice." Epilepsy & behavior : E&B vol. 2,4 (2001): 357-62. doi: https://doi.org/10.1006/ebeh.2001.0224
Nagatomo I, Akasaki Y, Hashiguchi W, Tominaga M, Uchida M, Takigawa M. A solvent used for antiepileptic drugs increases serum and brain zonisamide concentrations in seizure-susceptible el mice. Epilepsy Behav. 2001 Aug;2(4):357-62. doi: 10.1006/ebeh.2001.0224. PMID: 12609213.
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Facile synthesis of 5,10-diaryl-5,10-dihydrophenazines and application to EL devices.

Organic letters

Okamoto T, Terada E, Kozaki M, Uchida M, Kikukawa S, Okada K.
PMID: 12556195
Org Lett. 2003 Feb 06;5(3):373-6. doi: 10.1021/ol0274458.

[structures: see text] An efficient method for the synthesis of 5,10-diaryldihydrophenazine was developed using a recently developed Pd(0)-mediated cross-coupling reaction. The products 1k and 3c showed excellent properties as hole injection materials in electroluminescent (EL) devices.

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Okamoto T, Terada E, Kozaki M, et al. Facile synthesis of 5,10-diaryl-5,10-dihydrophenazines and application to EL devices. Org Lett. 2003;5(3):373-6doi: 10.1021/ol0274458.
Okamoto, T., Terada, E., Kozaki, M., Uchida, M., Kikukawa, S., & Okada, K. (2003). Facile synthesis of 5,10-diaryl-5,10-dihydrophenazines and application to EL devices. Organic letters, 5(3), 373-6. https://doi.org/10.1021/ol0274458
Okamoto, Toshihiro, et al. "Facile synthesis of 5,10-diaryl-5,10-dihydrophenazines and application to EL devices." Organic letters vol. 5,3 (2003): 373-6. doi: https://doi.org/10.1021/ol0274458
Okamoto T, Terada E, Kozaki M, Uchida M, Kikukawa S, Okada K. Facile synthesis of 5,10-diaryl-5,10-dihydrophenazines and application to EL devices. Org Lett. 2003 Feb 06;5(3):373-6. doi: 10.1021/ol0274458. PMID: 12556195.
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Excitation and decay of the isovector giant monopole resonances via the 208Pb(3He,t p) reaction at 410 MeV.

Physical review letters

Zegers RG, Abend H, Akimune H, van den Berg AM, Fujimura H, Fujita H, Fujita Y, Fujiwara M, Galès S, Hara K, Harakeh MN, Ishikawa T, Kawabata T, Kawase K, Mibe T, Nakanishi K, Nakayama S, Toyokawa H, Uchida M, Yamagata T, Yamasaki K, Yosoi M.
PMID: 12785887
Phys Rev Lett. 2003 May 23;90(20):202501. doi: 10.1103/PhysRevLett.90.202501. Epub 2003 May 20.

The excitation and subsequent proton decay of the isovector spin-flip giant monopole resonance (IVSGMR) is studied via the 208Pb(3He,t) reaction at 410 MeV. In the inclusive spectrum (60+/-5)% of the non-energy-weighted sum-rule strength for this 2 variant Planck's over...

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Zegers RG, Abend H, Akimune H, et al. Excitation and decay of the isovector giant monopole resonances via the 208Pb(3He,t p) reaction at 410 MeV. Phys Rev Lett. 2003;90(20):202501doi: 10.1103/PhysRevLett.90.202501.
Zegers, R. G., Abend, H., Akimune, H., van den Berg, A. M., Fujimura, H., Fujita, H., Fujita, Y., Fujiwara, M., Galès, S., Hara, K., Harakeh, M. N., Ishikawa, T., Kawabata, T., Kawase, K., Mibe, T., Nakanishi, K., Nakayama, S., Toyokawa, H., Uchida, M., Yamagata, T., Yamasaki, K., & Yosoi, M. (2003). Excitation and decay of the isovector giant monopole resonances via the 208Pb(3He,t p) reaction at 410 MeV. Physical review letters, 90(20), 202501. https://doi.org/10.1103/PhysRevLett.90.202501
Zegers, R G T, et al. "Excitation and decay of the isovector giant monopole resonances via the 208Pb(3He,t p) reaction at 410 MeV." Physical review letters vol. 90,20 (2003): 202501. doi: https://doi.org/10.1103/PhysRevLett.90.202501
Zegers RG, Abend H, Akimune H, van den Berg AM, Fujimura H, Fujita H, Fujita Y, Fujiwara M, Galès S, Hara K, Harakeh MN, Ishikawa T, Kawabata T, Kawase K, Mibe T, Nakanishi K, Nakayama S, Toyokawa H, Uchida M, Yamagata T, Yamasaki K, Yosoi M. Excitation and decay of the isovector giant monopole resonances via the 208Pb(3He,t p) reaction at 410 MeV. Phys Rev Lett. 2003 May 23;90(20):202501. doi: 10.1103/PhysRevLett.90.202501. Epub 2003 May 20. PMID: 12785887.
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Telomere length and telomerase activity in the process of human fibroblast immortalization.

Odontology

Kumakura S, Yamamoto A, Yagisawa J, Uchida M, Tsutsui T.
PMID: 12955560
Odontology. 2002 Sep;90(1):13-21. doi: 10.1007/s102660200002.

To examine the telomere maintenance mechanism in the process of human fibroblast immortalization, we studied telomere length, telomerase activity, chromosome instability, and minisatellite alterations in human fibroblasts following the introduction of the human papillomavirus type 16 E6 gene or...

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Kumakura S, Yamamoto A, Yagisawa J, et al. Telomere length and telomerase activity in the process of human fibroblast immortalization. Odontology. 2002;90(1):13-21doi: 10.1007/s102660200002.
Kumakura, S., Yamamoto, A., Yagisawa, J., Uchida, M., & Tsutsui, T. (2002). Telomere length and telomerase activity in the process of human fibroblast immortalization. Odontology, 90(1), 13-21. https://doi.org/10.1007/s102660200002
Kumakura, Shin-ichi, et al. "Telomere length and telomerase activity in the process of human fibroblast immortalization." Odontology vol. 90,1 (2002): 13-21. doi: https://doi.org/10.1007/s102660200002
Kumakura S, Yamamoto A, Yagisawa J, Uchida M, Tsutsui T. Telomere length and telomerase activity in the process of human fibroblast immortalization. Odontology. 2002 Sep;90(1):13-21. doi: 10.1007/s102660200002. PMID: 12955560.
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Decomposition of Pt-intercalated hydrotalcite-like nanocomposites to produce micro/mesoporous catalysts.

Chemical communications (Cambridge, England)

Machida M, Hamada S.
PMID: 12932054
Chem Commun (Camb). 2003 Aug 07;(15):1962-3. doi: 10.1039/b304352e.

Platinum intercalated into a hydrotalcite-like solid, Mg0.74Al0.26(OH)2(NO3)0.26, was found to catalytically reduce interlayer nitrate (NO3-) to N2/N2O so as to give rise to a large surface area micro/mesoporous structure at lower temperature of ca. 300 degrees C, compared to...

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Machida M, Hamada S. Decomposition of Pt-intercalated hydrotalcite-like nanocomposites to produce micro/mesoporous catalysts. Chem Commun (Camb). 2003;(15):1962-3doi: 10.1039/b304352e.
Machida, M., & Hamada, S. (2003). Decomposition of Pt-intercalated hydrotalcite-like nanocomposites to produce micro/mesoporous catalysts. Chemical communications (Cambridge, England), (15), 1962-3. https://doi.org/10.1039/b304352e
Machida, Masato, and Hamada, Shin. "Decomposition of Pt-intercalated hydrotalcite-like nanocomposites to produce micro/mesoporous catalysts." Chemical communications (Cambridge, England) vol. ,15 (2003): 1962-3. doi: https://doi.org/10.1039/b304352e
Machida M, Hamada S. Decomposition of Pt-intercalated hydrotalcite-like nanocomposites to produce micro/mesoporous catalysts. Chem Commun (Camb). 2003 Aug 07;(15):1962-3. doi: 10.1039/b304352e. PMID: 12932054.
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Ultraviolet high-spectral-resolution Rayleigh-Mie lidar with a dual-pass Fabry-Perot etalon for measuring atmospheric temperature profiles of the troposphere.

Optics letters

Hua D, Uchida M, Kobayashi T.
PMID: 15181986
Opt Lett. 2004 May 15;29(10):1063-5. doi: 10.1364/ol.29.001063.

We report what is believed to be the first demonstration of measurement of tropospheric temperature profiles in daytime by use of a high-spectral-resolution Rayleigh-Mie lidar at an eye-safe wavelength of 355 nm. Atmospheric temperature is determined from the linewidth...

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Hua D, Uchida M, Kobayashi T. Ultraviolet high-spectral-resolution Rayleigh-Mie lidar with a dual-pass Fabry-Perot etalon for measuring atmospheric temperature profiles of the troposphere. Opt Lett. 2004;29(10):1063-5doi: 10.1364/ol.29.001063.
Hua, D., Uchida, M., & Kobayashi, T. (2004). Ultraviolet high-spectral-resolution Rayleigh-Mie lidar with a dual-pass Fabry-Perot etalon for measuring atmospheric temperature profiles of the troposphere. Optics letters, 29(10), 1063-5. https://doi.org/10.1364/ol.29.001063
Hua, Dengxin, et al. "Ultraviolet high-spectral-resolution Rayleigh-Mie lidar with a dual-pass Fabry-Perot etalon for measuring atmospheric temperature profiles of the troposphere." Optics letters vol. 29,10 (2004): 1063-5. doi: https://doi.org/10.1364/ol.29.001063
Hua D, Uchida M, Kobayashi T. Ultraviolet high-spectral-resolution Rayleigh-Mie lidar with a dual-pass Fabry-Perot etalon for measuring atmospheric temperature profiles of the troposphere. Opt Lett. 2004 May 15;29(10):1063-5. doi: 10.1364/ol.29.001063. PMID: 15181986.
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Evidence for the existence of the [2 0 2]3/2 deformed band in mirror nuclei 25Mg and 25Al.

Physical review letters

Fujita Y, Hamamoto I, Fujita H, Shimbara Y, Adachi T, Berg GP, Fujita K, Hatanaka K, Kamiya J, Nakanishi K, Sakemi Y, Shimizu Y, Uchida M, Wakasa T, Yosoi M.
PMID: 14995233
Phys Rev Lett. 2004 Feb 13;92(6):062502. doi: 10.1103/PhysRevLett.92.062502. Epub 2004 Feb 13.

After 50 years of its prediction, the highest-lying [2 0 2]3/2 orbit among the six Nilsson single-particle orbits originating from the sd shells in prolately deformed nuclei and the rotational band on this orbit were identified. The band members...

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Fujita Y, Hamamoto I, Fujita H, et al. Evidence for the existence of the [2 0 2]3/2 deformed band in mirror nuclei 25Mg and 25Al. Phys Rev Lett. 2004;92(6):062502doi: 10.1103/PhysRevLett.92.062502.
Fujita, Y., Hamamoto, I., Fujita, H., Shimbara, Y., Adachi, T., Berg, G. P., Fujita, K., Hatanaka, K., Kamiya, J., Nakanishi, K., Sakemi, Y., Shimizu, Y., Uchida, M., Wakasa, T., & Yosoi, M. (2004). Evidence for the existence of the [2 0 2]3/2 deformed band in mirror nuclei 25Mg and 25Al. Physical review letters, 92(6), 062502. https://doi.org/10.1103/PhysRevLett.92.062502
Fujita, Y, et al. "Evidence for the existence of the [2 0 2]3/2 deformed band in mirror nuclei 25Mg and 25Al." Physical review letters vol. 92,6 (2004): 062502. doi: https://doi.org/10.1103/PhysRevLett.92.062502
Fujita Y, Hamamoto I, Fujita H, Shimbara Y, Adachi T, Berg GP, Fujita K, Hatanaka K, Kamiya J, Nakanishi K, Sakemi Y, Shimizu Y, Uchida M, Wakasa T, Yosoi M. Evidence for the existence of the [2 0 2]3/2 deformed band in mirror nuclei 25Mg and 25Al. Phys Rev Lett. 2004 Feb 13;92(6):062502. doi: 10.1103/PhysRevLett.92.062502. Epub 2004 Feb 13. PMID: 14995233.
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